Abstract：
:Olfaction is one of the major sensory modalities that regulates food consumption and is in turn regulated by the feeding state. Given that the olfactory bulb has been shown to be a metabolic sensor, we explored whether the anterior piriform cortex (aPCtx)-a higher olfactory cortical processing area-had the same capacity. Using immunocytochemical approaches, we report the localization of Kv1.3 channel, glucose transporter type 4, and the insulin receptor in the lateral olfactory tract and Layers II and III of the aPCtx. In current-clamped superficial pyramidal (SP) cells, we report the presence of two populations of SP cells: glucose responsive and non-glucose responsive. Using varied glucose concentrations and a glycolysis inhibitor, we found that insulin modulation of the instantaneous and spike firing frequency are both glucose dependent and require glucose metabolism. Using a plethysmograph to record sniffing frequency, rats microinjected with insulin failed to discriminate ratiometric enantiomers; considered a difficult task. Microinjection of glucose prevented discrimination of odorants of different chain-lengths, whereas injection of margatoxin increased the rate of habituation to repeated odor stimulation and enhanced discrimination. These data suggest that metabolic signaling pathways that are present in the aPCtx are capable of neuronal modulation and changing complex olfactory behaviors in higher olfactory centers.
journal_name
Brain Struct Functjournal_title
Brain structure & functionauthors
Al Koborssy D,Palouzier-Paulignan B,Canova V,Thevenet M,Fadool DA,Julliard AKdoi
10.1007/s00429-018-1776-0subject
Has Abstractpub_date
2019-01-01 00:00:00pages
315-336issue
1eissn
1863-2653issn
1863-2661pii
10.1007/s00429-018-1776-0journal_volume
224pub_type
杂志文章abstract：:The octopus arm contains a tridimensional array of muscles with a massive sensory-motor system. We herein provide the first evidence for the existence of serotonin (5-HT) in the octopus arm nervous system and investigated its distribution using immunohistochemistry. 5-HT-like immunoreactive (5-HT-lir) nerve cell bodie...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-017-1385-3
更新日期：2017-09-01 00:00:00
abstract：:Nitric oxide (NO) is well demonstrated to act as a neuronal messenger in neurotransmission in vertebrate animals. We are for the first time reporting nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) and neuronal nitric oxide synthase (nNOS) in the Mauthner cells (MC) of the carp, Labeo rohita brain dur...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-010-0292-7
更新日期：2011-03-01 00:00:00
abstract：:Growing evidence indicates that physical exercise increases hippocampal volume. This has consistently been shown in mice and men using magnetic resonance imaging. On the other hand, histological studies have reported profound alterations on a cellular level including increased adult hippocampal neurogenesis after exer...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0976-5
更新日期：2016-04-01 00:00:00
abstract：:An account of work performed at the UNA laboratories since 1992 on the detection and description of interlaminar glial processes, is presented. The incidental observation (serendipity) of longer than expected glial processes in the superficial layers of the cerebral cortex in hemiparkinsonian Cebus apella monkeys, was...
journal_title：Brain structure & function
pub_type： 历史文章,杂志文章,评审
doi：10.1007/s00429-016-1332-8
更新日期：2017-04-01 00:00:00
abstract：:Evidence suggests that extracellular matrix molecules of perivascular basal laminae help orchestrate the molecular assemblies at the gliovascular interface. Specifically, laminin and agrin are thought to tether the dystrophin-associated protein (DAP) complex to the astrocytic basal lamina. This complex includes α-synt...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-020-02036-3
更新日期：2020-03-01 00:00:00
abstract：:The axon initial segment (AIS) is responsible for both the modulation of action potentials and the maintenance of neuronal polarity. Yet, the molecular mechanisms controlling its assembly are incompletely understood. Our study in single electroporated motor neurons in mouse embryos revealed that AnkyrinG (AnkG), the A...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-013-0578-7
更新日期：2014-07-01 00:00:00
abstract：:Ghrelin is a stomach-derived hormone that regulates a variety of biological functions such as food intake, gastrointestinal function and blood glucose metabolism, among others. Ghrelin acts via the growth hormone secretagogue receptor (GHSR), a G-protein-coupled receptor located in key brain areas that mediate specifi...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-018-1682-5
更新日期：2018-09-01 00:00:00
abstract：:Children born very preterm (VPT) at less than 32 weeks' gestational age (GA) are prone to disrupted white matter maturation and impaired cognitive development. The aims of the present study were to identify differences in white matter microstructure and connectivity of children born VPT compared to term-born children,...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-018-1614-4
更新日期：2018-06-01 00:00:00
abstract：:To better understand information transfer along the hippocampal pathways and its plasticity, here we studied the antidromic responses of the dentate gyrus (DG) and CA3 to activation of the mossy fibers and Schaffer collaterals, respectively, in hippocampal slices from naïve and epileptic rats. We applied trains of 600...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-015-1003-1
更新日期：2016-05-01 00:00:00
abstract：:Early-life stress (ELS) exposure has long-term consequences for both brain structure and function and impacts cognitive and emotional behavior. The basolateral amygdala (BLA) plays an important role in anxiety and fear conditioning through its extensive anatomical and functional connections, in particular to the media...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-018-1720-3
更新日期：2018-11-01 00:00:00
abstract：:The extensive and increasing use of structural neuroimaging in the neurosciences rests on the assumption of an intimate relationship between structure and function in the human brain. However, few studies have examined the relationship between advanced magnetic resonance imaging (MRI) indices of cerebral structure and...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-013-0703-7
更新日期：2015-03-01 00:00:00
abstract：:In the embryonic head of vertebrates, neurogenic and non-neurogenic ectodermal placodes arise from the panplacodal primordium. Whether and how growth processes of the ectodermal layer, changes in the transcriptional precursor cell profile, or positional changes among precursor cells contribute to interplacodal boundar...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-012-0429-y
更新日期：2013-05-01 00:00:00
abstract：:The process of learning mainly depends on the ability to store new information, while the ability to retrieve this information and express appropriate behaviors are also crucial for the adaptation of individuals to environmental cues. Thereby, all three components contribute to the cognitive fitness of an individual. ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0882-x
更新日期：2015-11-01 00:00:00
abstract：:Previous diffusion tensor imaging (DTI) studies have shown that various factors can affect white matter (WM) tract diffusivity. The aim of the present study was to investigate the effects of childhood adversity (CA), age and gender on WM diffusivity in tracts that are thought to be involved in emotional regulation in ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0769-x
更新日期：2015-07-01 00:00:00
abstract：:The paraventricular nucleus of the thalamus (PVT) is part of a group of midline and intralaminar thalamic nuclei implicated in arousal and attention. Recent research points to anatomical and functional differences between the anterior (aPVT) and posterior PVT (pPVT). The present study re-examines the main sources of b...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-011-0360-7
更新日期：2012-04-01 00:00:00
abstract：:During the development of the central nervous system, the immature neurons suffer different migration processes. It is well known that Nkx2.1-positive ventricular layer give rise to critical tangential migrations into different regions of the developing forebrain. Our aim was to study this phenomenon in the hypothalam...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-020-02163-x
更新日期：2020-12-01 00:00:00
abstract：:In recent years, the demonstration that structural changes can occur in the human brain beyond those associated with development, ageing and neuropathology has revealed a new approach to studying the neural basis of behaviour. In this review paper, we focus on structural imaging studies of language that have utilised ...
journal_title：Brain structure & function
pub_type： 杂志文章,评审
doi：10.1007/s00429-009-0211-y
更新日期：2009-10-01 00:00:00
abstract：:To date, hampered physiological function after exposure to microgravity has been primarily attributed to deprived peripheral neuro-sensory systems. For the first time, this study elucidates alterations in human brain function after long-duration spaceflight. More specifically, we found significant differences in resti...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-015-1054-3
更新日期：2016-06-01 00:00:00
abstract：:Exercise (physical activity) has been proposed as a treatment for drug addiction. In rodents, voluntary wheel running reduces cocaine and nicotine seeking during extinction, and reinstatement of cocaine seeking triggered by drug-cues. The purpose of this study was to examine the effects of chronic wheel running during...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0905-7
更新日期：2016-01-01 00:00:00
abstract：:To establish the link between structure and function of any large area of the neocortex, it is helpful to identify its principles of organisation. One way to establish such principles is to investigate how differences in whole-brain connectivity are structured across the area. Here, we use Laplacian eigenmaps on diffu...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-020-02047-0
更新日期：2020-05-01 00:00:00
abstract：:The striosome (or patch) was first identified with anatomical techniques as neurons organized in a three-dimensional labyrinth inserted in and interdigitating the rest of neostriatum: the matrix. Striosome and matrix rapidly became known as two neuronal compartments expressing different biochemical markers, embryonic ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-015-1000-4
更新日期：2016-04-01 00:00:00
abstract：:The developing cerebellum is extremely vulnerable to hypoxia which can damage the Purkinje neurons. We hypothesized that this might be mediated by tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) derived from activated microglia as in other brain areas. One-day-old rats were subjected to hypoxia following, w...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-012-0491-5
更新日期：2014-01-01 00:00:00
abstract：:Different genotypic combinations of COMT and DRD2 can generate multiple subgroups with different levels of dopamine signaling. Its modulations on brain properties can be investigated by analyzing the combined gene effects of COMT and DRD2. However, the inherent association between modulation patterns of the dopamine s...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-015-1134-4
更新日期：2016-11-01 00:00:00
abstract：:Neuroimaging studies have demonstrated that mental imagery and perception share similar neural substrates, however, there are still ambiguities according to different auditory imagery content. In addition, there is still a lack of information regarding the underlying neural correlation between the two modalities. In t...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-019-01948-z
更新日期：2019-11-01 00:00:00
abstract：:Higher cognitive processes and emotional regulation depend on densely interconnected telencephalic and limbic areas. Central structures of this cortico-limbic network are ventral hippocampus (vHC), medial prefrontal cortex (PFC), basolateral amygdala (BLA) and nucleus accumbens (NAC). Human and animal studies have rev...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-020-02202-7
更新日期：2021-01-13 00:00:00
abstract：:Recently, there have been great interests for computer-aided diagnosis of Alzheimer's disease (AD) and its prodromal stage, mild cognitive impairment (MCI). Unlike the previous methods that considered simple low-level features such as gray matter tissue volumes from MRI, and mean signal intensities from PET, in this p...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-013-0687-3
更新日期：2015-03-01 00:00:00
abstract：:The acoustic radiation is a compact bundle of fibers conveying auditory information from the medial geniculate nucleus of the thalamus to the auditory cortex. Topographical knowledge of this bundle in primates is scarce and in vivo diffusion-based tractography reconstructions in humans remains challenging, especially ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-017-1471-6
更新日期：2018-01-01 00:00:00
abstract：:The amygdala and medial prefrontal cortex (mPFC) are highly interconnected telencephalic areas critical for cognitive processes, including associative learning and decision making. Both structures strongly innervate the lateral hypothalamus (LHA), an important component of the networks underlying the control of feedin...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-015-1081-0
更新日期：2016-07-01 00:00:00
abstract：:A recent virtual-lesion study using inhibitory repetitive transcranial magnetic stimulation (rTMS) confirmed the causal behavioral relevance of the precuneus in the evaluation of one's own memory performance (aka mnemonic metacognition). This study's goal is to elucidate how these TMS-induced neuromodulatory effects m...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-019-01909-6
更新日期：2019-09-01 00:00:00
abstract：:The midline and intralaminar thalamic nuclei (MITN), locus coeruleus (LC) and cingulate cortex contain nociceptive neurons. The MITN that project to cingulate cortex have a prominent innervation by norepinephrinergic axons primarily originating from the LC. The hypothesis explored in this study is that MITN neurons th...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-008-0178-0
更新日期：2008-08-01 00:00:00
