Abstract:
:Evidence suggests that extracellular matrix molecules of perivascular basal laminae help orchestrate the molecular assemblies at the gliovascular interface. Specifically, laminin and agrin are thought to tether the dystrophin-associated protein (DAP) complex to the astrocytic basal lamina. This complex includes α-syntrophin (α-Syn), which is believed to anchor aquaporin-4 (AQP4) to astrocytic endfoot membrane domains. We have previously shown that the size of the perivascular AQP4 pool differs considerably between brain regions in an α-Syn-dependent manner. Also, both AQP4 and α-Syn occur at higher densities in endfoot membrane domains facing pericytes than in endfoot membrane domains facing endothelial cells. The heterogeneous distribution of AQP4 at the regional and capillary level has been attributed to a direct interaction between AQP4 and α-Syn. This would be challenged (1) if the microdistributions of laminin and agrin fail to align with those of DAP and AQP4 and (2) if targeted deletion of α-Syn leads to a loss of laminin and/or agrin. Here, we provide the first detailed and quantitative analysis of laminin and agrin in brain basal laminae of mice. We show that the microdistributions of these molecules vary in a fashion that is well aligned with the previously reported microdistribution of AQP4. We also demonstrate that the expression patterns of laminin and agrin are insensitive to targeted deletion of α-Syn, suggesting that α-Syn deletion affects AQP4 directly and not indirectly via laminin or agrin. These data fill remaining voids in the current model of how key molecules are assembled and tethered at the gliovascular interface.
journal_name
Brain Struct Functjournal_title
Brain structure & functionauthors
Hoddevik EH,Rao SB,Zahl S,Boldt HB,Ottersen OP,Amiry-Moghaddam Mdoi
10.1007/s00429-020-02036-3subject
Has Abstractpub_date
2020-03-01 00:00:00pages
805-816issue
2eissn
1863-2653issn
1863-2661pii
10.1007/s00429-020-02036-3journal_volume
225pub_type
杂志文章abstract::Hippocampal atrophy and neuron loss are commonly found in Alzheimer's disease (AD). However, the underlying molecular mechanisms and the fate in the AD hippocampus of subpopulations of interneurons that express the calcium-binding proteins parvalbumin (PV) and calretinin (CR) has not yet been properly assessed. Using ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-010-0242-4
更新日期:2010-03-01 00:00:00
abstract::Growing evidence indicates that physical exercise increases hippocampal volume. This has consistently been shown in mice and men using magnetic resonance imaging. On the other hand, histological studies have reported profound alterations on a cellular level including increased adult hippocampal neurogenesis after exer...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0976-5
更新日期:2016-04-01 00:00:00
abstract::In the mammalian auditory system, the medial nucleus of the trapezoid body and the lateral superior olive (MNTB-LSO system) contribute to binaural intensity processing and lateralization. Localization precision varies with the sound frequencies. As recency of common ancestry with human beings increases, primates have ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-008-0201-5
更新日期:2009-09-01 00:00:00
abstract::The adult dentate gyrus produces new neurons that morphologically and functionally integrate into the hippocampal network. In the adult brain, most excitatory synapses are ensheathed by astrocytic perisynaptic processes that regulate synaptic structure and function. However, these processes are formed during embryonic...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0768-y
更新日期:2015-07-01 00:00:00
abstract::Sex differences are widespread across vertebrate nervous systems. Such differences are sometimes reflected in the neural substrate via neuroanatomical differences in brain region volume. One brain region that displays sex differences in its associated functions and pathologies is the striatum, including the caudate-pu...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-015-1158-9
更新日期:2016-11-01 00:00:00
abstract::The pedunculopontine nucleus (PPN), a cholinergic nucleus of the reticular activating system, is known to be involved in the regulation of sleep and wakefulness. Endogenous and exogenous cannabinoids, by systemic or local administration to the pedunculopontine nucleus, can both influence sleep. We previously demonstra...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1214-0
更新日期:2017-01-01 00:00:00
abstract::Multisensory integration does not only recruit higher-level association cortex, but also low-level and even primary sensory cortices. Here, we will describe and quantify two types of anatomical pathways, a thalamocortical and a corticocortical that possibly underlie short-latency multisensory integration processes in ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0694-4
更新日期:2015-03-01 00:00:00
abstract::Animal models of Alzheimer's disease (AD) can be used to determine the progressive neurodegeneration characteristics of AD in vivo using magnetic resonance imaging (MRI). Given the need for therapeutic interventions before the onset of frank AD, it is critical to examine if AD models demonstrate neuroanatomical remode...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1691-4
更新日期:2018-09-01 00:00:00
abstract::Diverse stress stimuli induce long-lasting cognitive deficits, but the underlying molecular mechanisms are still incompletely understood. Here, we report three different stress models demonstrating that stress-inducible increases in microRNA-132 (miR-132) and consequent decreases in its acetylcholinesterase (AChE) tar...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-011-0376-z
更新日期:2013-01-01 00:00:00
abstract::To establish the link between structure and function of any large area of the neocortex, it is helpful to identify its principles of organisation. One way to establish such principles is to investigate how differences in whole-brain connectivity are structured across the area. Here, we use Laplacian eigenmaps on diffu...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02047-0
更新日期:2020-05-01 00:00:00
abstract::Striatal fast-spiking interneurons (FSIs) potently inhibit the output neurons of the striatum and, as such, powerfully modulate action learning. Through electrical synaptic coupling, FSIs are theorized to temporally coordinate their activity. This has important implications for their ability to temporally summate inhi...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-019-01908-7
更新日期:2019-09-01 00:00:00
abstract::The present study documents the morphology of neurons in several regions of the neocortex from the bottlenose dolphin (Tursiops truncatus), the North Atlantic minke whale (Balaenoptera acutorostrata), and the humpback whale (Megaptera novaeangliae). Golgi-stained neurons (n = 210) were analyzed in the frontal and temp...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0860-3
更新日期:2015-11-01 00:00:00
abstract::Deficient prefrontal cortex (PFC) GABA function is hypothesized to play a role in schizophrenia and other psychiatric disorders. In rodents, PFC GABAA receptor antagonism produces cognitive and behavioral changes relevant to these disorders, including impaired spatial memory assessed with the traditional working/refer...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1769-z
更新日期:2019-01-01 00:00:00
abstract::Emerging data support roles for microRNA (miRNA) in the pathogenesis of various neurologic disorders including epilepsy. MicroRNA-134 (miR-134) is enriched in dendrites of hippocampal neurons, where it negatively regulates spine volume. Recent work identified upregulation of miR-134 in experimental and human epilepsy....
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0798-5
更新日期:2015-07-01 00:00:00
abstract::The functional specificity of brain areas is diminished with age and accompanied by the recruitment of additional brain regions in healthy older adults. This process has repeatedly been demonstrated within distinct functional domains, in particular the visual system. However, it is yet unclear, whether this phenomenon...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0530-x
更新日期:2014-03-01 00:00:00
abstract::Von Economo's neurons (VENs) are large, bipolar or corkscrew-shaped neurons located in layers III and V of the frontoinsular and the anterior cingulate cortices. VENs are reported to be altered in pathologies such as frontotemporal dementia and autism, in which the individual's self control is seriously compromised. T...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-012-0382-9
更新日期:2013-01-01 00:00:00
abstract::Previous work in the precocious rodent Octodon degus has shown that exposure to early life stress (ELS) (induced by repeated parental separation) results in changes of excitatory, inhibitory and modulatory transmitter systems in prefrontal and limbic regions of the male brain. The aim of this study was to test the hyp...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0688-2
更新日期:2015-03-01 00:00:00
abstract::Pitch is a primary perceptual dimension of sounds and is crucial in music and speech perception. When listening to melodies, most humans encode the relations between pitches into memory using an ability called relative pitch (RP). A small subpopulation, almost exclusively musicians, preferentially encode pitches using...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-019-01872-2
更新日期:2019-06-01 00:00:00
abstract::Identifying cerebral vulnerability in late life is of paramount importance to prevent pathological trajectories of aging before the onset of symptoms. Considerable evidence suggests that impaired antioxidant mechanisms are a fingerprint of aging-related conditions, but there is a lack of human research linking total a...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02039-0
更新日期:2020-03-01 00:00:00
abstract::Recently, neuroimaging-based Alzheimer's disease (AD) or mild cognitive impairment (MCI) diagnosis has attracted researchers in the field, due to the increasing prevalence of the diseases. Unfortunately, the unfavorable high-dimensional nature of neuroimaging data, but a limited small number of samples available, make...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-015-1059-y
更新日期:2016-06-01 00:00:00
abstract::The midline and intralaminar thalamic nuclei (MITN), locus coeruleus (LC) and cingulate cortex contain nociceptive neurons. The MITN that project to cingulate cortex have a prominent innervation by norepinephrinergic axons primarily originating from the LC. The hypothesis explored in this study is that MITN neurons th...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-008-0178-0
更新日期:2008-08-01 00:00:00
abstract::In the embryonic head of vertebrates, neurogenic and non-neurogenic ectodermal placodes arise from the panplacodal primordium. Whether and how growth processes of the ectodermal layer, changes in the transcriptional precursor cell profile, or positional changes among precursor cells contribute to interplacodal boundar...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-012-0429-y
更新日期:2013-05-01 00:00:00
abstract::Serotonin neurons arise from the brainstem raphe nuclei and send their projections throughout the brain to release 5-HT which acts as a modulator of several neuronal populations. Previous electron microscopy studies in rats have morphologically determined the distribution of 5-HT release sites (boutons) in certain bra...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1278-x
更新日期:2017-04-01 00:00:00
abstract::The basal ganglia are a group of subpallial nuclei that play an important role in motor, emotional, and cognitive functions. Morphological changes and disrupted afferent/efferent connections in the basal ganglia have been associated with a variety of neurological disorders including psychiatric and movement disorders....
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0572-0
更新日期:2014-07-01 00:00:00
abstract::The connectivity hub property of the hippocampus (HIP) and the medial prefrontal cortex (MPFC) is essential for their widespread involvement in cognition; however, the cooperation mechanism between them is far from clear. Herein, using resting-state functional MRI and Gaussian Bayesian network to describe the directed...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02077-8
更新日期:2020-06-01 00:00:00
abstract::The variety of different causal theories together with inconsistencies about the anatomical brain markers emphasize the heterogeneity of developmental dyslexia. Attempts were made to test on a behavioral level the existence of subtypes of dyslexia showing distinguishable cognitive deficits. Importantly, no research wa...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0595-6
更新日期:2014-09-01 00:00:00
abstract::Interest in the study of brain connectivity is growing, particularly in understanding the dynamics of the structural/functional connectivity relation. Structural and functional connectivity are most often analysed independently of each other. Track-weighted functional connectivity (TW-FC) was recently proposed as a me...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1431-1
更新日期:2017-11-01 00:00:00
abstract::Substance used during adolescent period increases the risk of psychiatric disorders in later life, but the underlying neural mechanisms remain unclear. We hypothesize that synaptic remodeling and changes of homeostasis in the medial prefrontal cortex (mPFC) following adolescent cocaine exposure may last for a long tim...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1590-0
更新日期:2018-05-01 00:00:00
abstract::The ventral striatum (VS) is of particular interest in the study of neuropsychiatric disorders. In this study, performed on non-human primates, we associated local perturbation with monosynaptic axonal tracer injection into medial, central and lateral VS to characterize anatomo-functional circuits underlying the respe...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0911-9
更新日期:2016-01-01 00:00:00
abstract::The dorsal part of the developing telencephalon is one of the brain areas that has suffered most drastic changes throughout vertebrate evolution. Its evolutionary increase in complexity was thought to be partly achieved by the appearance of a new neurogenic niche in the embryonic subventricular zone (SVZ). Here, a new...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1705-2
更新日期:2018-11-01 00:00:00