Possible anatomical pathways for short-latency multisensory integration processes in primary sensory cortices.

Abstract:

:Multisensory integration does not only recruit higher-level association cortex, but also low-level and even primary sensory cortices. Here, we will describe and quantify two types of anatomical pathways, a thalamocortical and a corticocortical that possibly underlie short-latency multisensory integration processes in the primary auditory (A1), somatosensory (S1), and visual cortex (V1). Results were obtained from Mongolian gerbils, a common model-species in neuroscience, using simultaneous injections of different retrograde tracers into A1, S1, and V1. Several auditory, visual, and somatosensory thalamic nuclei project not only to the primary sensory area of their own (matched) but also to areas of other (non-matched) modalities. The crossmodal output ratios of these nuclei, belonging to both core and non-core sensory pathways, vary between 0.4 and 63.5 % of the labeled neurons. Approximately 0.3 % of the sensory thalamic input to A1, 5.0 % to S1, and 2.1 % to V1 arise from non-matched nuclei. V1 has most crossmodal corticocortical connections, projecting strongest to S1 and receiving a similar amount of moderate inputs from A1 and S1. S1 is mainly interconnected with V1. A1 has slightly more projections to V1 than S1, but gets just faint inputs from there. Concerning the layer-specific distribution of the retrogradely labeled somata in cortex, V1 provides the most pronounced feedforward-type outputs and receives (together with S1) most pronounced feedback-type inputs. In contrast, A1 has most pronounced feedback-type outputs and feedforward-type inputs in this network. Functionally, the different sets of thalamocortical and corticocortical connections could underlie distinctive types of integration mechanisms for different modality pairings.

journal_name

Brain Struct Funct

authors

Henschke JU,Noesselt T,Scheich H,Budinger E

doi

10.1007/s00429-013-0694-4

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

955-77

issue

2

eissn

1863-2653

issn

1863-2661

journal_volume

220

pub_type

杂志文章
  • Hippocampal microRNA-132 mediates stress-inducible cognitive deficits through its acetylcholinesterase target.

    abstract::Diverse stress stimuli induce long-lasting cognitive deficits, but the underlying molecular mechanisms are still incompletely understood. Here, we report three different stress models demonstrating that stress-inducible increases in microRNA-132 (miR-132) and consequent decreases in its acetylcholinesterase (AChE) tar...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-011-0376-z

    authors: Shaltiel G,Hanan M,Wolf Y,Barbash S,Kovalev E,Shoham S,Soreq H

    更新日期:2013-01-01 00:00:00

  • Differential distribution of phospholipase C beta isoforms and diaglycerol kinase-beta in rodents cerebella corroborates the division of unipolar brush cells into two major subtypes.

    abstract::Sublineage diversification of specific neural cell classes occurs in complex as well as simply organized regions of the central and peripheral nervous systems; the significance of the phenomenon, however, remains insufficiently understood. The unipolar brush cells (UBCs) are glutamatergic cerebellar interneurons that ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0531-9

    authors: Sekerková G,Watanabe M,Martina M,Mugnaini E

    更新日期:2014-03-01 00:00:00

  • Assessing a signal model and identifying brain activity from fMRI data by a detrending-based fractal analysis.

    abstract::One of the major challenges of functional magnetic resonance imaging (fMRI) data analysis is to develop simple and reliable methods to correlate brain regions with functionality. In this paper, we employ a detrending-based fractal method, called detrended fluctuation analysis (DFA), to identify brain activity from fMR...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-007-0166-9

    authors: Hu J,Lee JM,Gao J,White KD,Crosson B

    更新日期:2008-02-01 00:00:00

  • Deficits in task-set maintenance and execution networks in Parkinson's disease.

    abstract::Patients with Parkinson's disease have difficulties with self-initiating a task and maintaining a steady task performance. We hypothesized that these difficulties relate to reorganization in the sensorimotor execution, cingulo-opercular task-set maintenance, and frontoparietal adaptive control networks. We tested this...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0981-8

    authors: Tinaz S,Lauro P,Hallett M,Horovitz SG

    更新日期:2016-04-01 00:00:00

  • Increased hippocampal excitability and impaired spatial memory function in mice lacking VGLUT2 selectively in neurons defined by tyrosine hydroxylase promoter activity.

    abstract::Three populations of neurons expressing the vesicular glutamate transporter 2 (Vglut2) were recently described in the A10 area of the mouse midbrain, of which two populations were shown to express the gene encoding, the rate-limiting enzyme for catecholamine synthesis, tyrosine hydroxylase (TH).One of these population...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0778-9

    authors: Nordenankar K,Smith-Anttila CJ,Schweizer N,Viereckel T,Birgner C,Mejia-Toiber J,Morales M,Leao RN,Wallén-Mackenzie Å

    更新日期:2015-07-01 00:00:00

  • Role of TRH/UCN3 neurons of the perifornical area/bed nucleus of stria terminalis region in the regulation of the anorexigenic POMC neurons of the arcuate nucleus in male mice and rats.

    abstract::Two anorexigenic peptides, thyrotropin-releasing hormone (TRH) and urocortin 3 (UCN3), are co-expressed in a continuous neuronal group that extends from the perifornical area to the bed nucleus of stria terminalis, raising the possibility that this cell group may be involved in the regulation of energy homeostasis. In...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-017-1553-5

    authors: Péterfi Z,Farkas E,Nagyunyomi-Sényi K,Kádár A,Ottó S,Horváth A,Füzesi T,Lechan RM,Fekete C

    更新日期:2018-04-01 00:00:00

  • Sensory properties of the caudal aspect of the macaque's superior parietal lobule.

    abstract::In the superior parietal lobule (SPL), the anterior part (area PE) is known to process somatosensory information, while the caudalmost part (areas V6Av and V6) processes visual information. Here we studied the visual and somatosensory properties of the areas PEc and V6Ad located in between the somatosensory and visual...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-017-1593-x

    authors: Gamberini M,Dal Bò G,Breveglieri R,Briganti S,Passarelli L,Fattori P,Galletti C

    更新日期:2018-05-01 00:00:00

  • Proprioceptive thalamus receiving forelimb and neck muscle spindle inputs via the external cuneate nucleus in the rat.

    abstract::Proprioceptive signals from body muscles have historically been considered to project to the rostrodorsal shell of the ventrobasal thalamic complex [the ventral posterolateral nucleus (VPL) and ventral posteromedial nucleus (VPM)]. However, we have recently found that proprioception from rat jaw-closing muscle spindle...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-020-02118-2

    authors: Uemura Y,Haque T,Sato F,Tsutsumi Y,Ohara H,Oka A,Furuta T,Bae YC,Yamashiro T,Tachibana Y,Yoshida A

    更新日期:2020-09-01 00:00:00

  • Genetic sex and the volumes of the caudate-putamen, nucleus accumbens core and shell: original data and a review.

    abstract::Sex differences are widespread across vertebrate nervous systems. Such differences are sometimes reflected in the neural substrate via neuroanatomical differences in brain region volume. One brain region that displays sex differences in its associated functions and pathologies is the striatum, including the caudate-pu...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-015-1158-9

    authors: Wong JE,Cao J,Dorris DM,Meitzen J

    更新日期:2016-11-01 00:00:00

  • Neuroligin-1 regulates excitatory synaptic transmission, LTP and EPSP-spike coupling in the dentate gyrus in vivo.

    abstract::Neuroligins are transmembrane cell adhesion proteins with a key role in the regulation of excitatory and inhibitory synapses. Based on previous in vitro and ex vivo studies, neuroligin-1 (NL1) has been suggested to play a selective role in the function of glutamatergic synapses. However, the role of NL1 has not yet be...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0636-1

    authors: Jedlicka P,Vnencak M,Krueger DD,Jungenitz T,Brose N,Schwarzacher SW

    更新日期:2015-01-01 00:00:00

  • Activation shift in elderly subjects across functional systems: an fMRI study.

    abstract::The functional specificity of brain areas is diminished with age and accompanied by the recruitment of additional brain regions in healthy older adults. This process has repeatedly been demonstrated within distinct functional domains, in particular the visual system. However, it is yet unclear, whether this phenomenon...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0530-x

    authors: Roski C,Caspers S,Lux S,Hoffstaedter F,Bergs R,Amunts K,Eickhoff SB

    更新日期:2014-03-01 00:00:00

  • Altered neuronal architecture and plasticity in the visual cortex of adult MMP-3-deficient mice.

    abstract::Matrix metalloproteinases (MMPs) are Zn(2+)-dependent endopeptidases considered to be essential for normal brain development and neuroplasticity by modulating extracellular matrix proteins, receptors, adhesion molecules, growth factors and cytoskeletal proteins. Specifically, MMP-3 has recently been implicated in syna...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0819-4

    authors: Aerts J,Nys J,Moons L,Hu TT,Arckens L

    更新日期:2015-09-01 00:00:00

  • Organization of connections between the amygdala, medial prefrontal cortex, and lateral hypothalamus: a single and double retrograde tracing study in rats.

    abstract::The amygdala and medial prefrontal cortex (mPFC) are highly interconnected telencephalic areas critical for cognitive processes, including associative learning and decision making. Both structures strongly innervate the lateral hypothalamus (LHA), an important component of the networks underlying the control of feedin...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-015-1081-0

    authors: Reppucci CJ,Petrovich GD

    更新日期:2016-07-01 00:00:00

  • Group-constrained sparse fMRI connectivity modeling for mild cognitive impairment identification.

    abstract::Emergence of advanced network analysis techniques utilizing resting-state functional magnetic resonance imaging (R-fMRI) has enabled a more comprehensive understanding of neurological disorders at a whole-brain level. However, inferring brain connectivity from R-fMRI is a challenging task, particularly when the ultima...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0524-8

    authors: Wee CY,Yap PT,Zhang D,Wang L,Shen D

    更新日期:2014-03-01 00:00:00

  • TMS of the occipital face area modulates cross-domain identity priming.

    abstract::Accumulating evidence suggests that besides its function in early facial feature processing, the role of the right occipital face area (rOFA) extends to higher level, image-independent processing. Recent studies hint at the possibility that the activity of this region can be modulated by semantic information as well. ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1768-0

    authors: Ambrus GG,Amado C,Krohn L,Kovács G

    更新日期:2019-01-01 00:00:00

  • Early life stress and sex-specific sensitivity of the catecholaminergic systems in prefrontal and limbic regions of Octodon degus.

    abstract::Previous work in the precocious rodent Octodon degus has shown that exposure to early life stress (ELS) (induced by repeated parental separation) results in changes of excitatory, inhibitory and modulatory transmitter systems in prefrontal and limbic regions of the male brain. The aim of this study was to test the hyp...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0688-2

    authors: Kunzler J,Braun K,Bock J

    更新日期:2015-03-01 00:00:00

  • Frontotemporal correlates of impulsivity and machine learning in retired professional athletes with a history of multiple concussions.

    abstract::The frontotemporal cortical network is associated with behaviours such as impulsivity and aggression. The health of the uncinate fasciculus (UF) that connects the orbitofrontal cortex (OFC) with the anterior temporal lobe (ATL) may be a crucial determinant of behavioural regulation. Behavioural changes can emerge afte...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-015-1012-0

    authors: Goswami R,Dufort P,Tartaglia MC,Green RE,Crawley A,Tator CH,Wennberg R,Mikulis DJ,Keightley M,Davis KD

    更新日期:2016-05-01 00:00:00

  • Direct presynaptic and indirect astrocyte-mediated mechanisms both contribute to endocannabinoid signaling in the pedunculopontine nucleus of mice.

    abstract::The pedunculopontine nucleus (PPN), a cholinergic nucleus of the reticular activating system, is known to be involved in the regulation of sleep and wakefulness. Endogenous and exogenous cannabinoids, by systemic or local administration to the pedunculopontine nucleus, can both influence sleep. We previously demonstra...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-016-1214-0

    authors: Kovács A,Bordás C,Bíró T,Hegyi Z,Antal M,Szücs P,Pál B

    更新日期:2017-01-01 00:00:00

  • Antagomirs targeting microRNA-134 increase hippocampal pyramidal neuron spine volume in vivo and protect against pilocarpine-induced status epilepticus.

    abstract::Emerging data support roles for microRNA (miRNA) in the pathogenesis of various neurologic disorders including epilepsy. MicroRNA-134 (miR-134) is enriched in dendrites of hippocampal neurons, where it negatively regulates spine volume. Recent work identified upregulation of miR-134 in experimental and human epilepsy....

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0798-5

    authors: Jimenez-Mateos EM,Engel T,Merino-Serrais P,Fernaud-Espinosa I,Rodriguez-Alvarez N,Reynolds J,Reschke CR,Conroy RM,McKiernan RC,deFelipe J,Henshall DC

    更新日期:2015-07-01 00:00:00

  • Altered functional connectivity networks in acallosal and socially impaired BTBR mice.

    abstract::Agenesis of the corpus callosum (AgCC) is a congenital condition associated with wide-ranging emotional and social impairments often overlapping with the diagnostic criteria for autism. Mapping functional connectivity in the acallosal brain can help identify neural correlates of the deficits associated with this condi...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0948-9

    authors: Sforazzini F,Bertero A,Dodero L,David G,Galbusera A,Scattoni ML,Pasqualetti M,Gozzi A

    更新日期:2016-03-01 00:00:00

  • Functional anatomy of cortical areas characterized by Von Economo neurons.

    abstract::Von Economo's neurons (VENs) are large, bipolar or corkscrew-shaped neurons located in layers III and V of the frontoinsular and the anterior cingulate cortices. VENs are reported to be altered in pathologies such as frontotemporal dementia and autism, in which the individual's self control is seriously compromised. T...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-012-0382-9

    authors: Cauda F,Torta DM,Sacco K,D'Agata F,Geda E,Duca S,Geminiani G,Vercelli A

    更新日期:2013-01-01 00:00:00

  • Effects of neonatal ethanol on cerebral cortex development through adolescence.

    abstract::Neonatal brain lesions cause deficits in structure and function of the cerebral cortex that sometimes are not fully expressed until adolescence. To better understand the onset and persistence of changes caused by postnatal day 7 (P7) ethanol treatment, we examined neocortical cell numbers, volume, surface area and thi...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-019-01881-1

    authors: Smiley JF,Bleiwas C,Masiello K,Petkova E,Betz J,Hui M,Wilson DA,Saito M

    更新日期:2019-06-01 00:00:00

  • Young, active and well-connected: adult-born neurons in the zebra finch are activated during singing.

    abstract::Neuronal replacement in the pallial song control nucleus HVC of adult zebra finches constitutes an interesting case of homeostatic plasticity; in spite of continuous addition and attrition of neurons in ensembles that code song elements, adult song remains remarkably invariant. New neurons migrate into HVC and later s...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-015-1006-y

    authors: Tokarev K,Boender AJ,Claßen GA,Scharff C

    更新日期:2016-05-01 00:00:00

  • The neostriatum: two entities, one structure?

    abstract::The striosome (or patch) was first identified with anatomical techniques as neurons organized in a three-dimensional labyrinth inserted in and interdigitating the rest of neostriatum: the matrix. Striosome and matrix rapidly became known as two neuronal compartments expressing different biochemical markers, embryonic ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-015-1000-4

    authors: Lopez-Huerta VG,Nakano Y,Bausenwein J,Jaidar O,Lazarus M,Cherassse Y,Garcia-Munoz M,Arbuthnott G

    更新日期:2016-04-01 00:00:00

  • Comparison of the locomotor-activating effects of bicuculline infusions into the preoptic area and ventral pallidum.

    abstract::Ambulatory locomotion in the rodent is robustly activated by unilateral infusions into the basal forebrain of type A gamma-aminobutyric acid receptor antagonists, such as bicuculline and picrotoxin. The present study was carried out to better localize the neuroanatomical substrate(s) underlying this effect. To accompl...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0514-x

    authors: Zahm DS,Schwartz ZM,Lavezzi HN,Yetnikoff L,Parsley KP

    更新日期:2014-03-01 00:00:00

  • Y-P30 promotes axonal growth by stabilizing growth cones.

    abstract::The 30-amino acid peptide Y-P30, generated from the N-terminus of the human dermcidin precursor protein, has been found to promote neuronal survival, cell migration and neurite outgrowth by enhancing the interaction of pleiotrophin and syndecan-3. We now show that Y-P30 activates Src kinase and extracellular signal-re...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0764-2

    authors: Neumann JR,Dash-Wagh S,Jüngling K,Tsai T,Meschkat M,Räk A,Schönfelder S,Riedel C,Hamad MI,Wiese S,Pape HC,Gottmann K,Kreutz MR,Wahle P

    更新日期:2015-07-01 00:00:00

  • Myosin II regulates actin rearrangement-related structural synaptic plasticity during conditioned taste aversion memory extinction.

    abstract::Similar to memory formation, memory extinction is also a new learning process that requires synaptic plasticity. Actin rearrangement is fundamental for synaptic plasticity, however, whether actin rearrangement in the infralimbic cortex (IL) plays a role in memory extinction, as well as the mechanisms underlying it, re...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0685-5

    authors: Bi AL,Wang Y,Zhang S,Li BQ,Sun ZP,Bi HS,Chen ZY

    更新日期:2015-03-01 00:00:00

  • Adolescent cocaine exposure induces prolonged synaptic modifications in medial prefrontal cortex of adult rats.

    abstract::Substance used during adolescent period increases the risk of psychiatric disorders in later life, but the underlying neural mechanisms remain unclear. We hypothesize that synaptic remodeling and changes of homeostasis in the medial prefrontal cortex (mPFC) following adolescent cocaine exposure may last for a long tim...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-017-1590-0

    authors: Zhu W,Ge X,Gao P,Li M,Guan Y,Guan X

    更新日期:2018-05-01 00:00:00

  • Influence of the DRD2/ANKK1 Taq1A polymorphism on caudate volume in older adults without dementia.

    abstract::Dopaminergic neuromodulation is critically important for brain and cognitive integrity. The DRD2/ANKK1 Taq1A polymorphism is associated with striatal dopamine (DA) D2 receptor availability. Some previous studies have found that the A allele of the Taq1A polymorphism influences brain structure, but the results are inco...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1650-0

    authors: Li X,Papenberg G,Kalpouzos G,Bäckman L,Persson J

    更新日期:2018-07-01 00:00:00

  • The hippocampus and exercise: histological correlates of MR-detected volume changes.

    abstract::Growing evidence indicates that physical exercise increases hippocampal volume. This has consistently been shown in mice and men using magnetic resonance imaging. On the other hand, histological studies have reported profound alterations on a cellular level including increased adult hippocampal neurogenesis after exer...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0976-5

    authors: Biedermann SV,Fuss J,Steinle J,Auer MK,Dormann C,Falfán-Melgoza C,Ende G,Gass P,Weber-Fahr W

    更新日期:2016-04-01 00:00:00