Abstract:
:Von Economo's neurons (VENs) are large, bipolar or corkscrew-shaped neurons located in layers III and V of the frontoinsular and the anterior cingulate cortices. VENs are reported to be altered in pathologies such as frontotemporal dementia and autism, in which the individual's self control is seriously compromised. To investigate the role of VENs in the active human brain, we have explored the functional connectivity of brain areas containing VENs by analyzing resting state functional connectivity (rsFC) in 20 healthy volunteers. Our results show that cortical areas containing VENs form a network of frontoparietal functional connectivity. With the use of fuzzy clustering techniques, we find that this network comprises four sub-networks: the first network cluster resembles a "saliency detection" attentional network, which includes superior frontal cortex (Brodmann's Area, BA 10), inferior parietal lobe, anterior insula, and dorsal anterior cingulate cortex; the second cluster, part of a "sensory-motor network", comprises the superior temporal, precentral and postcentral areas; the third cluster consists of frontal ventromedial and ventrodorsal areas constituted by parts of the "anterior default mode network"; and the fourth cluster encompasses dorsal anterior cingulate cortex, dorsomedial prefrontal, and superior frontal (BA 10) areas, resembling the anterior part of the "dorsal attentional network". Thus, the network that emerges from analyzing functional connectivity among areas that are known to contain VENs is primarily involved in functions of saliency detection and self-regulation. In addition, parts of this network constitute sub-networks that partially overlap with the default mode, the sensory-motor and the dorsal attentional networks.
journal_name
Brain Struct Functjournal_title
Brain structure & functionauthors
Cauda F,Torta DM,Sacco K,D'Agata F,Geda E,Duca S,Geminiani G,Vercelli Adoi
10.1007/s00429-012-0382-9subject
Has Abstractpub_date
2013-01-01 00:00:00pages
1-20issue
1eissn
1863-2653issn
1863-2661journal_volume
218pub_type
杂志文章abstract::Manual volumetric measurement of the brain's frontal lobe and its subregions from magnetic resonance images (MRIs) is an established method for researching neural correlates of clinical disorders or cognitive functions. However, there is no consensus between methods used to identify relevant boundaries of a given regi...
journal_title:Brain structure & function
pub_type: 杂志文章,评审
doi:10.1007/s00429-013-0527-5
更新日期:2014-01-01 00:00:00
abstract::Sensory neurons of the jugular vagal ganglia innervate the respiratory tract and project to the poorly studied medullary paratrigeminal nucleus. In the present study, we used neuroanatomical tracing, pharmacology and physiology in guinea pig to investigate the paratrigeminal neural circuits mediating jugular ganglia-e...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1732-z
更新日期:2018-12-01 00:00:00
abstract::Chaining or cascading of different actions and responses is necessary to accomplish a goal. Yet, little is known about the functional neuroanatomical-electrophysiological mechanisms mediating these processes. Computational models suggest that medium spiny neurons (MSNs) play an important role in action cascading, but ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0649-9
更新日期:2015-01-01 00:00:00
abstract::Interaction between the hippocampus and the medial prefrontal cortex (mPFC) has been identified as a key target in several neuropsychiatric disorders. However, the hippocampus-mPFC (H-PFC) pathway has not been outlined in mice, which are increasingly the leading choice for new animal models for neurological disorders....
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-015-1023-x
更新日期:2016-05-01 00:00:00
abstract::Although type 1 cannabinoid receptors (CB1Rs) are expressed abundantly throughout the brain, the presence of type 2 cannabinoid receptors (CB2Rs) in neurons is still somewhat controversial. Taking advantage of newly designed CB1R and CB2R mRNA riboprobes, we demonstrate by PCR and in situ hybridization that transcript...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0823-8
更新日期:2015-09-01 00:00:00
abstract::Recent studies of the neurobiology of the dorsal frontal cortex (FC) of the ferret have illuminated its key role in the attention network, top-down cognitive control of sensory processing, and goal directed behavior. To elucidate the neuroanatomical regions of the dorsal FC, and delineate the boundary between premotor...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02086-7
更新日期:2020-06-01 00:00:00
abstract::The inner ear is a morphologically complex sensory structure with auditory and vestibular functions. The developing otic epithelium gives rise to neurosensory and non-sensory elements of the adult membranous labyrinth. Extrinsic and intrinsic signals manage the patterning and cell specification of the developing otic ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1205-1
更新日期:2017-01-01 00:00:00
abstract::Previous work in the precocious rodent Octodon degus has shown that exposure to early life stress (ELS) (induced by repeated parental separation) results in changes of excitatory, inhibitory and modulatory transmitter systems in prefrontal and limbic regions of the male brain. The aim of this study was to test the hyp...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0688-2
更新日期:2015-03-01 00:00:00
abstract::The mammalian superior paraolivary nucleus (SPON) is a major source of GABAergic inhibition to neurons in the inferior colliculus (IC), a well-studied midbrain nucleus that is the site of convergence and integration for the majority ascending auditory pathways en route to the cortex. Neurons in the SPON and IC exhibit...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0815-8
更新日期:2015-09-01 00:00:00
abstract::Diffusion-weighted magnetic resonance spectroscopy of brain metabolites offers unique access to compartment-specific microstructural information on neural tissue. Here, we investigated in detail the diffusion characteristics of the neuronal/axonal markers N-acetylaspartate + N-acetyl aspartyl glutamate (tNAA) in a sma...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0600-0
更新日期:2014-09-01 00:00:00
abstract::In the embryonic head of vertebrates, neurogenic and non-neurogenic ectodermal placodes arise from the panplacodal primordium. Whether and how growth processes of the ectodermal layer, changes in the transcriptional precursor cell profile, or positional changes among precursor cells contribute to interplacodal boundar...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-012-0429-y
更新日期:2013-05-01 00:00:00
abstract::Stress impacts differently in distinct brain regions. However, so far few studies have focused on the differential responses triggered by stressful stimuli on the intrinsic functional heterogeneity of the hippocampal axis. In this study, we assessed the functional and structural alterations caused by exposure to a chr...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0713-0
更新日期:2015-03-01 00:00:00
abstract::Neonatal brain lesions cause deficits in structure and function of the cerebral cortex that sometimes are not fully expressed until adolescence. To better understand the onset and persistence of changes caused by postnatal day 7 (P7) ethanol treatment, we examined neocortical cell numbers, volume, surface area and thi...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-019-01881-1
更新日期:2019-06-01 00:00:00
abstract::In the primate cerebral cortex, dendritic spines rapidly increase in number after birth up to infancy or mid-childhood, and then decrease towards adulthood. Abnormalities in these processes accompany several psychiatric disorders. In this study, we examined developmental changes of basal dendrites and spines of layer ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0853-2
更新日期:2015-11-01 00:00:00
abstract::We investigated whether pre-operative MRI measures of focal brain atrophy could predict cognitive decline occurring after deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson's disease (PD). For that purpose, we prospectively collected data of 42 consecutive patients with PD who und...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1677-2
更新日期:2018-09-01 00:00:00
abstract::World-wide methamphetamine (meth) use is increasing at a rapid rate; therefore, it has become increasingly important to understand the synaptic changes and neural mechanisms affected by drug exposure. In rodents, 6-h access to contingent meth results in an escalation of drug intake and impaired cognitive sequelae typi...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1322-x
更新日期:2017-07-01 00:00:00
abstract::Glycoproteins are complex molecules of the cell surface and the extracellular matrix (ECM) playing a fundamental role in the migration, guidance and synapse formation of neurons. In the present study, the glycosylated protein composition and localization were investigated in the adult and developing CNS of an aquatic ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-009-0229-1
更新日期:2009-12-01 00:00:00
abstract::Neocortical layer VI is critically involved in thalamocortical activity changes during the sleep/wake cycle. It receives dense projections from thalamic nuclei sensitive to the wake-promoting neuropeptides orexins, and its deepest part, layer VIb, is the only cortical lamina reactive to orexins. This convergence of wa...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0869-7
更新日期:2015-11-01 00:00:00
abstract::The dorsal part of the developing telencephalon is one of the brain areas that has suffered most drastic changes throughout vertebrate evolution. Its evolutionary increase in complexity was thought to be partly achieved by the appearance of a new neurogenic niche in the embryonic subventricular zone (SVZ). Here, a new...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1705-2
更新日期:2018-11-01 00:00:00
abstract::The functional specificity of brain areas is diminished with age and accompanied by the recruitment of additional brain regions in healthy older adults. This process has repeatedly been demonstrated within distinct functional domains, in particular the visual system. However, it is yet unclear, whether this phenomenon...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0530-x
更新日期:2014-03-01 00:00:00
abstract::Olfaction is one of the major sensory modalities that regulates food consumption and is in turn regulated by the feeding state. Given that the olfactory bulb has been shown to be a metabolic sensor, we explored whether the anterior piriform cortex (aPCtx)-a higher olfactory cortical processing area-had the same capaci...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1776-0
更新日期:2019-01-01 00:00:00
abstract::How can the components of visual comprehension be characterized as brain activity? Making sense of a dynamic visual world involves perceiving streams of activity as discrete units such as eating breakfast or walking the dog. In order to parse activity into distinct events, the brain relies on both the perceptual (bott...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-007-0160-2
更新日期:2007-12-01 00:00:00
abstract::This study investigates the mechanism of action of spadin, a putative fast-acting peptidic antidepressant (AD) and a functional blocker of the K(+) TREK-1 channel, in relation with the medial prefrontal cortex (mPFC)-dorsal raphé (DRN) serotonergic (5-HT) neurons connectivity. Spadin increased 5-HT neuron firing rate ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0890-x
更新日期:2016-01-01 00:00:00
abstract::Recent advances in diffusion-weighted MRI (dMRI) and tractography have enabled identification of major long-range white matter tracts in the human brain. Yet, our understanding of shorter tracts, such as those within the parietal lobe, remains limited. Over a century ago, a tract connecting the superior and inferior p...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1492-1
更新日期:2018-01-01 00:00:00
abstract::The basal ganglia of the laboratory rat consist of a few core regions that are specifically interconnected by efferents and afferents of the central nervous system. In nearly 800 reports of tract-tracing investigations the connectivity of the basal ganglia is documented. The readout of connectivity data and the collat...
journal_title:Brain structure & function
pub_type: 杂志文章,meta分析
doi:10.1007/s00429-014-0936-0
更新日期:2016-03-01 00:00:00
abstract::Recent research has shown that at least two tryptophan hydroxylase (Tph) genes are present in gnathostome vertebrates, but it is not known when the duplication of the ancestral Tph gene took place during evolution. By their position as an out-group of gnathostomes, lampreys (agnathans) are key models to understand mo...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-012-0412-7
更新日期:2013-03-01 00:00:00
abstract::Achievement motivation can be defined as a recurrent need to improve one's past performance. Despite previous functional imaging studies on motivation-related functional activation, the relationship between regional gray matter (rGM) morphology and achievement motivation has never been investigated. We used voxel-base...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-012-0485-3
更新日期:2014-01-01 00:00:00
abstract::Multisensory integration does not only recruit higher-level association cortex, but also low-level and even primary sensory cortices. Here, we will describe and quantify two types of anatomical pathways, a thalamocortical and a corticocortical that possibly underlie short-latency multisensory integration processes in ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0694-4
更新日期:2015-03-01 00:00:00
abstract::Interest in the study of brain connectivity is growing, particularly in understanding the dynamics of the structural/functional connectivity relation. Structural and functional connectivity are most often analysed independently of each other. Track-weighted functional connectivity (TW-FC) was recently proposed as a me...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1431-1
更新日期:2017-11-01 00:00:00
abstract::Serotonin neurons arise from the brainstem raphe nuclei and send their projections throughout the brain to release 5-HT which acts as a modulator of several neuronal populations. Previous electron microscopy studies in rats have morphologically determined the distribution of 5-HT release sites (boutons) in certain bra...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1278-x
更新日期:2017-04-01 00:00:00