Abstract:
:The inner ear is a morphologically complex sensory structure with auditory and vestibular functions. The developing otic epithelium gives rise to neurosensory and non-sensory elements of the adult membranous labyrinth. Extrinsic and intrinsic signals manage the patterning and cell specification of the developing otic epithelium by establishing lineage-restricted compartments defined in turn by differential expression of regulatory genes. FGF3 and FGF16 are excellent candidates to govern these developmental events. Using the chick inner ear, we show that Fgf3 expression is present in the borders of all developing cristae. Strong Fgf16 expression was detected in a portion of the developing vertical and horizontal pouches, whereas the cristae show weaker or undetected Fgf16 expression at different developmental stages. Concerning the rest of the vestibular sensory elements, both the utricular and saccular maculae were Fgf3 positive. Interestingly, strong Fgf16 expression delimited these Fgf16-negative sensory patches. The Fgf3-negative macula neglecta and the Fgf3-positive macula lagena were included within weakly Fgf16-expressing areas. Therefore, different FGF-mediated mechanisms might regulate the specification of the anterior (utricular and saccular) and posterior (neglecta and lagena) maculae. In the developing cochlear duct, dynamic Fgf3 and Fgf16 expression suggests their cooperation in the early specification and later cell differentiation in the hearing system. The requirement of Fgf3 and Fgf16 genes in endolymphatic apparatus development and neurogenesis are discussed. Based on these observations, FGF3 and FGF16 seem to be key signaling pathways that control the inner ear plan by defining epithelial identities within the developing otic epithelium.
journal_name
Brain Struct Functjournal_title
Brain structure & functionauthors
Olaya-Sánchez D,Sánchez-Guardado LÓ,Ohta S,Chapman SC,Schoenwolf GC,Puelles L,Hidalgo-Sánchez Mdoi
10.1007/s00429-016-1205-1subject
Has Abstractpub_date
2017-01-01 00:00:00pages
131-149issue
1eissn
1863-2653issn
1863-2661pii
10.1007/s00429-016-1205-1journal_volume
222pub_type
杂志文章abstract::Von Economo's neurons (VENs) are large, bipolar or corkscrew-shaped neurons located in layers III and V of the frontoinsular and the anterior cingulate cortices. VENs are reported to be altered in pathologies such as frontotemporal dementia and autism, in which the individual's self control is seriously compromised. T...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-012-0382-9
更新日期:2013-01-01 00:00:00
abstract::We investigated whether pre-operative MRI measures of focal brain atrophy could predict cognitive decline occurring after deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson's disease (PD). For that purpose, we prospectively collected data of 42 consecutive patients with PD who und...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1677-2
更新日期:2018-09-01 00:00:00
abstract::Rho-associated protein kinases (ROCK) 1 and 2 are attractive drug targets for a range of neurologic disorders; however, a critical barrier to ROCK-based therapeutics is ambiguity over whether there are isoform-specific roles for ROCKs in neuronal structural plasticity. Here, we used a genetics approach to address this...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1748-4
更新日期:2018-12-01 00:00:00
abstract::A hierarchical and modular organization is a central hypothesis in the current primate model of auditory cortex (AC) but lacks validation in humans. Here we investigated whether fMRI connectivity at rest and during active tasks is informative of the functional organization of human AC. Identical pitch-varying sounds w...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1612-6
更新日期:2018-06-01 00:00:00
abstract::Diffusion-weighted magnetic resonance spectroscopy of brain metabolites offers unique access to compartment-specific microstructural information on neural tissue. Here, we investigated in detail the diffusion characteristics of the neuronal/axonal markers N-acetylaspartate + N-acetyl aspartyl glutamate (tNAA) in a sma...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0600-0
更新日期:2014-09-01 00:00:00
abstract::The extensive and increasing use of structural neuroimaging in the neurosciences rests on the assumption of an intimate relationship between structure and function in the human brain. However, few studies have examined the relationship between advanced magnetic resonance imaging (MRI) indices of cerebral structure and...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0703-7
更新日期:2015-03-01 00:00:00
abstract::The characterization of neuronal properties is a necessary first step toward understanding how the ventrolateral preoptic nucleus (VLPO) neuronal network regulates slow-wave sleep (SWS). Indeed, the electrophysiological heterogeneity of VLPO neurons suggests the existence of subtypes that could differently contribute ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1265-2
更新日期:2017-04-01 00:00:00
abstract::Evidence suggests that extracellular matrix molecules of perivascular basal laminae help orchestrate the molecular assemblies at the gliovascular interface. Specifically, laminin and agrin are thought to tether the dystrophin-associated protein (DAP) complex to the astrocytic basal lamina. This complex includes α-synt...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02036-3
更新日期:2020-03-01 00:00:00
abstract::Chaining or cascading of different actions and responses is necessary to accomplish a goal. Yet, little is known about the functional neuroanatomical-electrophysiological mechanisms mediating these processes. Computational models suggest that medium spiny neurons (MSNs) play an important role in action cascading, but ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0649-9
更新日期:2015-01-01 00:00:00
abstract::Early-life stress (ELS) exposure has long-term consequences for both brain structure and function and impacts cognitive and emotional behavior. The basolateral amygdala (BLA) plays an important role in anxiety and fear conditioning through its extensive anatomical and functional connections, in particular to the media...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1720-3
更新日期:2018-11-01 00:00:00
abstract::The structure of neurons in the central auditory system is vulnerable to various kinds of acoustic exposures during the critical postnatal developmental period. Here we explored long-term effects of exposure to an acoustically enriched environment (AEE) during the third and fourth weeks of the postnatal period in rat ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02104-8
更新日期:2020-09-01 00:00:00
abstract::Network-level analysis based on anatomical, pairwise similarities (e.g., cortical thickness) has been gaining increasing attention recently. However, there has not been a systematic study of the impact of spatial scale and edge definitions on predictive performance, which is necessary to obtain a clear understanding o...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02136-0
更新日期:2020-11-01 00:00:00
abstract::Two anorexigenic peptides, thyrotropin-releasing hormone (TRH) and urocortin 3 (UCN3), are co-expressed in a continuous neuronal group that extends from the perifornical area to the bed nucleus of stria terminalis, raising the possibility that this cell group may be involved in the regulation of energy homeostasis. In...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1553-5
更新日期:2018-04-01 00:00:00
abstract::Serotonergic cells are among the earliest neurons to be born in the developing central nervous system and serotonin is known to regulate the development of the nervous system. One of the major targets of the activity of serotonergic cells is the serotonin 1A receptor (5-HT1A), an ancestral archetypical serotonin recep...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-012-0461-y
更新日期:2013-09-01 00:00:00
abstract::Oscillation activities are the feature of neural network and correlated to different physiological states. The theta (θ) oscillation (2-7 Hz) has been reported in the basal ganglia, and the intrinsic resonance properties of individual neurons have provided a basis for this network oscillation. The basal ganglia neuron...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-011-0361-6
更新日期:2012-04-01 00:00:00
abstract::Neuroimaging studies have demonstrated that mental imagery and perception share similar neural substrates, however, there are still ambiguities according to different auditory imagery content. In addition, there is still a lack of information regarding the underlying neural correlation between the two modalities. In t...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-019-01948-z
更新日期:2019-11-01 00:00:00
abstract::The amygdala and medial prefrontal cortex (mPFC) are highly interconnected telencephalic areas critical for cognitive processes, including associative learning and decision making. Both structures strongly innervate the lateral hypothalamus (LHA), an important component of the networks underlying the control of feedin...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-015-1081-0
更新日期:2016-07-01 00:00:00
abstract::AMIGO2, or amphoterin-induced gene and ORF (open reading frame) 2, belongs to the leucine-rich repeats and immunoglobulin superfamilies. The protein is a downstream target of calcium-dependent survival signals and, therefore, promotes neuronal survival. Here, we describe the mRNA distribution pattern of AMIGO2 through...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-012-0387-4
更新日期:2013-01-01 00:00:00
abstract::Previous diffusion tensor imaging (DTI) studies have shown that various factors can affect white matter (WM) tract diffusivity. The aim of the present study was to investigate the effects of childhood adversity (CA), age and gender on WM diffusivity in tracts that are thought to be involved in emotional regulation in ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0769-x
更新日期:2015-07-01 00:00:00
abstract::Although type 1 cannabinoid receptors (CB1Rs) are expressed abundantly throughout the brain, the presence of type 2 cannabinoid receptors (CB2Rs) in neurons is still somewhat controversial. Taking advantage of newly designed CB1R and CB2R mRNA riboprobes, we demonstrate by PCR and in situ hybridization that transcript...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0823-8
更新日期:2015-09-01 00:00:00
abstract::Coordinated modulation of sympathetic and parasympathetic nervous activity is required for physiological regulation of tissue function. Anatomically, whilst the peripheral sympathetic and parasympathetic pathways are separate, the distribution of premotor neurons in higher brain regions often overlaps. This co-distrib...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0781-1
更新日期:2015-07-01 00:00:00
abstract::Diffusion tensor histology holds great promise for quantitative characterization of structural connectivity in mouse models of neurological and psychiatric conditions. There has been extensive study in both the clinical and preclinical domains on the complex tradeoffs between the spatial resolution, the number of samp...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1750-x
更新日期:2018-12-01 00:00:00
abstract::Despite being historically one of the first brain regions linked to memory loss, there remains controversy over the core features of diencephalic amnesia as well as the critical site for amnesia to occur. The mammillary bodies and thalamus appear to be the primary locus of pathology in the cases of diencephalic amnesi...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1330-x
更新日期:2017-07-01 00:00:00
abstract::To date, hampered physiological function after exposure to microgravity has been primarily attributed to deprived peripheral neuro-sensory systems. For the first time, this study elucidates alterations in human brain function after long-duration spaceflight. More specifically, we found significant differences in resti...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-015-1054-3
更新日期:2016-06-01 00:00:00
abstract::The developing cerebellum is extremely vulnerable to hypoxia which can damage the Purkinje neurons. We hypothesized that this might be mediated by tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) derived from activated microglia as in other brain areas. One-day-old rats were subjected to hypoxia following, w...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-012-0491-5
更新日期:2014-01-01 00:00:00
abstract::The bulk of brain energy expenditure is allocated for maintenance of perpetual intrinsic activity of neurons and neural circuits. Long-term electrophysiological and neuroimaging studies in anesthetized and behaving animals show, however, that the great majority of nerve cells in the intact brain do not fire action pot...
journal_title:Brain structure & function
pub_type: 杂志文章,评审
doi:10.1007/s00429-019-01835-7
更新日期:2019-04-01 00:00:00
abstract::The transcription factor Pax6 has been reported to specify neural progenitor cell fates during development and maintain neuronal commitments in the adult. The spatiotemporal patterns of Pax6 expression were examined in sagittal and horizontal sections of the embryonic, postnatal, and adult brains using immunohistochem...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-012-0397-2
更新日期:2013-03-01 00:00:00
abstract::The functional specificity of brain areas is diminished with age and accompanied by the recruitment of additional brain regions in healthy older adults. This process has repeatedly been demonstrated within distinct functional domains, in particular the visual system. However, it is yet unclear, whether this phenomenon...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0530-x
更新日期:2014-03-01 00:00:00
abstract::Neocortical layer VI is critically involved in thalamocortical activity changes during the sleep/wake cycle. It receives dense projections from thalamic nuclei sensitive to the wake-promoting neuropeptides orexins, and its deepest part, layer VIb, is the only cortical lamina reactive to orexins. This convergence of wa...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0869-7
更新日期:2015-11-01 00:00:00
abstract::Serotonin neurons arise from the brainstem raphe nuclei and send their projections throughout the brain to release 5-HT which acts as a modulator of several neuronal populations. Previous electron microscopy studies in rats have morphologically determined the distribution of 5-HT release sites (boutons) in certain bra...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1278-x
更新日期:2017-04-01 00:00:00