Antagomirs targeting microRNA-134 increase hippocampal pyramidal neuron spine volume in vivo and protect against pilocarpine-induced status epilepticus.

abstract：:The functional specificity of brain areas is diminished with age and accompanied by the recruitment of additional brain regions in healthy older adults. This process has repeatedly been demonstrated within distinct functional domains, in particular the visual system. However, it is yet unclear, whether this phenomenon...

journal_title：Brain structure & function

authors： Roski C,Caspers S,Lux S,Hoffstaedter F,Bergs R,Amunts K,Eickhoff SB

更新日期：2014-03-01 00:00:00

abstract：:In the neocortex, large layer 5B pyramidal neurons implement a high-density firing code. In contrast, other subtypes of pyramidal neurons, including those in layer 2/3, are functionally characterized by their sparse firing rate. Here, we investigate the synaptic basis of this behavior by comparing the properties of th...

journal_title：Brain structure & function

authors： Sempere-Ferràndez A,Martínez S,Geijo-Barrientos E

更新日期：2019-05-01 00:00:00

abstract：:Different genotypic combinations of COMT and DRD2 can generate multiple subgroups with different levels of dopamine signaling. Its modulations on brain properties can be investigated by analyzing the combined gene effects of COMT and DRD2. However, the inherent association between modulation patterns of the dopamine s...

journal_title：Brain structure & function

authors： Xu J,Qin W,Liu B,Jiang T,Yu C

更新日期：2016-11-01 00:00:00

abstract：:The cerebral cortex conveys major input to the granule cell layer of the cerebellar hemispheres by way of the pontine nuclei. Cerebrocortical projections terminate in multiple, widely distributed clusters in the pontine nuclei. This clustered organization is thought to provide the transition between the different orga...

journal_title：Brain structure & function

authors： Bolstad I,Leergaard TB,Bjaalie JG

更新日期：2007-07-01 00:00:00

abstract：:Chemically mediated synaptic transmission results from fusion of synaptic vesicles with the presynaptic plasma membrane, subsequent release of the vesicular content into the cleft and binding to postsynaptic receptors. Previous modelling studies of excitatory neurotransmitter glutamate were based on simplified geometr...

journal_title：Brain structure & function

authors： Boucher J,Kröger H,Sík A

更新日期：2010-07-01 00:00:00

abstract：:The architecture of the neocortex classically consists of six layers, based on cytological criteria and on the layout of intra/interlaminar connections. Yet, the comparison of cortical cytoarchitectonic features across different species proves overwhelmingly difficult, due to the lack of a reliable model to analyze th...

journal_title：Brain structure & function

authors： Cozzi B,De Giorgio A,Peruffo A,Montelli S,Panin M,Bombardi C,Grandis A,Pirone A,Zambenedetti P,Corain L,Granato A

更新日期：2017-08-01 00:00:00

abstract：:To establish the link between structure and function of any large area of the neocortex, it is helpful to identify its principles of organisation. One way to establish such principles is to investigate how differences in whole-brain connectivity are structured across the area. Here, we use Laplacian eigenmaps on diffu...

journal_title：Brain structure & function

authors： Blazquez Freches G,Haak KV,Bryant KL,Schurz M,Beckmann CF,Mars RB

更新日期：2020-05-01 00:00:00

abstract：:Anterior cingulate cortex (ACC) input to the claustrum is required for top-down cognitive control of action. By virtue of its widespread cortical connectivity, the claustrum is anatomically situated to process and broadcast top-down signals from ACC to downstream cortices. To gain a deeper understanding of claustrum p...

journal_title：Brain structure & function

authors： White MG,Mathur BN

更新日期：2018-12-01 00:00:00

abstract：:MRI was employed to follow the neurodegenerative foci and the localization of inflammatory cells by magnetically labeled CD4+ or CD8+ lymphocytes in the ischemia/reperfusion long-lived rats (9 and 13 months after 10 min of cardiac arrest). MRI of ischemic rats showed: (1) blood-brain barrier (BBB) leakage in the area ...

journal_title：Brain structure & function

authors： Sekeljic V,Bataveljic D,Stamenkovic S,Ułamek M,Jabłoński M,Radenovic L,Pluta R,Andjus PR

更新日期：2012-04-01 00:00:00

abstract：:Sublineage diversification of specific neural cell classes occurs in complex as well as simply organized regions of the central and peripheral nervous systems; the significance of the phenomenon, however, remains insufficiently understood. The unipolar brush cells (UBCs) are glutamatergic cerebellar interneurons that ...

journal_title：Brain structure & function

authors： Sekerková G,Watanabe M,Martina M,Mugnaini E

更新日期：2014-03-01 00:00:00

abstract：:A rapidly increasing number of studies are quantifying the system-level network architecture of the human brain based on structural-to-structural and functional-to-functional relationships. However, a largely unexplored area is the nature and existence of "cross-modal" structural-functional relationships, in which, fo...

journal_title：Brain structure & function

authors： Harms MP,Wang L,Csernansky JG,Barch DM

更新日期：2013-01-01 00:00:00

abstract：:Rho-associated protein kinases (ROCK) 1 and 2 are attractive drug targets for a range of neurologic disorders; however, a critical barrier to ROCK-based therapeutics is ambiguity over whether there are isoform-specific roles for ROCKs in neuronal structural plasticity. Here, we used a genetics approach to address this...

journal_title：Brain structure & function

authors： Greathouse KM,Boros BD,Deslauriers JF,Henderson BW,Curtis KA,Gentry EG,Herskowitz JH

更新日期：2018-12-01 00:00:00

abstract：:Understanding the intricate three-dimensional relationship between fiber bundles and subcortical nuclei is not a simple task. It is of paramount importance in neurosciences, especially in the field of functional neurosurgery. The current methods for in vivo and post mortem fiber tract visualization have shortcomings a...

journal_title：Brain structure & function

authors： Alho EJL,Fonoff ET,Di Lorenzo Alho AT,Nagy J,Heinsen H

更新日期：2021-01-03 00:00:00

abstract：:The fornix is the primary efferent pathway of the hippocampus and plays a central role in memory circuitry. Diffusion tensor imaging has shown changes in the fornix with typical development and aging. Here, the fornix was investigated in 903 healthy young adult participants aged 22-36 years old from the high-spatial r...

journal_title：Brain structure & function

authors： Cahn AJ,Little G,Beaulieu C,Tétreault P

更新日期：2021-01-02 00:00:00

abstract：:Neonatal brain lesions cause deficits in structure and function of the cerebral cortex that sometimes are not fully expressed until adolescence. To better understand the onset and persistence of changes caused by postnatal day 7 (P7) ethanol treatment, we examined neocortical cell numbers, volume, surface area and thi...

journal_title：Brain structure & function

authors： Smiley JF,Bleiwas C,Masiello K,Petkova E,Betz J,Hui M,Wilson DA,Saito M

更新日期：2019-06-01 00:00:00

abstract：:Emergence of advanced network analysis techniques utilizing resting-state functional magnetic resonance imaging (R-fMRI) has enabled a more comprehensive understanding of neurological disorders at a whole-brain level. However, inferring brain connectivity from R-fMRI is a challenging task, particularly when the ultima...

journal_title：Brain structure & function

authors： Wee CY,Yap PT,Zhang D,Wang L,Shen D

更新日期：2014-03-01 00:00:00

abstract：:In recent years, the demonstration that structural changes can occur in the human brain beyond those associated with development, ageing and neuropathology has revealed a new approach to studying the neural basis of behaviour. In this review paper, we focus on structural imaging studies of language that have utilised ...

journal_title：Brain structure & function

authors： Richardson FM,Price CJ

更新日期：2009-10-01 00:00:00

abstract：:Higher cognitive processes and emotional regulation depend on densely interconnected telencephalic and limbic areas. Central structures of this cortico-limbic network are ventral hippocampus (vHC), medial prefrontal cortex (PFC), basolateral amygdala (BLA) and nucleus accumbens (NAC). Human and animal studies have rev...

journal_title：Brain structure & function

authors： Khastkhodaei Z,Muthuraman M,Yang JW,Groppa S,Luhmann HJ

更新日期：2021-01-13 00:00:00

abstract：:What changes in cortical organisation characterise global and localised variation between humans and chimpanzees remains a topic of considerable interest in evolutionary neuroscience. Here, we examined regional variation in cortical thickness, gyrification and white matter in samples of human and chimpanzee brains. Bo...

journal_title：Brain structure & function

authors： Hopkins WD,Li X,Crow T,Roberts N

更新日期：2017-01-01 00:00:00

abstract：:Striatal fast-spiking interneurons (FSIs) potently inhibit the output neurons of the striatum and, as such, powerfully modulate action learning. Through electrical synaptic coupling, FSIs are theorized to temporally coordinate their activity. This has important implications for their ability to temporally summate inhi...

journal_title：Brain structure & function

authors： Roberts BM,White MG,Patton MH,Chen R,Mathur BN

更新日期：2019-09-01 00:00:00

abstract：:The medial prefrontal cortex (mPFC) has been associated with diverse functions including attentional processes, visceromotor activity, decision making, goal directed behavior, and working memory. Using retrograde tracing techniques, we examined, compared, and contrasted afferent projections to the four divisions of th...

journal_title：Brain structure & function

authors： Hoover WB,Vertes RP

更新日期：2007-09-01 00:00:00

abstract：:The developing cerebellum is extremely vulnerable to hypoxia which can damage the Purkinje neurons. We hypothesized that this might be mediated by tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) derived from activated microglia as in other brain areas. One-day-old rats were subjected to hypoxia following, w...

journal_title：Brain structure & function

authors： Kaur C,Sivakumar V,Zou Z,Ling EA

更新日期：2014-01-01 00:00:00

abstract：:The vestibulo-ocular reflex (VOR) adaptation is an ideal model for investigating how the neurosteroid 17 beta-estradiol (E2) contributes to the modification of behavior by regulating synaptic activities. We hypothesized that E2 impacts VOR adaptation by affecting cerebellar synaptic plasticity at the parallel fiber-Pu...

journal_title：Brain structure & function

authors： Dieni CV,Ferraresi A,Sullivan JA,Grassi S,Pettorossi VE,Panichi R

更新日期：2018-03-01 00:00:00

abstract：:The organization of the pallial derivatives across vertebrates follows a comparable elementary arrangement, although not all of them possess a layered cortical structure as sophisticated as the cerebral cortex of mammals. However, its expansion along evolution has only been possible by the development and coevolution ...

journal_title：Brain structure & function

authors： Jiménez S,López JM,Lozano D,Morona R,González A,Moreno N

更新日期：2020-09-01 00:00:00

abstract：:The pedunculopontine nucleus (PPN) is composed of neurons with different connectivity patterns that express different neurochemical markers, display distinct firing characteristics and are topographically organized in functional domains across its rostro-caudal axis. Previous reports have shown that the caudal region ...

journal_title：Brain structure & function

authors： Martinez-Gonzalez C,van Andel J,Bolam JP,Mena-Segovia J

更新日期：2014-07-01 00:00:00

abstract：:Patients with Parkinson's disease have difficulties with self-initiating a task and maintaining a steady task performance. We hypothesized that these difficulties relate to reorganization in the sensorimotor execution, cingulo-opercular task-set maintenance, and frontoparietal adaptive control networks. We tested this...

journal_title：Brain structure & function

authors： Tinaz S,Lauro P,Hallett M,Horovitz SG

更新日期：2016-04-01 00:00:00

abstract：:The beneficial effects of physical exercise on brain health are well documented, yet how exercise modulates cerebrovascular function is not well understood. This study used continuous arterial spin labeling magnetic resonance imaging with a hypercapnic challenge to examine changes in cerebral blood flow and vascular f...

journal_title：Brain structure & function

authors： Cahill LS,Bishop J,Gazdzinski LM,Dorr A,Stefanovic B,Sled JG

更新日期：2017-11-01 00:00:00

abstract：:To provide information on the glutamatergic synapses on the trigeminal motoneurons, which may be important for understanding the mechanism of control of jaw movements, we investigated the distribution of vesicular glutamate transporter (VGLUT)1-immunopositive (+) and VGLUT2 + axon terminals (boutons) on the rat jaw-cl...

journal_title：Brain structure & function

authors： Park SK,Ko SJ,Paik SK,Rah JC,Lee KJ,Bae YC

更新日期：2018-06-01 00:00:00

abstract：:Prolactin is fundamental for the expression of maternal behaviour. In virgin female rats, prolactin administered upon steroid hormone priming accelerates the onset of maternal care. By contrast, the role of prolactin in mice maternal behaviour remains unclear. This study aims at characterizing central prolactin activi...

journal_title：Brain structure & function

authors： Salais-López H,Lanuza E,Agustín-Pavón C,Martínez-García F

更新日期：2017-03-01 00:00:00

abstract：:Glutamatergic afferents from the cerebral cortex are the main excitatory drive of striatal projection neurons. The metabotropic glutamate receptor 4 (mGluR4) presynaptically modulates transmission at corticostriatal synapses, and is considered as a potent drug target for Parkinson's disease and other brain disorders. ...

journal_title：Brain structure & function

authors： Iskhakova L,Smith Y

更新日期：2016-12-01 00:00:00