mGluR4-containing corticostriatal terminals: synaptic interactions with direct and indirect pathway neurons in mice.

Abstract:

:Glutamatergic afferents from the cerebral cortex are the main excitatory drive of striatal projection neurons. The metabotropic glutamate receptor 4 (mGluR4) presynaptically modulates transmission at corticostriatal synapses, and is considered as a potent drug target for Parkinson's disease and other brain disorders. To better characterize the anatomical substrate that underlies the functional effects of mGluR4 in the striatum, we undertook electron microscopic localization studies of mGluR4 expression in the mouse striatum. Our data demonstrate that more than 80 % mGluR4-immunoreactive structures are accounted for by unmyelinated axons and axon terminals, and that almost 50 % putative glutamatergic terminals (i.e. forming asymmetric synapses) express mGluR4 in the mouse striatum. Using vGluT1 as a presynaptic marker of glutamatergic corticostriatal boutons, our findings indicate: (1) all striatal mGluR4-positive terminals co-express vGluT1 immunoreactivity, (2) 44.3 % total striatal glutamatergic terminals co-express vGluT1 and mGluR4, and (3) mGluR4 is expressed in 73.4 % of total striatal vGluT1-positive terminals. To determine if mGluR4 terminals target preferentially direct vs. indirect pathway neurons, mGluR4 immunostaining was combined with D1 receptor immunoreactivity. These data showed that around 30 % mGluR4-immunoreactive glutamatergic terminals target D1 receptor-positive spines (i.e. direct pathway neurons), while almost 70 % formed synapses with D1 receptor-negative spines (i.e. putative indirect pathway neurons). Thus, these immuno-electron microscopic studies suggest that pre-synaptic mGluR4 in striatal glutamatergic terminals is expressed almost exclusively in cortical boutons to subserve regulatory influences upon a large contingent of corticostriatal terminals that preferentially target putative "indirect" pathway striatal projection neurons in mice. These observations provide a rationale for the use of mGluR4 allosteric potentiator as a potential therapy in Parkinson's disease.

journal_name

Brain Struct Funct

authors

Iskhakova L,Smith Y

doi

10.1007/s00429-016-1187-z

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

4589-4599

issue

9

eissn

1863-2653

issn

1863-2661

pii

10.1007/s00429-016-1187-z

journal_volume

221

pub_type

杂志文章
  • The dark matter of the brain.

    abstract::The bulk of brain energy expenditure is allocated for maintenance of perpetual intrinsic activity of neurons and neural circuits. Long-term electrophysiological and neuroimaging studies in anesthetized and behaving animals show, however, that the great majority of nerve cells in the intact brain do not fire action pot...

    journal_title:Brain structure & function

    pub_type: 杂志文章,评审

    doi:10.1007/s00429-019-01835-7

    authors: Ovsepian SV

    更新日期:2019-04-01 00:00:00

  • Memory-guided attention: bilateral hippocampal volume positively predicts implicit contextual learning.

    abstract::Several studies have begun to demonstrate that contextual memories constitute an important mechanism to guide our attention. Although there is general consensus that the hippocampus is involved in the encoding of contextual memories, it is controversial whether this structure can support implicit forms of contextual m...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-019-01887-9

    authors: Rosero MA,Winkelmann T,Pohlack S,Cavalli J,Nees F,Flor H

    更新日期:2019-07-01 00:00:00

  • Dopaminergic innervation of pyramidal cells in the rat basolateral amygdala.

    abstract::Dopaminergic (DA) inputs to the basolateral nuclear complex of the amygdala (BLC) are critical for several important functions, including reward-related learning, drug-stimulus learning, and fear conditioning. Despite the importance of the DA projection to the BLC, very little is known about which neuronal subpopulati...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-008-0196-y

    authors: Muller JF,Mascagni F,McDonald AJ

    更新日期:2009-02-01 00:00:00

  • Targeting of neural stem cells in the hippocampus of adult rats by custom-made Ad vectors.

    abstract::Adult hippocampal neural stem cells (NSC) are an intriguing source for cell replacement or could serve as delivery vehicles for therapeutic genes. We recently reported selective transduction of adult mouse NSC in the DG by in vivo injection of GFP encoding adenoviral (Ad) vectors engineered to bind NSC-specific peptid...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-010-0275-8

    authors: Hildebrandt S,Schmidt A,Stoll A,Schmitt O,Köhling R,Wree A,Haas SJ,Pützer BM

    更新日期:2010-08-01 00:00:00

  • SK- and h-current contribute to the generation of theta-like resonance of rat substantia nigra pars compacta dopaminergic neurons at hyperpolarized membrane potentials.

    abstract::Oscillation activities are the feature of neural network and correlated to different physiological states. The theta (θ) oscillation (2-7 Hz) has been reported in the basal ganglia, and the intrinsic resonance properties of individual neurons have provided a basis for this network oscillation. The basal ganglia neuron...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-011-0361-6

    authors: Xue WN,Wang Y,He SM,Wang XL,Zhu JL,Gao GD

    更新日期:2012-04-01 00:00:00

  • Whole mouse brain structural connectomics using magnetic resonance histology.

    abstract::Diffusion tensor histology holds great promise for quantitative characterization of structural connectivity in mouse models of neurological and psychiatric conditions. There has been extensive study in both the clinical and preclinical domains on the complex tradeoffs between the spatial resolution, the number of samp...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1750-x

    authors: Wang N,Anderson RJ,Badea A,Cofer G,Dibb R,Qi Y,Johnson GA

    更新日期:2018-12-01 00:00:00

  • Dorsal prefrontal and premotor cortex of the ferret as defined by distinctive patterns of thalamo-cortical projections.

    abstract::Recent studies of the neurobiology of the dorsal frontal cortex (FC) of the ferret have illuminated its key role in the attention network, top-down cognitive control of sensory processing, and goal directed behavior. To elucidate the neuroanatomical regions of the dorsal FC, and delineate the boundary between premotor...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-020-02086-7

    authors: Radtke-Schuller S,Town SM,Yin P,Elgueda D,Schuller G,Bizley JK,Shamma SA,Fritz JB

    更新日期:2020-06-01 00:00:00

  • Hippocampal signatures of awake targeted memory reactivation.

    abstract::Dominant theories of episodic memory propose that a key mechanism of memory consolidation is replay-a process, whereby neural patterns of activation during learning are reinstated during offline post-learning periods. Here, we tested whether key signatures of replay defined by studies in rodents, such as recapitulatio...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1790-2

    authors: Alm KH,Ngo CT,Olson IR

    更新日期:2019-03-01 00:00:00

  • Quantitative mapping of the local and extrinsic sources of GABA and Reelin to the layer Ia neuropil in the adult rat neocortex.

    abstract::Inputs to apical dendritic tufts have been considered to be crucial for associative learning, attention and similar ''feedback'' interactions and are located in neocortical layer Ia. Excitatory thalamic projections to apical tufts in layer Ia have been well characterized and their role in the cortical circuit has been...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0591-x

    authors: Ramos-Moreno T,Clascá F

    更新日期:2014-09-01 00:00:00

  • Ascending serotonin neuron diversity under two umbrellas.

    abstract::Forebrain serotonin relevant for many psychological disorders arises in the hindbrain, primarily within the dorsal and median raphe nuclei (DR and MR). These nuclei are heterogeneous, containing several distinct groups of serotonin neurons. Here, new insight into the afferent and efferent connectivity of these areas i...

    journal_title:Brain structure & function

    pub_type: 杂志文章,评审

    doi:10.1007/s00429-015-1176-7

    authors: Commons KG

    更新日期:2016-09-01 00:00:00

  • The hippocampal to prefrontal cortex circuit in mice: a promising electrophysiological signature in models for psychiatric disorders.

    abstract::Interaction between the hippocampus and the medial prefrontal cortex (mPFC) has been identified as a key target in several neuropsychiatric disorders. However, the hippocampus-mPFC (H-PFC) pathway has not been outlined in mice, which are increasingly the leading choice for new animal models for neurological disorders....

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-015-1023-x

    authors: Tripathi A,Schenker E,Spedding M,Jay TM

    更新日期:2016-05-01 00:00:00

  • Reflex regulation of breathing by the paratrigeminal nucleus via multiple bulbar circuits.

    abstract::Sensory neurons of the jugular vagal ganglia innervate the respiratory tract and project to the poorly studied medullary paratrigeminal nucleus. In the present study, we used neuroanatomical tracing, pharmacology and physiology in guinea pig to investigate the paratrigeminal neural circuits mediating jugular ganglia-e...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1732-z

    authors: Driessen AK,Farrell MJ,Dutschmann M,Stanic D,McGovern AE,Mazzone SB

    更新日期:2018-12-01 00:00:00

  • Distribution of D1 and D5 dopamine receptors in the primate and rat basolateral amygdala.

    abstract::Dopamine, acting at the D1 family receptors (D1R) is critical for the functioning of the amygdala, including fear conditioning and cue-induced reinstatement of drug self administration. However, little is known about the different contributions of the two D1R subtypes, D(1) and D(5). We identified D(1)-immunoreactive ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-009-0214-8

    authors: Muly EC,Senyuz M,Khan ZU,Guo JD,Hazra R,Rainnie DG

    更新日期:2009-09-01 00:00:00

  • Multiscale single-cell analysis reveals unique phenotypes of raphe 5-HT neurons projecting to the forebrain.

    abstract::Serotonergic neurons of the raphe nuclei exhibit anatomical, neurochemical and elecrophysiological heterogeneity that likely underpins their specific role in multiple behaviors. However, the precise organization of serotonin (5-HT) neurons to orchestrate 5-HT release patterns throughout the brain is not well understoo...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-015-1142-4

    authors: Fernandez SP,Cauli B,Cabezas C,Muzerelle A,Poncer JC,Gaspar P

    更新日期:2016-11-01 00:00:00

  • Activation shift in elderly subjects across functional systems: an fMRI study.

    abstract::The functional specificity of brain areas is diminished with age and accompanied by the recruitment of additional brain regions in healthy older adults. This process has repeatedly been demonstrated within distinct functional domains, in particular the visual system. However, it is yet unclear, whether this phenomenon...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0530-x

    authors: Roski C,Caspers S,Lux S,Hoffstaedter F,Bergs R,Amunts K,Eickhoff SB

    更新日期:2014-03-01 00:00:00

  • Distribution of excitatory and inhibitory axon terminals on the rat hypoglossal motoneurons.

    abstract::Detailed information about the excitatory and inhibitory synapses on the hypoglossal motoneurons may help understand the neural mechanism for control of the hypoglossal motoneuron excitability and hence the precise and coordinated movements of the tongue during chewing, swallowing and licking. For this, we investigate...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-019-01874-0

    authors: Paik SK,Yoo HI,Choi SK,Bae JY,Park SK,Bae YC

    更新日期:2019-06-01 00:00:00

  • Postnatal exposure to an acoustically enriched environment alters the morphology of neurons in the adult rat auditory system.

    abstract::The structure of neurons in the central auditory system is vulnerable to various kinds of acoustic exposures during the critical postnatal developmental period. Here we explored long-term effects of exposure to an acoustically enriched environment (AEE) during the third and fourth weeks of the postnatal period in rat ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-020-02104-8

    authors: Svobodová Burianová J,Syka J

    更新日期:2020-09-01 00:00:00

  • Reduced resting-state functional connectivity of the basolateral amygdala to the medial prefrontal cortex in preweaning rats exposed to chronic early-life stress.

    abstract::Early-life stress (ELS) exposure has long-term consequences for both brain structure and function and impacts cognitive and emotional behavior. The basolateral amygdala (BLA) plays an important role in anxiety and fear conditioning through its extensive anatomical and functional connections, in particular to the media...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1720-3

    authors: Guadagno A,Kang MS,Devenyi GA,Mathieu AP,Rosa-Neto P,Chakravarty M,Walker CD

    更新日期:2018-11-01 00:00:00

  • Childhood adversity, depression, age and gender effects on white matter microstructure: a DTI study.

    abstract::Previous diffusion tensor imaging (DTI) studies have shown that various factors can affect white matter (WM) tract diffusivity. The aim of the present study was to investigate the effects of childhood adversity (CA), age and gender on WM diffusivity in tracts that are thought to be involved in emotional regulation in ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0769-x

    authors: Ugwu ID,Amico F,Carballedo A,Fagan AJ,Frodl T

    更新日期:2015-07-01 00:00:00

  • Structural MRI studies of language function in the undamaged brain.

    abstract::In recent years, the demonstration that structural changes can occur in the human brain beyond those associated with development, ageing and neuropathology has revealed a new approach to studying the neural basis of behaviour. In this review paper, we focus on structural imaging studies of language that have utilised ...

    journal_title:Brain structure & function

    pub_type: 杂志文章,评审

    doi:10.1007/s00429-009-0211-y

    authors: Richardson FM,Price CJ

    更新日期:2009-10-01 00:00:00

  • Analysis of pallial/cortical interneurons in key vertebrate models of Testudines, Anurans and Polypteriform fishes.

    abstract::The organization of the pallial derivatives across vertebrates follows a comparable elementary arrangement, although not all of them possess a layered cortical structure as sophisticated as the cerebral cortex of mammals. However, its expansion along evolution has only been possible by the development and coevolution ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-020-02123-5

    authors: Jiménez S,López JM,Lozano D,Morona R,González A,Moreno N

    更新日期:2020-09-01 00:00:00

  • Neurochemically distinct circuitry regulates locus coeruleus activity during female social stress depending on coping style.

    abstract::Stress-related psychiatric diseases are nearly twice as prevalent in women compared to men. We recently showed in male rats that the resident-intruder model of social stress differentially engages stress-related circuitry that regulates norepinephrine-containing neurons of the locus coeruleus (LC) depending on coping ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-019-01837-5

    authors: Reyes BAS,Zhang XY,Dufourt EC,Bhatnagar S,Valentino RJ,Van Bockstaele EJ

    更新日期:2019-05-01 00:00:00

  • Diffusion tensor imaging of hippocampal network plasticity.

    abstract::Diffusion tensor imaging (DTI) has become a valuable tool to investigate white matter integrity in the brain. DTI also gives contrast in gray matter, which has been relatively little explored in studies assessing post-injury structural abnormalities. The present study was designed to compare white and gray matter reor...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0683-7

    authors: Sierra A,Laitinen T,Gröhn O,Pitkänen A

    更新日期:2015-03-01 00:00:00

  • Absolute and relative pitch processing in the human brain: neural and behavioral evidence.

    abstract::Pitch is a primary perceptual dimension of sounds and is crucial in music and speech perception. When listening to melodies, most humans encode the relations between pitches into memory using an ability called relative pitch (RP). A small subpopulation, almost exclusively musicians, preferentially encode pitches using...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-019-01872-2

    authors: Leipold S,Brauchli C,Greber M,Jäncke L

    更新日期:2019-06-01 00:00:00

  • Proprioceptive thalamus receiving forelimb and neck muscle spindle inputs via the external cuneate nucleus in the rat.

    abstract::Proprioceptive signals from body muscles have historically been considered to project to the rostrodorsal shell of the ventrobasal thalamic complex [the ventral posterolateral nucleus (VPL) and ventral posteromedial nucleus (VPM)]. However, we have recently found that proprioception from rat jaw-closing muscle spindle...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-020-02118-2

    authors: Uemura Y,Haque T,Sato F,Tsutsumi Y,Ohara H,Oka A,Furuta T,Bae YC,Yamashiro T,Tachibana Y,Yoshida A

    更新日期:2020-09-01 00:00:00

  • Attentional function and basal forebrain cholinergic neuron morphology during aging in the Ts65Dn mouse model of Down syndrome.

    abstract::Individuals with Down syndrome (DS) exhibit intellectual disability and develop Alzheimer's disease-like neuropathology during the third decade of life. The Ts65Dn mouse model of DS exhibits key features of both disorders, including impairments in learning, attention and memory, as well as atrophy of basal forebrain c...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-015-1164-y

    authors: Powers BE,Velazquez R,Kelley CM,Ash JA,Strawderman MS,Alldred MJ,Ginsberg SD,Mufson EJ,Strupp BJ

    更新日期:2016-12-01 00:00:00

  • Modulation of olfactory-driven behavior by metabolic signals: role of the piriform cortex.

    abstract::Olfaction is one of the major sensory modalities that regulates food consumption and is in turn regulated by the feeding state. Given that the olfactory bulb has been shown to be a metabolic sensor, we explored whether the anterior piriform cortex (aPCtx)-a higher olfactory cortical processing area-had the same capaci...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1776-0

    authors: Al Koborssy D,Palouzier-Paulignan B,Canova V,Thevenet M,Fadool DA,Julliard AK

    更新日期:2019-01-01 00:00:00

  • Branching of individual somatosensory cerebropontine axons in rat: evidence of divergence.

    abstract::The cerebral cortex conveys major input to the granule cell layer of the cerebellar hemispheres by way of the pontine nuclei. Cerebrocortical projections terminate in multiple, widely distributed clusters in the pontine nuclei. This clustered organization is thought to provide the transition between the different orga...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-007-0145-1

    authors: Bolstad I,Leergaard TB,Bjaalie JG

    更新日期:2007-07-01 00:00:00

  • Functional anatomy of cortical areas characterized by Von Economo neurons.

    abstract::Von Economo's neurons (VENs) are large, bipolar or corkscrew-shaped neurons located in layers III and V of the frontoinsular and the anterior cingulate cortices. VENs are reported to be altered in pathologies such as frontotemporal dementia and autism, in which the individual's self control is seriously compromised. T...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-012-0382-9

    authors: Cauda F,Torta DM,Sacco K,D'Agata F,Geda E,Duca S,Geminiani G,Vercelli A

    更新日期:2013-01-01 00:00:00

  • The connectome of the basal ganglia.

    abstract::The basal ganglia of the laboratory rat consist of a few core regions that are specifically interconnected by efferents and afferents of the central nervous system. In nearly 800 reports of tract-tracing investigations the connectivity of the basal ganglia is documented. The readout of connectivity data and the collat...

    journal_title:Brain structure & function

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00429-014-0936-0

    authors: Schmitt O,Eipert P,Kettlitz R,Leßmann F,Wree A

    更新日期:2016-03-01 00:00:00