Assessing a signal model and identifying brain activity from fMRI data by a detrending-based fractal analysis.

Abstract:

:One of the major challenges of functional magnetic resonance imaging (fMRI) data analysis is to develop simple and reliable methods to correlate brain regions with functionality. In this paper, we employ a detrending-based fractal method, called detrended fluctuation analysis (DFA), to identify brain activity from fMRI data. We perform three tasks: (a) Estimating noise level from experimental fMRI data; (b) Assessing a signal model recently introduced by Birn et al.; and (c) Evaluating the effectiveness of DFA for discriminating brain activations from artifacts. By computing the receiver operating characteristic (ROC) curves, we find that the ROC curve for experimental data is similar to the curve for simulated data with similar signal-to-noise ratio (SNR). This suggests that the proposed algorithm for estimating noise level is very effective and that Birn's model fits our experimental data very well. The brain activation maps for experimental data derived by DFA are similar to maps derived by deconvolution using a widely used software, AFNI. Considering that deconvolution explicitly uses the information about the experimental paradigm to extract the activation patterns whereas DFA does not, it remains to be seen whether one can effectively integrate the two methods to improve accuracy for detecting brain areas related to functional activity.

journal_name

Brain Struct Funct

authors

Hu J,Lee JM,Gao J,White KD,Crosson B

doi

10.1007/s00429-007-0166-9

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

417-26

issue

5

eissn

1863-2653

issn

1863-2661

journal_volume

212

pub_type

杂志文章
  • Activation shift in elderly subjects across functional systems: an fMRI study.

    abstract::The functional specificity of brain areas is diminished with age and accompanied by the recruitment of additional brain regions in healthy older adults. This process has repeatedly been demonstrated within distinct functional domains, in particular the visual system. However, it is yet unclear, whether this phenomenon...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0530-x

    authors: Roski C,Caspers S,Lux S,Hoffstaedter F,Bergs R,Amunts K,Eickhoff SB

    更新日期:2014-03-01 00:00:00

  • Dopaminergic innervation of pyramidal cells in the rat basolateral amygdala.

    abstract::Dopaminergic (DA) inputs to the basolateral nuclear complex of the amygdala (BLC) are critical for several important functions, including reward-related learning, drug-stimulus learning, and fear conditioning. Despite the importance of the DA projection to the BLC, very little is known about which neuronal subpopulati...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-008-0196-y

    authors: Muller JF,Mascagni F,McDonald AJ

    更新日期:2009-02-01 00:00:00

  • Lectin-binding glycoproteins in the developing and adult snail CNS.

    abstract::Glycoproteins are complex molecules of the cell surface and the extracellular matrix (ECM) playing a fundamental role in the migration, guidance and synapse formation of neurons. In the present study, the glycosylated protein composition and localization were investigated in the adult and developing CNS of an aquatic ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-009-0229-1

    authors: Serfozo Z,Elekes K

    更新日期:2009-12-01 00:00:00

  • Organization of connections between the amygdala, medial prefrontal cortex, and lateral hypothalamus: a single and double retrograde tracing study in rats.

    abstract::The amygdala and medial prefrontal cortex (mPFC) are highly interconnected telencephalic areas critical for cognitive processes, including associative learning and decision making. Both structures strongly innervate the lateral hypothalamus (LHA), an important component of the networks underlying the control of feedin...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-015-1081-0

    authors: Reppucci CJ,Petrovich GD

    更新日期:2016-07-01 00:00:00

  • Reduced resting-state functional connectivity of the basolateral amygdala to the medial prefrontal cortex in preweaning rats exposed to chronic early-life stress.

    abstract::Early-life stress (ELS) exposure has long-term consequences for both brain structure and function and impacts cognitive and emotional behavior. The basolateral amygdala (BLA) plays an important role in anxiety and fear conditioning through its extensive anatomical and functional connections, in particular to the media...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1720-3

    authors: Guadagno A,Kang MS,Devenyi GA,Mathieu AP,Rosa-Neto P,Chakravarty M,Walker CD

    更新日期:2018-11-01 00:00:00

  • In vivo assembly of the axon initial segment in motor neurons.

    abstract::The axon initial segment (AIS) is responsible for both the modulation of action potentials and the maintenance of neuronal polarity. Yet, the molecular mechanisms controlling its assembly are incompletely understood. Our study in single electroporated motor neurons in mouse embryos revealed that AnkyrinG (AnkG), the A...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0578-7

    authors: Le Bras B,Fréal A,Czarnecki A,Legendre P,Bullier E,Komada M,Brophy PJ,Davenne M,Couraud F

    更新日期:2014-07-01 00:00:00

  • Distribution of the glucocorticoid receptor in the human amygdala; changes in mood disorder patients.

    abstract::Exposure to stress activates the hypothalamic-pituitary-adrenal (HPA) axis that stimulates glucocorticoid (GC) release from the adrenal. These hormones exert numerous effects in the body and brain and bind to a.o. glucocorticoid receptors (GR) expressed in the limbic system, including the hippocampus and amygdala. Hyp...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0589-4

    authors: Wang Q,Verweij EW,Krugers HJ,Joels M,Swaab DF,Lucassen PJ

    更新日期:2014-09-01 00:00:00

  • The neostriatum: two entities, one structure?

    abstract::The striosome (or patch) was first identified with anatomical techniques as neurons organized in a three-dimensional labyrinth inserted in and interdigitating the rest of neostriatum: the matrix. Striosome and matrix rapidly became known as two neuronal compartments expressing different biochemical markers, embryonic ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-015-1000-4

    authors: Lopez-Huerta VG,Nakano Y,Bausenwein J,Jaidar O,Lazarus M,Cherassse Y,Garcia-Munoz M,Arbuthnott G

    更新日期:2016-04-01 00:00:00

  • Pre-existing astrocytes form functional perisynaptic processes on neurons generated in the adult hippocampus.

    abstract::The adult dentate gyrus produces new neurons that morphologically and functionally integrate into the hippocampal network. In the adult brain, most excitatory synapses are ensheathed by astrocytic perisynaptic processes that regulate synaptic structure and function. However, these processes are formed during embryonic...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0768-y

    authors: Krzisch M,Temprana SG,Mongiat LA,Armida J,Schmutz V,Virtanen MA,Kocher-Braissant J,Kraftsik R,Vutskits L,Conzelmann KK,Bergami M,Gage FH,Schinder AF,Toni N

    更新日期:2015-07-01 00:00:00

  • Track-weighted dynamic functional connectivity (TW-dFC): a new method to study time-resolved functional connectivity.

    abstract::Interest in the study of brain connectivity is growing, particularly in understanding the dynamics of the structural/functional connectivity relation. Structural and functional connectivity are most often analysed independently of each other. Track-weighted functional connectivity (TW-FC) was recently proposed as a me...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-017-1431-1

    authors: Calamante F,Smith RE,Liang X,Zalesky A,Connelly A

    更新日期:2017-11-01 00:00:00

  • Sources of inputs to the anterior and posterior aspects of the paraventricular nucleus of the thalamus.

    abstract::The paraventricular nucleus of the thalamus (PVT) is part of a group of midline and intralaminar thalamic nuclei implicated in arousal and attention. Recent research points to anatomical and functional differences between the anterior (aPVT) and posterior PVT (pPVT). The present study re-examines the main sources of b...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-011-0360-7

    authors: Li S,Kirouac GJ

    更新日期:2012-04-01 00:00:00

  • Neuronal tangential migration from Nkx2.1-positive hypothalamus.

    abstract::During the development of the central nervous system, the immature neurons suffer different migration processes. It is well known that Nkx2.1-positive ventricular layer give rise to critical tangential migrations into different regions of the developing forebrain. Our aim was to study this phenomenon in the hypothalam...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-020-02163-x

    authors: Murcia-Ramón R,Company V,Juárez-Leal I,Andreu-Cervera A,Almagro-García F,Martínez S,Echevarría D,Puelles E

    更新日期:2020-12-01 00:00:00

  • Relationship among interthalamic adhesion size, thalamic anatomy and neuropsychological functions in healthy volunteers.

    abstract::The interthalamic adhesion (ITA) is an understudied neuroanatomical structure that forms a bridge of tissue connecting the thalamus of each hemisphere across the midline whose functional significance remains largely unknown. The likelihood of ITA absence has been reported in some studies to be increased in males, but ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-016-1334-6

    authors: Damle NR,Ikuta T,John M,Peters BD,DeRosse P,Malhotra AK,Szeszko PR

    更新日期:2017-07-01 00:00:00

  • Postnatal development of dendritic structure of layer III pyramidal neurons in the medial prefrontal cortex of marmoset.

    abstract::In the primate cerebral cortex, dendritic spines rapidly increase in number after birth up to infancy or mid-childhood, and then decrease towards adulthood. Abnormalities in these processes accompany several psychiatric disorders. In this study, we examined developmental changes of basal dendrites and spines of layer ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0853-2

    authors: Sasaki T,Aoi H,Oga T,Fujita I,Ichinohe N

    更新日期:2015-11-01 00:00:00

  • Mapping the connectivity of serotonin transporter immunoreactive axons to excitatory and inhibitory neurochemical synapses in the mouse limbic brain.

    abstract::Serotonin neurons arise from the brainstem raphe nuclei and send their projections throughout the brain to release 5-HT which acts as a modulator of several neuronal populations. Previous electron microscopy studies in rats have morphologically determined the distribution of 5-HT release sites (boutons) in certain bra...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-016-1278-x

    authors: Belmer A,Klenowski PM,Patkar OL,Bartlett SE

    更新日期:2017-04-01 00:00:00

  • The hippocampal to prefrontal cortex circuit in mice: a promising electrophysiological signature in models for psychiatric disorders.

    abstract::Interaction between the hippocampus and the medial prefrontal cortex (mPFC) has been identified as a key target in several neuropsychiatric disorders. However, the hippocampus-mPFC (H-PFC) pathway has not been outlined in mice, which are increasingly the leading choice for new animal models for neurological disorders....

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-015-1023-x

    authors: Tripathi A,Schenker E,Spedding M,Jay TM

    更新日期:2016-05-01 00:00:00

  • Divergent motor projections from the pedunculopontine nucleus are differentially regulated in Parkinsonism.

    abstract::The pedunculopontine nucleus (PPN) is composed of neurons with different connectivity patterns that express different neurochemical markers, display distinct firing characteristics and are topographically organized in functional domains across its rostro-caudal axis. Previous reports have shown that the caudal region ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0579-6

    authors: Martinez-Gonzalez C,van Andel J,Bolam JP,Mena-Segovia J

    更新日期:2014-07-01 00:00:00

  • Activity-dependent and graded BACE1 expression in the olfactory epithelium is mediated by the retinoic acid metabolizing enzyme CYP26B1.

    abstract::It is well established that environmental influences play a key role in sculpting neuronal connectivity in the brain. One example is the olfactory sensory map of topographic axonal connectivity. While intrinsic odorant receptor signaling in olfactory sensory neurons (OSN) determines anterior-posterior counter gradient...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0783-z

    authors: Login H,Butowt R,Bohm S

    更新日期:2015-07-01 00:00:00

  • Quantitative mapping of the local and extrinsic sources of GABA and Reelin to the layer Ia neuropil in the adult rat neocortex.

    abstract::Inputs to apical dendritic tufts have been considered to be crucial for associative learning, attention and similar ''feedback'' interactions and are located in neocortical layer Ia. Excitatory thalamic projections to apical tufts in layer Ia have been well characterized and their role in the cortical circuit has been...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0591-x

    authors: Ramos-Moreno T,Clascá F

    更新日期:2014-09-01 00:00:00

  • Multiparametric characterization of neuronal subpopulations in the ventrolateral preoptic nucleus.

    abstract::The characterization of neuronal properties is a necessary first step toward understanding how the ventrolateral preoptic nucleus (VLPO) neuronal network regulates slow-wave sleep (SWS). Indeed, the electrophysiological heterogeneity of VLPO neurons suggests the existence of subtypes that could differently contribute ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-016-1265-2

    authors: Dubourget R,Sangare A,Geoffroy H,Gallopin T,Rancillac A

    更新日期:2017-04-01 00:00:00

  • Rapid immunostaining method for three-dimensional volume imaging of biological tissues by magnetic force-induced focusing of the electric field.

    abstract::Recent surges in tissue clearing technology have greatly advanced 3-dimensional (3D) volume imaging. Cleared tissues need to be stained with fluorescence probes for imaging but the current staining methods are too laborious and inefficient for thick 3D samples, which impedes the broad application of clearing technolog...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-020-02160-0

    authors: Na M,Kim K,Lim HR,Ha CM,Chang S

    更新日期:2021-01-01 00:00:00

  • Systematic expression analysis of Hox genes at adulthood reveals novel patterns in the central nervous system.

    abstract::Hox proteins are key regulators of animal development, providing positional identity and patterning information to cells along the rostrocaudal axis of the embryo. Although their embryonic expression and function are well characterized, their presence and biological importance in adulthood remains poorly investigated....

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0965-8

    authors: Hutlet B,Theys N,Coste C,Ahn MT,Doshishti-Agolli K,Lizen B,Gofflot F

    更新日期:2016-04-01 00:00:00

  • Differential distribution of phospholipase C beta isoforms and diaglycerol kinase-beta in rodents cerebella corroborates the division of unipolar brush cells into two major subtypes.

    abstract::Sublineage diversification of specific neural cell classes occurs in complex as well as simply organized regions of the central and peripheral nervous systems; the significance of the phenomenon, however, remains insufficiently understood. The unipolar brush cells (UBCs) are glutamatergic cerebellar interneurons that ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0531-9

    authors: Sekerková G,Watanabe M,Martina M,Mugnaini E

    更新日期:2014-03-01 00:00:00

  • The rat orbital and agranular insular prefrontal cortical areas: a cytoarchitectonic and chemoarchitectonic study.

    abstract::Cytoarchitectonic characterization of borders is necessary for stereological studies (e.g., total cell number estimation), in which particular cortical areas have to be defined. In this study, cytoarchitectonic characteristics are described and illustrated for the rat ventral or orbital frontal cortical areas, i.e., t...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-007-0164-y

    authors: Van De Werd HJ,Uylings HB

    更新日期:2008-02-01 00:00:00

  • GABAergic neurons in the medial septum-diagonal band of Broca (MSDB) are important for acquisition of the classically conditioned eyeblink response.

    abstract::The medial septum and diagonal band of Broca (MSDB) influence hippocampal function through cholinergic, GABAergic, and glutamatergic septohippocampal neurons. Non-selective damage of the MSDB or intraseptal scopolamine impairs classical conditioning of the eyeblink response (CCER). Scopolamine preferentially inhibits ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0560-4

    authors: Roland JJ,Janke KL,Servatius RJ,Pang KC

    更新日期:2014-07-01 00:00:00

  • The superior paraolivary nucleus shapes temporal response properties of neurons in the inferior colliculus.

    abstract::The mammalian superior paraolivary nucleus (SPON) is a major source of GABAergic inhibition to neurons in the inferior colliculus (IC), a well-studied midbrain nucleus that is the site of convergence and integration for the majority ascending auditory pathways en route to the cortex. Neurons in the SPON and IC exhibit...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0815-8

    authors: Felix RA 2nd,Magnusson AK,Berrebi AS

    更新日期:2015-09-01 00:00:00

  • Group-constrained sparse fMRI connectivity modeling for mild cognitive impairment identification.

    abstract::Emergence of advanced network analysis techniques utilizing resting-state functional magnetic resonance imaging (R-fMRI) has enabled a more comprehensive understanding of neurological disorders at a whole-brain level. However, inferring brain connectivity from R-fMRI is a challenging task, particularly when the ultima...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0524-8

    authors: Wee CY,Yap PT,Zhang D,Wang L,Shen D

    更新日期:2014-03-01 00:00:00

  • Cellular markers of neuroinflammation and neurogenesis after ischemic brain injury in the long-term survival rat model.

    abstract::MRI was employed to follow the neurodegenerative foci and the localization of inflammatory cells by magnetically labeled CD4+ or CD8+ lymphocytes in the ischemia/reperfusion long-lived rats (9 and 13 months after 10 min of cardiac arrest). MRI of ischemic rats showed: (1) blood-brain barrier (BBB) leakage in the area ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-011-0336-7

    authors: Sekeljic V,Bataveljic D,Stamenkovic S,Ułamek M,Jabłoński M,Radenovic L,Pluta R,Andjus PR

    更新日期:2012-04-01 00:00:00

  • Cellular activation in limbic brain systems during social play behaviour in rats.

    abstract::Positive social interactions during the juvenile and adolescent phases of life are essential for proper social and cognitive development in mammals, including humans. During this developmental period, there is a marked increase in peer-peer interactions, signified by the abundance of social play behaviour. Despite its...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0558-y

    authors: van Kerkhof LW,Trezza V,Mulder T,Gao P,Voorn P,Vanderschuren LJ

    更新日期:2014-07-01 00:00:00

  • Altered neuronal architecture and plasticity in the visual cortex of adult MMP-3-deficient mice.

    abstract::Matrix metalloproteinases (MMPs) are Zn(2+)-dependent endopeptidases considered to be essential for normal brain development and neuroplasticity by modulating extracellular matrix proteins, receptors, adhesion molecules, growth factors and cytoskeletal proteins. Specifically, MMP-3 has recently been implicated in syna...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0819-4

    authors: Aerts J,Nys J,Moons L,Hu TT,Arckens L

    更新日期:2015-09-01 00:00:00