Abstract:
:Ghrelin is a stomach-derived hormone that regulates a variety of biological functions such as food intake, gastrointestinal function and blood glucose metabolism, among others. Ghrelin acts via the growth hormone secretagogue receptor (GHSR), a G-protein-coupled receptor located in key brain areas that mediate specific actions of the hormone. GHSR is highly expressed in the nucleus of the solitary tract (NTS), which is located in the medulla oblongata and controls essential functions, including orofacial, autonomic, neuroendocrine and behavioral responses. Here, we used a mouse model, in which the expression of enhanced green fluorescent protein (eGFP) is controlled by the promoter of GHSR (GHSR-eGFP mice), to gain neuroanatomical and functional insights of the GHSR-expressing neurons of the NTS. We found that GHSR-expressing neurons of the NTS are segregated in clusters that were symmetrically distributed to the midline: (1) a pair of rostral clusters, and (2) a caudal and medially located cluster. We also identified that a subset of GHSR neurons of the caudal NTS are GABAergic. Finally, we found that rostral NTS GHSR neurons increase the levels of the marker of neuronal activation c-Fos in mice exposed to fasting/refeeding or high-fat diet bingeing protocols, while caudal NTS GHSR neurons increase the levels of c-Fos in mice exposed to gastric distension or LiCl-induced malaise protocols. Thus, current data provide evidence that ghrelin receptor signaling seems to target segregated clusters of neurons within the NTS that, in turn, may be activated by different stimuli.
journal_name
Brain Struct Functjournal_title
Brain structure & functionauthors
Cornejo MP,De Francesco PN,García Romero G,Portiansky EL,Zigman JM,Reynaldo M,Perello Mdoi
10.1007/s00429-018-1682-5subject
Has Abstractpub_date
2018-09-01 00:00:00pages
3133-3147issue
7eissn
1863-2653issn
1863-2661pii
10.1007/s00429-018-1682-5journal_volume
223pub_type
杂志文章abstract::The octopus arm contains a tridimensional array of muscles with a massive sensory-motor system. We herein provide the first evidence for the existence of serotonin (5-HT) in the octopus arm nervous system and investigated its distribution using immunohistochemistry. 5-HT-like immunoreactive (5-HT-lir) nerve cell bodie...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1385-3
更新日期:2017-09-01 00:00:00
abstract::Stress-related psychiatric diseases are nearly twice as prevalent in women compared to men. We recently showed in male rats that the resident-intruder model of social stress differentially engages stress-related circuitry that regulates norepinephrine-containing neurons of the locus coeruleus (LC) depending on coping ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-019-01837-5
更新日期:2019-05-01 00:00:00
abstract::Similar to memory formation, memory extinction is also a new learning process that requires synaptic plasticity. Actin rearrangement is fundamental for synaptic plasticity, however, whether actin rearrangement in the infralimbic cortex (IL) plays a role in memory extinction, as well as the mechanisms underlying it, re...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0685-5
更新日期:2015-03-01 00:00:00
abstract::The midline and intralaminar thalamic nuclei (MITN), locus coeruleus (LC) and cingulate cortex contain nociceptive neurons. The MITN that project to cingulate cortex have a prominent innervation by norepinephrinergic axons primarily originating from the LC. The hypothesis explored in this study is that MITN neurons th...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-008-0178-0
更新日期:2008-08-01 00:00:00
abstract::Glucose metabolism produces, by oxidative phosphorylation, more than 15 times the amount of energy generated by aerobic glycolysis. Nonetheless, aerobic glycolysis remains a prevalent metabolic pathway in the brain. Here we review evidence suggesting that this pathway contributes essential molecules to the biomass of ...
journal_title:Brain structure & function
pub_type: 杂志文章,评审
doi:10.1007/s00429-013-0662-z
更新日期:2014-07-01 00:00:00
abstract::Diffusion-weighted magnetic resonance spectroscopy of brain metabolites offers unique access to compartment-specific microstructural information on neural tissue. Here, we investigated in detail the diffusion characteristics of the neuronal/axonal markers N-acetylaspartate + N-acetyl aspartyl glutamate (tNAA) in a sma...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0600-0
更新日期:2014-09-01 00:00:00
abstract::The vestibulo-ocular reflex (VOR) adaptation is an ideal model for investigating how the neurosteroid 17 beta-estradiol (E2) contributes to the modification of behavior by regulating synaptic activities. We hypothesized that E2 impacts VOR adaptation by affecting cerebellar synaptic plasticity at the parallel fiber-Pu...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1514-z
更新日期:2018-03-01 00:00:00
abstract::The hypoglossal motor nucleus is one of the efferent components of the neural network underlying the tongue prehension behavior of Ranid frogs. Although the appropriate pattern of the motor activity is determined by motor pattern generators, sensory inputs can modify the ongoing motor execution. Combination of fluores...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0988-1
更新日期:2016-04-01 00:00:00
abstract::The acoustic radiation is a compact bundle of fibers conveying auditory information from the medial geniculate nucleus of the thalamus to the auditory cortex. Topographical knowledge of this bundle in primates is scarce and in vivo diffusion-based tractography reconstructions in humans remains challenging, especially ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1471-6
更新日期:2018-01-01 00:00:00
abstract::Diffusion tensor imaging (DTI) has become a valuable tool to investigate white matter integrity in the brain. DTI also gives contrast in gray matter, which has been relatively little explored in studies assessing post-injury structural abnormalities. The present study was designed to compare white and gray matter reor...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0683-7
更新日期:2015-03-01 00:00:00
abstract::There is limited information on the role of GABA type A receptors (GABAARs) containing α1, α5 and γ2 subunits in learning and memory. Here, we assessed the possible role of such receptors in spatial learning using the multiple T-maze (MTM) paradigm. C57BL/6J mice were trained in the MTM which induced elevated levels o...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1233-x
更新日期:2017-01-01 00:00:00
abstract::Diffusion tensor histology holds great promise for quantitative characterization of structural connectivity in mouse models of neurological and psychiatric conditions. There has been extensive study in both the clinical and preclinical domains on the complex tradeoffs between the spatial resolution, the number of samp...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1750-x
更新日期:2018-12-01 00:00:00
abstract::Animal models of Alzheimer's disease (AD) can be used to determine the progressive neurodegeneration characteristics of AD in vivo using magnetic resonance imaging (MRI). Given the need for therapeutic interventions before the onset of frank AD, it is critical to examine if AD models demonstrate neuroanatomical remode...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1691-4
更新日期:2018-09-01 00:00:00
abstract::We are often faced with situations requiring the execution of a coordinated cascade of different actions to achieve a goal, but we can apply different strategies to do so. Until now, these different action cascading strategies have, however, not been examined with respect to possible effects of aging. We tackled this ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-015-1071-2
更新日期:2016-06-01 00:00:00
abstract::Deficient prefrontal cortex (PFC) GABA function is hypothesized to play a role in schizophrenia and other psychiatric disorders. In rodents, PFC GABAA receptor antagonism produces cognitive and behavioral changes relevant to these disorders, including impaired spatial memory assessed with the traditional working/refer...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1769-z
更新日期:2019-01-01 00:00:00
abstract::Using T 1-weighted MRI at two different magnetic field strengths, the enhanced longitudinal relaxivity due to paramagnetic manganese ions in mouse brain in vivo is shown to reflect reduced intracellular mobility. One day after systemic administration of manganese chloride, increases of the longitudinal relaxation rate...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0742-8
更新日期:2015-01-01 00:00:00
abstract::Neonatal brain lesions cause deficits in structure and function of the cerebral cortex that sometimes are not fully expressed until adolescence. To better understand the onset and persistence of changes caused by postnatal day 7 (P7) ethanol treatment, we examined neocortical cell numbers, volume, surface area and thi...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-019-01881-1
更新日期:2019-06-01 00:00:00
abstract::Serotonin neurons arise from the brainstem raphe nuclei and send their projections throughout the brain to release 5-HT which acts as a modulator of several neuronal populations. Previous electron microscopy studies in rats have morphologically determined the distribution of 5-HT release sites (boutons) in certain bra...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1278-x
更新日期:2017-04-01 00:00:00
abstract::Hox proteins are key regulators of animal development, providing positional identity and patterning information to cells along the rostrocaudal axis of the embryo. Although their embryonic expression and function are well characterized, their presence and biological importance in adulthood remains poorly investigated....
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0965-8
更新日期:2016-04-01 00:00:00
abstract::Glycoproteins are complex molecules of the cell surface and the extracellular matrix (ECM) playing a fundamental role in the migration, guidance and synapse formation of neurons. In the present study, the glycosylated protein composition and localization were investigated in the adult and developing CNS of an aquatic ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-009-0229-1
更新日期:2009-12-01 00:00:00
abstract::The fornix is the primary efferent pathway of the hippocampus and plays a central role in memory circuitry. Diffusion tensor imaging has shown changes in the fornix with typical development and aging. Here, the fornix was investigated in 903 healthy young adult participants aged 22-36 years old from the high-spatial r...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02181-9
更新日期:2021-01-02 00:00:00
abstract::Finding the neuroanatomical correlates of prematurity is vital to understanding which structures are affected, and to designing efficient prevention and treatment strategies. Converging results reveal that thalamic abnormalities are important indicators of prematurity. However, little is known about the localization o...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0921-7
更新日期:2016-01-01 00:00:00
abstract::Prolactin is fundamental for the expression of maternal behaviour. In virgin female rats, prolactin administered upon steroid hormone priming accelerates the onset of maternal care. By contrast, the role of prolactin in mice maternal behaviour remains unclear. This study aims at characterizing central prolactin activi...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1254-5
更新日期:2017-03-01 00:00:00
abstract::The amygdala and medial prefrontal cortex (mPFC) are highly interconnected telencephalic areas critical for cognitive processes, including associative learning and decision making. Both structures strongly innervate the lateral hypothalamus (LHA), an important component of the networks underlying the control of feedin...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-015-1081-0
更新日期:2016-07-01 00:00:00
abstract::Brain connectivity in non-human primates (NHPs) has been mainly investigated using tracer techniques and functional connectivity studies. Data on structural connections are scarce and come from diffusion tensor imaging (DTI), since gross anatomical white matter dissection studies in the NHP are lacking. The current st...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1718-x
更新日期:2018-11-01 00:00:00
abstract::The anorexigenic neuropeptide NEFA/nucleobindin 2 (NUCB2)/nesfatin-1-containing neurons are distributed in the brain regions involved in feeding regulation, including the hypothalamic paraventricular nucleus (PVN). Functionally, NUCB2/nesfatin-1 neurons in the PVN regulate feeding through the hypothalamus and brain st...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-015-1150-4
更新日期:2016-12-01 00:00:00
abstract::What changes in cortical organisation characterise global and localised variation between humans and chimpanzees remains a topic of considerable interest in evolutionary neuroscience. Here, we examined regional variation in cortical thickness, gyrification and white matter in samples of human and chimpanzee brains. Bo...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1213-1
更新日期:2017-01-01 00:00:00
abstract::Serotonergic neurons of the raphe nuclei exhibit anatomical, neurochemical and elecrophysiological heterogeneity that likely underpins their specific role in multiple behaviors. However, the precise organization of serotonin (5-HT) neurons to orchestrate 5-HT release patterns throughout the brain is not well understoo...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-015-1142-4
更新日期:2016-11-01 00:00:00
abstract::AMIGO2, or amphoterin-induced gene and ORF (open reading frame) 2, belongs to the leucine-rich repeats and immunoglobulin superfamilies. The protein is a downstream target of calcium-dependent survival signals and, therefore, promotes neuronal survival. Here, we describe the mRNA distribution pattern of AMIGO2 through...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-012-0387-4
更新日期:2013-01-01 00:00:00
abstract::The phylogenetic position of crocodilians in relation to birds and mammals makes them an interesting animal model for investigating the evolution of the nervous system in amniote vertebrates. A few neuroanatomical atlases are available for reptiles, but with a growing interest in these animals within the comparative n...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02028-3
更新日期:2020-03-01 00:00:00