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Deep sparse multi-task learning for feature selection in Alzheimer's disease diagnosis.

Abstract：

:Recently, neuroimaging-based Alzheimer's disease (AD) or mild cognitive impairment (MCI) diagnosis has attracted researchers in the field, due to the increasing prevalence of the diseases. Unfortunately, the unfavorable high-dimensional nature of neuroimaging data, but a limited small number of samples available, makes it challenging to build a robust computer-aided diagnosis system. Machine learning techniques have been considered as a useful tool in this respect and, among various methods, sparse regression has shown its validity in the literature. However, to our best knowledge, the existing sparse regression methods mostly try to select features based on the optimal regression coefficients in one step. We argue that since the training feature vectors are composed of both informative and uninformative or less informative features, the resulting optimal regression coefficients are inevidently affected by the uninformative or less informative features. To this end, we first propose a novel deep architecture to recursively discard uninformative features by performing sparse multi-task learning in a hierarchical fashion. We further hypothesize that the optimal regression coefficients reflect the relative importance of features in representing the target response variables. In this regard, we use the optimal regression coefficients learned in one hierarchy as feature weighting factors in the following hierarchy, and formulate a weighted sparse multi-task learning method. Lastly, we also take into account the distributional characteristics of samples per class and use clustering-induced subclass label vectors as target response values in our sparse regression model. In our experiments on the ADNI cohort, we performed both binary and multi-class classification tasks in AD/MCI diagnosis and showed the superiority of the proposed method by comparing with the state-of-the-art methods.

journal_name

Brain Struct Funct

journal_title

Brain structure & function

authors

Suk HI,Lee SW,Shen D,Alzheimer’s Disease Neuroimaging Initiative.

doi

10.1007/s00429-015-1059-y

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

2569-87

issue

eissn

1863-2653

issn

1863-2661

pii

10.1007/s00429-015-1059-y

journal_volume

221

pub_type

杂志文章

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Deep sparse multi-task learning for feature selection in Alzheimer's disease diagnosis.