Abstract：
:Serum response factor (SRF) is a major transcription factor that regulates the expression of several plasticity-associated genes in the brain. Although the developmental expression of SRF in excitatory neurons is crucial for establishing proper hippocampal circuitry, no substantial evidence of its role in unstimulated mature neurons has been provided. The present study used time-controlled, conditional SRF knockout mice and found that the lack of SRF in adult neurons led to decreased actin levels and inactivation of the actin-severing protein cofilin 1 through its increase in phosphorylation at Ser3. The augmentation of cofilin 1 phosphorylation correlated with an alteration of dendritic spine morphology in the dentate gyrus, which was reflected by an increase in the number of spines that clustered into the long-spine category. The changes in spine morphology coincided with a lower amplitude and frequency of miniature excitatory postsynaptic currents. Moreover, SRF knockout animals were hyperactive and exhibited impairments in hippocampus-dependent behaviors, such as digging, marble burying, and nesting. Altogether, our data indicate that the adult deletion of neuronal SRF leads to alterations of spine morphology and function and hippocampus-dependent behaviors. Thus, SRF deletion in adult neurons recapitulates some aspects of morphological, electrophysiological, and behavioral changes that are observed in such psychiatric disorders as schizophrenia and autism spectrum disorders.
journal_name
Brain Struct Functjournal_title
Brain structure & functionauthors
Nader K,Krysiak A,Beroun A,Pekala M,Szymanska M,Kuzniewska B,Radwanska K,Kaczmarek L,Kalita Kdoi
10.1007/s00429-019-01925-6subject
Has Abstractpub_date
2019-11-01 00:00:00pages
2691-2701issue
8eissn
1863-2653issn
1863-2661pii
10.1007/s00429-019-01925-6journal_volume
224pub_type
杂志文章abstract：:The purpose of this study was to measure the average corpus callosum volume of normal Koreans (aged in their 20s or 40s) and to analyze the effects of gender, age, and body parameters, such as height and weight on corpus callosum size. Magnetic resonance brain images were recorded for 68 people in their 20s (29 men, 3...
journal_title：Brain structure & function
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doi：10.1007/s00429-009-0209-5
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journal_title：Brain structure & function
pub_type： 杂志文章,评审
doi：10.1007/s00429-013-0527-5
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更新日期：2018-07-01 00:00:00
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journal_title：Brain structure & function
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doi：10.1007/s00429-013-0683-7
更新日期：2015-03-01 00:00:00
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journal_title：Brain structure & function
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pub_type： 杂志文章,meta分析
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pub_type： 历史文章,杂志文章,评审
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