Abstract:
:The extensive and increasing use of structural neuroimaging in the neurosciences rests on the assumption of an intimate relationship between structure and function in the human brain. However, few studies have examined the relationship between advanced magnetic resonance imaging (MRI) indices of cerebral structure and conventional measures of cerebral functioning in humans. Here we examined whether MRI-based morphometric measures of early visual cortex-estimated using a probabilistic anatomical mask of primary visual cortex (V1)-can predict the amplitude of the visual evoked potential (VEP), i.e., an electroencephalogram signal that primarily reflects postsynaptic potentials in early visual cortical areas. We found that left, right, and total V1 surface area positively predicted the VEP amplitude. In addition, we showed, using whole brain analysis of local surface areal expansion/contraction, that the association between VEP amplitude and surface area was highly specific for regions within bilateral V1. Together, these findings indicate a strong, selective relationship between MRI-based structural measures and functional properties of the human cerebral cortex.
journal_name
Brain Struct Functjournal_title
Brain structure & functionauthors
Elvsåshagen T,Moberget T,Bøen E,Hol PK,Malt UF,Andersson S,Westlye LTdoi
10.1007/s00429-013-0703-7subject
Has Abstractpub_date
2015-03-01 00:00:00pages
1229-36issue
2eissn
1863-2653issn
1863-2661journal_volume
220pub_type
杂志文章abstract::In the mammalian auditory system, the medial nucleus of the trapezoid body and the lateral superior olive (MNTB-LSO system) contribute to binaural intensity processing and lateralization. Localization precision varies with the sound frequencies. As recency of common ancestry with human beings increases, primates have ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-008-0201-5
更新日期:2009-09-01 00:00:00
abstract::Using sinusoidal oscillations of linear acceleration along both the horizontal and vertical planes to stimulate otolith organs in the inner ear, we charted the postnatal time at which responsive neurons in the rat inferior olive (IO) first showed Fos expression, an indicator of neuronal recruitment into the otolith ci...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-012-0432-3
更新日期:2013-07-01 00:00:00
abstract::Dominant theories of episodic memory propose that a key mechanism of memory consolidation is replay-a process, whereby neural patterns of activation during learning are reinstated during offline post-learning periods. Here, we tested whether key signatures of replay defined by studies in rodents, such as recapitulatio...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1790-2
更新日期:2019-03-01 00:00:00
abstract::Dopaminergic neuromodulation is critically important for brain and cognitive integrity. The DRD2/ANKK1 Taq1A polymorphism is associated with striatal dopamine (DA) D2 receptor availability. Some previous studies have found that the A allele of the Taq1A polymorphism influences brain structure, but the results are inco...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1650-0
更新日期:2018-07-01 00:00:00
abstract::The medial prefrontal cortex (mPFC) has been associated with diverse functions including attentional processes, visceromotor activity, decision making, goal directed behavior, and working memory. Using retrograde tracing techniques, we examined, compared, and contrasted afferent projections to the four divisions of th...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-007-0150-4
更新日期:2007-09-01 00:00:00
abstract::Finding the neuroanatomical correlates of prematurity is vital to understanding which structures are affected, and to designing efficient prevention and treatment strategies. Converging results reveal that thalamic abnormalities are important indicators of prematurity. However, little is known about the localization o...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0921-7
更新日期:2016-01-01 00:00:00
abstract::The Ly-6 superfamily of proteins, which affects diverse processes in the immune system, has attracted renewed attention due to the ability of some Ly-6 proteins to bind to and modulate the function of neuronal nicotinic acetylcholine receptors (nAChRs). However, there is a scarcity of knowledge regarding the distribut...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0611-x
更新日期:2014-11-01 00:00:00
abstract::The pedunculopontine nucleus (PPN) is composed of neurons with different connectivity patterns that express different neurochemical markers, display distinct firing characteristics and are topographically organized in functional domains across its rostro-caudal axis. Previous reports have shown that the caudal region ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0579-6
更新日期:2014-07-01 00:00:00
abstract::The organization of the serotonergic system, one of the most important neurotransmitter systems in the brain, has been carefully analyzed in most vertebrate groups, and major shared characteristics have been described, although traits particular to each vertebrate class have also been found. The present study is the f...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0661-0
更新日期:2015-01-01 00:00:00
abstract::Similar to memory formation, memory extinction is also a new learning process that requires synaptic plasticity. Actin rearrangement is fundamental for synaptic plasticity, however, whether actin rearrangement in the infralimbic cortex (IL) plays a role in memory extinction, as well as the mechanisms underlying it, re...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0685-5
更新日期:2015-03-01 00:00:00
abstract::Interest in the study of brain connectivity is growing, particularly in understanding the dynamics of the structural/functional connectivity relation. Structural and functional connectivity are most often analysed independently of each other. Track-weighted functional connectivity (TW-FC) was recently proposed as a me...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1431-1
更新日期:2017-11-01 00:00:00
abstract::The adult dentate gyrus produces new neurons that morphologically and functionally integrate into the hippocampal network. In the adult brain, most excitatory synapses are ensheathed by astrocytic perisynaptic processes that regulate synaptic structure and function. However, these processes are formed during embryonic...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0768-y
更新日期:2015-07-01 00:00:00
abstract::Animal models of Alzheimer's disease (AD) can be used to determine the progressive neurodegeneration characteristics of AD in vivo using magnetic resonance imaging (MRI). Given the need for therapeutic interventions before the onset of frank AD, it is critical to examine if AD models demonstrate neuroanatomical remode...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1691-4
更新日期:2018-09-01 00:00:00
abstract::The 30-amino acid peptide Y-P30, generated from the N-terminus of the human dermcidin precursor protein, has been found to promote neuronal survival, cell migration and neurite outgrowth by enhancing the interaction of pleiotrophin and syndecan-3. We now show that Y-P30 activates Src kinase and extracellular signal-re...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0764-2
更新日期:2015-07-01 00:00:00
abstract::World-wide methamphetamine (meth) use is increasing at a rapid rate; therefore, it has become increasingly important to understand the synaptic changes and neural mechanisms affected by drug exposure. In rodents, 6-h access to contingent meth results in an escalation of drug intake and impaired cognitive sequelae typi...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1322-x
更新日期:2017-07-01 00:00:00
abstract::The phylogenetic position of crocodilians in relation to birds and mammals makes them an interesting animal model for investigating the evolution of the nervous system in amniote vertebrates. A few neuroanatomical atlases are available for reptiles, but with a growing interest in these animals within the comparative n...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02028-3
更新日期:2020-03-01 00:00:00
abstract::Matrix metalloproteinases (MMPs) are Zn(2+)-dependent endopeptidases considered to be essential for normal brain development and neuroplasticity by modulating extracellular matrix proteins, receptors, adhesion molecules, growth factors and cytoskeletal proteins. Specifically, MMP-3 has recently been implicated in syna...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0819-4
更新日期:2015-09-01 00:00:00
abstract::The vestibulo-ocular reflex (VOR) adaptation is an ideal model for investigating how the neurosteroid 17 beta-estradiol (E2) contributes to the modification of behavior by regulating synaptic activities. We hypothesized that E2 impacts VOR adaptation by affecting cerebellar synaptic plasticity at the parallel fiber-Pu...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1514-z
更新日期:2018-03-01 00:00:00
abstract::Positive social interactions during the juvenile and adolescent phases of life are essential for proper social and cognitive development in mammals, including humans. During this developmental period, there is a marked increase in peer-peer interactions, signified by the abundance of social play behaviour. Despite its...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0558-y
更新日期:2014-07-01 00:00:00
abstract::Sensory neurons of the jugular vagal ganglia innervate the respiratory tract and project to the poorly studied medullary paratrigeminal nucleus. In the present study, we used neuroanatomical tracing, pharmacology and physiology in guinea pig to investigate the paratrigeminal neural circuits mediating jugular ganglia-e...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1732-z
更新日期:2018-12-01 00:00:00
abstract::Dopamine, acting at the D1 family receptors (D1R) is critical for the functioning of the amygdala, including fear conditioning and cue-induced reinstatement of drug self administration. However, little is known about the different contributions of the two D1R subtypes, D(1) and D(5). We identified D(1)-immunoreactive ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-009-0214-8
更新日期:2009-09-01 00:00:00
abstract::Agenesis of the corpus callosum (AgCC) is a congenital condition associated with wide-ranging emotional and social impairments often overlapping with the diagnostic criteria for autism. Mapping functional connectivity in the acallosal brain can help identify neural correlates of the deficits associated with this condi...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0948-9
更新日期:2016-03-01 00:00:00
abstract::The hypoglossal motor nucleus is one of the efferent components of the neural network underlying the tongue prehension behavior of Ranid frogs. Although the appropriate pattern of the motor activity is determined by motor pattern generators, sensory inputs can modify the ongoing motor execution. Combination of fluores...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0988-1
更新日期:2016-04-01 00:00:00
abstract::Von Economo's neurons (VENs) are large, bipolar or corkscrew-shaped neurons located in layers III and V of the frontoinsular and the anterior cingulate cortices. VENs are reported to be altered in pathologies such as frontotemporal dementia and autism, in which the individual's self control is seriously compromised. T...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-012-0382-9
更新日期:2013-01-01 00:00:00
abstract::The vascular organization of the human brain can determine neurological and neurophysiological functions, yet thus far it has not been comprehensively mapped. Aging and diseases such as dementia are known to be associated with changes to the vasculature and normative data could help detect these vascular changes in ne...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-019-01919-4
更新日期:2019-09-01 00:00:00
abstract::The amygdala and medial prefrontal cortex (mPFC) are highly interconnected telencephalic areas critical for cognitive processes, including associative learning and decision making. Both structures strongly innervate the lateral hypothalamus (LHA), an important component of the networks underlying the control of feedin...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-015-1081-0
更新日期:2016-07-01 00:00:00
abstract::Despite being historically one of the first brain regions linked to memory loss, there remains controversy over the core features of diencephalic amnesia as well as the critical site for amnesia to occur. The mammillary bodies and thalamus appear to be the primary locus of pathology in the cases of diencephalic amnesi...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1330-x
更新日期:2017-07-01 00:00:00
abstract::Sublineage diversification of specific neural cell classes occurs in complex as well as simply organized regions of the central and peripheral nervous systems; the significance of the phenomenon, however, remains insufficiently understood. The unipolar brush cells (UBCs) are glutamatergic cerebellar interneurons that ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0531-9
更新日期:2014-03-01 00:00:00
abstract::Glycoproteins are complex molecules of the cell surface and the extracellular matrix (ECM) playing a fundamental role in the migration, guidance and synapse formation of neurons. In the present study, the glycosylated protein composition and localization were investigated in the adult and developing CNS of an aquatic ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-009-0229-1
更新日期:2009-12-01 00:00:00
abstract::The characterization of neuronal properties is a necessary first step toward understanding how the ventrolateral preoptic nucleus (VLPO) neuronal network regulates slow-wave sleep (SWS). Indeed, the electrophysiological heterogeneity of VLPO neurons suggests the existence of subtypes that could differently contribute ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1265-2
更新日期:2017-04-01 00:00:00