Functional role of local GABAergic influences on the HPA axis.

Abstract:

:Neuronatomical and pharmacological studies have established GABA-mediated inhibition of the HPA axis at the level of the PVN. The origin of this innervation is a series of local hypothalamic and adjacent forebrain regions that project to stress-integrative hypophysiotropic CRH neurons. While a role in tonic inhibition of the stress axis is likely, this system of inhibitory loci is also capable of producing a dynamic braking capacity in the context of the neuroendocrine stress response. The latter function is mediated in large part by glutamatergic forebrain afferents that increase GABA release at the level of the PVN. In addition, this local GABA system can be inhibited by upstream GABAergic projection neurons, producing activation of the HPA axis via removal of GABAergic tone. This PVN projecting GABA network interfaces with a wide range of homeostatic mechanisms, and is capable of biochemical plasticity in response to chronic stress. Collectively, the elements of this system provide for exquisite control of neuroendocrine activation in the face of stressful stimuli, and loss of this regulatory capacity may underlie many stress-related disorders.

journal_name

Brain Struct Funct

authors

Cullinan WE,Ziegler DR,Herman JP

doi

10.1007/s00429-008-0192-2

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

63-72

issue

1-2

eissn

1863-2653

issn

1863-2661

journal_volume

213

pub_type

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