Abstract:
:Serotonergic cells are among the earliest neurons to be born in the developing central nervous system and serotonin is known to regulate the development of the nervous system. One of the major targets of the activity of serotonergic cells is the serotonin 1A receptor (5-HT1A), an ancestral archetypical serotonin receptor. In this study, we cloned and characterized the 3D structure of the sea lamprey 5-HT1A, and studied the expression of its transcript in the central nervous system by means of in situ hybridization. In phylogenetic analyses, the sea lamprey 5-HT1A sequence clustered together with 5-HT1A sequences of vertebrates and emerged as an outgroup to all gnathostome sequences. In situ hybridization analysis during prolarval, larval and adult stages showed a widespread expression of the lamprey 5-ht1a transcript. In P1 prolarvae 5-ht1a mRNA expression was observed in diencephalic nuclei, the rhombencephalon and rostral spinal cord. At P2 prolarval stage the 5-ht1a expression extended to other brain areas including telencephalic regions. 5-ht1a expression in larvae was observed throughout almost all the main brain regions with the strongest expression in the olfactory bulbs, lateral pallium, striatum, preoptic region, habenula, prethalamus, thalamus, pretectum, hypothalamus, rhombencephalic reticular area, dorsal column nucleus and rostral spinal cord. In adults, the 5-ht1a transcript was also observed in cells of the subcommissural organ. Comparison of the expression of 5-ht1a between the sea lamprey and other vertebrates reveals a conserved pattern in most of the brain regions, likely reflecting the ancestral vertebrate condition.
journal_name
Brain Struct Functjournal_title
Brain structure & functionauthors
Cornide-Petronio ME,Anadón R,Barreiro-Iglesias A,Rodicio MCdoi
10.1007/s00429-012-0461-ysubject
Has Abstractpub_date
2013-09-01 00:00:00pages
1317-35issue
5eissn
1863-2653issn
1863-2661journal_volume
218pub_type
杂志文章abstract::Patients with Parkinson's disease have difficulties with self-initiating a task and maintaining a steady task performance. We hypothesized that these difficulties relate to reorganization in the sensorimotor execution, cingulo-opercular task-set maintenance, and frontoparietal adaptive control networks. We tested this...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0981-8
更新日期:2016-04-01 00:00:00
abstract::Positive social interactions during the juvenile and adolescent phases of life are essential for proper social and cognitive development in mammals, including humans. During this developmental period, there is a marked increase in peer-peer interactions, signified by the abundance of social play behaviour. Despite its...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0558-y
更新日期:2014-07-01 00:00:00
abstract::The mammalian superior paraolivary nucleus (SPON) is a major source of GABAergic inhibition to neurons in the inferior colliculus (IC), a well-studied midbrain nucleus that is the site of convergence and integration for the majority ascending auditory pathways en route to the cortex. Neurons in the SPON and IC exhibit...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0815-8
更新日期:2015-09-01 00:00:00
abstract::Neuronatomical and pharmacological studies have established GABA-mediated inhibition of the HPA axis at the level of the PVN. The origin of this innervation is a series of local hypothalamic and adjacent forebrain regions that project to stress-integrative hypophysiotropic CRH neurons. While a role in tonic inhibition...
journal_title:Brain structure & function
pub_type: 杂志文章,评审
doi:10.1007/s00429-008-0192-2
更新日期:2008-09-01 00:00:00
abstract::Very preterm infants (≤ 31 weeks gestational age) are at high risk for brain injury and delayed development. Applying functional connectivity and graph theory methods to resting state MRI data (fcMRI), we tested the hypothesis that preterm infants would demonstrate alterations in connectivity measures both globally an...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1707-0
更新日期:2018-11-01 00:00:00
abstract::Children born very preterm (VPT) at less than 32 weeks' gestational age (GA) are prone to disrupted white matter maturation and impaired cognitive development. The aims of the present study were to identify differences in white matter microstructure and connectivity of children born VPT compared to term-born children,...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1614-4
更新日期:2018-06-01 00:00:00
abstract::Proprioceptive signals from body muscles have historically been considered to project to the rostrodorsal shell of the ventrobasal thalamic complex [the ventral posterolateral nucleus (VPL) and ventral posteromedial nucleus (VPM)]. However, we have recently found that proprioception from rat jaw-closing muscle spindle...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02118-2
更新日期:2020-09-01 00:00:00
abstract::In the superior parietal lobule (SPL), the anterior part (area PE) is known to process somatosensory information, while the caudalmost part (areas V6Av and V6) processes visual information. Here we studied the visual and somatosensory properties of the areas PEc and V6Ad located in between the somatosensory and visual...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1593-x
更新日期:2018-05-01 00:00:00
abstract::Anterior cingulate cortex (ACC) input to the claustrum is required for top-down cognitive control of action. By virtue of its widespread cortical connectivity, the claustrum is anatomically situated to process and broadcast top-down signals from ACC to downstream cortices. To gain a deeper understanding of claustrum p...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1731-0
更新日期:2018-12-01 00:00:00
abstract::The anatomic gene expression atlas (AGEA) of the adult mouse brain of the Allen Institute for Brain Science is a transcriptome-based atlas of the adult C57Bl/6 J mouse brain, based on the extensive in situ hybridization dataset of the Institute. This spatial mapping of the gene expression levels of mice under baseline...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02108-4
更新日期:2020-09-01 00:00:00
abstract::The effect of intracortical microstimulation has been studied in several cortical areas from motor to sensory areas. The frontal pole has received particular attention, and several microstimulation studies have been conducted in the frontal eye field, supplementary eye field, and the premotor ear-eye field, but no mic...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0682-8
更新日期:2015-03-01 00:00:00
abstract::There is limited information on the role of GABA type A receptors (GABAARs) containing α1, α5 and γ2 subunits in learning and memory. Here, we assessed the possible role of such receptors in spatial learning using the multiple T-maze (MTM) paradigm. C57BL/6J mice were trained in the MTM which induced elevated levels o...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1233-x
更新日期:2017-01-01 00:00:00
abstract::Three populations of neurons expressing the vesicular glutamate transporter 2 (Vglut2) were recently described in the A10 area of the mouse midbrain, of which two populations were shown to express the gene encoding, the rate-limiting enzyme for catecholamine synthesis, tyrosine hydroxylase (TH).One of these population...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0778-9
更新日期:2015-07-01 00:00:00
abstract::Multisensory integration does not only recruit higher-level association cortex, but also low-level and even primary sensory cortices. Here, we will describe and quantify two types of anatomical pathways, a thalamocortical and a corticocortical that possibly underlie short-latency multisensory integration processes in ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0694-4
更新日期:2015-03-01 00:00:00
abstract::It is well established that environmental influences play a key role in sculpting neuronal connectivity in the brain. One example is the olfactory sensory map of topographic axonal connectivity. While intrinsic odorant receptor signaling in olfactory sensory neurons (OSN) determines anterior-posterior counter gradient...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0783-z
更新日期:2015-07-01 00:00:00
abstract::Recent surges in tissue clearing technology have greatly advanced 3-dimensional (3D) volume imaging. Cleared tissues need to be stained with fluorescence probes for imaging but the current staining methods are too laborious and inefficient for thick 3D samples, which impedes the broad application of clearing technolog...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02160-0
更新日期:2021-01-01 00:00:00
abstract::Substance used during adolescent period increases the risk of psychiatric disorders in later life, but the underlying neural mechanisms remain unclear. We hypothesize that synaptic remodeling and changes of homeostasis in the medial prefrontal cortex (mPFC) following adolescent cocaine exposure may last for a long tim...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1590-0
更新日期:2018-05-01 00:00:00
abstract::The axon initial segment (AIS) is responsible for both the modulation of action potentials and the maintenance of neuronal polarity. Yet, the molecular mechanisms controlling its assembly are incompletely understood. Our study in single electroporated motor neurons in mouse embryos revealed that AnkyrinG (AnkG), the A...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0578-7
更新日期:2014-07-01 00:00:00
abstract::To better understand information transfer along the hippocampal pathways and its plasticity, here we studied the antidromic responses of the dentate gyrus (DG) and CA3 to activation of the mossy fibers and Schaffer collaterals, respectively, in hippocampal slices from naïve and epileptic rats. We applied trains of 600...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-015-1003-1
更新日期:2016-05-01 00:00:00
abstract::We are often faced with situations requiring the execution of a coordinated cascade of different actions to achieve a goal, but we can apply different strategies to do so. Until now, these different action cascading strategies have, however, not been examined with respect to possible effects of aging. We tackled this ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-015-1071-2
更新日期:2016-06-01 00:00:00
abstract::Neuroimaging studies have demonstrated that mental imagery and perception share similar neural substrates, however, there are still ambiguities according to different auditory imagery content. In addition, there is still a lack of information regarding the underlying neural correlation between the two modalities. In t...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-019-01948-z
更新日期:2019-11-01 00:00:00
abstract::Sensory neurons of the jugular vagal ganglia innervate the respiratory tract and project to the poorly studied medullary paratrigeminal nucleus. In the present study, we used neuroanatomical tracing, pharmacology and physiology in guinea pig to investigate the paratrigeminal neural circuits mediating jugular ganglia-e...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1732-z
更新日期:2018-12-01 00:00:00
abstract::MRI was employed to follow the neurodegenerative foci and the localization of inflammatory cells by magnetically labeled CD4+ or CD8+ lymphocytes in the ischemia/reperfusion long-lived rats (9 and 13 months after 10 min of cardiac arrest). MRI of ischemic rats showed: (1) blood-brain barrier (BBB) leakage in the area ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-011-0336-7
更新日期:2012-04-01 00:00:00
abstract::The pedunculopontine nucleus (PPN) is composed of neurons with different connectivity patterns that express different neurochemical markers, display distinct firing characteristics and are topographically organized in functional domains across its rostro-caudal axis. Previous reports have shown that the caudal region ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0579-6
更新日期:2014-07-01 00:00:00
abstract::Similar to memory formation, memory extinction is also a new learning process that requires synaptic plasticity. Actin rearrangement is fundamental for synaptic plasticity, however, whether actin rearrangement in the infralimbic cortex (IL) plays a role in memory extinction, as well as the mechanisms underlying it, re...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0685-5
更新日期:2015-03-01 00:00:00
abstract::Regulator of G protein signaling 14 (RGS14) is a multifunctional signaling protein primarily expressed in mouse pyramidal neurons of hippocampal area CA2 where it regulates synaptic plasticity important for learning and memory. However, very little is known about RGS14 protein expression in the primate brain. Here, we...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1487-y
更新日期:2018-01-01 00:00:00
abstract::We analyzed the developmental history of the subplate and related cellular compartments of the prenatal and early postnatal human cerebrum by combining postmortem histological analysis with in vivo MRI. Histological analysis was performed on 21 postmortem brains (age range: 26 postconceptional weeks to 6.5 years) usin...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-012-0496-0
更新日期:2014-01-01 00:00:00
abstract::How can the components of visual comprehension be characterized as brain activity? Making sense of a dynamic visual world involves perceiving streams of activity as discrete units such as eating breakfast or walking the dog. In order to parse activity into distinct events, the brain relies on both the perceptual (bott...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-007-0160-2
更新日期:2007-12-01 00:00:00
abstract::In recent years, the demonstration that structural changes can occur in the human brain beyond those associated with development, ageing and neuropathology has revealed a new approach to studying the neural basis of behaviour. In this review paper, we focus on structural imaging studies of language that have utilised ...
journal_title:Brain structure & function
pub_type: 杂志文章,评审
doi:10.1007/s00429-009-0211-y
更新日期:2009-10-01 00:00:00
abstract::Two anorexigenic peptides, thyrotropin-releasing hormone (TRH) and urocortin 3 (UCN3), are co-expressed in a continuous neuronal group that extends from the perifornical area to the bed nucleus of stria terminalis, raising the possibility that this cell group may be involved in the regulation of energy homeostasis. In...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1553-5
更新日期:2018-04-01 00:00:00