Abstract：
:Although several novel approaches for hippocampal subregion delineation have been developed, they need to be applied prospectively and may be limited by long scan times, the use of high field (>3T) imaging systems, and limited reliability metrics. Moreover, the majority of MR imaging data collected to date has employed a T1-weighted acquisition, creating a critical need for an approach that provides reliable hippocampal subregion segmentation using such a contrast. We present a highly reliable approach for the identification of six subregions comprising the hippocampal formation from MR images including the subiculum, dentate gyrus/cornu Ammonis 4 (DG/CA4), entorhinal cortex, fimbria, and anterior and posterior segments of cornu Ammonis 1-3 (CA1-3). MR images were obtained in the coronal plane using a standard 3D spoiled gradient sequence acquired on a GE 3T scanner through the whole head in approximately 10 min. The average ICC for inter-rater reliability across right and left volumetric regions-of-interest was 0.85 (range 0.71-0.98, median 0.86) and the average ICC for intra-rater reliability was 0.92 (range 0.66-0.99, median 0.97). The mean Dice index for inter-rater reliability across right and left hemisphere subregions was 0.75 (range 0.70-0.81, median 0.75) and the mean Dice index for intra-rater reliability was 0.85 (range 0.82-0.90, median 0.85). An investigation of hippocampal asymmetry revealed significantly greater right compared to left hemisphere volumes in the anterior segment of CA1-3 and in the subiculum.
journal_name
Brain Struct Functjournal_title
Brain structure & functionauthors
Rhindress K,Ikuta T,Wellington R,Malhotra AK,Szeszko PRdoi
10.1007/s00429-014-0854-1subject
Has Abstractpub_date
2015-11-01 00:00:00pages
3259-72issue
6eissn
1863-2653issn
1863-2661pii
10.1007/s00429-014-0854-1journal_volume
220pub_type
杂志文章abstract：:The ventral striatum (VS) is of particular interest in the study of neuropsychiatric disorders. In this study, performed on non-human primates, we associated local perturbation with monosynaptic axonal tracer injection into medial, central and lateral VS to characterize anatomo-functional circuits underlying the respe...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0911-9
更新日期：2016-01-01 00:00:00
abstract：:Normally, we are aware that our arms and legs belong to us and not to someone else. However, some stroke patients with hemiparesis/-plegia after right-sided stroke show a disturbed sensation of limb ownership and a disturbed self-awareness of actions and such patients with anosognosia for hemiparesis/plegia typically ...
journal_title：Brain structure & function
pub_type： 杂志文章,评审
doi：10.1007/s00429-010-0250-4
更新日期：2010-06-01 00:00:00
abstract：:The structure of neurons in the central auditory system is vulnerable to various kinds of acoustic exposures during the critical postnatal developmental period. Here we explored long-term effects of exposure to an acoustically enriched environment (AEE) during the third and fourth weeks of the postnatal period in rat ...
journal_title：Brain structure & function
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abstract：:In the neocortex, large layer 5B pyramidal neurons implement a high-density firing code. In contrast, other subtypes of pyramidal neurons, including those in layer 2/3, are functionally characterized by their sparse firing rate. Here, we investigate the synaptic basis of this behavior by comparing the properties of th...
journal_title：Brain structure & function
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doi：10.1007/s00429-019-01842-8
更新日期：2019-05-01 00:00:00
abstract：:Patients with Parkinson's disease have difficulties with self-initiating a task and maintaining a steady task performance. We hypothesized that these difficulties relate to reorganization in the sensorimotor execution, cingulo-opercular task-set maintenance, and frontoparietal adaptive control networks. We tested this...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0981-8
更新日期：2016-04-01 00:00:00
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journal_title：Brain structure & function
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doi：10.1007/s00429-016-1187-z
更新日期：2016-12-01 00:00:00
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journal_title：Brain structure & function
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doi：10.1007/s00429-012-0412-7
更新日期：2013-03-01 00:00:00
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journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-020-02096-5
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journal_title：Brain structure & function
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更新日期：2013-09-01 00:00:00
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journal_title：Brain structure & function
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journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-015-1158-9
更新日期：2016-11-01 00:00:00
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journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-011-0317-x
更新日期：2011-11-01 00:00:00
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journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-019-01908-7
更新日期：2019-09-01 00:00:00
abstract：:Recent surges in tissue clearing technology have greatly advanced 3-dimensional (3D) volume imaging. Cleared tissues need to be stained with fluorescence probes for imaging but the current staining methods are too laborious and inefficient for thick 3D samples, which impedes the broad application of clearing technolog...
journal_title：Brain structure & function
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doi：10.1007/s00429-020-02160-0
更新日期：2021-01-01 00:00:00
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journal_title：Brain structure & function
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doi：10.1007/s00429-014-0778-9
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journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-018-1662-9
更新日期：2018-07-01 00:00:00
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journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-016-1258-1
更新日期：2017-03-01 00:00:00
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journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0809-6
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journal_title：Brain structure & function
pub_type： 杂志文章
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journal_title：Brain structure & function
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更新日期：2014-11-01 00:00:00
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journal_title：Brain structure & function
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doi：10.1007/s00429-014-0988-1
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journal_title：Brain structure & function
pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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pub_type： 杂志文章
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