Abstract:
:Retinoic acid, the active form of the nutrient vitamin A, regulates several facets of neuronal plasticity in the hippocampus, including neurogenesis and synaptic strength, acting via specific retinoic acid receptors (RARs). Essential for conversion of vitamin A to retinoic acid is the enzyme retinaldehyde dehydrogenase (RALDH) and in the rodent hippocampus this is only present in the adjacent meninges where it must act as a locally released paracrine hormone. Little is known though about the expression of RALDHs and RARs in the human hippocampus. This study confirms that RALDH levels are very low in mouse neurons but, surprisingly, strong expression of RALDH protein is detected by immunohistochemistry in hippocampal neurons. The receptors RARα, β and γ were also detected, each receptor exhibiting differing subcellular locations implying their potential regulation of both transcription and non-genomic actions. These results imply an essential function of retinoic acid in the human hippocampus likely to include regulation of neuronal plasticity.
journal_name
Brain Struct Functjournal_title
Brain structure & functionauthors
Fragoso YD,Shearer KD,Sementilli A,de Carvalho LV,McCaffery PJdoi
10.1007/s00429-011-0359-0subject
Has Abstractpub_date
2012-04-01 00:00:00pages
473-83issue
2eissn
1863-2653issn
1863-2661journal_volume
217pub_type
杂志文章abstract::Cytoarchitectonic characterization of borders is necessary for stereological studies (e.g., total cell number estimation), in which particular cortical areas have to be defined. In this study, cytoarchitectonic characteristics are described and illustrated for the rat ventral or orbital frontal cortical areas, i.e., t...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-007-0164-y
更新日期:2008-02-01 00:00:00
abstract::The basal ganglia of the laboratory rat consist of a few core regions that are specifically interconnected by efferents and afferents of the central nervous system. In nearly 800 reports of tract-tracing investigations the connectivity of the basal ganglia is documented. The readout of connectivity data and the collat...
journal_title:Brain structure & function
pub_type: 杂志文章,meta分析
doi:10.1007/s00429-014-0936-0
更新日期:2016-03-01 00:00:00
abstract::Detailed information about the excitatory and inhibitory synapses on the hypoglossal motoneurons may help understand the neural mechanism for control of the hypoglossal motoneuron excitability and hence the precise and coordinated movements of the tongue during chewing, swallowing and licking. For this, we investigate...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-019-01874-0
更新日期:2019-06-01 00:00:00
abstract::Brain connectivity in non-human primates (NHPs) has been mainly investigated using tracer techniques and functional connectivity studies. Data on structural connections are scarce and come from diffusion tensor imaging (DTI), since gross anatomical white matter dissection studies in the NHP are lacking. The current st...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1718-x
更新日期:2018-11-01 00:00:00
abstract::Recently, neuroimaging-based Alzheimer's disease (AD) or mild cognitive impairment (MCI) diagnosis has attracted researchers in the field, due to the increasing prevalence of the diseases. Unfortunately, the unfavorable high-dimensional nature of neuroimaging data, but a limited small number of samples available, make...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-015-1059-y
更新日期:2016-06-01 00:00:00
abstract::The interthalamic adhesion (ITA) is an understudied neuroanatomical structure that forms a bridge of tissue connecting the thalamus of each hemisphere across the midline whose functional significance remains largely unknown. The likelihood of ITA absence has been reported in some studies to be increased in males, but ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1334-6
更新日期:2017-07-01 00:00:00
abstract::Pitch is a primary perceptual dimension of sounds and is crucial in music and speech perception. When listening to melodies, most humans encode the relations between pitches into memory using an ability called relative pitch (RP). A small subpopulation, almost exclusively musicians, preferentially encode pitches using...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-019-01872-2
更新日期:2019-06-01 00:00:00
abstract::The organization of the pallial derivatives across vertebrates follows a comparable elementary arrangement, although not all of them possess a layered cortical structure as sophisticated as the cerebral cortex of mammals. However, its expansion along evolution has only been possible by the development and coevolution ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02123-5
更新日期:2020-09-01 00:00:00
abstract::The process of learning mainly depends on the ability to store new information, while the ability to retrieve this information and express appropriate behaviors are also crucial for the adaptation of individuals to environmental cues. Thereby, all three components contribute to the cognitive fitness of an individual. ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0882-x
更新日期:2015-11-01 00:00:00
abstract::We investigated whether pre-operative MRI measures of focal brain atrophy could predict cognitive decline occurring after deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson's disease (PD). For that purpose, we prospectively collected data of 42 consecutive patients with PD who und...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1677-2
更新日期:2018-09-01 00:00:00
abstract::The hypoglossal motor nucleus is one of the efferent components of the neural network underlying the tongue prehension behavior of Ranid frogs. Although the appropriate pattern of the motor activity is determined by motor pattern generators, sensory inputs can modify the ongoing motor execution. Combination of fluores...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0988-1
更新日期:2016-04-01 00:00:00
abstract::Neuroligins are transmembrane cell adhesion proteins with a key role in the regulation of excitatory and inhibitory synapses. Based on previous in vitro and ex vivo studies, neuroligin-1 (NL1) has been suggested to play a selective role in the function of glutamatergic synapses. However, the role of NL1 has not yet be...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0636-1
更新日期:2015-01-01 00:00:00
abstract::In recent years, the demonstration that structural changes can occur in the human brain beyond those associated with development, ageing and neuropathology has revealed a new approach to studying the neural basis of behaviour. In this review paper, we focus on structural imaging studies of language that have utilised ...
journal_title:Brain structure & function
pub_type: 杂志文章,评审
doi:10.1007/s00429-009-0211-y
更新日期:2009-10-01 00:00:00
abstract::The vestibulo-ocular reflex (VOR) adaptation is an ideal model for investigating how the neurosteroid 17 beta-estradiol (E2) contributes to the modification of behavior by regulating synaptic activities. We hypothesized that E2 impacts VOR adaptation by affecting cerebellar synaptic plasticity at the parallel fiber-Pu...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1514-z
更新日期:2018-03-01 00:00:00
abstract::To establish the link between structure and function of any large area of the neocortex, it is helpful to identify its principles of organisation. One way to establish such principles is to investigate how differences in whole-brain connectivity are structured across the area. Here, we use Laplacian eigenmaps on diffu...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02047-0
更新日期:2020-05-01 00:00:00
abstract::Prolactin is fundamental for the expression of maternal behaviour. In virgin female rats, prolactin administered upon steroid hormone priming accelerates the onset of maternal care. By contrast, the role of prolactin in mice maternal behaviour remains unclear. This study aims at characterizing central prolactin activi...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1254-5
更新日期:2017-03-01 00:00:00
abstract::Ambulatory locomotion in the rodent is robustly activated by unilateral infusions into the basal forebrain of type A gamma-aminobutyric acid receptor antagonists, such as bicuculline and picrotoxin. The present study was carried out to better localize the neuroanatomical substrate(s) underlying this effect. To accompl...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0514-x
更新日期:2014-03-01 00:00:00
abstract::Childhood is defined by the development of cognitive abilities as well as brain growth and function. While prior neuroimaging studies have investigated early development fragmentally, we studied the typical development of functional network connectivity continuously from infancy to childhood (average of 24 months) in ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02027-4
更新日期:2020-03-01 00:00:00
abstract::The acoustic radiation is a compact bundle of fibers conveying auditory information from the medial geniculate nucleus of the thalamus to the auditory cortex. Topographical knowledge of this bundle in primates is scarce and in vivo diffusion-based tractography reconstructions in humans remains challenging, especially ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1471-6
更新日期:2018-01-01 00:00:00
abstract::Goal-directed behavior has been shown to be affected by consciously and subliminally induced conflicts. Both types of conflict conjointly modulate behavioral performance, but the underlying neuronal mechanisms have remained unclear. While cognitive control is linked to oscillations in the theta frequency band, there a...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-019-01866-0
更新日期:2019-06-01 00:00:00
abstract::Chaining or cascading of different actions and responses is necessary to accomplish a goal. Yet, little is known about the functional neuroanatomical-electrophysiological mechanisms mediating these processes. Computational models suggest that medium spiny neurons (MSNs) play an important role in action cascading, but ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0649-9
更新日期:2015-01-01 00:00:00
abstract::Sex differences are widespread across vertebrate nervous systems. Such differences are sometimes reflected in the neural substrate via neuroanatomical differences in brain region volume. One brain region that displays sex differences in its associated functions and pathologies is the striatum, including the caudate-pu...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-015-1158-9
更新日期:2016-11-01 00:00:00
abstract::What changes in cortical organisation characterise global and localised variation between humans and chimpanzees remains a topic of considerable interest in evolutionary neuroscience. Here, we examined regional variation in cortical thickness, gyrification and white matter in samples of human and chimpanzee brains. Bo...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1213-1
更新日期:2017-01-01 00:00:00
abstract::Von Economo's neurons (VENs) are large, bipolar or corkscrew-shaped neurons located in layers III and V of the frontoinsular and the anterior cingulate cortices. VENs are reported to be altered in pathologies such as frontotemporal dementia and autism, in which the individual's self control is seriously compromised. T...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-012-0382-9
更新日期:2013-01-01 00:00:00
abstract::Recent surges in tissue clearing technology have greatly advanced 3-dimensional (3D) volume imaging. Cleared tissues need to be stained with fluorescence probes for imaging but the current staining methods are too laborious and inefficient for thick 3D samples, which impedes the broad application of clearing technolog...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02160-0
更新日期:2021-01-01 00:00:00
abstract::To date, hampered physiological function after exposure to microgravity has been primarily attributed to deprived peripheral neuro-sensory systems. For the first time, this study elucidates alterations in human brain function after long-duration spaceflight. More specifically, we found significant differences in resti...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-015-1054-3
更新日期:2016-06-01 00:00:00
abstract::The default mode network (DMN) in humans has been extensively studied using seed-based correlation analysis (SCA) and independent component analysis (ICA). While DMN has been observed in monkeys as well, there are conflicting reports on whether they exist in rodents. Dogs are higher mammals than rodents, but cognitive...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0700-x
更新日期:2015-03-01 00:00:00
abstract::Regulator of G protein signaling 14 (RGS14) is a multifunctional signaling protein primarily expressed in mouse pyramidal neurons of hippocampal area CA2 where it regulates synaptic plasticity important for learning and memory. However, very little is known about RGS14 protein expression in the primate brain. Here, we...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1487-y
更新日期:2018-01-01 00:00:00
abstract::In the primate cerebral cortex, dendritic spines rapidly increase in number after birth up to infancy or mid-childhood, and then decrease towards adulthood. Abnormalities in these processes accompany several psychiatric disorders. In this study, we examined developmental changes of basal dendrites and spines of layer ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0853-2
更新日期:2015-11-01 00:00:00
abstract::SK2 (KCa2.2) channels are voltage-independent Ca2+-activated K+ channels that regulate neuronal excitability in brain regions important for memory formation. In this study, we investigated the distribution and expression of SK2 channels in human brain by Western blot analysis and immunohistochemistry. Immunoblot analy...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1258-1
更新日期:2017-03-01 00:00:00