Aerobic glycolysis in the primate brain: reconsidering the implications for growth and maintenance.

Abstract:

:Glucose metabolism produces, by oxidative phosphorylation, more than 15 times the amount of energy generated by aerobic glycolysis. Nonetheless, aerobic glycolysis remains a prevalent metabolic pathway in the brain. Here we review evidence suggesting that this pathway contributes essential molecules to the biomass of the brain. Aerobic metabolism is the dominant metabolic pathway during early postnatal development when lipids and proteins are needed for the processes of axonal elongation, synaptogenesis, and myelination. Furthermore, aerobic metabolism may continue into adulthood to supply biomolecules for activity-related changes at the synapse and turnover of constituent structural components of neurons. Conversely, oxidative phosphorylation appears to be the main metabolic support for synaptic transmission, and, therefore, this pathway seems to be more dominant in brain structures and at time points in the lifespan that are characterized by increased synaptic density. We present the case for differing relationships between aerobic glycolysis and oxidative phosphorylation across primates in association with species-specific variation in neurodevelopmental trajectories. In doing so, we provide an alternative interpretation for the assessment of radiolabeled glucose positron emission tomography studies that regularly attribute increases in glucose uptake to neural activity alone, and propose a new model for the contribution of metabolic pathways for energetic demand and neural tissue growth. We conclude that comparative studies of metabolic appropriation in the brain may contribute to the discussion of human cognitive evolution and to the understanding of human-specific aging and the etiology of neuropsychiatric diseases.

journal_name

Brain Struct Funct

authors

Bauernfeind AL,Barks SK,Duka T,Grossman LI,Hof PR,Sherwood CC

doi

10.1007/s00429-013-0662-z

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

1149-67

issue

4

eissn

1863-2653

issn

1863-2661

journal_volume

219

pub_type

杂志文章,评审
  • Regional gray matter density is associated with achievement motivation: evidence from voxel-based morphometry.

    abstract::Achievement motivation can be defined as a recurrent need to improve one's past performance. Despite previous functional imaging studies on motivation-related functional activation, the relationship between regional gray matter (rGM) morphology and achievement motivation has never been investigated. We used voxel-base...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-012-0485-3

    authors: Takeuchi H,Taki Y,Nouchi R,Sekiguchi A,Kotozaki Y,Miyauchi CM,Yokoyama R,Iizuka K,Hashizume H,Nakagawa S,Kunitoki K,Sassa Y,Kawashima R

    更新日期:2014-01-01 00:00:00

  • The rat corticospinal system is functionally and anatomically segregated.

    abstract::The descending corticospinal (CS) projection has been considered a key element for motor control, which results from direct and indirect modulation of spinal cord pre-motor interneurons in the intermediate gray matter of the spinal cord, which, in turn, influences motoneurons in the ventral horn. The CS tract (CST) is...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-017-1447-6

    authors: Olivares-Moreno R,Moreno-Lopez Y,Concha L,Martínez-Lorenzana G,Condés-Lara M,Cordero-Erausquin M,Rojas-Piloni G

    更新日期:2017-12-01 00:00:00

  • SK- and h-current contribute to the generation of theta-like resonance of rat substantia nigra pars compacta dopaminergic neurons at hyperpolarized membrane potentials.

    abstract::Oscillation activities are the feature of neural network and correlated to different physiological states. The theta (θ) oscillation (2-7 Hz) has been reported in the basal ganglia, and the intrinsic resonance properties of individual neurons have provided a basis for this network oscillation. The basal ganglia neuron...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-011-0361-6

    authors: Xue WN,Wang Y,He SM,Wang XL,Zhu JL,Gao GD

    更新日期:2012-04-01 00:00:00

  • Vesicular glutamate transporter 1 (VGLUT1)- and VGLUT2-immunopositive axon terminals on the rat jaw-closing and jaw-opening motoneurons.

    abstract::To provide information on the glutamatergic synapses on the trigeminal motoneurons, which may be important for understanding the mechanism of control of jaw movements, we investigated the distribution of vesicular glutamate transporter (VGLUT)1-immunopositive (+) and VGLUT2 + axon terminals (boutons) on the rat jaw-cl...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1636-y

    authors: Park SK,Ko SJ,Paik SK,Rah JC,Lee KJ,Bae YC

    更新日期:2018-06-01 00:00:00

  • Direct presynaptic and indirect astrocyte-mediated mechanisms both contribute to endocannabinoid signaling in the pedunculopontine nucleus of mice.

    abstract::The pedunculopontine nucleus (PPN), a cholinergic nucleus of the reticular activating system, is known to be involved in the regulation of sleep and wakefulness. Endogenous and exogenous cannabinoids, by systemic or local administration to the pedunculopontine nucleus, can both influence sleep. We previously demonstra...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-016-1214-0

    authors: Kovács A,Bordás C,Bíró T,Hegyi Z,Antal M,Szücs P,Pál B

    更新日期:2017-01-01 00:00:00

  • Deficits in task-set maintenance and execution networks in Parkinson's disease.

    abstract::Patients with Parkinson's disease have difficulties with self-initiating a task and maintaining a steady task performance. We hypothesized that these difficulties relate to reorganization in the sensorimotor execution, cingulo-opercular task-set maintenance, and frontoparietal adaptive control networks. We tested this...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0981-8

    authors: Tinaz S,Lauro P,Hallett M,Horovitz SG

    更新日期:2016-04-01 00:00:00

  • White matter tract anatomy in the rhesus monkey: a fiber dissection study.

    abstract::Brain connectivity in non-human primates (NHPs) has been mainly investigated using tracer techniques and functional connectivity studies. Data on structural connections are scarce and come from diffusion tensor imaging (DTI), since gross anatomical white matter dissection studies in the NHP are lacking. The current st...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1718-x

    authors: Decramer T,Swinnen S,van Loon J,Janssen P,Theys T

    更新日期:2018-11-01 00:00:00

  • Inducible nitric oxide synthase is present in motor neuron mitochondria and Schwann cells and contributes to disease mechanisms in ALS mice.

    abstract::Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of motor neurons (MNs). The molecular pathogenesis of ALS is not understood, thus effective therapies for this disease are lacking. Some forms of ALS are inherited by mutations in the superoxide dismutase-1 (SOD1) gene. Transgenic mice expressing...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-009-0226-4

    authors: Chen K,Northington FJ,Martin LJ

    更新日期:2010-03-01 00:00:00

  • Influence of the DRD2/ANKK1 Taq1A polymorphism on caudate volume in older adults without dementia.

    abstract::Dopaminergic neuromodulation is critically important for brain and cognitive integrity. The DRD2/ANKK1 Taq1A polymorphism is associated with striatal dopamine (DA) D2 receptor availability. Some previous studies have found that the A allele of the Taq1A polymorphism influences brain structure, but the results are inco...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1650-0

    authors: Li X,Papenberg G,Kalpouzos G,Bäckman L,Persson J

    更新日期:2018-07-01 00:00:00

  • Brain-wide resting-state connectivity regulation by the hippocampus and medial prefrontal cortex is associated with fluid intelligence.

    abstract::The connectivity hub property of the hippocampus (HIP) and the medial prefrontal cortex (MPFC) is essential for their widespread involvement in cognition; however, the cooperation mechanism between them is far from clear. Herein, using resting-state functional MRI and Gaussian Bayesian network to describe the directed...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-020-02077-8

    authors: Li R,Zhang J,Wu X,Wen X,Han B

    更新日期:2020-06-01 00:00:00

  • Whole mouse brain structural connectomics using magnetic resonance histology.

    abstract::Diffusion tensor histology holds great promise for quantitative characterization of structural connectivity in mouse models of neurological and psychiatric conditions. There has been extensive study in both the clinical and preclinical domains on the complex tradeoffs between the spatial resolution, the number of samp...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1750-x

    authors: Wang N,Anderson RJ,Badea A,Cofer G,Dibb R,Qi Y,Johnson GA

    更新日期:2018-12-01 00:00:00

  • Distribution of excitatory and inhibitory axon terminals on the rat hypoglossal motoneurons.

    abstract::Detailed information about the excitatory and inhibitory synapses on the hypoglossal motoneurons may help understand the neural mechanism for control of the hypoglossal motoneuron excitability and hence the precise and coordinated movements of the tongue during chewing, swallowing and licking. For this, we investigate...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-019-01874-0

    authors: Paik SK,Yoo HI,Choi SK,Bae JY,Park SK,Bae YC

    更新日期:2019-06-01 00:00:00

  • Functional anatomy of cortical areas characterized by Von Economo neurons.

    abstract::Von Economo's neurons (VENs) are large, bipolar or corkscrew-shaped neurons located in layers III and V of the frontoinsular and the anterior cingulate cortices. VENs are reported to be altered in pathologies such as frontotemporal dementia and autism, in which the individual's self control is seriously compromised. T...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-012-0382-9

    authors: Cauda F,Torta DM,Sacco K,D'Agata F,Geda E,Duca S,Geminiani G,Vercelli A

    更新日期:2013-01-01 00:00:00

  • Development of the mouse anterior amygdalar radial unit marked by Lhx9-expression.

    abstract::The amygdala in mammals plays a key role in emotional processing and learning, being subdivided in pallial and subpallial derivatives. Recently, the cortical ring model and the pallial amygdalar radial model (Puelles et al. 2019; Garcia-Calero et al. 2020) described the pallial amygdala as an histogenetic field extern...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-020-02201-8

    authors: Garcia-Calero E,Puelles L

    更新日期:2021-01-30 00:00:00

  • Acute inhibition of estradiol synthesis impacts vestibulo-ocular reflex adaptation and cerebellar long-term potentiation in male rats.

    abstract::The vestibulo-ocular reflex (VOR) adaptation is an ideal model for investigating how the neurosteroid 17 beta-estradiol (E2) contributes to the modification of behavior by regulating synaptic activities. We hypothesized that E2 impacts VOR adaptation by affecting cerebellar synaptic plasticity at the parallel fiber-Pu...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-017-1514-z

    authors: Dieni CV,Ferraresi A,Sullivan JA,Grassi S,Pettorossi VE,Panichi R

    更新日期:2018-03-01 00:00:00

  • Realistic modelling of receptor activation in hippocampal excitatory synapses: analysis of multivesicular release, release location, temperature and synaptic cross-talk.

    abstract::Chemically mediated synaptic transmission results from fusion of synaptic vesicles with the presynaptic plasma membrane, subsequent release of the vesicular content into the cleft and binding to postsynaptic receptors. Previous modelling studies of excitatory neurotransmitter glutamate were based on simplified geometr...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-010-0273-x

    authors: Boucher J,Kröger H,Sík A

    更新日期:2010-07-01 00:00:00

  • Cellular markers of neuroinflammation and neurogenesis after ischemic brain injury in the long-term survival rat model.

    abstract::MRI was employed to follow the neurodegenerative foci and the localization of inflammatory cells by magnetically labeled CD4+ or CD8+ lymphocytes in the ischemia/reperfusion long-lived rats (9 and 13 months after 10 min of cardiac arrest). MRI of ischemic rats showed: (1) blood-brain barrier (BBB) leakage in the area ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-011-0336-7

    authors: Sekeljic V,Bataveljic D,Stamenkovic S,Ułamek M,Jabłoński M,Radenovic L,Pluta R,Andjus PR

    更新日期:2012-04-01 00:00:00

  • Memory-guided attention: bilateral hippocampal volume positively predicts implicit contextual learning.

    abstract::Several studies have begun to demonstrate that contextual memories constitute an important mechanism to guide our attention. Although there is general consensus that the hippocampus is involved in the encoding of contextual memories, it is controversial whether this structure can support implicit forms of contextual m...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-019-01887-9

    authors: Rosero MA,Winkelmann T,Pohlack S,Cavalli J,Nees F,Flor H

    更新日期:2019-07-01 00:00:00

  • Enhanced representation of natural sound sequences in the ventral auditory midbrain.

    abstract::The auditory midbrain (inferior colliculus, IC) plays an important role in sound processing, acting as hub for acoustic information extraction and for the implementation of fast audio-motor behaviors. IC neurons are topographically organized according to their sound frequency preference: dorsal IC regions encode low f...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-020-02188-2

    authors: González-Palomares E,López-Jury L,García-Rosales F,Hechavarria JC

    更新日期:2021-01-01 00:00:00

  • Decreasing predictability of visual motion enhances feed-forward processing in visual cortex when stimuli are behaviorally relevant.

    abstract::Recent views of information processing in the (human) brain emphasize the hierarchical structure of the central nervous system, which is assumed to form the basis of a functional hierarchy. Hierarchical predictive processing refers to the notion that higher levels try to predict activity in lower areas, while lower le...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-016-1251-8

    authors: Kellermann T,Scholle R,Schneider F,Habel U

    更新日期:2017-03-01 00:00:00

  • A volumetric study of the corpus callosum in 20s and 40s Korean people.

    abstract::The purpose of this study was to measure the average corpus callosum volume of normal Koreans (aged in their 20s or 40s) and to analyze the effects of gender, age, and body parameters, such as height and weight on corpus callosum size. Magnetic resonance brain images were recorded for 68 people in their 20s (29 men, 3...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-009-0209-5

    authors: Lee BY,Sohn JH,Choi MH,Lee SJ,Kim HS,Yang JW,Choi JS,Kim HS,Yi JH,Tack GR,Chung SC

    更新日期:2009-09-01 00:00:00

  • The neocortex of cetartiodactyls: I. A comparative Golgi analysis of neuronal morphology in the bottlenose dolphin (Tursiops truncatus), the minke whale (Balaenoptera acutorostrata), and the humpback whale (Megaptera novaeangliae).

    abstract::The present study documents the morphology of neurons in several regions of the neocortex from the bottlenose dolphin (Tursiops truncatus), the North Atlantic minke whale (Balaenoptera acutorostrata), and the humpback whale (Megaptera novaeangliae). Golgi-stained neurons (n = 210) were analyzed in the frontal and temp...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0860-3

    authors: Butti C,Janeway CM,Townshend C,Wicinski BA,Reidenberg JS,Ridgway SH,Sherwood CC,Hof PR,Jacobs B

    更新日期:2015-11-01 00:00:00

  • TBSS and probabilistic tractography reveal white matter connections for attention to object features.

    abstract::Selective attention to features of interest facilitates object processing in a cluttered and dynamic environment. Previous research found that distinct networks of regions across cortex are activated depending on the attended feature. These networks typically consist of posterior feature-preferring regions and anterio...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0631-6

    authors: Mayer KM,Vuong QC

    更新日期:2014-11-01 00:00:00

  • Functional role of local GABAergic influences on the HPA axis.

    abstract::Neuronatomical and pharmacological studies have established GABA-mediated inhibition of the HPA axis at the level of the PVN. The origin of this innervation is a series of local hypothalamic and adjacent forebrain regions that project to stress-integrative hypophysiotropic CRH neurons. While a role in tonic inhibition...

    journal_title:Brain structure & function

    pub_type: 杂志文章,评审

    doi:10.1007/s00429-008-0192-2

    authors: Cullinan WE,Ziegler DR,Herman JP

    更新日期:2008-09-01 00:00:00

  • Neuroligin-1 regulates excitatory synaptic transmission, LTP and EPSP-spike coupling in the dentate gyrus in vivo.

    abstract::Neuroligins are transmembrane cell adhesion proteins with a key role in the regulation of excitatory and inhibitory synapses. Based on previous in vitro and ex vivo studies, neuroligin-1 (NL1) has been suggested to play a selective role in the function of glutamatergic synapses. However, the role of NL1 has not yet be...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0636-1

    authors: Jedlicka P,Vnencak M,Krueger DD,Jungenitz T,Brose N,Schwarzacher SW

    更新日期:2015-01-01 00:00:00

  • Y-P30 promotes axonal growth by stabilizing growth cones.

    abstract::The 30-amino acid peptide Y-P30, generated from the N-terminus of the human dermcidin precursor protein, has been found to promote neuronal survival, cell migration and neurite outgrowth by enhancing the interaction of pleiotrophin and syndecan-3. We now show that Y-P30 activates Src kinase and extracellular signal-re...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0764-2

    authors: Neumann JR,Dash-Wagh S,Jüngling K,Tsai T,Meschkat M,Räk A,Schönfelder S,Riedel C,Hamad MI,Wiese S,Pape HC,Gottmann K,Kreutz MR,Wahle P

    更新日期:2015-07-01 00:00:00

  • Modulation of olfactory-driven behavior by metabolic signals: role of the piriform cortex.

    abstract::Olfaction is one of the major sensory modalities that regulates food consumption and is in turn regulated by the feeding state. Given that the olfactory bulb has been shown to be a metabolic sensor, we explored whether the anterior piriform cortex (aPCtx)-a higher olfactory cortical processing area-had the same capaci...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1776-0

    authors: Al Koborssy D,Palouzier-Paulignan B,Canova V,Thevenet M,Fadool DA,Julliard AK

    更新日期:2019-01-01 00:00:00

  • Neuronal networks underlying the conjoint modulation of response selection by subliminal and consciously induced cognitive conflicts.

    abstract::Goal-directed behavior has been shown to be affected by consciously and subliminally induced conflicts. Both types of conflict conjointly modulate behavioral performance, but the underlying neuronal mechanisms have remained unclear. While cognitive control is linked to oscillations in the theta frequency band, there a...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-019-01866-0

    authors: Bensmann W,Zink N,Mückschel M,Beste C,Stock AK

    更新日期:2019-06-01 00:00:00

  • Differential distribution of phospholipase C beta isoforms and diaglycerol kinase-beta in rodents cerebella corroborates the division of unipolar brush cells into two major subtypes.

    abstract::Sublineage diversification of specific neural cell classes occurs in complex as well as simply organized regions of the central and peripheral nervous systems; the significance of the phenomenon, however, remains insufficiently understood. The unipolar brush cells (UBCs) are glutamatergic cerebellar interneurons that ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0531-9

    authors: Sekerková G,Watanabe M,Martina M,Mugnaini E

    更新日期:2014-03-01 00:00:00

  • Mapping the intersection of language and reading: the neural bases of the primary systems hypothesis.

    abstract::The primary systems framework has been used to relate behavioural performance across many different language activities to the status of core underpinning domain-general cognitive systems. This study provided the first quantitative investigation of this account at both behavioural and neural levels in a group of patie...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1716-z

    authors: Woollams AM,Halai A,Lambon Ralph MA

    更新日期:2018-11-01 00:00:00