Abstract：
:We analyzed the developmental history of the subplate and related cellular compartments of the prenatal and early postnatal human cerebrum by combining postmortem histological analysis with in vivo MRI. Histological analysis was performed on 21 postmortem brains (age range: 26 postconceptional weeks to 6.5 years) using Nissl staining, AChE-histochemistry, PAS-Alcian blue histochemistry, Gallyas' silver impregnation, and immunocytochemistry for MAP2, synaptophysin, neurofilament, chondroitin sulfate, fibronectin, and myelin basic protein. The histological findings were correlated with in vivo MRI findings obtained in 30 age-matched fetuses, infants, and children. We analyzed developmental reorganization of major cellular (cell bodies, growing axons) and extracellular (extracellular matrix) components of the subplate and the developing cortex/white matter interface. We found that perinatal and postnatal reorganization of these tissue components is protracted (extending into the second year of life) and characterized by well-delineated, transient and previously undescribed structural and molecular changes at the cortex/white matter interface. The findings of this study are clinically relevant because they may inform and guide a proper interpretation of highly dynamic and hitherto puzzling changes of cortical thickness and cortical/white matter interface as described in current in vivo MRI studies.
journal_name
Brain Struct Functjournal_title
Brain structure & functionauthors
Kostović I,Jovanov-Milošević N,Radoš M,Sedmak G,Benjak V,Kostović-Srzentić M,Vasung L,Čuljat M,Radoš M,Hüppi P,Judaš Mdoi
10.1007/s00429-012-0496-0subject
Has Abstractpub_date
2014-01-01 00:00:00pages
231-53issue
1eissn
1863-2653issn
1863-2661journal_volume
219pub_type
杂志文章abstract：:Using sinusoidal oscillations of linear acceleration along both the horizontal and vertical planes to stimulate otolith organs in the inner ear, we charted the postnatal time at which responsive neurons in the rat inferior olive (IO) first showed Fos expression, an indicator of neuronal recruitment into the otolith ci...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-012-0432-3
更新日期：2013-07-01 00:00:00
abstract：:A hierarchical and modular organization is a central hypothesis in the current primate model of auditory cortex (AC) but lacks validation in humans. Here we investigated whether fMRI connectivity at rest and during active tasks is informative of the functional organization of human AC. Identical pitch-varying sounds w...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-018-1612-6
更新日期：2018-06-01 00:00:00
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journal_title：Brain structure & function
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doi：10.1007/s00429-018-1682-5
更新日期：2018-09-01 00:00:00
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journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0905-7
更新日期：2016-01-01 00:00:00
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journal_title：Brain structure & function
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journal_title：Brain structure & function
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journal_title：Brain structure & function
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journal_title：Brain structure & function
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doi：10.1007/s00429-013-0600-0
更新日期：2014-09-01 00:00:00
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journal_title：Brain structure & function
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pub_type： 杂志文章
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更新日期：2010-03-01 00:00:00
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journal_title：Brain structure & function
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journal_title：Brain structure & function
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doi：10.1007/s00429-017-1431-1
更新日期：2017-11-01 00:00:00
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journal_title：Brain structure & function
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journal_title：Brain structure & function
pub_type： 杂志文章
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更新日期：2018-04-01 00:00:00
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journal_title：Brain structure & function
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journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-020-02187-3
更新日期：2021-01-03 00:00:00
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journal_title：Brain structure & function
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journal_title：Brain structure & function
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journal_title：Brain structure & function
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journal_title：Brain structure & function
pub_type： 杂志文章
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