Abstract:
:The number of peer-reviewed articles published during the 2017 solar year and retrieved using the "autoimmunity" key word increased significantly compared to 2016 while maintaining a stable share within the immunology field, following years with alternated fortunes. A detailed arbitrary analysis of the published articles in leading immunology and autoimmunity journals provides a privileged viewpoint on the current trends of research from both basic and clinical studies. Indeed, we are observing that major steps forward are found for rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis, among others. In particular, the new data on pregnancy success in lupus or biomarkers in systemic sclerosis are believed to change our management of these systemic conditions. In the case of rheumatoid arthritis, we have obtained data with significant implications in the understanding of the disease pathogenesis (as in the case of platelets), disease phenotyping, and new treatment options. Furthermore, the exponential growth of treatment options for cancer based on immune checkpoint modulation is paralleled by the need to address the potential autoimmunity side effects while taking advantage of new information obtained in paraneoplastic autoimmune conditions. Cumulatively, 2017 has been a very exciting year for autoimmune diseases, and we foresee that most of the data discussed herein will be followed by more extensive studies in the upcoming months.
journal_name
Clin Rev Allergy Immunoljournal_title
Clinical reviews in allergy & immunologyauthors
Selmi Cdoi
10.1007/s12016-018-8699-7subject
Has Abstractpub_date
2018-12-01 00:00:00pages
239-253issue
3eissn
1080-0549issn
1559-0267pii
10.1007/s12016-018-8699-7journal_volume
55pub_type
杂志文章,评审abstract::Wegener's granulomatosis (WG) is a chronic, relapsing, systemic necrotizing vasculitis with typical pathologic findings of granulomatous inflammation and pauci-immune vasculitis. Untreated, the condition has a very high mortality, and contemporary treatment strategies carry a high risk of treatment-related morbidity. ...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-007-8057-7
更新日期:2008-06-01 00:00:00
abstract::Strategies to improve patients' adherence to treatment are essential to reduce the great health and economic burden of allergic rhinitis and asthma. Mobile phone applications (apps) for a better management of allergic diseases are growing in number, but their usefulness for doctors and patients is still debated. Contr...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s12016-016-8542-y
更新日期:2019-04-01 00:00:00
abstract::During the last decade, B regulatory cells are appreciated to have a central role in preventing autoimmunity and maintaining self-tolerance. They are characterized by expressing different phenotypic markers and the production of either IL-10 or TGF-β or both. The recent recognition of Fas ligand expressing B regulator...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-016-8572-5
更新日期:2017-06-01 00:00:00
abstract::Most investigators currently advocate prophylactic-dose heparin plus low-dose aspirin as the preferred treatment of otherwise healthy women with obstetric antiphospholipid syndrome, whilst women with a history of vascular thrombosis alone or associated with pregnancy morbidity are usually treated with therapeutic hepa...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-016-8571-6
更新日期:2017-08-01 00:00:00
abstract::One of the important factors and consequences in persistent asthma is the change in the vasculature of the airways and lung parenchyma. These changes could contribute to worsening asthma control and predispose asthmatics to critical asthma syndromes. For many years, the contribution of vasculature to severe asthma was...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-014-8420-4
更新日期:2015-02-01 00:00:00
abstract::Beta-agonists have clearly demonstrated benefits for the treatment of both acute and chronic asthma. Therefore, it is perhaps surprising that many of the articles in this issue have focused on concerns about their safety. Much of this concern can be traced back to the "beta-agonist controversy"--the association of hig...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章
doi:10.1385/criai:31:2:279
更新日期:2006-10-01 00:00:00
abstract::Contact dermatitis accounts for 95% of occupational skin disorders. Irritant contact dermatitis (ICD) is often caused by cumulative exposure to weak irritants, accounting for 80% of all cases of contact dermatitis. ICD can co-exist with atopic dermatitis (AD) and allergic contact dermatitis (ACD). Patients with AD and...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-018-8713-0
更新日期:2019-02-01 00:00:00
abstract::Previously believed to have an exclusive role in the release of cytotoxic mediators in the defense against helminthic infections, eosinophils are now considered key players in inflammatory reaction and regulation of immune response. Through activation of a large variety of membrane receptors and production of various ...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1385/CRIAI:30:1:013
更新日期:2006-02-01 00:00:00
abstract::Therapy of atopic dermatitis should comprise emollients, topical glucocorticosteroids, or calcineurin inhibitors, phototherapies, immunosuppressants like cyclosporin A, and other treatments. All these treatments should be improved, thanks to research. But new therapeutic perspectives should be given by topical anti-in...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-010-8226-y
更新日期:2011-12-01 00:00:00
abstract::Atherosclerosis is an inflammatory disease, and several antigens have been shown to activate the immune response and affect the development of atherogenesis. This suggests that modulation of the immune system could represent a useful approach to prevent and/or treat this disorder. A vaccination approach might be a use...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-009-8145-y
更新日期:2010-04-01 00:00:00
abstract::Patients with immunodeficiencies or some types of autoimmune diseases are dependent on safe therapy with intravenous immunoglobulins. State-of-the-art manufacturing processes provide a high safety standard by incorporating virus elimination procedures into the manufacturing process. Based on their mechanism, these pro...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1385/CRIAI:29:3:333
更新日期:2005-12-01 00:00:00
abstract::Food allergy is a potentially life-threatening condition with no approved curative therapy. A number of food allergen immunotherapies are being investigated in phase II/III trials; however, these are limited in their ability to restore immune tolerance to food allergens and often result in high rates of allergic side ...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-018-8694-z
更新日期:2018-10-01 00:00:00
abstract::Over the years, the commonly used term to describe juvenile idiopathic arthritis (JIA) has changed. By definition, JIA includes all types of arthritis with no apparent cause, lasting more than 6 weeks, in patients aged less than 16 years at onset. JIA pathogenesis is still poorly understood: the interaction between en...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-014-8460-9
更新日期:2015-10-01 00:00:00
abstract::Bronchiolitis is a common, acute, contagious lower respiratory tract illness of infants and young children. The majority of cases are secondary to respiratory syncytial virus. There are a number of risk factors for severe disease, including children less than six weeks of age and patients with atopy and/or asthma. The...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1385/CRIAI:25:3:249
更新日期:2003-12-01 00:00:00
abstract::The gold standard for diagnosing asthma in children is based on clinical history of respiratory symptoms, physical examination, and respiratory function testing. Recent advances indicate that a non-invasive measure of airway inflammation, fractional exhaled nitric oxide (FeNO), provides objective data for use in asthm...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,meta分析
doi:10.1007/s12016-016-8573-4
更新日期:2019-04-01 00:00:00
abstract::Calcium is the most abundant mineral in the human body and is central to many physiological processes, including immune system activation and maintenance. Studies continue to reveal the intricacies of calcium signalling within the immune system. Perhaps the most well-understood mechanism of calcium influx into cells i...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-020-08824-3
更新日期:2021-01-06 00:00:00
abstract::Intravenous immunoglobulin (IVIg) has been used as an immunomodulatory therapy for the treatment of multiple sclerosis (MS). In the current review, we summarize the up-to-date data related to IVIg clinical trials in MS, and the suggested mechanisms of action by which IVIg modulates the relevant immunological pathways ...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1385/CRIAI:29:3:247
更新日期:2005-12-01 00:00:00
abstract::In the vast database of peer-reviewed articles, the number of 2018 papers published retrieved using the "autoimmunity" keyword remained unchanged compared with the brilliant results of 2017 while returning above a 5% share within the immunology field, after the brisk decrease of this ratio in 2017. As in the past 12 y...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章
doi:10.1007/s12016-019-08745-w
更新日期:2019-06-01 00:00:00
abstract::Sarcoidosis has innumerable clinical manifestations, as the disease may affect every body organ. Furthermore, the severity of sarcoidosis involvement may range from an asymptomatic state to a life-threatening condition. This manuscript reviews a wide variety of common and less common clinical characteristics of sarcoi...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-014-8450-y
更新日期:2015-08-01 00:00:00
abstract::What makes an antigen an allergen? This question has been at the core of much research regarding the basic mechanisms of allergy as well as the development of diagnostic and therapeutic allergen products. Great strides have been made since Kjell Aas asked this question in his classic review in Allergy (1), but we appe...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章
doi:10.1385/CRIAI:30:2:71
更新日期:2006-04-01 00:00:00
abstract::As physiological pathways of intercellular communication produced by all cells, cytokines are involved in the pathogenesis of inflammatory insulitis as well as pivotal mediators of immune homeostasis. Proinflammatory cytokines including interleukins, interferons, transforming growth factor-β, tumor necrosis factor-α, ...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-016-8587-y
更新日期:2017-06-01 00:00:00
abstract::Pulmonary function testing is useful for the diagnosis and management of a variety of pulmonary conditions, and the most commonly obtained component is spirometry. Spirometry is most useful in the evaluation of obstructive airway disorders but can be a helpful tool in the management of patients with chest restriction ...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-009-8128-z
更新日期:2009-12-01 00:00:00
abstract::Eosinophilic esophagitis (EoE) is an emerging chronic atopic clinical-pathologic disease with an estimated prevalence of 1/1000 similar to the one of Crohn's diseases. Usually, EoE is firstly suspected due to symptoms that are caused by esophageal dysfunction and/or fibrosis. EoE diagnosis is confirmed if the esophage...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-015-8501-z
更新日期:2016-04-01 00:00:00
abstract::Alopecia areata is a common hair loss condition that is characterized by acute onset of non-scarring hair loss in usually sharply defined areas ranging from small patches to extensive or less frequently diffuse involvement. Depending on its acuity and extent, hair loss is an important cause of anxiety and disability. ...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-017-8620-9
更新日期:2018-02-01 00:00:00
abstract::Patients presenting to the emergency department (ED) or clinic with acute exacerbation of asthma (AEA) can be very challenging varying in both severity and response to therapy. High-dose, frequent or continuous nebulized short-acting beta2 agonist (SABA) therapy that can be combined with a short-acting muscarinic anta...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-014-8448-5
更新日期:2015-02-01 00:00:00
abstract::Air pollution is defined as the presence of noxious substances in the air at levels that impose a health hazard. Thus, there has been long-standing interest in the possible role of indoor and outdoor air pollutants on the development of respiratory disease. In this regard, asthma has been of particular interest but ma...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-019-08730-3
更新日期:2019-12-01 00:00:00
abstract::Rheumatoid arthritis and spondyloarthritis are inflammatory joint disorders with an autoimmune pathogenesis and systemic involvement. The skin is one of the most frequently affected extraarticular sites with a number of manifestations or distinct diseases, including common conditions, such as rheumatoid nodules and ps...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-017-8629-0
更新日期:2018-04-01 00:00:00
abstract::Systemic vasculitides are a group of rare diseases characterized by inflammation of the arterial or venous vessel wall, causing stenosis or thrombosis. Clinical symptoms may be limited to skin or to other organs or may include multiple manifestations as systemic conditions. The pathogenesis is related to the presence ...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-014-8453-8
更新日期:2015-12-01 00:00:00
abstract::Tumor necrosis factor-α (TNF-α) is a central regulator of inflammation, and TNF-α antagonists may be effective in treating inflammatory disorders in which TNF-α plays a major pathogenic role. TNF-α has also been associated with inflammatory mechanisms related to implantation, placentation, and pregnancy outcome. TNF-α...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-016-8596-x
更新日期:2017-08-01 00:00:00
abstract::AECAs have been found in 26% of patients with uveoretinitis in studies arising from three different laboratories, and their presence cannot simply be explained by coexisting extraocular disease. There is little correlation with ocular disease activity or other markers of systemic inflammation and vascular damage that ...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/BF02828276
更新日期:1997-04-01 00:00:00