Abstract:
:Most investigators currently advocate prophylactic-dose heparin plus low-dose aspirin as the preferred treatment of otherwise healthy women with obstetric antiphospholipid syndrome, whilst women with a history of vascular thrombosis alone or associated with pregnancy morbidity are usually treated with therapeutic heparin doses in association with low-dose aspirin in an attempt to prevent both thrombosis and pregnancy morbidity. However, the protocols outlined above fail in about 20 % of pregnant women with antiphospholipid syndrome. Identifying risk factors associated with pregnancy failure when conventional therapies are utilized is an important step in establishing guidelines to manage these high-risk patients. Some clinical and laboratory risk factors have been found to be related to maternal-foetal complications in pregnant women on conventional therapy. However, the most efficacious treatments to administer to high-risk antiphospholipid syndrome women in addition to conventional therapy in order to avoid pregnancy complications are as yet unestablished. This is a comprehensive review on this topic and an invitation to participate in a multicentre study in order to identify the best additional treatments to be used in this subset of antiphospholipid syndrome patients.
journal_name
Clin Rev Allergy Immunoljournal_title
Clinical reviews in allergy & immunologyauthors
Ruffatti A,Hoxha A,Favaro M,Tonello M,Colpo A,Cucchini U,Banzato A,Pengo Vdoi
10.1007/s12016-016-8571-6subject
Has Abstractpub_date
2017-08-01 00:00:00pages
28-39issue
1eissn
1080-0549issn
1559-0267pii
10.1007/s12016-016-8571-6journal_volume
53pub_type
杂志文章,评审abstract::Although the relative contributions of T cells and B cells in Sjögren's syndrome (SS) are far from being settled, recent studies have suggested a crucial role for B cells in its pathophysiology. Early investigations have focused on the ability of B cells to produce autoantibodies, and new studies have enlarged the ran...
journal_title:Clinical reviews in allergy & immunology
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abstract::Celiac disease is a complex immune-mediated gluten-sensitive enteropathy with protean clinical manifestations. It is manifest in genetically predisposed individuals who ingest gluten in varying amounts. In broad terms, it is thought to affect 1% of the population in the USA. More specifically, the prevalence increases...
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abstract::Many immune-mediated diseases like inflammatory bowel disease, multiple sclerosis, type 1 diabetes, asthma, and food allergy appeared to have increased in frequency in developed countries in the latter part of the twentieth century. Reports from less developed countries suggest that the "epidemic" of immune-mediated d...
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abstract::Primary biliary cirrhosis (PBC) is a rare inflammatory liver disease for which ursodeoxycholic acid (UDCA) is the only therapy approved by the U.S. Food and Drug Administration. Patients with a biochemical response to UDCA therapy have a similar survival rate compared to the general population. However, up to 40% of P...
journal_title:Clinical reviews in allergy & immunology
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journal_title:Clinical reviews in allergy & immunology
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doi:10.1007/s12016-014-8453-8
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journal_title:Clinical reviews in allergy & immunology
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/BF02737614
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journal_title:Clinical reviews in allergy & immunology
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-010-8226-y
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
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更新日期:1997-04-01 00:00:00
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1385/CRIAI:25:1:41
更新日期:2003-08-01 00:00:00
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-018-8713-0
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journal_title:Clinical reviews in allergy & immunology
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journal_title:Clinical reviews in allergy & immunology
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journal_title:Clinical reviews in allergy & immunology
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abstract::Primary sclerosing cholangitis (PSC) is a rare chronic cholestatic disease of the liver and bile ducts that is associated with inflammatory bowel disease, generally leads to end-stage liver disease, and is complicated by malignancies of the biliary tree and the large intestine. The pathogenesis of PSC remains enigmati...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
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abstract::Bronchial hyperresponsiveness (BHR) is an essential part of the definition of asthma. Although our understanding of the allergic inflammatory and immunologic mechanisms of asthma have markedly increased, the mechanism of BHR remains to be elucidated. Increased BHR is associated temporally with exposure to allergens, c...
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