Abstract：
:Systemic lupus erythmatosus (SLE) is a multi-system autoimmune disease characterized by auto-reactive cells and auto-antibodies, which can potentially affect all organ systems. Typical organ systems that are affected include the heart, lungs, skin, kidneys, and central nervous system. Its expression is believed to be dependent on various factors such as genetic predisposition, environmental agents, immune dysregulation, crossreactivity with auto-antigens, alterations in auto-antigens, or most likely, a combination of these. Parvovirus B19, a virus which commonly runs an asymptomatic or benign self-limiting course such as erythema infectiosum, transient aplastic crisis, flu-like symptoms, rash, arthalgia, and arthritis, has recently been associated with a number of rheumatic diseases, more specifically with SLE. Like SLE, it can present with multi- systemic symptoms resembling SLE both clinically and serologically. Similarities have been so striking that patients have been initially misdiagnosed with SLE, having fulfilled 3-5 of the criteria of the American College of Rheumatology, currently used for the diagnosis of SLE, only to discover later that they were infected by parvovirus B19. This paper will discuss parvovirus' link to SLE, its similarities and differences, and whether parvovirus can act as a trigger of, or simply mimic, SLE.
journal_name
Clin Rev Allergy Immunoljournal_title
Clinical reviews in allergy & immunologyauthors
Severin MC,Levy Y,Shoenfeld Ydoi
10.1385/CRIAI:25:1:41subject
Has Abstractpub_date
2003-08-01 00:00:00pages
41-8issue
1eissn
1080-0549issn
1559-0267pii
CRIAI:25:1:41journal_volume
25pub_type
杂志文章,评审abstract：:Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene that results in abnormal viscous mucoid secretions in multiple organs and whose main clinical features are pancreatic insufficiency and chronic endobronchial infection. Although it was i...
journal_title：Clinical reviews in allergy & immunology
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journal_title：Clinical reviews in allergy & immunology
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更新日期：2008-02-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,meta分析
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
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journal_title：Clinical reviews in allergy & immunology
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
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更新日期：2013-10-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
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更新日期：2016-12-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章
doi：10.1385/criai:31:2:279
更新日期：2006-10-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
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更新日期：2019-08-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
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更新日期：2009-12-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-013-8390-y
更新日期：2014-12-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
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更新日期：2015-10-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-009-8175-5
更新日期：2010-04-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
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更新日期：2018-02-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
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更新日期：2017-08-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
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更新日期：2006-10-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
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更新日期：2005-06-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
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更新日期：2021-01-07 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1385/CRIAI:29:3:247
更新日期：2005-12-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章
doi：10.1007/s12016-019-08745-w
更新日期：2019-06-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
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更新日期：2019-12-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章
doi：10.1007/s12016-010-8246-7
更新日期：2012-04-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/BF02737598
更新日期：1999-04-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-013-8376-9
更新日期：2014-02-01 00:00:00
abstract：:Autoimmune diseases are immune disorders characterized by T cell hyperactivity and B cell overstimulation leading to overproduction of autoantibodies. Although the pathogenesis of various autoimmune diseases remains to be elucidated, environmental factors have been thought to contribute to the initiation and maintenan...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-013-8402-y
更新日期：2014-10-01 00:00:00
