New Insights on the Role of TRP Channels in Calcium Signalling and Immunomodulation: Review of Pathways and Implications for Clinical Practice.

abstract：:G protein-coupled receptors (GPCRs) constitute the largest family of plasma membrane receptors in nature and mediate the effects of a variety of extracellular signals, such as hormone, neurotransmitter, odor, and light signals. Due to their involvement in a broad range of physiological and pathological processes and t...

journal_title：Clinical reviews in allergy & immunology

authors： Zhao M,Wang Z,Yang M,Ding Y,Zhao M,Wu H,Zhang Y,Lu Q

更新日期：2021-01-07 00:00:00

abstract：:Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene that results in abnormal viscous mucoid secretions in multiple organs and whose main clinical features are pancreatic insufficiency and chronic endobronchial infection. Although it was i...

journal_title：Clinical reviews in allergy & immunology

authors： Voter KZ,Ren CL

更新日期：2008-12-01 00:00:00

abstract：:Resolvins, belonging to the group of specialized proresolving mediators (SPMs), are metabolic products of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and are synthesized during the initial phases of acute inflammatory responses to promote the resolution of inflammation. Resolvins are produced for termination of ne...

journal_title：Clinical reviews in allergy & immunology

authors： Abdolmaleki F,Kovanen PT,Mardani R,Gheibi-Hayat SM,Bo S,Sahebkar A

更新日期：2020-02-01 00:00:00

abstract：:Atherosclerosis is an inflammatory disease, and several antigens have been shown to activate the immune response and affect the development of atherogenesis. This suggests that modulation of the immune system could represent a useful approach to prevent and/or treat this disorder. A vaccination approach might be a use...

journal_title：Clinical reviews in allergy & immunology

authors： de Carvalho JF,Pereira RM,Shoenfeld Y

更新日期：2010-04-01 00:00:00

abstract：:Patients presenting to the emergency department (ED) or clinic with acute exacerbation of asthma (AEA) can be very challenging varying in both severity and response to therapy. High-dose, frequent or continuous nebulized short-acting beta2 agonist (SABA) therapy that can be combined with a short-acting muscarinic anta...

journal_title：Clinical reviews in allergy & immunology

authors： Albertson TE,Sutter ME,Chan AL

更新日期：2015-02-01 00:00:00

abstract：:Many immune-mediated diseases like inflammatory bowel disease, multiple sclerosis, type 1 diabetes, asthma, and food allergy appeared to have increased in frequency in developed countries in the latter part of the twentieth century. Reports from less developed countries suggest that the "epidemic" of immune-mediated d...

journal_title：Clinical reviews in allergy & immunology

authors： Weinstock JV

更新日期：2015-10-01 00:00:00

abstract：:Wegener's granulomatosis (WG) is a chronic, relapsing, systemic necrotizing vasculitis with typical pathologic findings of granulomatous inflammation and pauci-immune vasculitis. Untreated, the condition has a very high mortality, and contemporary treatment strategies carry a high risk of treatment-related morbidity. ...

journal_title：Clinical reviews in allergy & immunology

authors： Hinze CH,Colbert RA

更新日期：2008-06-01 00:00:00

abstract：:Systemic lupus erythmatosus (SLE) is a multi-system autoimmune disease characterized by auto-reactive cells and auto-antibodies, which can potentially affect all organ systems. Typical organ systems that are affected include the heart, lungs, skin, kidneys, and central nervous system. Its expression is believed to be ...

journal_title：Clinical reviews in allergy & immunology

authors： Severin MC,Levy Y,Shoenfeld Y

更新日期：2003-08-01 00:00:00

abstract：:Cryoglobulins are immunoglobulins that reversibly precipitate in the cold. They come in different flavours and, as such, are differentially associated with lymphoproliferative diseases (type I), or systemic autoimmune diseases, and/or infectious diseases (type II/III). The clinical manifestations of cryoglobulinaemia ...

journal_title：Clinical reviews in allergy & immunology

authors： Damoiseaux J,Cohen Tervaert JW

更新日期：2014-12-01 00:00:00

abstract：:Biological rhythms are fundamental for homeostasis and have recently been involved in the regulatory processes of various organs and systems. Circadian cycle proteins and hormones have a direct effect on the inflammatory response and have shown pro- or anti-inflammatory effects in animal models of autoimmune diseases....

journal_title：Clinical reviews in allergy & immunology

authors： Torres-Ruiz J,Sulli A,Cutolo M,Shoenfeld Y

更新日期：2017-08-01 00:00:00

abstract：:Alopecia areata is a common hair loss condition that is characterized by acute onset of non-scarring hair loss in usually sharply defined areas ranging from small patches to extensive or less frequently diffuse involvement. Depending on its acuity and extent, hair loss is an important cause of anxiety and disability. ...

journal_title：Clinical reviews in allergy & immunology

authors： Trüeb RM,Dias MFRG

更新日期：2018-02-01 00:00:00

abstract：:During the last decade, B regulatory cells are appreciated to have a central role in preventing autoimmunity and maintaining self-tolerance. They are characterized by expressing different phenotypic markers and the production of either IL-10 or TGF-β or both. The recent recognition of Fas ligand expressing B regulator...

journal_title：Clinical reviews in allergy & immunology

authors： Vadasz Z,Toubi E

更新日期：2017-06-01 00:00:00

abstract：:Bronchiolitis is a common, acute, contagious lower respiratory tract illness of infants and young children. The majority of cases are secondary to respiratory syncytial virus. There are a number of risk factors for severe disease, including children less than six weeks of age and patients with atopy and/or asthma. The...

journal_title：Clinical reviews in allergy & immunology

authors： Jhawar S

更新日期：2003-12-01 00:00:00

abstract：:Intravenous immunoglobulin (IVIg) has been used as an immunomodulatory therapy for the treatment of multiple sclerosis (MS). In the current review, we summarize the up-to-date data related to IVIg clinical trials in MS, and the suggested mechanisms of action by which IVIg modulates the relevant immunological pathways ...

journal_title：Clinical reviews in allergy & immunology

authors： Achiron A,Miron S

更新日期：2005-12-01 00:00:00

abstract：:As summarized in Table 1, the literature consistently supports the hypothesis that allergic asthmatic patients have seasonal BHR changes that parallel allergen exposure. These seasonal changes appear to be preventable by treatment with corticosteroids (systemic, inhaled, or nasal), disodium cromoglycate, and immunothe...

journal_title：Clinical reviews in allergy & immunology

authors： Tilles SA,Bardana EJ Jr

更新日期：1997-07-01 00:00:00

abstract：:Strategies to improve patients' adherence to treatment are essential to reduce the great health and economic burden of allergic rhinitis and asthma. Mobile phone applications (apps) for a better management of allergic diseases are growing in number, but their usefulness for doctors and patients is still debated. Contr...

journal_title：Clinical reviews in allergy & immunology

authors： Huang X,Matricardi PM

更新日期：2019-04-01 00:00:00

abstract：:The incidence of autoimmune diseases is increasing in Western countries, possibly due to the improved sanitary conditions and reduced exposure to infections in childhood (the hygiene hypothesis). There is an ongoing debate whether infection prevents or precipitates autoimmune diseases. Various helminths species used i...

journal_title：Clinical reviews in allergy & immunology

authors： Ben-Ami Shor D,Harel M,Eliakim R,Shoenfeld Y

更新日期：2013-10-01 00:00:00

abstract：:Antityrosinase antibody is a newly detected antibody in the sera of patients with melanoma or vitiligo. The serum level of the antibody is measured by enzyme-linked immunosorbent assay (ELISA). The autoantigen is tyrosinase itself, the enzyme that participates in pigment (melanin) formation by both melanocytes and mel...

journal_title：Clinical reviews in allergy & immunology

authors： Merimsky O,Shoenfeld Y,Fishman P

更新日期：1998-10-01 00:00:00

abstract：:Inhibitors to factor VIII (FVIII) are alloantibodies directed against epitopes able to neutralise FVIII procoagulant activity. They may render FVIII replacement therapy ineffective. They represent the most severe complication of haemophilia A. At least three mechanisms of FVIII neutralisation activity by anti-FVIII an...

journal_title：Clinical reviews in allergy & immunology

authors： Tellier Z,André MH,Polack B

更新日期：2009-10-01 00:00:00

abstract：:Prognosis of several autoimmune diseases, especially rheumatoid arthritis (RA), ankylosing spondylitis, Crohn's disease (CD), and psoriasis, usually refractory to conventional treatment improved considerably with the introduction of tumor necrosis factor alpha (TNF-alpha) antagonistic agents, which is now available (i...

journal_title：Clinical reviews in allergy & immunology

authors： Emi Aikawa N,de Carvalho JF,Artur Almeida Silva C,Bonfá E

更新日期：2010-04-01 00:00:00

abstract：:Over the years, the commonly used term to describe juvenile idiopathic arthritis (JIA) has changed. By definition, JIA includes all types of arthritis with no apparent cause, lasting more than 6 weeks, in patients aged less than 16 years at onset. JIA pathogenesis is still poorly understood: the interaction between en...

journal_title：Clinical reviews in allergy & immunology

authors： Rigante D,Bosco A,Esposito S

更新日期：2015-10-01 00:00:00

abstract：:AECAs have been found in 26% of patients with uveoretinitis in studies arising from three different laboratories, and their presence cannot simply be explained by coexisting extraocular disease. There is little correlation with ocular disease activity or other markers of systemic inflammation and vascular damage that ...

journal_title：Clinical reviews in allergy & immunology

authors： Edelsten C,D'Cruz DP

更新日期：1997-04-01 00:00:00

abstract：:Eosinophils can regulate local and systemic inflammation, and their presence in higher numbers appears to play an important role in the pathology of various atopic and inflammatory diseases. Eosinophil maturation, recruitment, and survival depend on several cytokine regulators, including interleukin (IL)-5, IL-4, and ...

journal_title：Clinical reviews in allergy & immunology

authors： Sriaroon P,Ballow M

更新日期：2016-04-01 00:00:00

abstract：:Atherosclerosis is a disease of the vascular wall, which predominantly affects large and medium-sized arteries. It represents a leading cause of morbidity and mortality in the Western world. In the last few decades, it has been clearly shown that immune system plays a relevant role in atherogenesis. The effectors of b...

journal_title：Clinical reviews in allergy & immunology

authors： Bassi N,Zampieri S,Ghirardello A,Tonon M,Zen M,Cozzi F,Doria A

更新日期：2009-08-01 00:00:00

abstract：:Illicit stimulants, such as cocaine, amphetamine, and their derivatives (e.g., "ecstasy"), continue to exact heavy toll on health care in both developed and developing countries. The US Department of Health and Human Service reported over one million illicit drug-related emergency department visits in 2010, which was ...

journal_title：Clinical reviews in allergy & immunology

authors： Tseng W,Sutter ME,Albertson TE

更新日期：2014-02-01 00:00:00

abstract：:It has been shown that many hereditary motor neuron diseases are caused by mutation of RNA processing enzymes. Survival of motor neuron 1 (SMN1) is well-known as a causative gene for spinal muscular atrophy (SMA) and mutations of glycyl- and tyrosyl-tRNA synthetases are identified as a cause of distal SMA and Charcot-...

journal_title：Clinical reviews in allergy & immunology

authors： Satoh M,Ceribelli A,Chan EK

更新日期：2012-02-01 00:00:00

abstract：:Pulmonary function testing is useful for the diagnosis and management of a variety of pulmonary conditions, and the most commonly obtained component is spirometry. Spirometry is most useful in the evaluation of obstructive airway disorders but can be a helpful tool in the management of patients with chest restriction ...

journal_title：Clinical reviews in allergy & immunology

authors： Liou TG,Kanner RE

更新日期：2009-12-01 00:00:00

abstract：:Over the past few years, the rates of food allergies have dramatically increased. As a result, the lives of patients and their caregivers have been dramatically altered. While most attention surrounding food allergies has focused on treatment, less consideration has been given to the mental health ramifications of liv...

journal_title：Clinical reviews in allergy & immunology

authors： Feng C,Kim JH

更新日期：2019-08-01 00:00:00

abstract：:Air pollution is defined as the presence of noxious substances in the air at levels that impose a health hazard. Thus, there has been long-standing interest in the possible role of indoor and outdoor air pollutants on the development of respiratory disease. In this regard, asthma has been of particular interest but ma...

journal_title：Clinical reviews in allergy & immunology

authors： Hassoun Y,James C,Bernstein DI

更新日期：2019-12-01 00:00:00

abstract：:The Zika virus outbreaks highlight the growing importance need for a reliable, specific and rapid diagnostic device to detect Zika virus, as it is often recognized as a mild disease without being identified. Many Zika virus infection cases have been misdiagnosed or underreported because of the non-specific clinical pr...

journal_title：Clinical reviews in allergy & immunology

authors： Maharajan MK,Ranjan A,Chu JF,Foo WL,Chai ZX,Lau EY,Ye HM,Theam XJ,Lok YL

更新日期：2016-12-01 00:00:00