Abstract:
:Eosinophils can regulate local and systemic inflammation, and their presence in higher numbers appears to play an important role in the pathology of various atopic and inflammatory diseases. Eosinophil maturation, recruitment, and survival depend on several cytokine regulators, including interleukin (IL)-5, IL-4, and IL-13 as well as growth factors such as GM-CSF. Over the last decade, the approach to treating eosinophilic diseases has changed greatly. A number of biologic modulators have been developed to target eosinophilic inflammatory pathways, and their usage has resulted in variable clinical improvement in the treatment of eosinophilic-associated conditions. Novel targeted therapies that are safe and effective for treating these disorders are being investigated. This review summarizes the clinical use of biologic agents that have been studied in clinical trials or approved for treating eosinophilic diseases.
journal_name
Clin Rev Allergy Immunoljournal_title
Clinical reviews in allergy & immunologyauthors
Sriaroon P,Ballow Mdoi
10.1007/s12016-014-8444-9subject
Has Abstractpub_date
2016-04-01 00:00:00pages
252-72issue
2eissn
1080-0549issn
1559-0267pii
10.1007/s12016-014-8444-9journal_volume
50pub_type
杂志文章,评审abstract::Many immune-mediated diseases like inflammatory bowel disease, multiple sclerosis, type 1 diabetes, asthma, and food allergy appeared to have increased in frequency in developed countries in the latter part of the twentieth century. Reports from less developed countries suggest that the "epidemic" of immune-mediated d...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
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更新日期:2015-10-01 00:00:00
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-015-8501-z
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
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journal_title:Clinical reviews in allergy & immunology
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更新日期:2019-04-01 00:00:00
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,meta分析
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
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更新日期:2006-06-01 00:00:00
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/BF02737598
更新日期:1999-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2010-02-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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journal_title:Clinical reviews in allergy & immunology
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更新日期:2006-04-01 00:00:00
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更新日期:2017-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-06-01 00:00:00
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