Abstract:
:Resolvins, belonging to the group of specialized proresolving mediators (SPMs), are metabolic products of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and are synthesized during the initial phases of acute inflammatory responses to promote the resolution of inflammation. Resolvins are produced for termination of neutrophil infiltration, stimulation of the clearance of apoptotic cells by macrophages, and promotion of tissue remodeling and homeostasis. Metabolic dysregulation due to either uncontrolled activity of pro-inflammatory responses or to inefficient resolution of inflammation results in chronic inflammation and may also lead to atherosclerosis or other chronic autoimmune diseases such as rheumatoid arthritis, psoriasis, systemic lupus erythematosus, vasculitis, inflammatory bowel diseases, and type 1 diabetes mellitus. The pathogenesis of such diseases involves a complex interplay between the immune system and, environmental factors (non-infectious or infectious), and critically depends on individual susceptibility to such factors. In the present review, resolvins and their roles in the resolution of inflammation, as well as the role of these mediators as potential therapeutic agents to counteract specific chronic autoimmune and inflammatory diseases are discussed.
journal_name
Clin Rev Allergy Immunoljournal_title
Clinical reviews in allergy & immunologyauthors
Abdolmaleki F,Kovanen PT,Mardani R,Gheibi-Hayat SM,Bo S,Sahebkar Adoi
10.1007/s12016-019-08754-9subject
Has Abstractpub_date
2020-02-01 00:00:00pages
82-91issue
1eissn
1080-0549issn
1559-0267pii
10.1007/s12016-019-08754-9journal_volume
58pub_type
杂志文章,评审abstract::Hereditary angioedema (HAE) patients experience recurrent local swelling in various parts of the body including painful swelling of the intestine and life-threatening laryngeal oedema. Most HAE literature is about attacks located in one anatomical site, though it is mentioned that HAE attacks may also involve multiple...
journal_title:Clinical reviews in allergy & immunology
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journal_title:Clinical reviews in allergy & immunology
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doi:10.1385/CRIAI:30:2:71
更新日期:2006-04-01 00:00:00
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
doi:10.1007/s12016-017-8599-2
更新日期:2017-08-01 00:00:00
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1385/CRIAI:25:1:41
更新日期:2003-08-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2014-04-01 00:00:00
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doi:10.1007/s12016-019-08730-3
更新日期:2019-12-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Clinical reviews in allergy & immunology
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journal_title:Clinical reviews in allergy & immunology
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更新日期:2013-08-01 00:00:00
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
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更新日期:2007-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2005-06-01 00:00:00