Irritant Contact Dermatitis.

abstract：:Previously believed to have an exclusive role in the release of cytotoxic mediators in the defense against helminthic infections, eosinophils are now considered key players in inflammatory reaction and regulation of immune response. Through activation of a large variety of membrane receptors and production of various ...

journal_title：Clinical reviews in allergy & immunology

authors： Staumont-Sallé D,Dombrowicz D,Capron M,Delaporte E

更新日期：2006-02-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder with a broad spectrum of clinical presentations and association with multiple immunological abnormalities. Recent research of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway-revealed aberrant STAT s...

journal_title：Clinical reviews in allergy & immunology

authors： Goropevšek A,Holcar M,Avčin T

更新日期：2017-04-01 00:00:00

abstract：:Skin tests by prick technique offer considerable guidance in the diagnosis of food allergy. Negative prick skin tests are powerful evidence against food allergy. Positive food skin tests are slightly to moderately predictive of reaction to a food on DBPCFC. Oral food challenge is necessary for confirmation of food all...

journal_title：Clinical reviews in allergy & immunology

authors： Williams LW,Bock SA

更新日期：1999-10-01 00:00:00

abstract：:Chronic hyperplastic eosinophilic sinusitis (CHES) is a T-helper (Th)2-like, lymphocyteinitiated, eosinophil-rich inflammatory disease. The complex immune interactions required to orchestrate these processes begin with the presentation of antigen by mature dendritic cells to Th lymphocytes that display the appropriate...

journal_title：Clinical reviews in allergy & immunology

authors： Borish L,Rosenwasser L,Steinke JW

更新日期：2006-06-01 00:00:00

abstract：:Rheumatoid arthritis and spondyloarthritis are inflammatory joint disorders with an autoimmune pathogenesis and systemic involvement. The skin is one of the most frequently affected extraarticular sites with a number of manifestations or distinct diseases, including common conditions, such as rheumatoid nodules and ps...

journal_title：Clinical reviews in allergy & immunology

authors： Cugno M,Gualtierotti R,Meroni PL,Marzano AV

更新日期：2018-04-01 00:00:00

abstract：:The functions of macrophages that lead to effective host responses are critical for protection against Staphylococcus aureus. Deep tissue-invading S. aureus initially countered by macrophages trigger macrophage accumulation and induce inflammatory responses through surface receptors, especially toll-like receptor 2 (T...

journal_title：Clinical reviews in allergy & immunology

authors： Wang YC,Ma HD,Yin XY,Wang YH,Liu QZ,Yang JB,Shi QH,Sun B,Gershwin ME,Lian ZX

更新日期：2016-12-01 00:00:00

abstract：:Systemic lupus erythmatosus (SLE) is a multi-system autoimmune disease characterized by auto-reactive cells and auto-antibodies, which can potentially affect all organ systems. Typical organ systems that are affected include the heart, lungs, skin, kidneys, and central nervous system. Its expression is believed to be ...

journal_title：Clinical reviews in allergy & immunology

authors： Severin MC,Levy Y,Shoenfeld Y

更新日期：2003-08-01 00:00:00

abstract：:Patients presenting to the emergency department (ED) or clinic with acute exacerbation of asthma (AEA) can be very challenging varying in both severity and response to therapy. High-dose, frequent or continuous nebulized short-acting beta2 agonist (SABA) therapy that can be combined with a short-acting muscarinic anta...

journal_title：Clinical reviews in allergy & immunology

authors： Albertson TE,Sutter ME,Chan AL

更新日期：2015-02-01 00:00:00

abstract：:Systemic vasculitides are a group of rare diseases characterized by inflammation of the arterial or venous vessel wall, causing stenosis or thrombosis. Clinical symptoms may be limited to skin or to other organs or may include multiple manifestations as systemic conditions. The pathogenesis is related to the presence ...

journal_title：Clinical reviews in allergy & immunology

authors： Chimenti MS,Ballanti E,Triggianese P,Perricone R

更新日期：2015-12-01 00:00:00

abstract：:Autoimmune diseases are immune disorders characterized by T cell hyperactivity and B cell overstimulation leading to overproduction of autoantibodies. Although the pathogenesis of various autoimmune diseases remains to be elucidated, environmental factors have been thought to contribute to the initiation and maintenan...

journal_title：Clinical reviews in allergy & immunology

authors： Liu Y,Yin H,Zhao M,Lu Q

更新日期：2014-10-01 00:00:00

abstract：:As summarized in Table 1, the literature consistently supports the hypothesis that allergic asthmatic patients have seasonal BHR changes that parallel allergen exposure. These seasonal changes appear to be preventable by treatment with corticosteroids (systemic, inhaled, or nasal), disodium cromoglycate, and immunothe...

journal_title：Clinical reviews in allergy & immunology

authors： Tilles SA,Bardana EJ Jr

更新日期：1997-07-01 00:00:00

abstract：:The provider's ability to judge the severity of a patient's illness is a vital part of the care of chronic disorders. In the treatment of asthma, it should extend beyond the objectively quantifiable measures of obstruction or inflammation. "Interference with activities of daily living" is a highly subjective assessmen...

journal_title：Clinical reviews in allergy & immunology

authors： Sherman R,Milgrom H

更新日期：2005-10-01 00:00:00

abstract：:The gold standard for diagnosing asthma in children is based on clinical history of respiratory symptoms, physical examination, and respiratory function testing. Recent advances indicate that a non-invasive measure of airway inflammation, fractional exhaled nitric oxide (FeNO), provides objective data for use in asthm...

journal_title：Clinical reviews in allergy & immunology

authors： Tang S,Xie Y,Yuan C,Sun X,Cui Y

更新日期：2019-04-01 00:00:00

abstract：:In the vast database of peer-reviewed articles, the number of 2018 papers published retrieved using the "autoimmunity" keyword remained unchanged compared with the brilliant results of 2017 while returning above a 5% share within the immunology field, after the brisk decrease of this ratio in 2017. As in the past 12 y...

journal_title：Clinical reviews in allergy & immunology

authors： Selmi C

更新日期：2019-06-01 00:00:00

abstract：:The diagnosis of celiac disease (CD) remains a clinical challenge based on the incomplete specificity and sensitivity rates of current non-invasive tests. Furthermore, histological assessments fail to identify all overt cases and, in particular, do not manifest pathognomonic alterations in silent cases. Accordingly, t...

journal_title：Clinical reviews in allergy & immunology

authors： Matthias T,Pfeiffer S,Selmi C,Eric Gershwin M

更新日期：2010-04-01 00:00:00

abstract：:Pemphigus is a group of rare, potentially devastating autoimmune diseases of the skin and mucous membranes with high morbidity and potentially lethal outcome. The major clinical variant, pemphigus vulgaris (PV) is caused by a loss of intercellular adhesion of epidermal keratinocytes which is induced by IgG autoantibod...

journal_title：Clinical reviews in allergy & immunology

authors： Pollmann R,Schmidt T,Eming R,Hertl M

更新日期：2018-02-01 00:00:00

abstract：:Allergic diseases are surprisingly common, chronic health conditions. The primary location where the vast majority of people are exposed to allergens and other substances is in their home. This means it is important to understand home environments and how a home's systems function and interact-and that how we occupy t...

journal_title：Clinical reviews in allergy & immunology

authors： Kennedy K,Allenbrand R,Bowles E

更新日期：2019-12-01 00:00:00

abstract：:Therapy of atopic dermatitis should comprise emollients, topical glucocorticosteroids, or calcineurin inhibitors, phototherapies, immunosuppressants like cyclosporin A, and other treatments. All these treatments should be improved, thanks to research. But new therapeutic perspectives should be given by topical anti-in...

journal_title：Clinical reviews in allergy & immunology

authors： Misery L

更新日期：2011-12-01 00:00:00

abstract：:Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene that results in abnormal viscous mucoid secretions in multiple organs and whose main clinical features are pancreatic insufficiency and chronic endobronchial infection. Although it was i...

journal_title：Clinical reviews in allergy & immunology

authors： Voter KZ,Ren CL

更新日期：2008-12-01 00:00:00

abstract：:Primary sclerosing cholangitis (PSC) is a rare chronic cholestatic disease of the liver and bile ducts that is associated with inflammatory bowel disease, generally leads to end-stage liver disease, and is complicated by malignancies of the biliary tree and the large intestine. The pathogenesis of PSC remains enigmati...

journal_title：Clinical reviews in allergy & immunology

authors： Beuers U,Kullak-Ublick GA,Pusl T,Rauws ER,Rust C

更新日期：2009-02-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a chronic immune-mediated inflammatory condition primarily involving the gastrointestinal tract. It includes Crohn's disease (CD), ulcerative colitis (UC), and a less common phenotype-indeterminate colitis. It is thought to result from a complex interplay of environmental, microbial...

journal_title：Clinical reviews in allergy & immunology

authors： Clarke K,Chintanaboina J

更新日期：2019-10-01 00:00:00

abstract：:One of the important factors and consequences in persistent asthma is the change in the vasculature of the airways and lung parenchyma. These changes could contribute to worsening asthma control and predispose asthmatics to critical asthma syndromes. For many years, the contribution of vasculature to severe asthma was...

journal_title：Clinical reviews in allergy & immunology

authors： Avdalovic M

更新日期：2015-02-01 00:00:00

abstract：:Non-alcoholic steatohepatitis (NASH) is the progressive phenotype of non-alcoholic fatty liver disease associated with the metabolic syndrome. The existence of autoimmune features in NASH has been reported, but its significance remains unclear. We herein report the autoantibody profile of 54 patients with histological...

journal_title：Clinical reviews in allergy & immunology

authors： Tsuneyama K,Baba H,Kikuchi K,Nishida T,Nomoto K,Hayashi S,Miwa S,Nakajima T,Nakanishi Y,Masuda S,Terada M,Imura J,Selmi C

更新日期：2013-08-01 00:00:00

abstract：:Strategies to improve patients' adherence to treatment are essential to reduce the great health and economic burden of allergic rhinitis and asthma. Mobile phone applications (apps) for a better management of allergic diseases are growing in number, but their usefulness for doctors and patients is still debated. Contr...

journal_title：Clinical reviews in allergy & immunology

authors： Huang X,Matricardi PM

更新日期：2019-04-01 00:00:00

abstract：:Bronchial hyperresponsiveness (BHR) is an essential part of the definition of asthma. Although our understanding of the allergic inflammatory and immunologic mechanisms of asthma have markedly increased, the mechanism of BHR remains to be elucidated. Increased BHR is associated temporally with exposure to allergens, c...

journal_title：Clinical reviews in allergy & immunology

authors： Townley RG,Horiba M

更新日期：2003-02-01 00:00:00

abstract：:Mixed cryoglobulinemia (MC) syndrome is an immune complex-mediated vasculitis characterized by the clinical triad of purpura, weakness, and arthralgias, the morbidity of which is mainly related to kidney and peripheral nervous system dysfunction as well as to the development of a secondary lymphoma (Ferri et al. Autoi...

journal_title：Clinical reviews in allergy & immunology

authors： Lidar M,Lipschitz N,Agmon-Levin N,Langevitz P,Barzilai O,Ram M,Porat-Katz BS,Bizzaro N,Damoiseaux J,Tervaert JW,deVita S,Bombardieri S,Shoenfeld Y

更新日期：2012-04-01 00:00:00

abstract：:Intravenous immunoglobulin (IVIg) has been used as an immunomodulatory therapy for the treatment of multiple sclerosis (MS). In the current review, we summarize the up-to-date data related to IVIg clinical trials in MS, and the suggested mechanisms of action by which IVIg modulates the relevant immunological pathways ...

journal_title：Clinical reviews in allergy & immunology

authors： Achiron A,Miron S

更新日期：2005-12-01 00:00:00

abstract：:With the implementation of vaccination programs and the use of antibiotics, developed countries have seen a decline in infection-related pediatric bronchiectasis. However, significant morbidity from bronchiectasis is still seen and both infectious and noninfectious causes of bronchiectasis in the pediatric population ...

journal_title：Clinical reviews in allergy & immunology

authors： Boren EJ,Teuber SS,Gershwin ME

更新日期：2008-04-01 00:00:00

abstract：:G protein-coupled receptors (GPCRs) constitute the largest family of plasma membrane receptors in nature and mediate the effects of a variety of extracellular signals, such as hormone, neurotransmitter, odor, and light signals. Due to their involvement in a broad range of physiological and pathological processes and t...

journal_title：Clinical reviews in allergy & immunology

authors： Zhao M,Wang Z,Yang M,Ding Y,Zhao M,Wu H,Zhang Y,Lu Q

更新日期：2021-01-07 00:00:00

abstract：:The heart is a target organ in antiphospholipid syndrome (APS). Endocardial disease, intracardiac thrombosis, myocardial involvement including coronary heart disease and microvascular thrombosis, as well as pulmonary hypertension have all been described in APS patients. Valvular involvement is the most common manifest...

journal_title：Clinical reviews in allergy & immunology

authors： Amigo MC

更新日期：2007-04-01 00:00:00