Abstract：
:Therapy of atopic dermatitis should comprise emollients, topical glucocorticosteroids, or calcineurin inhibitors, phototherapies, immunosuppressants like cyclosporin A, and other treatments. All these treatments should be improved, thanks to research. But new therapeutic perspectives should be given by topical anti-inflammatory substances, selective glucocorticoid receptor agonists, probiotics, interferon γ, TNFα inhibitors, inhibition of T cells or B cells, inhibition of IgE binding, and many other possibilities.
journal_name
Clin Rev Allergy Immunoljournal_title
Clinical reviews in allergy & immunologyauthors
Misery Ldoi
10.1007/s12016-010-8226-ysubject
Has Abstractpub_date
2011-12-01 00:00:00pages
267-71issue
3eissn
1080-0549issn
1559-0267journal_volume
41pub_type
杂志文章,评审abstract：:Cryoglobulins are immunoglobulins that reversibly precipitate in the cold. They come in different flavours and, as such, are differentially associated with lymphoproliferative diseases (type I), or systemic autoimmune diseases, and/or infectious diseases (type II/III). The clinical manifestations of cryoglobulinaemia ...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-013-8390-y
更新日期：2014-12-01 00:00:00
abstract：:Sarcoidosis is a systemic granulomatous disease that frequently involves the lung. Although classically thought of as a restrictive lung disease, airway obstruction has become a recognized feature of the disease in the past years. Sarcoidosis can affect the airway at any level and when the involvement includes small a...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1385/CRIAI:25:2:115
更新日期：2003-10-01 00:00:00
abstract：:Alopecia areata is a common hair loss condition that is characterized by acute onset of non-scarring hair loss in usually sharply defined areas ranging from small patches to extensive or less frequently diffuse involvement. Depending on its acuity and extent, hair loss is an important cause of anxiety and disability. ...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-017-8620-9
更新日期：2018-02-01 00:00:00
abstract：:Autoimmune diseases are immune disorders characterized by T cell hyperactivity and B cell overstimulation leading to overproduction of autoantibodies. Although the pathogenesis of various autoimmune diseases remains to be elucidated, environmental factors have been thought to contribute to the initiation and maintenan...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-013-8402-y
更新日期：2014-10-01 00:00:00
abstract：:Inhibitors to factor VIII (FVIII) are alloantibodies directed against epitopes able to neutralise FVIII procoagulant activity. They may render FVIII replacement therapy ineffective. They represent the most severe complication of haemophilia A. At least three mechanisms of FVIII neutralisation activity by anti-FVIII an...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-009-8115-4
更新日期：2009-10-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder with a broad spectrum of clinical presentations and association with multiple immunological abnormalities. Recent research of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway-revealed aberrant STAT s...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-016-8550-y
更新日期：2017-04-01 00:00:00
abstract：:Prognosis of several autoimmune diseases, especially rheumatoid arthritis (RA), ankylosing spondylitis, Crohn's disease (CD), and psoriasis, usually refractory to conventional treatment improved considerably with the introduction of tumor necrosis factor alpha (TNF-alpha) antagonistic agents, which is now available (i...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-009-8140-3
更新日期：2010-04-01 00:00:00
abstract：:Hereditary angioedema (HAE) patients experience recurrent local swelling in various parts of the body including painful swelling of the intestine and life-threatening laryngeal oedema. Most HAE literature is about attacks located in one anatomical site, though it is mentioned that HAE attacks may also involve multiple...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章
doi：10.1007/s12016-014-8463-6
更新日期：2016-02-01 00:00:00
abstract：:Cashew plant (Anacardium occidentale L.) is the most relevant species of the Anacardium genus. It presents high economic value since it is widely used in human nutrition and in several industrial applications. Cashew nut is a well-appreciated food (belongs to the tree nut group), being widely consumed as snacks and in...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-016-8580-5
更新日期：2019-08-01 00:00:00
abstract：:Primary biliary cirrhosis (PBC) is a rare inflammatory liver disease for which ursodeoxycholic acid (UDCA) is the only therapy approved by the U.S. Food and Drug Administration. Patients with a biochemical response to UDCA therapy have a similar survival rate compared to the general population. However, up to 40% of P...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-014-8456-5
更新日期：2015-06-01 00:00:00
abstract：:Intravenous immunoglobulin (IVIg) has been used as an immunomodulatory therapy for the treatment of multiple sclerosis (MS). In the current review, we summarize the up-to-date data related to IVIg clinical trials in MS, and the suggested mechanisms of action by which IVIg modulates the relevant immunological pathways ...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1385/CRIAI:29:3:247
更新日期：2005-12-01 00:00:00
abstract：:Systemic lupus erythmatosus (SLE) is a multi-system autoimmune disease characterized by auto-reactive cells and auto-antibodies, which can potentially affect all organ systems. Typical organ systems that are affected include the heart, lungs, skin, kidneys, and central nervous system. Its expression is believed to be ...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1385/CRIAI:25:1:41
更新日期：2003-08-01 00:00:00
abstract：:Activated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of intracellular granule components that function by capturing and destroying microbes, including viral, fungal, bacterial, and protozoal pat...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-020-08804-7
更新日期：2020-08-01 00:00:00
abstract：:The diagnosis of celiac disease (CD) remains a clinical challenge based on the incomplete specificity and sensitivity rates of current non-invasive tests. Furthermore, histological assessments fail to identify all overt cases and, in particular, do not manifest pathognomonic alterations in silent cases. Accordingly, t...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-009-8160-z
更新日期：2010-04-01 00:00:00
abstract：:Every 2 years, an International Congress of Autoimmunity is organized and held with the intent of creating a new base for continuing interdisciplinary and international research, including further opportunities to train in the field of autoimmunity. In September 2008, the Congress of Autoimmunity was held in Porto, Po...
journal_title：Clinical reviews in allergy & immunology
pub_type：
doi：10.1007/s12016-009-8141-2
更新日期：2010-04-01 00:00:00
abstract：:Acute graft-versus-host disease (GVHD) conceptually may be divided into three evolutionary stages: allostimulation, effector cell homing to specific tissues, and cellular targeting and injury. Surprisingly, little is known regarding the targeting stage of GVHD. Recently, we have learned that epithelial target cell inj...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-007-0028-5
更新日期：2007-10-01 00:00:00
abstract：:The critical asthma syndrome (CAS) encompasses the most severe, persistent, refractory asthma patients for the clinician to manage. Personalized pharmacotherapy is necessary to prevent the next acute severe asthma exacerbation, not just the control of symptoms. The 2007 National Asthma Education and Prevention Program...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-013-8393-8
更新日期：2015-02-01 00:00:00
abstract：:The provider's ability to judge the severity of a patient's illness is a vital part of the care of chronic disorders. In the treatment of asthma, it should extend beyond the objectively quantifiable measures of obstruction or inflammation. "Interference with activities of daily living" is a highly subjective assessmen...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1385/CRIAI:29:2:159
更新日期：2005-10-01 00:00:00
abstract：:Wegener's granulomatosis (WG) is a chronic, relapsing, systemic necrotizing vasculitis with typical pathologic findings of granulomatous inflammation and pauci-immune vasculitis. Untreated, the condition has a very high mortality, and contemporary treatment strategies carry a high risk of treatment-related morbidity. ...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-007-8057-7
更新日期：2008-06-01 00:00:00
abstract：:To investigate the prevalence of anti-third generation cyclic citrullinated peptide antibodies (anti-CCP3) in patients with systemic connective tissue diseases, we assembled a training set consisting of 115 patients with rheumatoid arthritis (RA), 52 with Calcinosis, Raynaud's phenomenon, oesophageal dysmotility, scle...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章
doi：10.1007/BF02686081
更新日期：2007-02-01 00:00:00
abstract：:Food allergy is a potentially life-threatening condition with no approved curative therapy. A number of food allergen immunotherapies are being investigated in phase II/III trials; however, these are limited in their ability to restore immune tolerance to food allergens and often result in high rates of allergic side ...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-018-8694-z
更新日期：2018-10-01 00:00:00
abstract：:Although allergic asthma was described to be associated with the presence of mucosal T helper (Th)2 cells, it is not entirely clear which factors are responsible for priming of T cells to differentiate into Th2 effector cells in this disease. Interleukin (IL)-6 has been recognized as important because it is secreted b...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1385/CRIAI:28:3:257
更新日期：2005-06-01 00:00:00
abstract：:Adult-onset Still's disease (AOSD) is a rare multisystem autoinflammatory disorder of unknown etiology. AOSD is generally characterized by high spiking fever, arthralgia or arthritis, skin rash, leukocytosis, and hyperferritinemia. Traditionally, AOSD has been treated with non-steroidal anti-inflammatory drugs, cortic...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-019-08747-8
更新日期：2020-02-01 00:00:00
abstract：:The heart is a target organ in antiphospholipid syndrome (APS). Endocardial disease, intracardiac thrombosis, myocardial involvement including coronary heart disease and microvascular thrombosis, as well as pulmonary hypertension have all been described in APS patients. Valvular involvement is the most common manifest...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-007-0013-z
更新日期：2007-04-01 00:00:00
abstract：:Patients presenting to the emergency department (ED) or clinic with acute exacerbation of asthma (AEA) can be very challenging varying in both severity and response to therapy. High-dose, frequent or continuous nebulized short-acting beta2 agonist (SABA) therapy that can be combined with a short-acting muscarinic anta...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-014-8448-5
更新日期：2015-02-01 00:00:00
abstract：:Primary sclerosing cholangitis (PSC) is a rare chronic cholestatic disease of the liver and bile ducts that is associated with inflammatory bowel disease, generally leads to end-stage liver disease, and is complicated by malignancies of the biliary tree and the large intestine. The pathogenesis of PSC remains enigmati...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-008-8085-y
更新日期：2009-02-01 00:00:00
abstract：:Over the years, the commonly used term to describe juvenile idiopathic arthritis (JIA) has changed. By definition, JIA includes all types of arthritis with no apparent cause, lasting more than 6 weeks, in patients aged less than 16 years at onset. JIA pathogenesis is still poorly understood: the interaction between en...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-014-8460-9
更新日期：2015-10-01 00:00:00
abstract：:Systemic vasculitides are a group of rare diseases characterized by inflammation of the arterial or venous vessel wall, causing stenosis or thrombosis. Clinical symptoms may be limited to skin or to other organs or may include multiple manifestations as systemic conditions. The pathogenesis is related to the presence ...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-014-8453-8
更新日期：2015-12-01 00:00:00
abstract：:The hyper IgM syndromes are a group of rare inherited immune deficiency disorders characterized by impairment of immunoglobulin isotype switching resulting from defects in the CD40 ligand/CD40 signaling pathway. X-linked forms of hyper IgM are caused by defects in the CD40 ligand gene or NF-κB essential modulator, whi...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-013-8378-7
更新日期：2014-04-01 00:00:00
abstract：:G protein-coupled receptors (GPCRs) constitute the largest family of plasma membrane receptors in nature and mediate the effects of a variety of extracellular signals, such as hormone, neurotransmitter, odor, and light signals. Due to their involvement in a broad range of physiological and pathological processes and t...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-020-08829-y
更新日期：2021-01-07 00:00:00
