Abstract:
:The diagnosis of celiac disease (CD) remains a clinical challenge based on the incomplete specificity and sensitivity rates of current non-invasive tests. Furthermore, histological assessments fail to identify all overt cases and, in particular, do not manifest pathognomonic alterations in silent cases. Accordingly, the majority of CD cases are diagnosed with great delay. Recent research into the pathogenesis of CD, allowed us to identify a neo-antigen that appears to be the most promising serological tool for the detection of anti-tissue transglutaminase as well as anti-gliadin antibodies.
journal_name
Clin Rev Allergy Immunoljournal_title
Clinical reviews in allergy & immunologyauthors
Matthias T,Pfeiffer S,Selmi C,Eric Gershwin Mdoi
10.1007/s12016-009-8160-zsubject
Has Abstractpub_date
2010-04-01 00:00:00pages
298-301issue
2-3eissn
1080-0549issn
1559-0267journal_volume
38pub_type
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