Diagnostic challenges in celiac disease and the role of the tissue transglutaminase-neo-epitope.

Abstract:

:The diagnosis of celiac disease (CD) remains a clinical challenge based on the incomplete specificity and sensitivity rates of current non-invasive tests. Furthermore, histological assessments fail to identify all overt cases and, in particular, do not manifest pathognomonic alterations in silent cases. Accordingly, the majority of CD cases are diagnosed with great delay. Recent research into the pathogenesis of CD, allowed us to identify a neo-antigen that appears to be the most promising serological tool for the detection of anti-tissue transglutaminase as well as anti-gliadin antibodies.

authors

Matthias T,Pfeiffer S,Selmi C,Eric Gershwin M

doi

10.1007/s12016-009-8160-z

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

298-301

issue

2-3

eissn

1080-0549

issn

1559-0267

journal_volume

38

pub_type

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