Abstract：
:Sarcoidosis has innumerable clinical manifestations, as the disease may affect every body organ. Furthermore, the severity of sarcoidosis involvement may range from an asymptomatic state to a life-threatening condition. This manuscript reviews a wide variety of common and less common clinical characteristics of sarcoidosis. These manifestations are presented organ by organ, although additional sections describe systemic and multiorgan presentations of sarcoidosis. The lung is the organ most commonly involved with sarcoidosis with at least 90 % of sarcoidosis patients demonstrating lung involvement in most series. The skin, eye, liver, and peripheral lymph node are the next most commonly clinically involved organs in most series, with the frequency of involvement ranging from 10 to 30 %. The actual frequency of sarcoidosis organ involvement is probably much higher as it is frequently asymptomatic and may avoid detection. This is particularly common with lung, liver, cardiac, and bone involvement. Cardiac sarcoidosis is present in 25 % of all sarcoidosis but only causes clinical problems in 5 % of them. Nevertheless, unlike sarcoidosis involvement of most other organs, it may be suddenly fatal. Therefore, it is important to screen for cardiac sarcoidosis in all sarcoidosis patients. All sarcoidosis patients should also be screened for eye involvement as asymptomatic patients may have eye involvement that may cause permanent vision impairment. Pulmonary fibrosis from sarcoidosis is usually slowly progressive but may be life-threatening because of the development of respiratory failure, pulmonary hypertension, or hemoptysis related to a mycetoma or bronchiectasis. Some manifestations of sarcoidosis are not organ-specific and probably are the result of a release of mediators from the sarcoid granuloma. Two such manifestations include small fiber neuropathy and fatigue syndromes, and they are observed in a large percentage of patients.
journal_name
Clin Rev Allergy Immunoljournal_title
Clinical reviews in allergy & immunologyauthors
Judson MAdoi
10.1007/s12016-014-8450-ysubject
Has Abstractpub_date
2015-08-01 00:00:00pages
63-78issue
1eissn
1080-0549issn
1559-0267journal_volume
49pub_type
杂志文章,评审abstract：:It has been shown that many hereditary motor neuron diseases are caused by mutation of RNA processing enzymes. Survival of motor neuron 1 (SMN1) is well-known as a causative gene for spinal muscular atrophy (SMA) and mutations of glycyl- and tyrosyl-tRNA synthetases are identified as a cause of distal SMA and Charcot-...
journal_title：Clinical reviews in allergy & immunology
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更新日期：2012-02-01 00:00:00
abstract：:Although allergic asthma was described to be associated with the presence of mucosal T helper (Th)2 cells, it is not entirely clear which factors are responsible for priming of T cells to differentiate into Th2 effector cells in this disease. Interleukin (IL)-6 has been recognized as important because it is secreted b...
journal_title：Clinical reviews in allergy & immunology
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pub_type： 杂志文章,评审
doi：10.1007/s12016-009-8135-0
更新日期：2010-02-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
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journal_title：Clinical reviews in allergy & immunology
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更新日期：2008-04-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
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journal_title：Clinical reviews in allergy & immunology
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doi：10.1007/s12016-014-8460-9
更新日期：2015-10-01 00:00:00
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更新日期：2019-10-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/BF02828276
更新日期：1997-04-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/BF02737614
更新日期：1999-10-01 00:00:00
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更新日期：2019-08-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章
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更新日期：2007-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1385/CRIAI:30:2:71
更新日期：2006-04-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/BF02737633
更新日期：1998-10-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
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更新日期：2010-04-01 00:00:00
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更新日期：2017-08-01 00:00:00
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更新日期：2008-12-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
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更新日期：2009-08-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
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更新日期：2007-06-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/BF02737598
更新日期：1999-04-01 00:00:00
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更新日期：2014-08-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
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更新日期：2014-12-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
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更新日期：2020-08-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章
doi：10.1007/s12016-010-8246-7
更新日期：2012-04-01 00:00:00
