The strategies used for treatment of experimental autoimmune neuritis (EAN): a beneficial effect of glatiramer acetate administered intraperitoneally.

abstract：:Over the years, the commonly used term to describe juvenile idiopathic arthritis (JIA) has changed. By definition, JIA includes all types of arthritis with no apparent cause, lasting more than 6 weeks, in patients aged less than 16 years at onset. JIA pathogenesis is still poorly understood: the interaction between en...

journal_title：Clinical reviews in allergy & immunology

authors： Rigante D,Bosco A,Esposito S

更新日期：2015-10-01 00:00:00

abstract：:Available data on small numbers of patients with refractory and/or relapsing Wegener's granulomatosis support very good overall outcomes with rituximab, an anti-CD20 biotherapy targeting B cells, in combination with ongoing immunosuppressants, apparently independently of antineutrophil cytoplasm antibody (ANCA) status...

journal_title：Clinical reviews in allergy & immunology

authors： Aouba A,Pagnoux C,Bienvenu B,Mahr A,Guillevin L

更新日期：2008-02-01 00:00:00

abstract：:Most investigators currently advocate prophylactic-dose heparin plus low-dose aspirin as the preferred treatment of otherwise healthy women with obstetric antiphospholipid syndrome, whilst women with a history of vascular thrombosis alone or associated with pregnancy morbidity are usually treated with therapeutic hepa...

journal_title：Clinical reviews in allergy & immunology

authors： Ruffatti A,Hoxha A,Favaro M,Tonello M,Colpo A,Cucchini U,Banzato A,Pengo V

更新日期：2017-08-01 00:00:00

abstract：:The Zika virus outbreaks highlight the growing importance need for a reliable, specific and rapid diagnostic device to detect Zika virus, as it is often recognized as a mild disease without being identified. Many Zika virus infection cases have been misdiagnosed or underreported because of the non-specific clinical pr...

journal_title：Clinical reviews in allergy & immunology

authors： Maharajan MK,Ranjan A,Chu JF,Foo WL,Chai ZX,Lau EY,Ye HM,Theam XJ,Lok YL

更新日期：2016-12-01 00:00:00

abstract：:Intravenous immunoglobulin (IVIg) has been used as an immunomodulatory therapy for the treatment of multiple sclerosis (MS). In the current review, we summarize the up-to-date data related to IVIg clinical trials in MS, and the suggested mechanisms of action by which IVIg modulates the relevant immunological pathways ...

journal_title：Clinical reviews in allergy & immunology

authors： Achiron A,Miron S

更新日期：2005-12-01 00:00:00

abstract：:Bronchiolitis is a common, acute, contagious lower respiratory tract illness of infants and young children. The majority of cases are secondary to respiratory syncytial virus. There are a number of risk factors for severe disease, including children less than six weeks of age and patients with atopy and/or asthma. The...

journal_title：Clinical reviews in allergy & immunology

authors： Jhawar S

更新日期：2003-12-01 00:00:00

abstract：:Therapy of atopic dermatitis should comprise emollients, topical glucocorticosteroids, or calcineurin inhibitors, phototherapies, immunosuppressants like cyclosporin A, and other treatments. All these treatments should be improved, thanks to research. But new therapeutic perspectives should be given by topical anti-in...

journal_title：Clinical reviews in allergy & immunology

authors： Misery L

更新日期：2011-12-01 00:00:00

abstract：:Pruritus, fatigue, and metabolic bone disease are frequent complications of cholestatic liver diseases, which can be quite distressing for the patient and can considerably reduce the quality of life. The molecular pathogenesis of these extrahepatic manifestations of cholestasis is poorly understood, and hypotheses to ...

journal_title：Clinical reviews in allergy & immunology

authors： Pusl T,Beuers U

更新日期：2005-04-01 00:00:00

abstract：:Prognosis of several autoimmune diseases, especially rheumatoid arthritis (RA), ankylosing spondylitis, Crohn's disease (CD), and psoriasis, usually refractory to conventional treatment improved considerably with the introduction of tumor necrosis factor alpha (TNF-alpha) antagonistic agents, which is now available (i...

journal_title：Clinical reviews in allergy & immunology

authors： Emi Aikawa N,de Carvalho JF,Artur Almeida Silva C,Bonfá E

更新日期：2010-04-01 00:00:00

abstract：:Activated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of intracellular granule components that function by capturing and destroying microbes, including viral, fungal, bacterial, and protozoal pat...

journal_title：Clinical reviews in allergy & immunology

authors： Mutua V,Gershwin LJ

更新日期：2020-08-01 00:00:00

abstract：:Sarcoidosis has innumerable clinical manifestations, as the disease may affect every body organ. Furthermore, the severity of sarcoidosis involvement may range from an asymptomatic state to a life-threatening condition. This manuscript reviews a wide variety of common and less common clinical characteristics of sarcoi...

journal_title：Clinical reviews in allergy & immunology

authors： Judson MA

更新日期：2015-08-01 00:00:00

abstract：:Bronchial hyperresponsiveness (BHR) is a characteristic feature of asthma, and individuals with this disease respond to a range of physiological and chemical insults that are otherwise innocuous to healthy subjects, suggesting that the mechanisms underlying this phenomenon are characteristic of the asthma phenotype. B...

journal_title：Clinical reviews in allergy & immunology

authors： Page CP,Spina D

更新日期：2006-10-01 00:00:00

abstract：:Legumes belonging to Fabaceae family of the order Fabales are a rich and important source of proteins and many essential elements. Due to its nutritious elements, these are preferably included in human diet in most part of the world. But, unfortunately, IgE binding proteins have been identified in majority of legumes,...

journal_title：Clinical reviews in allergy & immunology

authors： Verma AK,Kumar S,Das M,Dwivedi PD

更新日期：2013-08-01 00:00:00

abstract：:Wegener's granulomatosis (WG) is a chronic, relapsing, systemic necrotizing vasculitis with typical pathologic findings of granulomatous inflammation and pauci-immune vasculitis. Untreated, the condition has a very high mortality, and contemporary treatment strategies carry a high risk of treatment-related morbidity. ...

journal_title：Clinical reviews in allergy & immunology

authors： Hinze CH,Colbert RA

更新日期：2008-06-01 00:00:00

abstract：:Pemphigus is a group of rare, potentially devastating autoimmune diseases of the skin and mucous membranes with high morbidity and potentially lethal outcome. The major clinical variant, pemphigus vulgaris (PV) is caused by a loss of intercellular adhesion of epidermal keratinocytes which is induced by IgG autoantibod...

journal_title：Clinical reviews in allergy & immunology

authors： Pollmann R,Schmidt T,Eming R,Hertl M

更新日期：2018-02-01 00:00:00

abstract：:Skin tests by prick technique offer considerable guidance in the diagnosis of food allergy. Negative prick skin tests are powerful evidence against food allergy. Positive food skin tests are slightly to moderately predictive of reaction to a food on DBPCFC. Oral food challenge is necessary for confirmation of food all...

journal_title：Clinical reviews in allergy & immunology

authors： Williams LW,Bock SA

更新日期：1999-10-01 00:00:00

abstract：:12/15-Lipoxygenase is a highly regulated lipid-peroxidating enzyme whose expression and arachidonic acid metabolites are implicated in several important inflammatory conditions including airway and glomerular inflammation as well as atherosclerosis. Tissue expression of the original 12/15-lipoxygenase is well characte...

journal_title：Clinical reviews in allergy & immunology

authors： Conrad DJ

更新日期：1999-04-01 00:00:00

abstract：:Although allergic asthma was described to be associated with the presence of mucosal T helper (Th)2 cells, it is not entirely clear which factors are responsible for priming of T cells to differentiate into Th2 effector cells in this disease. Interleukin (IL)-6 has been recognized as important because it is secreted b...

journal_title：Clinical reviews in allergy & immunology

authors： Doganci A,Sauer K,Karwot R,Finotto S

更新日期：2005-06-01 00:00:00

abstract：:Several factors have been associated with the development of asthma and asthma-related morbidity and mortality. Exposures in the environment such as allergens and air pollutants have traditionally been linked to the risk of asthma and asthma outcomes. More recent literature has identified chronic psychosocial stress a...

journal_title：Clinical reviews in allergy & immunology

authors： Barnthouse M,Jones BL

更新日期：2019-12-01 00:00:00

abstract：:Asthma is the most common potentially serious medical problem to complicate pregnancy. Recent reports suggest that 7 of every 100 pregnant women suffer from asthma during pregnancy. Asthmatic women have been shown to be at an increased risk of complications during pregnancy. This may be secondary to inadequately contr...

journal_title：Clinical reviews in allergy & immunology

authors： Namazy JA,Schatz M

更新日期：2004-06-01 00:00:00

abstract：:Celiac disease is a complex immune-mediated gluten-sensitive enteropathy with protean clinical manifestations. It is manifest in genetically predisposed individuals who ingest gluten in varying amounts. In broad terms, it is thought to affect 1% of the population in the USA. More specifically, the prevalence increases...

journal_title：Clinical reviews in allergy & immunology

authors： McAllister BP,Williams E,Clarke K

更新日期：2019-10-01 00:00:00

abstract：:The functions of macrophages that lead to effective host responses are critical for protection against Staphylococcus aureus. Deep tissue-invading S. aureus initially countered by macrophages trigger macrophage accumulation and induce inflammatory responses through surface receptors, especially toll-like receptor 2 (T...

journal_title：Clinical reviews in allergy & immunology

authors： Wang YC,Ma HD,Yin XY,Wang YH,Liu QZ,Yang JB,Shi QH,Sun B,Gershwin ME,Lian ZX

更新日期：2016-12-01 00:00:00

abstract：:The provider's ability to judge the severity of a patient's illness is a vital part of the care of chronic disorders. In the treatment of asthma, it should extend beyond the objectively quantifiable measures of obstruction or inflammation. "Interference with activities of daily living" is a highly subjective assessmen...

journal_title：Clinical reviews in allergy & immunology

authors： Sherman R,Milgrom H

更新日期：2005-10-01 00:00:00

abstract：:Calcium is the most abundant mineral in the human body and is central to many physiological processes, including immune system activation and maintenance. Studies continue to reveal the intricacies of calcium signalling within the immune system. Perhaps the most well-understood mechanism of calcium influx into cells i...

journal_title：Clinical reviews in allergy & immunology

authors： Froghi S,Grant CR,Tandon R,Quaglia A,Davidson B,Fuller B

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:The last 5 years have seen the emergence and establishment of antibodies to citrullinated antigens as the diagnostic marker for rheumatoid arthritis (RA). Initially, these were detected using a synthetic peptide, which has undergone a number of modifications to give a diagnostic test with a sensitivity of 65...

journal_title：Clinical reviews in allergy & immunology

authors： Poulsom H,Charles PJ

更新日期：2008-02-01 00:00:00

abstract：:Systemic lupus erythmatosus (SLE) is a multi-system autoimmune disease characterized by auto-reactive cells and auto-antibodies, which can potentially affect all organ systems. Typical organ systems that are affected include the heart, lungs, skin, kidneys, and central nervous system. Its expression is believed to be ...

journal_title：Clinical reviews in allergy & immunology

authors： Severin MC,Levy Y,Shoenfeld Y

更新日期：2003-08-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder with a broad spectrum of clinical presentations and association with multiple immunological abnormalities. Recent research of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway-revealed aberrant STAT s...

journal_title：Clinical reviews in allergy & immunology

authors： Goropevšek A,Holcar M,Avčin T

更新日期：2017-04-01 00:00:00

abstract：:Pulmonary function testing is useful for the diagnosis and management of a variety of pulmonary conditions, and the most commonly obtained component is spirometry. Spirometry is most useful in the evaluation of obstructive airway disorders but can be a helpful tool in the management of patients with chest restriction ...

journal_title：Clinical reviews in allergy & immunology

authors： Liou TG,Kanner RE

更新日期：2009-12-01 00:00:00

abstract：:Non-alcoholic steatohepatitis (NASH) is the progressive phenotype of non-alcoholic fatty liver disease associated with the metabolic syndrome. The existence of autoimmune features in NASH has been reported, but its significance remains unclear. We herein report the autoantibody profile of 54 patients with histological...

journal_title：Clinical reviews in allergy & immunology

authors： Tsuneyama K,Baba H,Kikuchi K,Nishida T,Nomoto K,Hayashi S,Miwa S,Nakajima T,Nakanishi Y,Masuda S,Terada M,Imura J,Selmi C

更新日期：2013-08-01 00:00:00

abstract：:Contact dermatitis accounts for 95% of occupational skin disorders. Irritant contact dermatitis (ICD) is often caused by cumulative exposure to weak irritants, accounting for 80% of all cases of contact dermatitis. ICD can co-exist with atopic dermatitis (AD) and allergic contact dermatitis (ACD). Patients with AD and...

journal_title：Clinical reviews in allergy & immunology

authors： Bains SN,Nash P,Fonacier L

更新日期：2019-02-01 00:00:00