Extrahepatic manifestations of cholestatic liver diseases: pathogenesis and therapy.

abstract：:Asthma is a chronic immunological disease affecting all age groups, but often starting in childhood. Although it has long been ascribed to a single pathology, recent studies have highlighted its heterogeneity due to the potential involvement of various pathogenic mechanisms. Here, we present our current understanding ...

journal_title：Clinical reviews in allergy & immunology

authors： Victor JR,Lezmi G,Leite-de-Moraes M

更新日期：2020-12-01 00:00:00

abstract：:Although the relative contributions of T cells and B cells in Sjögren's syndrome (SS) are far from being settled, recent studies have suggested a crucial role for B cells in its pathophysiology. Early investigations have focused on the ability of B cells to produce autoantibodies, and new studies have enlarged the ran...

journal_title：Clinical reviews in allergy & immunology

authors： Youinou P,Devauchelle V,Hutin P,Le Berre R,Saraux A,Pers JO

更新日期：2007-06-01 00:00:00

abstract：:Glatiramer acetate (GA) significantly ameliorates multiple sclerosis and was initially discovered through its effects on the animal model experimental autoimmune encephalomyelitis (EAE). Guillain-Barré syndrome (GBS) is a relatively common demyelinating disease of peripheral nerves for which there is a parallel animal...

journal_title：Clinical reviews in allergy & immunology

authors： Aronovich R,Katzav A,Chapman J

更新日期：2012-04-01 00:00:00

abstract：:The relationship between autoimmunity and reproduction has long been recognized. This relationship is bidirectional and includes many diverse issues, but in this review article, we focus on which autoimmune disturbances are the basic cause of recurrent pregnancy losses in patients with autoimmune diseases. The antipho...

journal_title：Clinical reviews in allergy & immunology

authors： Cervera R,Balasch J

更新日期：2010-12-01 00:00:00

abstract：:Over the past few years, the rates of food allergies have dramatically increased. As a result, the lives of patients and their caregivers have been dramatically altered. While most attention surrounding food allergies has focused on treatment, less consideration has been given to the mental health ramifications of liv...

journal_title：Clinical reviews in allergy & immunology

authors： Feng C,Kim JH

更新日期：2019-08-01 00:00:00

abstract：:Available data on small numbers of patients with refractory and/or relapsing Wegener's granulomatosis support very good overall outcomes with rituximab, an anti-CD20 biotherapy targeting B cells, in combination with ongoing immunosuppressants, apparently independently of antineutrophil cytoplasm antibody (ANCA) status...

journal_title：Clinical reviews in allergy & immunology

authors： Aouba A,Pagnoux C,Bienvenu B,Mahr A,Guillevin L

更新日期：2008-02-01 00:00:00

abstract：:Activated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of intracellular granule components that function by capturing and destroying microbes, including viral, fungal, bacterial, and protozoal pat...

journal_title：Clinical reviews in allergy & immunology

authors： Mutua V,Gershwin LJ

更新日期：2020-08-01 00:00:00

abstract：:Airway remodeling is an established feature of asthma. Histologic examination is essential in the assessment of remodeling that is a pathologic concept. Examinations of autopsied or resected lung have enabled detailed morphologic and morphometric studies and have provided fundamental knowledge of airway remodeling in ...

journal_title：Clinical reviews in allergy & immunology

authors： Niimi A,Matsumoto H,Takemura M,Ueda T,Nakano Y,Mishima M

更新日期：2004-08-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a chronic immune-mediated inflammatory condition primarily involving the gastrointestinal tract. It includes Crohn's disease (CD), ulcerative colitis (UC), and a less common phenotype-indeterminate colitis. It is thought to result from a complex interplay of environmental, microbial...

journal_title：Clinical reviews in allergy & immunology

authors： Clarke K,Chintanaboina J

更新日期：2019-10-01 00:00:00

abstract：:The critical asthma syndrome (CAS) encompasses the most severe, persistent, refractory asthma patients for the clinician to manage. Personalized pharmacotherapy is necessary to prevent the next acute severe asthma exacerbation, not just the control of symptoms. The 2007 National Asthma Education and Prevention Program...

journal_title：Clinical reviews in allergy & immunology

authors： Albertson TE,Schivo M,Gidwani N,Kenyon NJ,Sutter ME,Chan AL,Louie S

更新日期：2015-02-01 00:00:00

abstract：:Chronic hyperplastic eosinophilic sinusitis (CHES) is a T-helper (Th)2-like, lymphocyteinitiated, eosinophil-rich inflammatory disease. The complex immune interactions required to orchestrate these processes begin with the presentation of antigen by mature dendritic cells to Th lymphocytes that display the appropriate...

journal_title：Clinical reviews in allergy & immunology

authors： Borish L,Rosenwasser L,Steinke JW

更新日期：2006-06-01 00:00:00

abstract：:During the last decade, B regulatory cells are appreciated to have a central role in preventing autoimmunity and maintaining self-tolerance. They are characterized by expressing different phenotypic markers and the production of either IL-10 or TGF-β or both. The recent recognition of Fas ligand expressing B regulator...

journal_title：Clinical reviews in allergy & immunology

authors： Vadasz Z,Toubi E

更新日期：2017-06-01 00:00:00

abstract：:To investigate the prevalence of anti-third generation cyclic citrullinated peptide antibodies (anti-CCP3) in patients with systemic connective tissue diseases, we assembled a training set consisting of 115 patients with rheumatoid arthritis (RA), 52 with Calcinosis, Raynaud's phenomenon, oesophageal dysmotility, scle...

journal_title：Clinical reviews in allergy & immunology

authors： Wu R,Shovman O,Zhang Y,Gilburd B,Zandman-Goddard G,Shoenfeld Y

更新日期：2007-02-01 00:00:00

abstract：:Bronchiolitis is a common, acute, contagious lower respiratory tract illness of infants and young children. The majority of cases are secondary to respiratory syncytial virus. There are a number of risk factors for severe disease, including children less than six weeks of age and patients with atopy and/or asthma. The...

journal_title：Clinical reviews in allergy & immunology

authors： Jhawar S

更新日期：2003-12-01 00:00:00

abstract：:Alopecia areata is a common hair loss condition that is characterized by acute onset of non-scarring hair loss in usually sharply defined areas ranging from small patches to extensive or less frequently diffuse involvement. Depending on its acuity and extent, hair loss is an important cause of anxiety and disability. ...

journal_title：Clinical reviews in allergy & immunology

authors： Trüeb RM,Dias MFRG

更新日期：2018-02-01 00:00:00

abstract：:Strategies to improve patients' adherence to treatment are essential to reduce the great health and economic burden of allergic rhinitis and asthma. Mobile phone applications (apps) for a better management of allergic diseases are growing in number, but their usefulness for doctors and patients is still debated. Contr...

journal_title：Clinical reviews in allergy & immunology

authors： Huang X,Matricardi PM

更新日期：2019-04-01 00:00:00

abstract：:The functions of macrophages that lead to effective host responses are critical for protection against Staphylococcus aureus. Deep tissue-invading S. aureus initially countered by macrophages trigger macrophage accumulation and induce inflammatory responses through surface receptors, especially toll-like receptor 2 (T...

journal_title：Clinical reviews in allergy & immunology

authors： Wang YC,Ma HD,Yin XY,Wang YH,Liu QZ,Yang JB,Shi QH,Sun B,Gershwin ME,Lian ZX

更新日期：2016-12-01 00:00:00

abstract：:The gold standard for diagnosing asthma in children is based on clinical history of respiratory symptoms, physical examination, and respiratory function testing. Recent advances indicate that a non-invasive measure of airway inflammation, fractional exhaled nitric oxide (FeNO), provides objective data for use in asthm...

journal_title：Clinical reviews in allergy & immunology

authors： Tang S,Xie Y,Yuan C,Sun X,Cui Y

更新日期：2019-04-01 00:00:00

abstract：:A bulk of literature demonstrated that respiratory allergy, and especially asthma, is prevalent in males during childhood, while it becomes more frequent in females from adolescence, i.e., after menarche, to adulthood. The mechanisms underlying the difference between females and males are the effects on the immune res...

journal_title：Clinical reviews in allergy & immunology

authors： Ridolo E,Incorvaia C,Martignago I,Caminati M,Canonica GW,Senna G

更新日期：2019-06-01 00:00:00

abstract：:The Zika virus outbreaks highlight the growing importance need for a reliable, specific and rapid diagnostic device to detect Zika virus, as it is often recognized as a mild disease without being identified. Many Zika virus infection cases have been misdiagnosed or underreported because of the non-specific clinical pr...

journal_title：Clinical reviews in allergy & immunology

authors： Maharajan MK,Ranjan A,Chu JF,Foo WL,Chai ZX,Lau EY,Ye HM,Theam XJ,Lok YL

更新日期：2016-12-01 00:00:00

abstract：:Although allergic asthma was described to be associated with the presence of mucosal T helper (Th)2 cells, it is not entirely clear which factors are responsible for priming of T cells to differentiate into Th2 effector cells in this disease. Interleukin (IL)-6 has been recognized as important because it is secreted b...

journal_title：Clinical reviews in allergy & immunology

authors： Doganci A,Sauer K,Karwot R,Finotto S

更新日期：2005-06-01 00:00:00

abstract：:Intravenous immunoglobulin (IVIg) has been used as an immunomodulatory therapy for the treatment of multiple sclerosis (MS). In the current review, we summarize the up-to-date data related to IVIg clinical trials in MS, and the suggested mechanisms of action by which IVIg modulates the relevant immunological pathways ...

journal_title：Clinical reviews in allergy & immunology

authors： Achiron A,Miron S

更新日期：2005-12-01 00:00:00

abstract：:Allergic diseases are surprisingly common, chronic health conditions. The primary location where the vast majority of people are exposed to allergens and other substances is in their home. This means it is important to understand home environments and how a home's systems function and interact-and that how we occupy t...

journal_title：Clinical reviews in allergy & immunology

authors： Kennedy K,Allenbrand R,Bowles E

更新日期：2019-12-01 00:00:00

abstract：:Asthma is the most common potentially serious medical problem to complicate pregnancy. Recent reports suggest that 7 of every 100 pregnant women suffer from asthma during pregnancy. Asthmatic women have been shown to be at an increased risk of complications during pregnancy. This may be secondary to inadequately contr...

journal_title：Clinical reviews in allergy & immunology

authors： Namazy JA,Schatz M

更新日期：2004-06-01 00:00:00

abstract：:Prognosis of several autoimmune diseases, especially rheumatoid arthritis (RA), ankylosing spondylitis, Crohn's disease (CD), and psoriasis, usually refractory to conventional treatment improved considerably with the introduction of tumor necrosis factor alpha (TNF-alpha) antagonistic agents, which is now available (i...

journal_title：Clinical reviews in allergy & immunology

authors： Emi Aikawa N,de Carvalho JF,Artur Almeida Silva C,Bonfá E

更新日期：2010-04-01 00:00:00

abstract：:Eosinophilic esophagitis (EoE) is an emerging chronic atopic clinical-pathologic disease with an estimated prevalence of 1/1000 similar to the one of Crohn's diseases. Usually, EoE is firstly suspected due to symptoms that are caused by esophageal dysfunction and/or fibrosis. EoE diagnosis is confirmed if the esophage...

journal_title：Clinical reviews in allergy & immunology

authors： Cianferoni A,Spergel J

更新日期：2016-04-01 00:00:00

abstract：:The provider's ability to judge the severity of a patient's illness is a vital part of the care of chronic disorders. In the treatment of asthma, it should extend beyond the objectively quantifiable measures of obstruction or inflammation. "Interference with activities of daily living" is a highly subjective assessmen...

journal_title：Clinical reviews in allergy & immunology

authors： Sherman R,Milgrom H

更新日期：2005-10-01 00:00:00

abstract：:Patients with immunodeficiencies or some types of autoimmune diseases are dependent on safe therapy with intravenous immunoglobulins. State-of-the-art manufacturing processes provide a high safety standard by incorporating virus elimination procedures into the manufacturing process. Based on their mechanism, these pro...

journal_title：Clinical reviews in allergy & immunology

authors： Boschetti N,Stucki M,Späth PJ,Kempf C

更新日期：2005-12-01 00:00:00

abstract：:Cryoglobulins are immunoglobulins that reversibly precipitate in the cold. They come in different flavours and, as such, are differentially associated with lymphoproliferative diseases (type I), or systemic autoimmune diseases, and/or infectious diseases (type II/III). The clinical manifestations of cryoglobulinaemia ...

journal_title：Clinical reviews in allergy & immunology

authors： Damoiseaux J,Cohen Tervaert JW

更新日期：2014-12-01 00:00:00

abstract：:Patients with primary immunodeficiencies are prone to develop enteropathy of unknown pathogenesis. We hypothesize that ineffective clearance of gastrointestinal pathogens, particularly viruses, in combination with defective immune regulation may cause inflammatory enteropathy in certain immunodeficient hosts. We revie...

journal_title：Clinical reviews in allergy & immunology

authors： van de Ven AA,Hoytema van Konijnenburg DP,Wensing AM,van Montfrans JM

更新日期：2012-02-01 00:00:00