Abstract：
:Activated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of intracellular granule components that function by capturing and destroying microbes, including viral, fungal, bacterial, and protozoal pathogens. The positive effects of pathogen control are countered by pro-inflammatory effects as demonstrated in a variety of diseases. Components of NETS are non-specific, and other than controlling microbes, they cause injury to surrounding tissue by themselves or by increasing the pro-inflammatory response. NETs can play a role in enhancement of the inflammation seen in autoimmune diseases including psoriasis, rheumatoid arthritis, and systemic lupus erythematosis. In addition, autoinflammatory diseases such as gout have been associated with NETosis. Inhibition of NETs may decrease the severity of many diseases improving survival. Herein, we describe NETosis in different diseases focusing on the detrimental effect of NETs and outline possible therapeutics that can be used to mitigate netosis. There is a need for more studies and clinical trials on these and other compounds that could prevent or destroy NETs, thereby decreasing damage to patients.
journal_name
Clin Rev Allergy Immunoljournal_title
Clinical reviews in allergy & immunologyauthors
Mutua V,Gershwin LJdoi
10.1007/s12016-020-08804-7subject
Has Abstractpub_date
2020-08-01 00:00:00eissn
1080-0549issn
1559-0267pii
10.1007/s12016-020-08804-7pub_type
杂志文章,评审abstract：:12/15-Lipoxygenase is a highly regulated lipid-peroxidating enzyme whose expression and arachidonic acid metabolites are implicated in several important inflammatory conditions including airway and glomerular inflammation as well as atherosclerosis. Tissue expression of the original 12/15-lipoxygenase is well characte...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/BF02737598
更新日期：1999-04-01 00:00:00
abstract：:The Zika virus outbreaks highlight the growing importance need for a reliable, specific and rapid diagnostic device to detect Zika virus, as it is often recognized as a mild disease without being identified. Many Zika virus infection cases have been misdiagnosed or underreported because of the non-specific clinical pr...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-016-8554-7
更新日期：2016-12-01 00:00:00
abstract：:One of the important factors and consequences in persistent asthma is the change in the vasculature of the airways and lung parenchyma. These changes could contribute to worsening asthma control and predispose asthmatics to critical asthma syndromes. For many years, the contribution of vasculature to severe asthma was...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-014-8420-4
更新日期：2015-02-01 00:00:00
abstract：:What makes an antigen an allergen? This question has been at the core of much research regarding the basic mechanisms of allergy as well as the development of diagnostic and therapeutic allergen products. Great strides have been made since Kjell Aas asked this question in his classic review in Allergy (1), but we appe...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章
doi：10.1385/CRIAI:30:2:71
更新日期：2006-04-01 00:00:00
abstract：:This review includes a variety of extremely rare and unusual hymenoptera sting (HS) circumstances with regard to sting localization, geographic region, massivity of multiple stings, and particularly related to clinical symptoms. Such reactions occur in a temporal relationship to HS (s), differ from typical allergic sy...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-014-8434-y
更新日期：2014-08-01 00:00:00
abstract：:Rheumatoid arthritis and spondyloarthritis are inflammatory joint disorders with an autoimmune pathogenesis and systemic involvement. The skin is one of the most frequently affected extraarticular sites with a number of manifestations or distinct diseases, including common conditions, such as rheumatoid nodules and ps...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-017-8629-0
更新日期：2018-04-01 00:00:00
abstract：:Pulmonary function testing is useful for the diagnosis and management of a variety of pulmonary conditions, and the most commonly obtained component is spirometry. Spirometry is most useful in the evaluation of obstructive airway disorders but can be a helpful tool in the management of patients with chest restriction ...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-009-8128-z
更新日期：2009-12-01 00:00:00
abstract：:The hyper IgM syndromes are a group of rare inherited immune deficiency disorders characterized by impairment of immunoglobulin isotype switching resulting from defects in the CD40 ligand/CD40 signaling pathway. X-linked forms of hyper IgM are caused by defects in the CD40 ligand gene or NF-κB essential modulator, whi...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-013-8378-7
更新日期：2014-04-01 00:00:00
abstract：:Legumes belonging to Fabaceae family of the order Fabales are a rich and important source of proteins and many essential elements. Due to its nutritious elements, these are preferably included in human diet in most part of the world. But, unfortunately, IgE binding proteins have been identified in majority of legumes,...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-012-8310-6
更新日期：2013-08-01 00:00:00
abstract：:Previously believed to have an exclusive role in the release of cytotoxic mediators in the defense against helminthic infections, eosinophils are now considered key players in inflammatory reaction and regulation of immune response. Through activation of a large variety of membrane receptors and production of various ...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1385/CRIAI:30:1:013
更新日期：2006-02-01 00:00:00
abstract：:Intravenous immunoglobulin (IVIg) has been used as an immunomodulatory therapy for the treatment of multiple sclerosis (MS). In the current review, we summarize the up-to-date data related to IVIg clinical trials in MS, and the suggested mechanisms of action by which IVIg modulates the relevant immunological pathways ...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1385/CRIAI:29:3:247
更新日期：2005-12-01 00:00:00
abstract：:Skin tests by prick technique offer considerable guidance in the diagnosis of food allergy. Negative prick skin tests are powerful evidence against food allergy. Positive food skin tests are slightly to moderately predictive of reaction to a food on DBPCFC. Oral food challenge is necessary for confirmation of food all...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/BF02737614
更新日期：1999-10-01 00:00:00
abstract：:Every 2 years, an International Congress of Autoimmunity is organized and held with the intent of creating a new base for continuing interdisciplinary and international research, including further opportunities to train in the field of autoimmunity. In September 2008, the Congress of Autoimmunity was held in Porto, Po...
journal_title：Clinical reviews in allergy & immunology
pub_type：
doi：10.1007/s12016-009-8141-2
更新日期：2010-04-01 00:00:00
abstract：:Eosinophils can regulate local and systemic inflammation, and their presence in higher numbers appears to play an important role in the pathology of various atopic and inflammatory diseases. Eosinophil maturation, recruitment, and survival depend on several cytokine regulators, including interleukin (IL)-5, IL-4, and ...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-014-8444-9
更新日期：2016-04-01 00:00:00
abstract：:Hereditary angioedema (HAE) patients experience recurrent local swelling in various parts of the body including painful swelling of the intestine and life-threatening laryngeal oedema. Most HAE literature is about attacks located in one anatomical site, though it is mentioned that HAE attacks may also involve multiple...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章
doi：10.1007/s12016-014-8463-6
更新日期：2016-02-01 00:00:00
abstract：:Asthma is the most common potentially serious medical problem to complicate pregnancy. Recent reports suggest that 7 of every 100 pregnant women suffer from asthma during pregnancy. Asthmatic women have been shown to be at an increased risk of complications during pregnancy. This may be secondary to inadequately contr...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1385/CRIAI:26:3:139
更新日期：2004-06-01 00:00:00
abstract：:Familial hypercholesterolemia (FH) is the most common inherited form of dyslipidemia and a major cause of premature cardiovascular disease. Management of FH mainly relies on the efficiency of treatments that reduce plasma low-density lipoprotein (LDL) cholesterol (LDL-C) concentrations. MicroRNAs (miRs) have been sugg...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-017-8611-x
更新日期：2018-04-01 00:00:00
abstract：:Omalizumab is a humanized mouse monoclonal antibody that binds specifically to the constant region of the immunoglobulin (Ig)E heavy chain. Omalizumab exerts its effects by reducing free serum IgE levels and FcepsilonRI expression on several cell types. These effects have been shown to result in decreased airway infla...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1385/CRIAI:29:1:003
更新日期：2005-08-01 00:00:00
abstract：:The functions of macrophages that lead to effective host responses are critical for protection against Staphylococcus aureus. Deep tissue-invading S. aureus initially countered by macrophages trigger macrophage accumulation and induce inflammatory responses through surface receptors, especially toll-like receptor 2 (T...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s12016-016-8531-1
更新日期：2016-12-01 00:00:00
abstract：:The relationship between autoimmunity and reproduction has long been recognized. This relationship is bidirectional and includes many diverse issues, but in this review article, we focus on which autoimmune disturbances are the basic cause of recurrent pregnancy losses in patients with autoimmune diseases. The antipho...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-009-8179-1
更新日期：2010-12-01 00:00:00
abstract：:Systemic lupus erythmatosus (SLE) is a multi-system autoimmune disease characterized by auto-reactive cells and auto-antibodies, which can potentially affect all organ systems. Typical organ systems that are affected include the heart, lungs, skin, kidneys, and central nervous system. Its expression is believed to be ...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1385/CRIAI:25:1:41
更新日期：2003-08-01 00:00:00
abstract：:Celiac disease is a complex immune-mediated gluten-sensitive enteropathy with protean clinical manifestations. It is manifest in genetically predisposed individuals who ingest gluten in varying amounts. In broad terms, it is thought to affect 1% of the population in the USA. More specifically, the prevalence increases...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-018-8691-2
更新日期：2019-10-01 00:00:00
abstract：:Strategies to improve patients' adherence to treatment are essential to reduce the great health and economic burden of allergic rhinitis and asthma. Mobile phone applications (apps) for a better management of allergic diseases are growing in number, but their usefulness for doctors and patients is still debated. Contr...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s12016-016-8542-y
更新日期：2019-04-01 00:00:00
abstract：:Calcium is the most abundant mineral in the human body and is central to many physiological processes, including immune system activation and maintenance. Studies continue to reveal the intricacies of calcium signalling within the immune system. Perhaps the most well-understood mechanism of calcium influx into cells i...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-020-08824-3
更新日期：2021-01-06 00:00:00
abstract：:As summarized in Table 1, the literature consistently supports the hypothesis that allergic asthmatic patients have seasonal BHR changes that parallel allergen exposure. These seasonal changes appear to be preventable by treatment with corticosteroids (systemic, inhaled, or nasal), disodium cromoglycate, and immunothe...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/BF02826585
更新日期：1997-07-01 00:00:00
abstract：:Atherosclerosis is an inflammatory disease, and several antigens have been shown to activate the immune response and affect the development of atherogenesis. This suggests that modulation of the immune system could represent a useful approach to prevent and/or treat this disorder. A vaccination approach might be a use...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-009-8145-y
更新日期：2010-04-01 00:00:00
abstract：:To investigate the prevalence of anti-third generation cyclic citrullinated peptide antibodies (anti-CCP3) in patients with systemic connective tissue diseases, we assembled a training set consisting of 115 patients with rheumatoid arthritis (RA), 52 with Calcinosis, Raynaud's phenomenon, oesophageal dysmotility, scle...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章
doi：10.1007/BF02686081
更新日期：2007-02-01 00:00:00
abstract：:Alopecia areata is a common hair loss condition that is characterized by acute onset of non-scarring hair loss in usually sharply defined areas ranging from small patches to extensive or less frequently diffuse involvement. Depending on its acuity and extent, hair loss is an important cause of anxiety and disability. ...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-017-8620-9
更新日期：2018-02-01 00:00:00
abstract：:A bulk of literature demonstrated that respiratory allergy, and especially asthma, is prevalent in males during childhood, while it becomes more frequent in females from adolescence, i.e., after menarche, to adulthood. The mechanisms underlying the difference between females and males are the effects on the immune res...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-017-8661-0
更新日期：2019-06-01 00:00:00
abstract：:Acid anhydrides are used by chemical industries as plasticizers. Trimellitic acid (TMA) is an acid anhydride widely utilized in factories to produce paints, varnishes, and plastics. In addition to causing direct irritant effects, TMA can augment antibody responses in exposed factory workers leading to occupational ast...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-020-08801-w
更新日期：2020-08-01 00:00:00
