Abstract:
:Although the relative contributions of T cells and B cells in Sjögren's syndrome (SS) are far from being settled, recent studies have suggested a crucial role for B cells in its pathophysiology. Early investigations have focused on the ability of B cells to produce autoantibodies, and new studies have enlarged the range of their functions. For example, beyond the paradigm that T lymphocytes maintain strict control over B cells, the latter cells are now acknowledged to solicit their own help from the former cells and release a flurry of cytokines. Further, some of these B cells act as antigen-presenting cells. Increased levels of the B cell activating factor (BAFF) found in SS may be responsible for high numbers of circulating Bm2/Bm2' cells and associated functional abnormalities of B cells, such as a BAFF-induced increased expression of CD19, which decreases the required strength generated by antigen binding for transmitting its signal. This review reports compelling evidence that B cells are involved in the pathophysiology of SS. As this brings novel prospects for the treatment of the disease, it is no surprise that B cell ablative treatment has proven to be relatively efficacious in SS.
journal_name
Clin Rev Allergy Immunoljournal_title
Clinical reviews in allergy & immunologyauthors
Youinou P,Devauchelle V,Hutin P,Le Berre R,Saraux A,Pers JOdoi
10.1007/s12016-007-8000-ysubject
Has Abstractpub_date
2007-06-01 00:00:00pages
231-7issue
3eissn
1080-0549issn
1559-0267journal_volume
32pub_type
杂志文章,评审abstract::The term "mold" is utilized to define the ubiquitous fungal species commonly found in household dust and observed as visible multicellular filaments. Several well-defined human diseases are known to be caused or exacerbated by mold or by exposure to their byproducts. Among these, a solid connection has been establishe...
journal_title:Clinical reviews in allergy & immunology
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journal_title:Clinical reviews in allergy & immunology
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journal_title:Clinical reviews in allergy & immunology
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journal_title:Clinical reviews in allergy & immunology
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
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更新日期:2008-12-01 00:00:00
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journal_title:Clinical reviews in allergy & immunology
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
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更新日期:2014-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-06-01 00:00:00
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-014-8450-y
更新日期:2015-08-01 00:00:00
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
doi:10.1385/CRIAI:28:2:147
更新日期:2005-04-01 00:00:00
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-015-8482-y
更新日期:2015-06-01 00:00:00
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-013-8383-x
更新日期:2013-08-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
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更新日期:2010-12-01 00:00:00
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
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更新日期:2009-08-01 00:00:00
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journal_title:Clinical reviews in allergy & immunology
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更新日期:2005-10-01 00:00:00
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章
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更新日期:2016-02-01 00:00:00
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
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更新日期:2006-10-01 00:00:00
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
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更新日期:2016-04-01 00:00:00
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journal_title:Clinical reviews in allergy & immunology
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更新日期:2013-08-01 00:00:00
abstract::Acute graft-versus-host disease (GVHD) conceptually may be divided into three evolutionary stages: allostimulation, effector cell homing to specific tissues, and cellular targeting and injury. Surprisingly, little is known regarding the targeting stage of GVHD. Recently, we have learned that epithelial target cell inj...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-007-0028-5
更新日期:2007-10-01 00:00:00
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1385/CRIAI:26:3:139
更新日期:2004-06-01 00:00:00