New therapies for primary biliary cirrhosis.

abstract：:Pemphigus is a group of rare, potentially devastating autoimmune diseases of the skin and mucous membranes with high morbidity and potentially lethal outcome. The major clinical variant, pemphigus vulgaris (PV) is caused by a loss of intercellular adhesion of epidermal keratinocytes which is induced by IgG autoantibod...

journal_title：Clinical reviews in allergy & immunology

authors： Pollmann R,Schmidt T,Eming R,Hertl M

更新日期：2018-02-01 00:00:00

abstract：:Asthma is the most common potentially serious medical problem to complicate pregnancy. Recent reports suggest that 7 of every 100 pregnant women suffer from asthma during pregnancy. Asthmatic women have been shown to be at an increased risk of complications during pregnancy. This may be secondary to inadequately contr...

journal_title：Clinical reviews in allergy & immunology

authors： Namazy JA,Schatz M

更新日期：2004-06-01 00:00:00

abstract：:Autoimmune diseases are immune disorders characterized by T cell hyperactivity and B cell overstimulation leading to overproduction of autoantibodies. Although the pathogenesis of various autoimmune diseases remains to be elucidated, environmental factors have been thought to contribute to the initiation and maintenan...

journal_title：Clinical reviews in allergy & immunology

authors： Liu Y,Yin H,Zhao M,Lu Q

更新日期：2014-10-01 00:00:00

abstract：:Several factors have been associated with the development of asthma and asthma-related morbidity and mortality. Exposures in the environment such as allergens and air pollutants have traditionally been linked to the risk of asthma and asthma outcomes. More recent literature has identified chronic psychosocial stress a...

journal_title：Clinical reviews in allergy & immunology

authors： Barnthouse M,Jones BL

更新日期：2019-12-01 00:00:00

abstract：:Adult-onset Still's disease (AOSD) is a rare multisystem autoinflammatory disorder of unknown etiology. AOSD is generally characterized by high spiking fever, arthralgia or arthritis, skin rash, leukocytosis, and hyperferritinemia. Traditionally, AOSD has been treated with non-steroidal anti-inflammatory drugs, cortic...

journal_title：Clinical reviews in allergy & immunology

authors： Li S,Zheng S,Tang S,Pan Y,Zhang S,Fang H,Qiao J

更新日期：2020-02-01 00:00:00

abstract：:Glatiramer acetate (GA) significantly ameliorates multiple sclerosis and was initially discovered through its effects on the animal model experimental autoimmune encephalomyelitis (EAE). Guillain-Barré syndrome (GBS) is a relatively common demyelinating disease of peripheral nerves for which there is a parallel animal...

journal_title：Clinical reviews in allergy & immunology

authors： Aronovich R,Katzav A,Chapman J

更新日期：2012-04-01 00:00:00

abstract：:Eosinophils can regulate local and systemic inflammation, and their presence in higher numbers appears to play an important role in the pathology of various atopic and inflammatory diseases. Eosinophil maturation, recruitment, and survival depend on several cytokine regulators, including interleukin (IL)-5, IL-4, and ...

journal_title：Clinical reviews in allergy & immunology

authors： Sriaroon P,Ballow M

更新日期：2016-04-01 00:00:00

abstract：:Over the past few years, the rates of food allergies have dramatically increased. As a result, the lives of patients and their caregivers have been dramatically altered. While most attention surrounding food allergies has focused on treatment, less consideration has been given to the mental health ramifications of liv...

journal_title：Clinical reviews in allergy & immunology

authors： Feng C,Kim JH

更新日期：2019-08-01 00:00:00

abstract：:A bulk of literature demonstrated that respiratory allergy, and especially asthma, is prevalent in males during childhood, while it becomes more frequent in females from adolescence, i.e., after menarche, to adulthood. The mechanisms underlying the difference between females and males are the effects on the immune res...

journal_title：Clinical reviews in allergy & immunology

authors： Ridolo E,Incorvaia C,Martignago I,Caminati M,Canonica GW,Senna G

更新日期：2019-06-01 00:00:00

abstract：:The incidence of autoimmune diseases is increasing in Western countries, possibly due to the improved sanitary conditions and reduced exposure to infections in childhood (the hygiene hypothesis). There is an ongoing debate whether infection prevents or precipitates autoimmune diseases. Various helminths species used i...

journal_title：Clinical reviews in allergy & immunology

authors： Ben-Ami Shor D,Harel M,Eliakim R,Shoenfeld Y

更新日期：2013-10-01 00:00:00

abstract：:Alopecia areata is a common hair loss condition that is characterized by acute onset of non-scarring hair loss in usually sharply defined areas ranging from small patches to extensive or less frequently diffuse involvement. Depending on its acuity and extent, hair loss is an important cause of anxiety and disability. ...

journal_title：Clinical reviews in allergy & immunology

authors： Trüeb RM,Dias MFRG

更新日期：2018-02-01 00:00:00

abstract：:Reduced bone mineral density is frequently found especially in adult celiac disease (CD) and dietary guidelines favor vitamin D supplementation in adults and children with CD. Vitamin D serum levels were investigated in CD populations in order to challenge its routine supplementation. Israeli (61), Spanish (59), CD ch...

journal_title：Clinical reviews in allergy & immunology

authors： Lerner A,Shapira Y,Agmon-Levin N,Pacht A,Ben-Ami Shor D,López HM,Sanchez-Castanon M,Shoenfeld Y

更新日期：2012-06-01 00:00:00

abstract：:In the vast database of peer-reviewed articles, the number of 2018 papers published retrieved using the "autoimmunity" keyword remained unchanged compared with the brilliant results of 2017 while returning above a 5% share within the immunology field, after the brisk decrease of this ratio in 2017. As in the past 12 y...

journal_title：Clinical reviews in allergy & immunology

authors： Selmi C

更新日期：2019-06-01 00:00:00

abstract：:Bronchiolitis is a common, acute, contagious lower respiratory tract illness of infants and young children. The majority of cases are secondary to respiratory syncytial virus. There are a number of risk factors for severe disease, including children less than six weeks of age and patients with atopy and/or asthma. The...

journal_title：Clinical reviews in allergy & immunology

authors： Jhawar S

更新日期：2003-12-01 00:00:00

abstract：:Atherosclerosis is a disease of the vascular wall, which predominantly affects large and medium-sized arteries. It represents a leading cause of morbidity and mortality in the Western world. In the last few decades, it has been clearly shown that immune system plays a relevant role in atherogenesis. The effectors of b...

journal_title：Clinical reviews in allergy & immunology

authors： Bassi N,Zampieri S,Ghirardello A,Tonon M,Zen M,Cozzi F,Doria A

更新日期：2009-08-01 00:00:00

abstract：:Although allergic asthma was described to be associated with the presence of mucosal T helper (Th)2 cells, it is not entirely clear which factors are responsible for priming of T cells to differentiate into Th2 effector cells in this disease. Interleukin (IL)-6 has been recognized as important because it is secreted b...

journal_title：Clinical reviews in allergy & immunology

authors： Doganci A,Sauer K,Karwot R,Finotto S

更新日期：2005-06-01 00:00:00

abstract：:Bronchial hyperresponsiveness (BHR) is a characteristic feature of asthma, and individuals with this disease respond to a range of physiological and chemical insults that are otherwise innocuous to healthy subjects, suggesting that the mechanisms underlying this phenomenon are characteristic of the asthma phenotype. B...

journal_title：Clinical reviews in allergy & immunology

authors： Page CP,Spina D

更新日期：2006-10-01 00:00:00

abstract：:Sarcoidosis has innumerable clinical manifestations, as the disease may affect every body organ. Furthermore, the severity of sarcoidosis involvement may range from an asymptomatic state to a life-threatening condition. This manuscript reviews a wide variety of common and less common clinical characteristics of sarcoi...

journal_title：Clinical reviews in allergy & immunology

authors： Judson MA

更新日期：2015-08-01 00:00:00

abstract：:This review includes a variety of extremely rare and unusual hymenoptera sting (HS) circumstances with regard to sting localization, geographic region, massivity of multiple stings, and particularly related to clinical symptoms. Such reactions occur in a temporal relationship to HS (s), differ from typical allergic sy...

journal_title：Clinical reviews in allergy & immunology

authors： Mingomataj EÇ,Bakiri AH,Ibranji A,Sturm GJ

更新日期：2014-08-01 00:00:00

abstract：:Inhibitors to factor VIII (FVIII) are alloantibodies directed against epitopes able to neutralise FVIII procoagulant activity. They may render FVIII replacement therapy ineffective. They represent the most severe complication of haemophilia A. At least three mechanisms of FVIII neutralisation activity by anti-FVIII an...

journal_title：Clinical reviews in allergy & immunology

authors： Tellier Z,André MH,Polack B

更新日期：2009-10-01 00:00:00

abstract：:Systemic vasculitides are a group of rare diseases characterized by inflammation of the arterial or venous vessel wall, causing stenosis or thrombosis. Clinical symptoms may be limited to skin or to other organs or may include multiple manifestations as systemic conditions. The pathogenesis is related to the presence ...

journal_title：Clinical reviews in allergy & immunology

authors： Chimenti MS,Ballanti E,Triggianese P,Perricone R

更新日期：2015-12-01 00:00:00

abstract：:Bronchial hyperresponsiveness (BHR) is an essential part of the definition of asthma. Although our understanding of the allergic inflammatory and immunologic mechanisms of asthma have markedly increased, the mechanism of BHR remains to be elucidated. Increased BHR is associated temporally with exposure to allergens, c...

journal_title：Clinical reviews in allergy & immunology

authors： Townley RG,Horiba M

更新日期：2003-02-01 00:00:00

abstract：:Sarcoidosis is a systemic granulomatous disease that frequently involves the lung. Although classically thought of as a restrictive lung disease, airway obstruction has become a recognized feature of the disease in the past years. Sarcoidosis can affect the airway at any level and when the involvement includes small a...

journal_title：Clinical reviews in allergy & immunology

authors： Laohaburanakit P,Chan A

更新日期：2003-10-01 00:00:00

abstract：:The diagnosis of celiac disease (CD) remains a clinical challenge based on the incomplete specificity and sensitivity rates of current non-invasive tests. Furthermore, histological assessments fail to identify all overt cases and, in particular, do not manifest pathognomonic alterations in silent cases. Accordingly, t...

journal_title：Clinical reviews in allergy & immunology

authors： Matthias T,Pfeiffer S,Selmi C,Eric Gershwin M

更新日期：2010-04-01 00:00:00

abstract：:The functions of macrophages that lead to effective host responses are critical for protection against Staphylococcus aureus. Deep tissue-invading S. aureus initially countered by macrophages trigger macrophage accumulation and induce inflammatory responses through surface receptors, especially toll-like receptor 2 (T...

journal_title：Clinical reviews in allergy & immunology

authors： Wang YC,Ma HD,Yin XY,Wang YH,Liu QZ,Yang JB,Shi QH,Sun B,Gershwin ME,Lian ZX

更新日期：2016-12-01 00:00:00

abstract：:Illicit stimulants, such as cocaine, amphetamine, and their derivatives (e.g., "ecstasy"), continue to exact heavy toll on health care in both developed and developing countries. The US Department of Health and Human Service reported over one million illicit drug-related emergency department visits in 2010, which was ...

journal_title：Clinical reviews in allergy & immunology

authors： Tseng W,Sutter ME,Albertson TE

更新日期：2014-02-01 00:00:00

abstract：:Non-alcoholic steatohepatitis (NASH) is the progressive phenotype of non-alcoholic fatty liver disease associated with the metabolic syndrome. The existence of autoimmune features in NASH has been reported, but its significance remains unclear. We herein report the autoantibody profile of 54 patients with histological...

journal_title：Clinical reviews in allergy & immunology

authors： Tsuneyama K,Baba H,Kikuchi K,Nishida T,Nomoto K,Hayashi S,Miwa S,Nakajima T,Nakanishi Y,Masuda S,Terada M,Imura J,Selmi C

更新日期：2013-08-01 00:00:00

abstract：:The Zika virus outbreaks highlight the growing importance need for a reliable, specific and rapid diagnostic device to detect Zika virus, as it is often recognized as a mild disease without being identified. Many Zika virus infection cases have been misdiagnosed or underreported because of the non-specific clinical pr...

journal_title：Clinical reviews in allergy & immunology

authors： Maharajan MK,Ranjan A,Chu JF,Foo WL,Chai ZX,Lau EY,Ye HM,Theam XJ,Lok YL

更新日期：2016-12-01 00:00:00

abstract：:One of the important factors and consequences in persistent asthma is the change in the vasculature of the airways and lung parenchyma. These changes could contribute to worsening asthma control and predispose asthmatics to critical asthma syndromes. For many years, the contribution of vasculature to severe asthma was...

journal_title：Clinical reviews in allergy & immunology

authors： Avdalovic M

更新日期：2015-02-01 00:00:00

abstract：:Hereditary angioedema (HAE) patients experience recurrent local swelling in various parts of the body including painful swelling of the intestine and life-threatening laryngeal oedema. Most HAE literature is about attacks located in one anatomical site, though it is mentioned that HAE attacks may also involve multiple...

journal_title：Clinical reviews in allergy & immunology

authors： Hofman ZL,Relan A,Hack CE

更新日期：2016-02-01 00:00:00