The arachidonate 12/15 lipoxygenases. A review of tissue expression and biologic function.

abstract：:Primary biliary cirrhosis (PBC) is characterized histologically by the presence of chronic non-suppurative destructive cholangitis of the small interlobular bile duct, leading to chronic progressive cholestasis. Most PBC patients are asymptomatic and have a reasonable prognosis, but a few develop esophageal varices or...

journal_title：Clinical reviews in allergy & immunology

authors： Katsumi T,Tomita K,Leung PS,Yang GX,Gershwin ME,Ueno Y

更新日期：2015-06-01 00:00:00

abstract：:Eosinophils can regulate local and systemic inflammation, and their presence in higher numbers appears to play an important role in the pathology of various atopic and inflammatory diseases. Eosinophil maturation, recruitment, and survival depend on several cytokine regulators, including interleukin (IL)-5, IL-4, and ...

journal_title：Clinical reviews in allergy & immunology

authors： Sriaroon P,Ballow M

更新日期：2016-04-01 00:00:00

abstract：:Every 2 years, an International Congress of Autoimmunity is organized and held with the intent of creating a new base for continuing interdisciplinary and international research, including further opportunities to train in the field of autoimmunity. In September 2008, the Congress of Autoimmunity was held in Porto, Po...

journal_title：Clinical reviews in allergy & immunology

authors： Matthias T,Shoenfeld Y

更新日期：2010-04-01 00:00:00

abstract：:The hyper IgM syndromes are a group of rare inherited immune deficiency disorders characterized by impairment of immunoglobulin isotype switching resulting from defects in the CD40 ligand/CD40 signaling pathway. X-linked forms of hyper IgM are caused by defects in the CD40 ligand gene or NF-κB essential modulator, whi...

journal_title：Clinical reviews in allergy & immunology

authors： Qamar N,Fuleihan RL

更新日期：2014-04-01 00:00:00

abstract：:Atherosclerosis is an inflammatory disease, and several antigens have been shown to activate the immune response and affect the development of atherogenesis. This suggests that modulation of the immune system could represent a useful approach to prevent and/or treat this disorder. A vaccination approach might be a use...

journal_title：Clinical reviews in allergy & immunology

authors： de Carvalho JF,Pereira RM,Shoenfeld Y

更新日期：2010-04-01 00:00:00

abstract：:Beta-agonists have clearly demonstrated benefits for the treatment of both acute and chronic asthma. Therefore, it is perhaps surprising that many of the articles in this issue have focused on concerns about their safety. Much of this concern can be traced back to the "beta-agonist controversy"--the association of hig...

journal_title：Clinical reviews in allergy & immunology

authors： Hancox RJ

更新日期：2006-10-01 00:00:00

abstract：:Strategies to improve patients' adherence to treatment are essential to reduce the great health and economic burden of allergic rhinitis and asthma. Mobile phone applications (apps) for a better management of allergic diseases are growing in number, but their usefulness for doctors and patients is still debated. Contr...

journal_title：Clinical reviews in allergy & immunology

authors： Huang X,Matricardi PM

更新日期：2019-04-01 00:00:00

abstract：:Biological rhythms are fundamental for homeostasis and have recently been involved in the regulatory processes of various organs and systems. Circadian cycle proteins and hormones have a direct effect on the inflammatory response and have shown pro- or anti-inflammatory effects in animal models of autoimmune diseases....

journal_title：Clinical reviews in allergy & immunology

authors： Torres-Ruiz J,Sulli A,Cutolo M,Shoenfeld Y

更新日期：2017-08-01 00:00:00

abstract：:Over the past few years, the rates of food allergies have dramatically increased. As a result, the lives of patients and their caregivers have been dramatically altered. While most attention surrounding food allergies has focused on treatment, less consideration has been given to the mental health ramifications of liv...

journal_title：Clinical reviews in allergy & immunology

authors： Feng C,Kim JH

更新日期：2019-08-01 00:00:00

abstract：:Pemphigus is a group of rare, potentially devastating autoimmune diseases of the skin and mucous membranes with high morbidity and potentially lethal outcome. The major clinical variant, pemphigus vulgaris (PV) is caused by a loss of intercellular adhesion of epidermal keratinocytes which is induced by IgG autoantibod...

journal_title：Clinical reviews in allergy & immunology

authors： Pollmann R,Schmidt T,Eming R,Hertl M

更新日期：2018-02-01 00:00:00

abstract：:Patients presenting to the emergency department (ED) or clinic with acute exacerbation of asthma (AEA) can be very challenging varying in both severity and response to therapy. High-dose, frequent or continuous nebulized short-acting beta2 agonist (SABA) therapy that can be combined with a short-acting muscarinic anta...

journal_title：Clinical reviews in allergy & immunology

authors： Albertson TE,Sutter ME,Chan AL

更新日期：2015-02-01 00:00:00

abstract：:It has been shown that many hereditary motor neuron diseases are caused by mutation of RNA processing enzymes. Survival of motor neuron 1 (SMN1) is well-known as a causative gene for spinal muscular atrophy (SMA) and mutations of glycyl- and tyrosyl-tRNA synthetases are identified as a cause of distal SMA and Charcot-...

journal_title：Clinical reviews in allergy & immunology

authors： Satoh M,Ceribelli A,Chan EK

更新日期：2012-02-01 00:00:00

abstract：:Pulmonary function testing is useful for the diagnosis and management of a variety of pulmonary conditions, and the most commonly obtained component is spirometry. Spirometry is most useful in the evaluation of obstructive airway disorders but can be a helpful tool in the management of patients with chest restriction ...

journal_title：Clinical reviews in allergy & immunology

authors： Liou TG,Kanner RE

更新日期：2009-12-01 00:00:00

abstract：:The gold standard for diagnosing asthma in children is based on clinical history of respiratory symptoms, physical examination, and respiratory function testing. Recent advances indicate that a non-invasive measure of airway inflammation, fractional exhaled nitric oxide (FeNO), provides objective data for use in asthm...

journal_title：Clinical reviews in allergy & immunology

authors： Tang S,Xie Y,Yuan C,Sun X,Cui Y

更新日期：2019-04-01 00:00:00

abstract：:Previously believed to have an exclusive role in the release of cytotoxic mediators in the defense against helminthic infections, eosinophils are now considered key players in inflammatory reaction and regulation of immune response. Through activation of a large variety of membrane receptors and production of various ...

journal_title：Clinical reviews in allergy & immunology

authors： Staumont-Sallé D,Dombrowicz D,Capron M,Delaporte E

更新日期：2006-02-01 00:00:00

abstract：:Contact dermatitis accounts for 95% of occupational skin disorders. Irritant contact dermatitis (ICD) is often caused by cumulative exposure to weak irritants, accounting for 80% of all cases of contact dermatitis. ICD can co-exist with atopic dermatitis (AD) and allergic contact dermatitis (ACD). Patients with AD and...

journal_title：Clinical reviews in allergy & immunology

authors： Bains SN,Nash P,Fonacier L

更新日期：2019-02-01 00:00:00

abstract：:The provider's ability to judge the severity of a patient's illness is a vital part of the care of chronic disorders. In the treatment of asthma, it should extend beyond the objectively quantifiable measures of obstruction or inflammation. "Interference with activities of daily living" is a highly subjective assessmen...

journal_title：Clinical reviews in allergy & immunology

authors： Sherman R,Milgrom H

更新日期：2005-10-01 00:00:00

abstract：:Intravenous immunoglobulin (IVIg) has been used as an immunomodulatory therapy for the treatment of multiple sclerosis (MS). In the current review, we summarize the up-to-date data related to IVIg clinical trials in MS, and the suggested mechanisms of action by which IVIg modulates the relevant immunological pathways ...

journal_title：Clinical reviews in allergy & immunology

authors： Achiron A,Miron S

更新日期：2005-12-01 00:00:00

abstract：:Prognosis of several autoimmune diseases, especially rheumatoid arthritis (RA), ankylosing spondylitis, Crohn's disease (CD), and psoriasis, usually refractory to conventional treatment improved considerably with the introduction of tumor necrosis factor alpha (TNF-alpha) antagonistic agents, which is now available (i...

journal_title：Clinical reviews in allergy & immunology

authors： Emi Aikawa N,de Carvalho JF,Artur Almeida Silva C,Bonfá E

更新日期：2010-04-01 00:00:00

abstract：:As summarized in Table 1, the literature consistently supports the hypothesis that allergic asthmatic patients have seasonal BHR changes that parallel allergen exposure. These seasonal changes appear to be preventable by treatment with corticosteroids (systemic, inhaled, or nasal), disodium cromoglycate, and immunothe...

journal_title：Clinical reviews in allergy & immunology

authors： Tilles SA,Bardana EJ Jr

更新日期：1997-07-01 00:00:00

abstract：:Therapy of atopic dermatitis should comprise emollients, topical glucocorticosteroids, or calcineurin inhibitors, phototherapies, immunosuppressants like cyclosporin A, and other treatments. All these treatments should be improved, thanks to research. But new therapeutic perspectives should be given by topical anti-in...

journal_title：Clinical reviews in allergy & immunology

authors： Misery L

更新日期：2011-12-01 00:00:00

abstract：:Asthma is a chronic immunological disease affecting all age groups, but often starting in childhood. Although it has long been ascribed to a single pathology, recent studies have highlighted its heterogeneity due to the potential involvement of various pathogenic mechanisms. Here, we present our current understanding ...

journal_title：Clinical reviews in allergy & immunology

authors： Victor JR,Lezmi G,Leite-de-Moraes M

更新日期：2020-12-01 00:00:00

abstract：:Patients with primary immunodeficiencies are prone to develop enteropathy of unknown pathogenesis. We hypothesize that ineffective clearance of gastrointestinal pathogens, particularly viruses, in combination with defective immune regulation may cause inflammatory enteropathy in certain immunodeficient hosts. We revie...

journal_title：Clinical reviews in allergy & immunology

authors： van de Ven AA,Hoytema van Konijnenburg DP,Wensing AM,van Montfrans JM

更新日期：2012-02-01 00:00:00

abstract：:Air pollution is defined as the presence of noxious substances in the air at levels that impose a health hazard. Thus, there has been long-standing interest in the possible role of indoor and outdoor air pollutants on the development of respiratory disease. In this regard, asthma has been of particular interest but ma...

journal_title：Clinical reviews in allergy & immunology

authors： Hassoun Y,James C,Bernstein DI

更新日期：2019-12-01 00:00:00

abstract：:Activated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of intracellular granule components that function by capturing and destroying microbes, including viral, fungal, bacterial, and protozoal pat...

journal_title：Clinical reviews in allergy & immunology

authors： Mutua V,Gershwin LJ

更新日期：2020-08-01 00:00:00

abstract：:Although the relative contributions of T cells and B cells in Sjögren's syndrome (SS) are far from being settled, recent studies have suggested a crucial role for B cells in its pathophysiology. Early investigations have focused on the ability of B cells to produce autoantibodies, and new studies have enlarged the ran...

journal_title：Clinical reviews in allergy & immunology

authors： Youinou P,Devauchelle V,Hutin P,Le Berre R,Saraux A,Pers JO

更新日期：2007-06-01 00:00:00

abstract：:The relationship between autoimmunity and reproduction has long been recognized. This relationship is bidirectional and includes many diverse issues, but in this review article, we focus on which autoimmune disturbances are the basic cause of recurrent pregnancy losses in patients with autoimmune diseases. The antipho...

journal_title：Clinical reviews in allergy & immunology

authors： Cervera R,Balasch J

更新日期：2010-12-01 00:00:00

abstract：:G protein-coupled receptors (GPCRs) constitute the largest family of plasma membrane receptors in nature and mediate the effects of a variety of extracellular signals, such as hormone, neurotransmitter, odor, and light signals. Due to their involvement in a broad range of physiological and pathological processes and t...

journal_title：Clinical reviews in allergy & immunology

authors： Zhao M,Wang Z,Yang M,Ding Y,Zhao M,Wu H,Zhang Y,Lu Q

更新日期：2021-01-07 00:00:00

abstract：:Systemic vasculitides are a group of rare diseases characterized by inflammation of the arterial or venous vessel wall, causing stenosis or thrombosis. Clinical symptoms may be limited to skin or to other organs or may include multiple manifestations as systemic conditions. The pathogenesis is related to the presence ...

journal_title：Clinical reviews in allergy & immunology

authors： Chimenti MS,Ballanti E,Triggianese P,Perricone R

更新日期：2015-12-01 00:00:00

abstract：:Calcium is the most abundant mineral in the human body and is central to many physiological processes, including immune system activation and maintenance. Studies continue to reveal the intricacies of calcium signalling within the immune system. Perhaps the most well-understood mechanism of calcium influx into cells i...

journal_title：Clinical reviews in allergy & immunology

authors： Froghi S,Grant CR,Tandon R,Quaglia A,Davidson B,Fuller B

更新日期：2021-01-06 00:00:00