Abstract:
:Previously believed to have an exclusive role in the release of cytotoxic mediators in the defense against helminthic infections, eosinophils are now considered key players in inflammatory reaction and regulation of immune response. Through activation of a large variety of membrane receptors and production of various pharmacologically active mediators, eosinophils may exert a detrimental role in tissues in which they have been recruited and may contribute to the perennization of inflammatory processes. The crucial role of eosinophils has been documented in several eosinophilic skin diseases, such as hypereosinophilic syndrome and bullous pemphigoid, and the literature provides strong evidence for their role in urticaria. The aim of this article is to discuss the mechanisms of specific tissue recruitment of eosinophils, the factors of eosinophil activation, and the contribution of these cells to inflammation and immunoregulation in urticaria. Recent advances in the knowledge of eosinophils will certainly help toward developing new strategies for the management of antihistamines resistant to urticaria.
journal_name
Clin Rev Allergy Immunoljournal_title
Clinical reviews in allergy & immunologyauthors
Staumont-Sallé D,Dombrowicz D,Capron M,Delaporte Edoi
10.1385/CRIAI:30:1:013subject
Has Abstractpub_date
2006-02-01 00:00:00pages
13-8issue
1eissn
1080-0549issn
1559-0267pii
CRIAI:30:1:013journal_volume
30pub_type
杂志文章,评审abstract::During the last decade, B regulatory cells are appreciated to have a central role in preventing autoimmunity and maintaining self-tolerance. They are characterized by expressing different phenotypic markers and the production of either IL-10 or TGF-β or both. The recent recognition of Fas ligand expressing B regulator...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-016-8572-5
更新日期:2017-06-01 00:00:00
abstract::Bronchiolitis is a common, acute, contagious lower respiratory tract illness of infants and young children. The majority of cases are secondary to respiratory syncytial virus. There are a number of risk factors for severe disease, including children less than six weeks of age and patients with atopy and/or asthma. The...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1385/CRIAI:25:3:249
更新日期:2003-12-01 00:00:00
abstract::Non-alcoholic steatohepatitis (NASH) is the progressive phenotype of non-alcoholic fatty liver disease associated with the metabolic syndrome. The existence of autoimmune features in NASH has been reported, but its significance remains unclear. We herein report the autoantibody profile of 54 patients with histological...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-013-8383-x
更新日期:2013-08-01 00:00:00
abstract::Hereditary angioedema (HAE) patients experience recurrent local swelling in various parts of the body including painful swelling of the intestine and life-threatening laryngeal oedema. Most HAE literature is about attacks located in one anatomical site, though it is mentioned that HAE attacks may also involve multiple...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章
doi:10.1007/s12016-014-8463-6
更新日期:2016-02-01 00:00:00
abstract::The incidence of autoimmune diseases is increasing in Western countries, possibly due to the improved sanitary conditions and reduced exposure to infections in childhood (the hygiene hypothesis). There is an ongoing debate whether infection prevents or precipitates autoimmune diseases. Various helminths species used i...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-012-8352-9
更新日期:2013-10-01 00:00:00
abstract::A bulk of literature demonstrated that respiratory allergy, and especially asthma, is prevalent in males during childhood, while it becomes more frequent in females from adolescence, i.e., after menarche, to adulthood. The mechanisms underlying the difference between females and males are the effects on the immune res...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-017-8661-0
更新日期:2019-06-01 00:00:00
abstract::Antityrosinase antibody is a newly detected antibody in the sera of patients with melanoma or vitiligo. The serum level of the antibody is measured by enzyme-linked immunosorbent assay (ELISA). The autoantigen is tyrosinase itself, the enzyme that participates in pigment (melanin) formation by both melanocytes and mel...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/BF02737633
更新日期:1998-10-01 00:00:00
abstract::Beta-agonists have clearly demonstrated benefits for the treatment of both acute and chronic asthma. Therefore, it is perhaps surprising that many of the articles in this issue have focused on concerns about their safety. Much of this concern can be traced back to the "beta-agonist controversy"--the association of hig...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章
doi:10.1385/criai:31:2:279
更新日期:2006-10-01 00:00:00
abstract::Most investigators currently advocate prophylactic-dose heparin plus low-dose aspirin as the preferred treatment of otherwise healthy women with obstetric antiphospholipid syndrome, whilst women with a history of vascular thrombosis alone or associated with pregnancy morbidity are usually treated with therapeutic hepa...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-016-8571-6
更新日期:2017-08-01 00:00:00
abstract::Food allergy is a potentially life-threatening condition with no approved curative therapy. A number of food allergen immunotherapies are being investigated in phase II/III trials; however, these are limited in their ability to restore immune tolerance to food allergens and often result in high rates of allergic side ...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-018-8694-z
更新日期:2018-10-01 00:00:00
abstract::Prognosis of several autoimmune diseases, especially rheumatoid arthritis (RA), ankylosing spondylitis, Crohn's disease (CD), and psoriasis, usually refractory to conventional treatment improved considerably with the introduction of tumor necrosis factor alpha (TNF-alpha) antagonistic agents, which is now available (i...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-009-8140-3
更新日期:2010-04-01 00:00:00
abstract::The expert panel report version 2 (EPR-2) is a comprehensive set of recommendations for the evaluation and treatment of asthma. However, physicians demonstrate scant adoption of many of the key evaluation and treatment components of the EPR-2, with primary care physicians being less likely to adopt EPR-2 recommendatio...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1385/CRIAI:27:2:065
更新日期:2004-10-01 00:00:00
abstract::The relationship between autoimmunity and reproduction has long been recognized. This relationship is bidirectional and includes many diverse issues, but in this review article, we focus on which autoimmune disturbances are the basic cause of recurrent pregnancy losses in patients with autoimmune diseases. The antipho...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-009-8179-1
更新日期:2010-12-01 00:00:00
abstract::Contact dermatitis accounts for 95% of occupational skin disorders. Irritant contact dermatitis (ICD) is often caused by cumulative exposure to weak irritants, accounting for 80% of all cases of contact dermatitis. ICD can co-exist with atopic dermatitis (AD) and allergic contact dermatitis (ACD). Patients with AD and...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-018-8713-0
更新日期:2019-02-01 00:00:00
abstract::Rheumatoid arthritis and spondyloarthritis are inflammatory joint disorders with an autoimmune pathogenesis and systemic involvement. The skin is one of the most frequently affected extraarticular sites with a number of manifestations or distinct diseases, including common conditions, such as rheumatoid nodules and ps...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-017-8629-0
更新日期:2018-04-01 00:00:00
abstract::With the implementation of vaccination programs and the use of antibiotics, developed countries have seen a decline in infection-related pediatric bronchiectasis. However, significant morbidity from bronchiectasis is still seen and both infectious and noninfectious causes of bronchiectasis in the pediatric population ...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-007-8036-z
更新日期:2008-04-01 00:00:00
abstract::Strategies to improve patients' adherence to treatment are essential to reduce the great health and economic burden of allergic rhinitis and asthma. Mobile phone applications (apps) for a better management of allergic diseases are growing in number, but their usefulness for doctors and patients is still debated. Contr...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s12016-016-8542-y
更新日期:2019-04-01 00:00:00
abstract::Illicit stimulants, such as cocaine, amphetamine, and their derivatives (e.g., "ecstasy"), continue to exact heavy toll on health care in both developed and developing countries. The US Department of Health and Human Service reported over one million illicit drug-related emergency department visits in 2010, which was ...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-013-8376-9
更新日期:2014-02-01 00:00:00
abstract::Celiac disease is a complex immune-mediated gluten-sensitive enteropathy with protean clinical manifestations. It is manifest in genetically predisposed individuals who ingest gluten in varying amounts. In broad terms, it is thought to affect 1% of the population in the USA. More specifically, the prevalence increases...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-018-8691-2
更新日期:2019-10-01 00:00:00
abstract::Calcium is the most abundant mineral in the human body and is central to many physiological processes, including immune system activation and maintenance. Studies continue to reveal the intricacies of calcium signalling within the immune system. Perhaps the most well-understood mechanism of calcium influx into cells i...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-020-08824-3
更新日期:2021-01-06 00:00:00
abstract::Alopecia areata is a common hair loss condition that is characterized by acute onset of non-scarring hair loss in usually sharply defined areas ranging from small patches to extensive or less frequently diffuse involvement. Depending on its acuity and extent, hair loss is an important cause of anxiety and disability. ...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-017-8620-9
更新日期:2018-02-01 00:00:00
abstract::Eosinophilic esophagitis (EoE) is an emerging chronic atopic clinical-pathologic disease with an estimated prevalence of 1/1000 similar to the one of Crohn's diseases. Usually, EoE is firstly suspected due to symptoms that are caused by esophageal dysfunction and/or fibrosis. EoE diagnosis is confirmed if the esophage...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-015-8501-z
更新日期:2016-04-01 00:00:00
abstract::Primary biliary cirrhosis (PBC) is a rare inflammatory liver disease for which ursodeoxycholic acid (UDCA) is the only therapy approved by the U.S. Food and Drug Administration. Patients with a biochemical response to UDCA therapy have a similar survival rate compared to the general population. However, up to 40% of P...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-014-8456-5
更新日期:2015-06-01 00:00:00
abstract::Pruritus, fatigue, and metabolic bone disease are frequent complications of cholestatic liver diseases, which can be quite distressing for the patient and can considerably reduce the quality of life. The molecular pathogenesis of these extrahepatic manifestations of cholestasis is poorly understood, and hypotheses to ...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1385/CRIAI:28:2:147
更新日期:2005-04-01 00:00:00
abstract::In the vast database of peer-reviewed articles, the number of 2018 papers published retrieved using the "autoimmunity" keyword remained unchanged compared with the brilliant results of 2017 while returning above a 5% share within the immunology field, after the brisk decrease of this ratio in 2017. As in the past 12 y...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章
doi:10.1007/s12016-019-08745-w
更新日期:2019-06-01 00:00:00
abstract::Primary sclerosing cholangitis (PSC) is a rare chronic cholestatic disease of the liver and bile ducts that is associated with inflammatory bowel disease, generally leads to end-stage liver disease, and is complicated by malignancies of the biliary tree and the large intestine. The pathogenesis of PSC remains enigmati...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-008-8085-y
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:The last 5 years have seen the emergence and establishment of antibodies to citrullinated antigens as the diagnostic marker for rheumatoid arthritis (RA). Initially, these were detected using a synthetic peptide, which has undergone a number of modifications to give a diagnostic test with a sensitivity of 65...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章
doi:10.1007/s12016-007-8016-3
更新日期:2008-02-01 00:00:00
abstract::Bronchial hyperresponsiveness (BHR) is a characteristic feature of asthma, and individuals with this disease respond to a range of physiological and chemical insults that are otherwise innocuous to healthy subjects, suggesting that the mechanisms underlying this phenomenon are characteristic of the asthma phenotype. B...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1385/CRIAI:31:2:143
更新日期:2006-10-01 00:00:00
abstract::Resolvins, belonging to the group of specialized proresolving mediators (SPMs), are metabolic products of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and are synthesized during the initial phases of acute inflammatory responses to promote the resolution of inflammation. Resolvins are produced for termination of ne...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1007/s12016-019-08754-9
更新日期:2020-02-01 00:00:00
abstract::The gold standard for diagnosing asthma in children is based on clinical history of respiratory symptoms, physical examination, and respiratory function testing. Recent advances indicate that a non-invasive measure of airway inflammation, fractional exhaled nitric oxide (FeNO), provides objective data for use in asthm...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,meta分析
doi:10.1007/s12016-016-8573-4
更新日期:2019-04-01 00:00:00