abstract：:In inflammatory rheumatic disorders, the immune system attacks and damages the connective tissues and invariably internal organs. During the past decade, remarkable advances having been made towards our understanding on the cellular and molecular mechanisms involved in rheumatic diseases. The discovery of IL-23/IL-17 ...

journal_title：Clinical reviews in allergy & immunology

authors： Li H,Tsokos GC

更新日期：2021-02-01 00:00:00

abstract：:Hereditary angioedema (HAE) is a rare disease that causes episodic attacks of subcutaneous and submucosal edema, which can be painful, incapacitating, and potentially fatal. These attacks are mediated by excessive bradykinin production, as a result of uncontrolled activation of the plasma kallikrein/kinin system, whic...

journal_title：Clinical reviews in allergy & immunology

authors： Fijen LM,Bork K,Cohn DM

更新日期：2021-01-09 00:00:00

abstract：:G protein-coupled receptors (GPCRs) constitute the largest family of plasma membrane receptors in nature and mediate the effects of a variety of extracellular signals, such as hormone, neurotransmitter, odor, and light signals. Due to their involvement in a broad range of physiological and pathological processes and t...

journal_title：Clinical reviews in allergy & immunology

authors： Zhao M,Wang Z,Yang M,Ding Y,Zhao M,Wu H,Zhang Y,Lu Q

更新日期：2021-01-07 00:00:00

abstract：:Calcium is the most abundant mineral in the human body and is central to many physiological processes, including immune system activation and maintenance. Studies continue to reveal the intricacies of calcium signalling within the immune system. Perhaps the most well-understood mechanism of calcium influx into cells i...

journal_title：Clinical reviews in allergy & immunology

authors： Froghi S,Grant CR,Tandon R,Quaglia A,Davidson B,Fuller B

更新日期：2021-01-06 00:00:00

abstract：:Asthma is a chronic immunological disease affecting all age groups, but often starting in childhood. Although it has long been ascribed to a single pathology, recent studies have highlighted its heterogeneity due to the potential involvement of various pathogenic mechanisms. Here, we present our current understanding ...

journal_title：Clinical reviews in allergy & immunology

authors： Victor JR,Lezmi G,Leite-de-Moraes M

更新日期：2020-12-01 00:00:00

abstract：:Acid anhydrides are used by chemical industries as plasticizers. Trimellitic acid (TMA) is an acid anhydride widely utilized in factories to produce paints, varnishes, and plastics. In addition to causing direct irritant effects, TMA can augment antibody responses in exposed factory workers leading to occupational ast...

journal_title：Clinical reviews in allergy & immunology

authors： Ghosh D,Bernstein JA

更新日期：2020-08-01 00:00:00

abstract：:Activated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of intracellular granule components that function by capturing and destroying microbes, including viral, fungal, bacterial, and protozoal pat...

journal_title：Clinical reviews in allergy & immunology

authors： Mutua V,Gershwin LJ

更新日期：2020-08-01 00:00:00

abstract：:Adult-onset Still's disease (AOSD) is a rare multisystem autoinflammatory disorder of unknown etiology. AOSD is generally characterized by high spiking fever, arthralgia or arthritis, skin rash, leukocytosis, and hyperferritinemia. Traditionally, AOSD has been treated with non-steroidal anti-inflammatory drugs, cortic...

journal_title：Clinical reviews in allergy & immunology

authors： Li S,Zheng S,Tang S,Pan Y,Zhang S,Fang H,Qiao J

更新日期：2020-02-01 00:00:00

abstract：:Resolvins, belonging to the group of specialized proresolving mediators (SPMs), are metabolic products of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and are synthesized during the initial phases of acute inflammatory responses to promote the resolution of inflammation. Resolvins are produced for termination of ne...

journal_title：Clinical reviews in allergy & immunology

authors： Abdolmaleki F,Kovanen PT,Mardani R,Gheibi-Hayat SM,Bo S,Sahebkar A

更新日期：2020-02-01 00:00:00

abstract：:Several factors have been associated with the development of asthma and asthma-related morbidity and mortality. Exposures in the environment such as allergens and air pollutants have traditionally been linked to the risk of asthma and asthma outcomes. More recent literature has identified chronic psychosocial stress a...

journal_title：Clinical reviews in allergy & immunology

authors： Barnthouse M,Jones BL

更新日期：2019-12-01 00:00:00

abstract：:Air pollution is defined as the presence of noxious substances in the air at levels that impose a health hazard. Thus, there has been long-standing interest in the possible role of indoor and outdoor air pollutants on the development of respiratory disease. In this regard, asthma has been of particular interest but ma...

journal_title：Clinical reviews in allergy & immunology

authors： Hassoun Y,James C,Bernstein DI

更新日期：2019-12-01 00:00:00

abstract：:Allergic diseases are surprisingly common, chronic health conditions. The primary location where the vast majority of people are exposed to allergens and other substances is in their home. This means it is important to understand home environments and how a home's systems function and interact-and that how we occupy t...

journal_title：Clinical reviews in allergy & immunology

authors： Kennedy K,Allenbrand R,Bowles E

更新日期：2019-12-01 00:00:00

abstract：:Celiac disease is a complex immune-mediated gluten-sensitive enteropathy with protean clinical manifestations. It is manifest in genetically predisposed individuals who ingest gluten in varying amounts. In broad terms, it is thought to affect 1% of the population in the USA. More specifically, the prevalence increases...

journal_title：Clinical reviews in allergy & immunology

authors： McAllister BP,Williams E,Clarke K

更新日期：2019-10-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a chronic immune-mediated inflammatory condition primarily involving the gastrointestinal tract. It includes Crohn's disease (CD), ulcerative colitis (UC), and a less common phenotype-indeterminate colitis. It is thought to result from a complex interplay of environmental, microbial...

journal_title：Clinical reviews in allergy & immunology

authors： Clarke K,Chintanaboina J

更新日期：2019-10-01 00:00:00

abstract：:Over the past few years, the rates of food allergies have dramatically increased. As a result, the lives of patients and their caregivers have been dramatically altered. While most attention surrounding food allergies has focused on treatment, less consideration has been given to the mental health ramifications of liv...

journal_title：Clinical reviews in allergy & immunology

authors： Feng C,Kim JH

更新日期：2019-08-01 00:00:00

abstract：:Cashew plant (Anacardium occidentale L.) is the most relevant species of the Anacardium genus. It presents high economic value since it is widely used in human nutrition and in several industrial applications. Cashew nut is a well-appreciated food (belongs to the tree nut group), being widely consumed as snacks and in...

journal_title：Clinical reviews in allergy & immunology

authors： Mendes C,Costa J,Vicente AA,Oliveira MBPP,Mafra I

更新日期：2019-08-01 00:00:00

abstract：:A bulk of literature demonstrated that respiratory allergy, and especially asthma, is prevalent in males during childhood, while it becomes more frequent in females from adolescence, i.e., after menarche, to adulthood. The mechanisms underlying the difference between females and males are the effects on the immune res...

journal_title：Clinical reviews in allergy & immunology

authors： Ridolo E,Incorvaia C,Martignago I,Caminati M,Canonica GW,Senna G

更新日期：2019-06-01 00:00:00

abstract：:In the vast database of peer-reviewed articles, the number of 2018 papers published retrieved using the "autoimmunity" keyword remained unchanged compared with the brilliant results of 2017 while returning above a 5% share within the immunology field, after the brisk decrease of this ratio in 2017. As in the past 12 y...

journal_title：Clinical reviews in allergy & immunology

authors： Selmi C

更新日期：2019-06-01 00:00:00

abstract：:Strategies to improve patients' adherence to treatment are essential to reduce the great health and economic burden of allergic rhinitis and asthma. Mobile phone applications (apps) for a better management of allergic diseases are growing in number, but their usefulness for doctors and patients is still debated. Contr...

journal_title：Clinical reviews in allergy & immunology

authors： Huang X,Matricardi PM

更新日期：2019-04-01 00:00:00

abstract：:The gold standard for diagnosing asthma in children is based on clinical history of respiratory symptoms, physical examination, and respiratory function testing. Recent advances indicate that a non-invasive measure of airway inflammation, fractional exhaled nitric oxide (FeNO), provides objective data for use in asthm...

journal_title：Clinical reviews in allergy & immunology

authors： Tang S,Xie Y,Yuan C,Sun X,Cui Y

更新日期：2019-04-01 00:00:00

abstract：:Contact dermatitis accounts for 95% of occupational skin disorders. Irritant contact dermatitis (ICD) is often caused by cumulative exposure to weak irritants, accounting for 80% of all cases of contact dermatitis. ICD can co-exist with atopic dermatitis (AD) and allergic contact dermatitis (ACD). Patients with AD and...

journal_title：Clinical reviews in allergy & immunology

authors： Bains SN,Nash P,Fonacier L

更新日期：2019-02-01 00:00:00

abstract：:The number of peer-reviewed articles published during the 2017 solar year and retrieved using the "autoimmunity" key word increased significantly compared to 2016 while maintaining a stable share within the immunology field, following years with alternated fortunes. A detailed arbitrary analysis of the published artic...

journal_title：Clinical reviews in allergy & immunology

authors： Selmi C

更新日期：2018-12-01 00:00:00

abstract：:Food allergy is a potentially life-threatening condition with no approved curative therapy. A number of food allergen immunotherapies are being investigated in phase II/III trials; however, these are limited in their ability to restore immune tolerance to food allergens and often result in high rates of allergic side ...

journal_title：Clinical reviews in allergy & immunology

authors： Virkud YV,Wang J,Shreffler WG

更新日期：2018-10-01 00:00:00

abstract：:Familial hypercholesterolemia (FH) is the most common inherited form of dyslipidemia and a major cause of premature cardiovascular disease. Management of FH mainly relies on the efficiency of treatments that reduce plasma low-density lipoprotein (LDL) cholesterol (LDL-C) concentrations. MicroRNAs (miRs) have been sugg...

journal_title：Clinical reviews in allergy & immunology

authors： Momtazi AA,Banach M,Pirro M,Stein EA,Sahebkar A

更新日期：2018-04-01 00:00:00

abstract：:Rheumatoid arthritis and spondyloarthritis are inflammatory joint disorders with an autoimmune pathogenesis and systemic involvement. The skin is one of the most frequently affected extraarticular sites with a number of manifestations or distinct diseases, including common conditions, such as rheumatoid nodules and ps...

journal_title：Clinical reviews in allergy & immunology

authors： Cugno M,Gualtierotti R,Meroni PL,Marzano AV

更新日期：2018-04-01 00:00:00

abstract：:Pemphigus is a group of rare, potentially devastating autoimmune diseases of the skin and mucous membranes with high morbidity and potentially lethal outcome. The major clinical variant, pemphigus vulgaris (PV) is caused by a loss of intercellular adhesion of epidermal keratinocytes which is induced by IgG autoantibod...

journal_title：Clinical reviews in allergy & immunology

authors： Pollmann R,Schmidt T,Eming R,Hertl M

更新日期：2018-02-01 00:00:00

abstract：:Alopecia areata is a common hair loss condition that is characterized by acute onset of non-scarring hair loss in usually sharply defined areas ranging from small patches to extensive or less frequently diffuse involvement. Depending on its acuity and extent, hair loss is an important cause of anxiety and disability. ...

journal_title：Clinical reviews in allergy & immunology

authors： Trüeb RM,Dias MFRG

更新日期：2018-02-01 00:00:00

abstract：:Biological rhythms are fundamental for homeostasis and have recently been involved in the regulatory processes of various organs and systems. Circadian cycle proteins and hormones have a direct effect on the inflammatory response and have shown pro- or anti-inflammatory effects in animal models of autoimmune diseases....

journal_title：Clinical reviews in allergy & immunology

authors： Torres-Ruiz J,Sulli A,Cutolo M,Shoenfeld Y

更新日期：2017-08-01 00:00:00

abstract：:Tumor necrosis factor-α (TNF-α) is a central regulator of inflammation, and TNF-α antagonists may be effective in treating inflammatory disorders in which TNF-α plays a major pathogenic role. TNF-α has also been associated with inflammatory mechanisms related to implantation, placentation, and pregnancy outcome. TNF-α...

journal_title：Clinical reviews in allergy & immunology

authors： Alijotas-Reig J,Esteve-Valverde E,Ferrer-Oliveras R,Llurba E,Gris JM

更新日期：2017-08-01 00:00:00

abstract：:Most investigators currently advocate prophylactic-dose heparin plus low-dose aspirin as the preferred treatment of otherwise healthy women with obstetric antiphospholipid syndrome, whilst women with a history of vascular thrombosis alone or associated with pregnancy morbidity are usually treated with therapeutic hepa...

journal_title：Clinical reviews in allergy & immunology

authors： Ruffatti A,Hoxha A,Favaro M,Tonello M,Colpo A,Cucchini U,Banzato A,Pengo V

更新日期：2017-08-01 00:00:00

abstract：:As physiological pathways of intercellular communication produced by all cells, cytokines are involved in the pathogenesis of inflammatory insulitis as well as pivotal mediators of immune homeostasis. Proinflammatory cytokines including interleukins, interferons, transforming growth factor-β, tumor necrosis factor-α, ...

journal_title：Clinical reviews in allergy & immunology

authors： Kaminitz A,Ash S,Askenasy N

更新日期：2017-06-01 00:00:00

abstract：:During the last decade, B regulatory cells are appreciated to have a central role in preventing autoimmunity and maintaining self-tolerance. They are characterized by expressing different phenotypic markers and the production of either IL-10 or TGF-β or both. The recent recognition of Fas ligand expressing B regulator...

journal_title：Clinical reviews in allergy & immunology

authors： Vadasz Z,Toubi E

更新日期：2017-06-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder with a broad spectrum of clinical presentations and association with multiple immunological abnormalities. Recent research of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway-revealed aberrant STAT s...

journal_title：Clinical reviews in allergy & immunology

authors： Goropevšek A,Holcar M,Avčin T

更新日期：2017-04-01 00:00:00

abstract：:The Zika virus outbreaks highlight the growing importance need for a reliable, specific and rapid diagnostic device to detect Zika virus, as it is often recognized as a mild disease without being identified. Many Zika virus infection cases have been misdiagnosed or underreported because of the non-specific clinical pr...

journal_title：Clinical reviews in allergy & immunology

authors： Maharajan MK,Ranjan A,Chu JF,Foo WL,Chai ZX,Lau EY,Ye HM,Theam XJ,Lok YL

更新日期：2016-12-01 00:00:00

abstract：:The functions of macrophages that lead to effective host responses are critical for protection against Staphylococcus aureus. Deep tissue-invading S. aureus initially countered by macrophages trigger macrophage accumulation and induce inflammatory responses through surface receptors, especially toll-like receptor 2 (T...

journal_title：Clinical reviews in allergy & immunology

authors： Wang YC,Ma HD,Yin XY,Wang YH,Liu QZ,Yang JB,Shi QH,Sun B,Gershwin ME,Lian ZX

更新日期：2016-12-01 00:00:00

abstract：:Eosinophils can regulate local and systemic inflammation, and their presence in higher numbers appears to play an important role in the pathology of various atopic and inflammatory diseases. Eosinophil maturation, recruitment, and survival depend on several cytokine regulators, including interleukin (IL)-5, IL-4, and ...

journal_title：Clinical reviews in allergy & immunology

authors： Sriaroon P,Ballow M

更新日期：2016-04-01 00:00:00

abstract：:Eosinophilic esophagitis (EoE) is an emerging chronic atopic clinical-pathologic disease with an estimated prevalence of 1/1000 similar to the one of Crohn's diseases. Usually, EoE is firstly suspected due to symptoms that are caused by esophageal dysfunction and/or fibrosis. EoE diagnosis is confirmed if the esophage...

journal_title：Clinical reviews in allergy & immunology

authors： Cianferoni A,Spergel J

更新日期：2016-04-01 00:00:00

abstract：:Hereditary angioedema (HAE) patients experience recurrent local swelling in various parts of the body including painful swelling of the intestine and life-threatening laryngeal oedema. Most HAE literature is about attacks located in one anatomical site, though it is mentioned that HAE attacks may also involve multiple...

journal_title：Clinical reviews in allergy & immunology

authors： Hofman ZL,Relan A,Hack CE

更新日期：2016-02-01 00:00:00

abstract：:Systemic vasculitides are a group of rare diseases characterized by inflammation of the arterial or venous vessel wall, causing stenosis or thrombosis. Clinical symptoms may be limited to skin or to other organs or may include multiple manifestations as systemic conditions. The pathogenesis is related to the presence ...

journal_title：Clinical reviews in allergy & immunology

authors： Chimenti MS,Ballanti E,Triggianese P,Perricone R

更新日期：2015-12-01 00:00:00

abstract：:Over the years, the commonly used term to describe juvenile idiopathic arthritis (JIA) has changed. By definition, JIA includes all types of arthritis with no apparent cause, lasting more than 6 weeks, in patients aged less than 16 years at onset. JIA pathogenesis is still poorly understood: the interaction between en...

journal_title：Clinical reviews in allergy & immunology

authors： Rigante D,Bosco A,Esposito S

更新日期：2015-10-01 00:00:00