Abstract：
:Air pollution is defined as the presence of noxious substances in the air at levels that impose a health hazard. Thus, there has been long-standing interest in the possible role of indoor and outdoor air pollutants on the development of respiratory disease. In this regard, asthma has been of particular interest but many studies have also been conducted to explore the relationship between air pollution, allergic rhinitis, and atopic dermatitis. Traffic-related air pollutants or TRAP refers to a broad group of pollutants including elemental carbon, black soot, nitrogen dioxide (NO2), nitric oxide (NO), sulfur dioxide (SO2), particulate matter (PM2.5 and PM10), carbon monoxide (CO), and carbon dioxide (CO2). In this review, we aim to examine the current literature regarding the impact of early childhood exposure to TRAP on the development of asthma, allergic rhinitis, and atopic dermatitis. Although there is growing evidence suggesting significant associations, definitive conclusions cannot be made with regard to the effect of TRAP on these diseases. This conundrum may be due to a variety of factors, including different definitions used to define TRAP, case definitions under consideration, a limited number of studies, variation in study designs, and disparities between studies in consideration of confounding factors. Regardless, this review highlights the need for future studies to be conducted, particularly with birth cohorts that explore this relationship further. Such studies may assist in understanding more clearly the pathogenesis of these diseases, as well as other methods by which these diseases could be treated.
journal_name
Clin Rev Allergy Immunoljournal_title
Clinical reviews in allergy & immunologyauthors
Hassoun Y,James C,Bernstein DIdoi
10.1007/s12016-019-08730-3subject
Has Abstractpub_date
2019-12-01 00:00:00pages
403-414issue
3eissn
1080-0549issn
1559-0267pii
10.1007/s12016-019-08730-3journal_volume
57pub_type
杂志文章,评审abstract：:Food allergy is a potentially life-threatening condition with no approved curative therapy. A number of food allergen immunotherapies are being investigated in phase II/III trials; however, these are limited in their ability to restore immune tolerance to food allergens and often result in high rates of allergic side ...
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pub_type： 杂志文章,评审
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更新日期：2018-10-01 00:00:00
abstract：:Hereditary angioedema (HAE) is a rare disease that causes episodic attacks of subcutaneous and submucosal edema, which can be painful, incapacitating, and potentially fatal. These attacks are mediated by excessive bradykinin production, as a result of uncontrolled activation of the plasma kallikrein/kinin system, whic...
journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
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更新日期：2021-01-09 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
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更新日期：2015-02-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-011-8292-9
更新日期：2012-02-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
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更新日期：2015-02-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-008-8078-x
更新日期：2008-12-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-015-8501-z
更新日期：2016-04-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章
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更新日期：2012-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s12016-019-08745-w
更新日期：2019-06-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
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更新日期：2010-04-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2018-02-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
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更新日期：2008-06-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1007/s12016-017-8599-2
更新日期：2017-08-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2019-08-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1007/s12016-020-08823-4
更新日期：2021-02-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1007/s12016-019-08736-x
更新日期：2019-12-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1385/CRIAI:25:2:115
更新日期：2003-10-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2005-12-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2013-10-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1007/BF02828276
更新日期：1997-04-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2018-02-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
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更新日期：2007-04-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2016-12-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-007-8036-z
更新日期：2008-04-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
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更新日期：2014-10-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1385/CRIAI:31:2:143
更新日期：2006-10-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
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更新日期：2019-08-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1007/s12016-014-8456-5
更新日期：2015-06-01 00:00:00
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journal_title：Clinical reviews in allergy & immunology
pub_type： 杂志文章,评审
doi：10.1385/CRIAI:29:2:159
更新日期：2005-10-01 00:00:00
