Abstract:
:Several factors have been associated with the development of asthma and asthma-related morbidity and mortality. Exposures in the environment such as allergens and air pollutants have traditionally been linked to the risk of asthma and asthma outcomes. More recent literature has identified chronic psychosocial stress as an additional environmental exposure to consider in relation to asthma. Adverse childhood events (ACEs) and chronic and toxic stress have been associated with chronic diseases such as cardiovascular disease, cancer, and chronic obstructive pulmonary disease. Chronic stress has also been shown to result in biological changes such as expression of immunologic genes, changes in expression of the beta-adrenergic (B2AR) and the glucocorticoid receptor (GR-α) genes, cytokine regulation, and alterations in the hypothalamic pituitary axis and cortisol levels which all may affect asthma pathophysiology and therapeutic response among patients exposed to chronic stress. Recent research has revealed associations between ACEs and chronic and toxic stress and asthma risk in pre-conception to early childhood as well as morbidity and response to asthma treatments among pediatric and adult age groups. As some populations are more significantly impacted by asthma such as racial and ethnic minority groups, the influence of psychosocial stress has also been explored as a potential factor responsible for observed disparities in asthma prevalence and outcomes among these groups which also experience higher rates of psychosocial stress. Racial discrimination has specifically been shown to affect asthma-related outcomes among minority groups. Interventions to address the impact of chronic and toxic stress such as yoga and meditation have been shown to improve asthma outcome measures. Chronic and toxic stress is an important environmental exposure to further consider as we continue to explore the differences in underlying asthma pathophysiology leading to various disease phenotypes among patients and clinical/therapeutic response to interventions and treatments.
journal_name
Clin Rev Allergy Immunoljournal_title
Clinical reviews in allergy & immunologyauthors
Barnthouse M,Jones BLdoi
10.1007/s12016-019-08736-xsubject
Has Abstractpub_date
2019-12-01 00:00:00pages
427-438issue
3eissn
1080-0549issn
1559-0267pii
10.1007/s12016-019-08736-xjournal_volume
57pub_type
杂志文章,评审abstract::One of the important factors and consequences in persistent asthma is the change in the vasculature of the airways and lung parenchyma. These changes could contribute to worsening asthma control and predispose asthmatics to critical asthma syndromes. For many years, the contribution of vasculature to severe asthma was...
journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
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journal_title:Clinical reviews in allergy & immunology
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journal_title:Clinical reviews in allergy & immunology
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journal_title:Clinical reviews in allergy & immunology
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journal_title:Clinical reviews in allergy & immunology
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journal_title:Clinical reviews in allergy & immunology
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pub_type: 杂志文章,meta分析,评审
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journal_title:Clinical reviews in allergy & immunology
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journal_title:Clinical reviews in allergy & immunology
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pub_type: 杂志文章,评审
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journal_title:Clinical reviews in allergy & immunology
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journal_title:Clinical reviews in allergy & immunology
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更新日期:2019-06-01 00:00:00
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journal_title:Clinical reviews in allergy & immunology
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journal_title:Clinical reviews in allergy & immunology
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