Abstract:
:Mixed cryoglobulinemia (MC) syndrome is an immune complex-mediated vasculitis characterized by the clinical triad of purpura, weakness, and arthralgias, the morbidity of which is mainly related to kidney and peripheral nervous system dysfunction as well as to the development of a secondary lymphoma (Ferri et al. Autoimmun Rev 7:114-120, 2007, Lidar et al. Ann N Y Acad Sci 1173:649-657, 2009, Trejo et al. Semin Arthritis Rheum 33:19-28, 2003). MC is associated with infectious and systemic disorders, principally autoimmune and lymphoproliferative diseases. Since the 1990s, a striking association (>90%) between MC and hepatitis C virus (HCV) infection has been established (Ferri and Bombardieri 2004; Pascual et al. J Infect Dis 162:569-570, 1990). However, information regarding the etiopathogenesis of HCV-negative MC is scant (Mascia et al. Dig Liver Dis 39:61-64, 2007). We hereby present our findings, as well as previously published data, regarding the presence of antibodies against infectious agents and autoantibodies in patients with MC in an attempt to establish novel associations which may shed light on the etiopathogenesis of this disease.
journal_name
Clin Rev Allergy Immunoljournal_title
Clinical reviews in allergy & immunologyauthors
Lidar M,Lipschitz N,Agmon-Levin N,Langevitz P,Barzilai O,Ram M,Porat-Katz BS,Bizzaro N,Damoiseaux J,Tervaert JW,deVita S,Bombardieri S,Shoenfeld Ydoi
10.1007/s12016-011-8275-xsubject
Has Abstractpub_date
2012-04-01 00:00:00pages
238-46issue
2eissn
1080-0549issn
1559-0267journal_volume
42pub_type
杂志文章,评审abstract::Eosinophils can regulate local and systemic inflammation, and their presence in higher numbers appears to play an important role in the pathology of various atopic and inflammatory diseases. Eosinophil maturation, recruitment, and survival depend on several cytokine regulators, including interleukin (IL)-5, IL-4, and ...
journal_title:Clinical reviews in allergy & immunology
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pub_type: 杂志文章,评审
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Clinical reviews in allergy & immunology
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更新日期:2006-06-01 00:00:00
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2005-12-01 00:00:00
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
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更新日期:2014-04-01 00:00:00
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,meta分析
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更新日期:2020-12-01 00:00:00
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journal_title:Clinical reviews in allergy & immunology
pub_type: 杂志文章,评审
doi:10.1385/CRIAI:28:2:147
更新日期:2005-04-01 00:00:00
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