Inflammatory Profiles of the Interleukin Family and Network in Cerebral Hemorrhage.

abstract：:1. We have devised a radioimmunoassay for atrial natriueretic factor (ANF). Its application to rat brain extract led to the discovery of ANF in the brain. In addition to the hypothalamus and the pontine medullary region, it was widely distributed. 2. ANF in the brain is stored in a low molecular weight form, in contra...

journal_title：Cellular and molecular neurobiology

authors： Inagami T,Tanaka I,McKenzie JC,Nakamaru M,Takayanagi R,Imada T,Pochet R,Resibois A,Naruse M,Naruse K

更新日期：1989-03-01 00:00:00

abstract：:Microelectrophoretic application of sex hormones onto pineal cells in guinea pigs has shown different responses in pregnant females as compared to males. In pregnant females estrone caused excitation in 74% of the cells tested, while progesterone and testosterone, prolactin, and HCG were inhibitory in a majority of th...

journal_title：Cellular and molecular neurobiology

authors： Semm P,Demaine C,Vollrath L

更新日期：1981-09-01 00:00:00

abstract：:1. Coexisting with oxytocin or vasopressin in the cell bodies and nerve terminals of the hypothalamic-neurohypophysial system are smaller amounts of other peptides. For a number of these "copeptides" there is strong evidence of corelease with the major magnocellular hormones. Guided by the location of their specific r...

journal_title：Cellular and molecular neurobiology

authors： Bondy CA,Whitnall MH,Brady LS,Gainer H

更新日期：1989-12-01 00:00:00

abstract：:The stimulation of peripheral opioid receptors counteracts thermal hyperalgesia produced by the intratibial inoculation of NCTC 2472 cells in mice, through the activation of the nitric oxide/cGMP/ATP-sensitive K+-channels (NO/cGMP/K(+) (ATP)) cascade (Menéndez et al. 2007, Neuropharmacology 53:71-80). We aimed to eluc...

journal_title：Cellular and molecular neurobiology

authors： Curto-Reyes V,Juárez L,García-Pérez E,Fresno MF,Hidalgo A,Menéndez L,Baamonde A

更新日期：2008-11-01 00:00:00

abstract：:The hypothesis that peripheral, skeletal muscle tissue contains a trophic factor supporting central neurons has recently been investigated in vitro by supplementing the culture medium of spinal cord neurons with muscle extracts and fractions of extract. We extended these studies asking whether or not a trophic factor ...

journal_title：Cellular and molecular neurobiology

authors： Popiela H,Porter T,Beach RL,Festoff BW

更新日期：1984-03-01 00:00:00

abstract：:We have previously demonstrated that alpha2-adrenoceptors regulate hypothalamic magnocellular oxytocinergic (OXY) neurons in Sprague Dawley rats. Here we investigated whether activation/inhibition of alpha2-adrenoceptors may similarly trigger/downregulate the activity of OXY neurons in control Long Evans (+/+) and per...

journal_title：Cellular and molecular neurobiology

authors： Bundzikova J,Pirnik Z,Zelena D,Mikkelsen JD,Kiss A

更新日期：2009-09-01 00:00:00

abstract：:Reactive microglia clustering around amyloid plaques in brain is a histopathological feature of Alzheimer's disease (AD) and reflects the contribution of neuroinflammation in AD pathogenesis. β-Amyloid peptide (Aβ) has been shown to induce a range of microglial responses including chemotaxis, cytotoxicity and inflamma...

journal_title：Cellular and molecular neurobiology

authors： Zhang X,Ye P,Wang D,Liu Y,Cao L,Wang Y,Xu Y,Zhu C

更新日期：2019-07-01 00:00:00

abstract：:1. A high expression of angiotensin II receptors and of angiotensin-converting enzyme (ACE) activity was detected in confluent NIH 3T3 fibroblasts. 2. Characterization with selective ligands, dithiothreitol, and GTP gamma S, indicated that only the AT2 subtype was expressed. 3. AT2 receptors and ACE expression were st...

journal_title：Cellular and molecular neurobiology

authors： Heemskerk FM,Zorad S,Xu N,Gutkind SJ,Saavedra JM

更新日期：1999-04-01 00:00:00

abstract：:1. In this study we investigated the effect of 7-nitroindazole (7-NI), a preferential inhibitor of neuronal nitric oxide synthase (nNOS), on kainic acid (KA) induced neurotoxicity in rats. Choline acetyltransferase activity (CAT), a cholinergic marker, and histological changes were employed to assess neurotoxicity. 2....

journal_title：Cellular and molecular neurobiology

authors： Guevara BH,Cespedes GC,Cubeddu LX

更新日期：2002-12-01 00:00:00

abstract：:1. Data obtained studying permeability characteristics of single Deiters' membranes in a microchamber system show that intracellular GABA can activate chloride in-->out passage with a GABAA pharmacology. 2. The overall data suggest the presence of a chloride extrusion pump in these neurons based on intracellular GABA ...

journal_title：Cellular and molecular neurobiology

authors： Rapallino MV,Cupello A,Hydén H

更新日期：1999-12-01 00:00:00

abstract：:The L-type calcium channel blocker nimodipine improves clinical outcome produced by delayed cortical ischemia or vasospasm associated with subarachnoid hemorrhage. While vasoactive mechanisms are strongly implicated in these therapeutic actions of nimodipine, we sought to test whether nimodipine might also regulate ne...

journal_title：Cellular and molecular neurobiology

authors： Koskimäki J,Matsui N,Umemori J,Rantamäki T,Castrén E

更新日期：2015-03-01 00:00:00

abstract：:Glioma stem cells (GSCs) are thought to be critical for resistance to radiotherapy and chemotherapy and for tumor recurrence after surgery in glioma patients. Identification of new therapeutic strategies that can target GSCs may thus be critical for improving patient survival. MicroRNAs (miRNAs) are small non-coding R...

journal_title：Cellular and molecular neurobiology

authors： Chen L,Chen XR,Chen FF,Liu Y,Li P,Zhang R,Yan K,Yi YJ,Xu ZM,Jiang XD

更新日期：2013-07-01 00:00:00

abstract：:The dopaminergic system plays important roles in neuromodulation, such as motor control, motivation, reward, cognitive function, maternal, and reproductive behaviors. Dopamine is a neurotransmitter, synthesized in both central nervous system and the periphery, that exerts its actions upon binding to G protein-coupled ...

journal_title：Cellular and molecular neurobiology

authors： Klein MO,Battagello DS,Cardoso AR,Hauser DN,Bittencourt JC,Correa RG

更新日期：2019-01-01 00:00:00

abstract：:Hypoxia in neonates can lead to biochemical and molecular alterations mediated through changes in neurotransmitters resulting in permanent damage to brain. In this study, we evaluated the changes in the receptor status of GABA(A) in the cerebral cortex and brainstem of hypoxic neonatal rats and hypoxic rats supplement...

journal_title：Cellular and molecular neurobiology

authors： Anju TR,Peeyush Kumar T,Paulose CS

更新日期：2010-05-01 00:00:00

abstract：:1. The analogies between the processing of amyloid precursor protein (APP) and other transmembrane sterol regulatory element binding proteins (SREBPs) inspired us to conduct further studies on whether beta-amyloid (Abeta) affects aromatase by interacting with APP and SREBP. 2. In this study, cultured human neuroblasto...

journal_title：Cellular and molecular neurobiology

authors： Kelicen P,Nordberg A

更新日期：2006-05-01 00:00:00

abstract：:Alpha-synuclein (alpha-SYN) is one of the major components of intracellular fibrillary aggregates in the brains of a subset of neurodegenerative disorders. Although alpha-SYN expression has been found in developing mouse brain, a detailed distribution during mouse-embryonic development has not been made. Here we descr...

journal_title：Cellular and molecular neurobiology

authors： Zhong SC,Luo X,Chen XS,Cai QY,Liu J,Chen XH,Yao ZX

更新日期：2010-04-01 00:00:00

abstract：:We have characterized a newly generated mouse model of obesity, a mouse strain deficient in all five previously described leptin receptor isoforms. These transgenic mice, named the db (333)/db (333) mice, were identified from an ENU mutagenesis screen and carry a point mutation in the seventh exon of the db gene encod...

journal_title：Cellular and molecular neurobiology

authors： Osborn O,Sanchez-Alavez M,Brownell SE,Ross B,Klaus J,Dubins J,Beutler B,Conti B,Bartfai T

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:The diagnosis of multiple sclerosis (MS) is still challenging recently due to the lack of a specific diagnostic test. Proteomics analysis was applied to biomarkers discovery and their pathways study. METHODS:First, the proteins of CSF from MS patients and control group were analyzed individually with 2D-DIGE...

journal_title：Cellular and molecular neurobiology

authors： Qin Z,Qin Y,Liu S

更新日期：2009-03-01 00:00:00

abstract：:1. Tau, which is a microtubule-associated protein, with mRNA targeted to the axon and growth cone, is involved in axonal elongation. During postnatal development in mouse, Tau expression in cerebellar granule cells is reduced afte the second postnatal week. The aim of this work was to study the regulation of the rate ...

journal_title：Cellular and molecular neurobiology

authors： Vilá-Ortiz GJ,Santa-Coloma TA,Carminatti H,Radrizzani M

更新日期：2001-10-01 00:00:00

abstract：:Phenylketonuria (PKU) is an inherited metabolic disorder caused by deficiency of phenylalanine hydroxylase which leads to accumulation of phenylalanine and its metabolites in tissues of patients with severe neurological involvement. Recently, many studies in animal models or patients have reported the role of oxidativ...

journal_title：Cellular and molecular neurobiology

authors： Moraes TB,Jacques CE,Rosa AP,Dalazen GR,Terra M,Coelho JG,Dutra-Filho CS

更新日期：2013-03-01 00:00:00

abstract：:Exposure to stress induces profound physiological and behavioral changes in the organisms and some of these changes may be important regarding stress-induced pathologies and animal models of psychiatric diseases. Consequences of stress are dependent on the duration of exposure to stressors (acute, chronic), but also o...

journal_title：Cellular and molecular neurobiology

authors： Armario A,Daviu N,Muñoz-Abellán C,Rabasa C,Fuentes S,Belda X,Gagliano H,Nadal R

更新日期：2012-07-01 00:00:00

abstract：:The inhibitory effects of various opiates on developing rat vas deferens were studied by determining the degree of depression of mechanical responses elicited by electrical field stimulation. All agonists showed decreased effects with maturation, but the decrease occurred at different times. With normorphine the loss ...

journal_title：Cellular and molecular neurobiology

authors： Rónai AZ,Berzétei IP,Kurgyis J

更新日期：1981-12-01 00:00:00

abstract：:Alzheimer disease is a complex neurodegenerative disorder. It is the common form of dementia in elderly people. The etiology of this disease is multifactorial, pathologically it is accompanied with accumulation of amyloid beta and neurofibrillary tangles. Accumulation of amyloid beta and mitochondrial dysfunction lead...

journal_title：Cellular and molecular neurobiology

authors： Sajjad N,Wani A,Sharma A,Ali R,Hassan S,Hamid R,Habib H,Ganai BA

更新日期：2019-04-01 00:00:00

abstract：:Oxysophocarpine (OSC), an alkaloid isolated from Sophora flavescens Ait, has been traditionally used as a medicinal agent based on the observed pharmacological effects. In this study, the direct effect of OSC against neuronal injuries induced by oxygen and glucose deprivation (OGD) in neonatal rat primary-cultured hip...

journal_title：Cellular and molecular neurobiology

authors： Zhao P,Chang RY,Liu N,Wang J,Zhou R,Qi X,Liu Y,Ma L,Niu Y,Sun T,Li YX,He YP,Yu JQ

更新日期：2018-03-01 00:00:00

abstract：:1. Alzheimer's disease is characterized by the deposition in the brain of extracellular amyloid plaques and vascular deposits consisting mostly of amyloid beta-peptide (A beta). A beta, a polypeptide of 39-43 amino acids (M(r), approximately 4 kDa), is derived proteolytically from a family of proteins of 695-770 amino...

journal_title：Cellular and molecular neurobiology

authors： Lahiri DK

更新日期：1994-08-01 00:00:00

abstract：:Calmodulin is known to transduce Ca(2+) signals by interacting with specific target proteins. In order to determine the role of calmodulin in regulating neuronal survival and death, we examined, whether calmodulin inhibitors induce caspase-dependent apoptotic cell death, and whether glycogen synthase kinase-3 is invol...

journal_title：Cellular and molecular neurobiology

authors： Takadera T,Ohyashiki T

更新日期：2007-09-01 00:00:00

abstract：:Modulation of enzyme activity through nitrosylation has recently been identified as a new physiological activity of nitric oxide (NO). We hypothesized that NO enhances the TNF-α-induced death of retinal neurons through a suppression of nuclear factor-κB (NF-κB) by nitrosylation. In this study, cells from the RGC-5 lin...

journal_title：Cellular and molecular neurobiology

authors： Nakaizumi A,Horie T,Kida T,Kurimoto T,Sugiyama T,Ikeda T,Oku H

更新日期：2012-01-01 00:00:00

abstract：:We provide a comprehensive review of the available evidence on the pathophysiological implications of genetic variants in the human trace amine-associated receptor (TAAR) superfamily. Genes coding for trace amine-associated receptors (taars) represent a multigene family of G-protein-coupled receptors, clustered to a s...

journal_title：Cellular and molecular neurobiology

authors： Rutigliano G,Zucchi R

更新日期：2020-03-01 00:00:00

abstract：:The pathogenesis of Alzheimer's disease (AD) has been strongly associated with the accumulation of amyloid beta (Aβ) peptides in brain, and immunotherapy targeting Aβ provides potential for AD prevention. A clinical trial in which AD patients were immunized with Aβ42 peptide was stopped when 6% of participants showed ...

journal_title：Cellular and molecular neurobiology

authors： Lambracht-Washington D,Qu BX,Fu M,Anderson LD Jr,Stüve O,Eagar TN,Rosenberg RN

更新日期：2011-08-01 00:00:00

abstract：:The intention of this review is to emphasize the current knowledge about the extent and importance of the substances co-localized with magnocellular arginine vasopressin (AVP) and oxytocin (OXY) as potential candidates for the gradual clarification of their actual role in the regulation of hydromineral homeostasis. Ma...

journal_title：Cellular and molecular neurobiology

authors： Bundzikova J,Pirnik Z,Zelena D,Mikkelsen JD,Kiss A

更新日期：2008-12-01 00:00:00