Effect of ionophores on the processing of the beta-amyloid precursor protein in different cell lines.

abstract：:Non-muscle myosin heavy chain IIA (NMMHC IIA), a member of Myosin II family, plays a critical role in various cellular physiological processes. Our previous research had suggested that NMMHC IIA could participate in regulating tight junction morphological changes induced by ischemia stroke. Thus, in the current study,...

journal_title：Cellular and molecular neurobiology

authors： Lv Y,Liu W,Ruan Z,Xu Z,Fu L

更新日期：2019-03-01 00:00:00

abstract：:Traumatic brain injury (TBI) causes permanent neurological and cognitive impairments. Effective pharmacological interventions remain elusive. Spermidine is a polyamine compound found in our body that may play a role in brain development and congenital function. In this study, we aimed to investigate the therapeutic po...

journal_title：Cellular and molecular neurobiology

authors： Huang J,Zhang H,Zhang J,Yu H,Lin Z,Cai Y

更新日期：2020-08-01 00:00:00

abstract：:Naked2 (NKD2), one member of Naked family, has been shown to negatively regulate Wnt/β-catenin signaling pathway. It has been recognized that NKD2 plays a vital role in cell homeostasis and prevention of tumorigenesis. However, NKD2 expression and its functional role in the brain in neuroinflammatory processes remain ...

journal_title：Cellular and molecular neurobiology

authors： Cui Z,Zhou L,Song Y,Liu C,Zhu G,Wu X,Yan Y,Xia X,Duan C,Zhou Y,Huang Y,Zhang D

更新日期：2016-01-01 00:00:00

abstract：:The mechanisms of impairment in long-term potentiation after status epilepticus (SE) remain unclear. We investigated the properties of LTP induced by theta-burst stimulation in hippocampal slices of rats 3 h and 1, 3, and 7 days after SE. Seizures were induced in 3-week old rats by a single injection of pentylenetetra...

journal_title：Cellular and molecular neurobiology

authors： Postnikova TY,Trofimova AM,Ergina JL,Zubareva OE,Kalemenev SV,Zaitsev AV

更新日期：2019-03-01 00:00:00

abstract：:We provide a comprehensive review of the available evidence on the pathophysiological implications of genetic variants in the human trace amine-associated receptor (TAAR) superfamily. Genes coding for trace amine-associated receptors (taars) represent a multigene family of G-protein-coupled receptors, clustered to a s...

journal_title：Cellular and molecular neurobiology

authors： Rutigliano G,Zucchi R

更新日期：2020-03-01 00:00:00

abstract：:Secretory phospholipases A2 (sPLA2) form a diverse family of enzymes involved in physiologic and pathologic processes. Common among all sPLA2 is the ability to cleave acyl groups of phospholipids at C2 of the glycerol backbone, thereby releasing fatty acid and a lysophospholipid. Several sPLA2 have been cloned and cha...

journal_title：Cellular and molecular neurobiology

authors： Kolko M,Christoffersen NR,Varoqui H,Bazan NG

更新日期：2005-11-01 00:00:00

abstract：:Shengmai (SM) formula, a classical traditional Chinese medicine formula, is composed of Panax ginseng (Pg), Ophiopogon japonicus (Oj), and Schisandra Chinesis (Sc). SM has been clinically used to treat heart failure and ischemic heart disease. Although SM formula has been reported to be potential for fighting against ...

journal_title：Cellular and molecular neurobiology

authors： Zhang W,Zhi D,Ren H,Wang D,Wang X,Zhang Z,Fei D,Zhu H,Li H

更新日期：2016-11-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is an adult-onset, progressive, and fatal neurodegenerative disease caused by selective loss of motor neurons. Both ALS model mice and patients with sporadic ALS have increased levels of prostaglandin E2 (PGE2). Furthermore, the protein levels of microsomal PGE synthase-1 and cycloo...

journal_title：Cellular and molecular neurobiology

authors： Miyagishi H,Kosuge Y,Takano A,Endo M,Nango H,Yamagata-Murayama S,Hirose D,Kano R,Tanaka Y,Ishige K,Ito Y

更新日期：2017-04-01 00:00:00

abstract：:The study was performed to investigate the effect of combination therapy with aminoguanidine (AG) and dexamethasone (DEX) on the compression spinal cord injury (SCI) in rat. Compared to the control group, the combination therapy group with AG (75 mg/kg) and DEX (0.025 mg/kg) significantly reduced the degree of (1) spi...

journal_title：Cellular and molecular neurobiology

authors： Xu WB,Lv G,Wang YF,Lu XH,Huang T,Zhu Y,Jia LS

更新日期：2009-07-01 00:00:00

abstract：:Matrix metalloproteinase-1 (MMP-1), a member of the matrix metalloproteinases family, plays an integral role in extracellular matrix degradation and has been reportedly involved in the regulation of the brain or spinal cord traumatic neurovascular remodeling. Although the critical involvement of MMP-1 in the metastasi...

journal_title：Cellular and molecular neurobiology

authors： Zhou Y,Cui Z,Xia X,Liu C,Zhu X,Cao J,Wu Y,Zhou L,Ben Z,Song Y,Zhang H,Zhang D

更新日期：2014-11-01 00:00:00

abstract：:Diabetic retinopathy (DR) is widely recognized as a neurovascular disease. Retina, being a neuronal tissue of the eye, produces neurotrophic factors for its maintenance. However, diabetes dysregulates their levels and thereby may damage the retina. Among neurotrophins, brain derived neurotrophic factor (BDNF) is the m...

journal_title：Cellular and molecular neurobiology

authors： Ola MS,Nawaz MI,El-Asrar AA,Abouammoh M,Alhomida AS

更新日期：2013-04-01 00:00:00

abstract：:1. The sensory functions of the inner ear (hearing and balance) critically depend on the precise regulation of two fluid compartments of highly desparate ion composition, i.e., the endolymph and the perilymph. 2. The parameters volume, ion composition, and pH need to be held at homeostasis irrespective of the hydratio...

journal_title：Cellular and molecular neurobiology

authors： Beitz E,Zenner HP,Schultz JE

更新日期：2003-06-01 00:00:00

abstract：AIM:In Alzheimer's disease (AD) it is well known that specific regions of the brain are particularly vulnerable to the pathologic insults of the disease. In particular, the hippocampus is affected very early in the disease and by end stage AD is ravaged by neurofibrillary tangles and senile plaques (i.e., the pathologi...

journal_title：Cellular and molecular neurobiology

authors： Armstrong DM,Sheffield R,Mishizen-Eberz AJ,Carter TL,Rissman RA,Mizukami K,Ikonomovic MD

更新日期：2003-10-01 00:00:00

abstract：:1. The HCS2 (Helix command specific 2) gene expressed in giant command neurons for withdrawal behavior of the terrestrial snail Helix lucorum encodes a unique hybrid precursor protein that contains a Ca-binding (EF-hand motif) protein and four small peptides (CNP1-CNP4) with similar Tyr-Pro-Arg-X aminoacid sequence at...

journal_title：Cellular and molecular neurobiology

authors： Ivanova JL,Leonova OG,Popenko VI,Ierusalimsky VN,Korshunova TA,Boguslavsky DV,Malyshev AY,Balaban PM,Belyavsky AV

更新日期：2006-03-01 00:00:00

abstract：:(1) A Little information exists on the distribution of Slit-Robo-GTPase activating proteins (srGAPs), particularly about their intracellular locations, which may provide further clues to their functions. The purpose of this study is to elucidate the expression patterns of the three srGAPs in wild-type rat brains at ad...

journal_title：Cellular and molecular neurobiology

authors： Yao Q,Jin WL,Wang Y,Ju G

更新日期：2008-02-01 00:00:00

abstract：:Modulation of enzyme activity through nitrosylation has recently been identified as a new physiological activity of nitric oxide (NO). We hypothesized that NO enhances the TNF-α-induced death of retinal neurons through a suppression of nuclear factor-κB (NF-κB) by nitrosylation. In this study, cells from the RGC-5 lin...

journal_title：Cellular and molecular neurobiology

authors： Nakaizumi A,Horie T,Kida T,Kurimoto T,Sugiyama T,Ikeda T,Oku H

更新日期：2012-01-01 00:00:00

abstract：:In chromaffin cells, SNARE proteins, forming the basic exocytotic machinery are present in membrane clusters of 500-600 nm in diameter. These microdomains containing both SNAP-25 and syntaxin-1 are dynamic and the expression of altered forms of SNAREs modifies not only their motion but also the mobility of the associa...

journal_title：Cellular and molecular neurobiology

authors： Torregrosa-Hetland CJ,Villanueva J,López-Font I,Garcia-Martinez V,Gil A,Gonzalez-Vélez V,Segura J,Viniegra S,Gutiérrez LM

更新日期：2010-11-01 00:00:00

abstract：:Sulfur dioxide (SO2) is a common gas pollutant that is detrimental to many organs. Previous studies have shown that SO2 exposure is involved in neurotoxicity and increased risk of many brain disorders; however, our understanding of the mechanisms underlying SO2-induced cytotoxicity on neuronal cells remains elusive. T...

journal_title：Cellular and molecular neurobiology

authors： Guan DF,Ren PY,Hu W,Zhang YL

更新日期：2015-05-01 00:00:00

abstract：:One of the few areas of the adult CNS, that are known to be competent for neuronal proliferation, is the subventricular zone (SVZ) lining the brain lateral ventricles. Cells proliferating in the SVZ migrate along a defined pathway, the rostral migratory stream (RMS), where their proliferation continues until reaching ...

journal_title：Cellular and molecular neurobiology

authors： Bálentová S,Raceková E,Martoncíková M,Misúrová E

更新日期：2006-10-01 00:00:00

abstract：:1. The cytochrome P450 enzyme family is one of the major drug metabolizing systems in man. 2. Factors such as age, gender, race, environment, and drug treatment may have considerable influence on the activity of these enzymes. 3. There are now well-established in vitro techniques for assessing the role of specific cyt...

journal_title：Cellular and molecular neurobiology

authors： Glue P,Clement RP

更新日期：1999-06-01 00:00:00

abstract：:The mammalian stress response is an integrated physiological and psychological reaction to real or perceived adversity. Glucocorticoids (GCs) are an important component of this response, acting to redistribute energy resources to both optimize survival in the face of challenge and restore homeostasis after the immedia...

journal_title：Cellular and molecular neurobiology

authors： Myers B,McKlveen JM,Herman JP

更新日期：2012-02-01 00:00:00

abstract：:Contextual fear conditioning is a paradigm for investigating cellular mechanisms involved in hippocampus-dependent memory. Earlier, we showed that standardised extract of Bacopa monniera (CDRI-08) improves hippocampus-dependent learning in postnatal rats by elevating the level of serotonin (5-hydroxytryptamine, 5-HT),...

journal_title：Cellular and molecular neurobiology

authors： Preethi J,Singh HK,Venkataraman JS,Rajan KE

更新日期：2014-05-01 00:00:00

abstract：:1. 125I-Endothelin (ET)-1 binding to the rat anterior pituitary gland was saturable and single, with a Kd of 71 pM and a Bmax of 120 fmol/mg. 2. When 1.0 microM BQ-123 (ETA antagonist) was added to the incubation buffer, the binding parameters were 8.3 pM and 8.0 fmol/mg, whereas 10 nM sarafotoxin S6c (ETB agonist) ex...

journal_title：Cellular and molecular neurobiology

authors： Himeno A,Shigematsu K,Taguchi T,Niwa M

更新日期：1998-08-01 00:00:00

abstract：:1. Photoreceptor terminals in the flies Musca domestica and Drosophila melanogaster have been reconstructed in three dimensions from serial EM to reveal the surface distributions of afferent tetrad synapses. 2. The terminals are cylindrical and surround two target cells; they have synaptic sites distributed along thei...

journal_title：Cellular and molecular neurobiology

authors： Meinertzhagen IA,Hu X

更新日期：1996-12-01 00:00:00

abstract：:1. Aminoalkylindoles, typified by WIN 55212-2, bind to G protein-coupled cannabinoid receptors in brain. Although cannabinoids inhibit adenylyl cyclase in NG108-15 neuroblastoma x glioma hybrid cells, cannabinoid receptor binding in these cells has not been described previously. This study compares pharmacological cha...

journal_title：Cellular and molecular neurobiology

authors： Stark S,Pacheco MA,Childers SR

更新日期：1997-10-01 00:00:00

abstract：AIMS:Treatments that increase acetylcholine release from brain slices decrease the synthesis of phosphatidylcholine by, and its levels in, the slices. We examined whether adding cytidine or uridine to the slice medium, which increases the utilization of choline to form phospholipids, also decreases acetylcholine levels...

journal_title：Cellular and molecular neurobiology

authors： Ulus IH,Watkins CJ,Cansev M,Wurtman RJ

更新日期：2006-07-01 00:00:00

abstract：:We have characterized a newly generated mouse model of obesity, a mouse strain deficient in all five previously described leptin receptor isoforms. These transgenic mice, named the db (333)/db (333) mice, were identified from an ENU mutagenesis screen and carry a point mutation in the seventh exon of the db gene encod...

journal_title：Cellular and molecular neurobiology

authors： Osborn O,Sanchez-Alavez M,Brownell SE,Ross B,Klaus J,Dubins J,Beutler B,Conti B,Bartfai T

更新日期：2010-01-01 00:00:00

abstract：:Perinatal hypoxia can lead to multiple chronic neurological deficits, e.g., mental retardation, behavioral abnormalities, and epilepsy. Levetiracetam (LEV), 2S-(2-oxo-1-pyrrolidiny1) butanamide, is an anticonvulsant drug with proven efficiency in treating patients with focal and generalized seizures. Rats were underwe...

journal_title：Cellular and molecular neurobiology

authors： Pozdnyakova N,Dudarenko M,Borisova T

更新日期：2019-07-01 00:00:00

abstract：:1. The possibility that a long-lasting neuronal activation regulates the expression of muscarinic cholinergic receptors was studied with three cultured neuronal cell lines. 2. Continuous depolarization of a subclone of the neuroblastoma-glioma NG108-15 hybrid cells with potassium chloride increased by 45-75% the numbe...

journal_title：Cellular and molecular neurobiology

authors： Simantov R,Levy R

更新日期：1989-03-01 00:00:00

abstract：:Cell cycle re-entry, in which Fra-1 (transcription factor FOS-related antigen 1) plays an important role, is a key process in neuronal apoptosis. However, the expression and function of Fra-1 in retinal ganglion cell (RGC) apoptosis are unknown. To investigate whether Fra-1 was involved in RGC apoptosis, we performed ...

journal_title：Cellular and molecular neurobiology

authors： Liu X,Yang X,Zhu R,Dai M,Zhu M,Shen Y,Fang H,Sang A,Chen H

更新日期：2017-01-01 00:00:00