Abstract：
:One of the few areas of the adult CNS, that are known to be competent for neuronal proliferation, is the subventricular zone (SVZ) lining the brain lateral ventricles. Cells proliferating in the SVZ migrate along a defined pathway, the rostral migratory stream (RMS), where their proliferation continues until reaching the olfactory bulb. 1. In relation to the fact that brain is, in general, regarded as a radioresistant organ composed from non dividing cells, the aim of the present study was to investigate effect of ionizing radiation on proliferating cell numbers in the RMS of adult rats. 2. Male Wistar rats were investigated 25 and 80 days after whole body gamma irradiation with the dose of 3 Gy. Dividing cells were labeled by bromodeoxyuridine (BrdU). BrdU-positive cells were counted by Disector program. The mean number of BrdU(+) cells in the whole RMS and in its individual parts (vertical arm, elbow, and horizontal arm) was evaluated. 3. Temporary increase in proliferating cell number (by 30%) was seen in the whole RMS at the 25th day after irradiation. 4. The most expressive increase occurred in the vertical arm (by 60%) and elbow (about 37%). The values reduced till the 80th day after exposure. Our results show that ionizing irradiation significantly influences the extent of cell proliferation and migration in the adult rat RMS.
journal_name
Cell Mol Neurobioljournal_title
Cellular and molecular neurobiologyauthors
Bálentová S,Raceková E,Martoncíková M,Misúrová Edoi
10.1007/s10571-006-9067-3subject
Has Abstractpub_date
2006-10-01 00:00:00pages
1131-39issue
7-8eissn
0272-4340issn
1573-6830journal_volume
26pub_type
杂志文章abstract：:Abeta accumulation, a hallmark of Alzheimer's disease, promotes the disease progress in multiple facets. Abeta is formed through amyloidogenic cleavage pathway of amyloid precursor protein (APP). Production of Abeta can be decreased via activation of 5-HT2C receptor, which enhances alternative APP non-amyloidogenic cl...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-014-0138-6
更新日期：2015-04-01 00:00:00
abstract：:1. Innervation of the mammalian pineal gland is mainly sympathetic. Pineal synthesis of melatonin and its levels in the circulation are thought to be under strict adrenergic control of serotonin N-acetyltransferase (NAT). In addition, several putative pineal neurotransmitters modulate melatonin synthesis and secretion...
journal_title：Cellular and molecular neurobiology
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journal_title：Cellular and molecular neurobiology
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-016-0359-y
更新日期：2017-03-01 00:00:00
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-007-9148-y
更新日期：2007-09-01 00:00:00
abstract：:1. Golgi-Kopsch preparations of the oral ventral nuclei of human thalamus were analyzed in an attempt to classify the neuronal types. 2. Three types of neurons are described for the first time in humans. Type I neurons are large or medium in size and bear dendrites with protrusions, spines, and short hair-like appenda...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-013-9988-6
更新日期：2014-01-01 00:00:00
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章,评审
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章,评审
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
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更新日期：2016-10-01 00:00:00
abstract：:Diabetic retinopathy (DR) is widely recognized as a neurovascular disease. Retina, being a neuronal tissue of the eye, produces neurotrophic factors for its maintenance. However, diabetes dysregulates their levels and thereby may damage the retina. Among neurotrophins, brain derived neurotrophic factor (BDNF) is the m...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-012-9901-8
更新日期：2013-04-01 00:00:00
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-014-0129-7
更新日期：2015-04-01 00:00:00
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-012-9865-8
更新日期：2013-01-01 00:00:00
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1023/a:1012610407025
更新日期：2001-08-01 00:00:00
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/BF00711111
更新日期：1986-09-01 00:00:00
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章,评审
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
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journal_title：Cellular and molecular neurobiology
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journal_title：Cellular and molecular neurobiology
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
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更新日期：2020-04-01 00:00:00
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
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更新日期：1998-10-01 00:00:00
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章,评审
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-020-00922-2
更新日期：2020-07-18 00:00:00
abstract：:1. Spatio-temporal changes in phosphorylated (pNFP) and nonphosphorylated (npNFP) neurofilament proteins were assessed immunocytochemicaly in adult rat cerebellum, 2-30 days following unilateral injection of kainic acid (KA) or physiological saline (s.c.). 2. Analysis of the staining intensity and pattern demonstrated...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1023/b:cemn.0000022769.44211.2b
更新日期：2004-06-01 00:00:00
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-020-01001-2
更新日期：2020-11-13 00:00:00
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-013-9984-x
更新日期：2014-01-01 00:00:00
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journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1023/a:1007055626632
更新日期：2000-10-01 00:00:00
abstract：:To clarify the role of angiotensin II (Ang II) in the regulation of sensory signaling, we studied the effect of subpressor dose (150 ng/kg/min) of Ang II on pain-related behavior in relation with neuronal injury and activation of satellite glial cells (SGCs) in the dorsal root ganglia (DRGs) after chronic constriction...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-013-9934-7
更新日期：2013-07-01 00:00:00
