Myosin IIA Regulated Tight Junction in Oxygen Glucose-Deprived Brain Endothelial Cells Via Activation of TLR4/PI3K/Akt/JNK1/2/14-3-3ε/NF-κB/MMP9 Signal Transduction Pathway.

abstract：:1. Hypothalamic magnocellular neurons synthesize, store, and secrete large quantities of the neuropeptides, vasopressin (VP) and oxytocin (OT), which are synthesized as protein precursors also containing proteins called neurophysins. These protein precursors are sorted through the regulated secretory pathway (RSP), pa...

journal_title：Cellular and molecular neurobiology

authors： Zhang BJ,Yamashita M,Fields R,Kusano K,Gainer H

更新日期：2005-06-01 00:00:00

abstract：:1. Transient forebrain ischemia in adult rats, induced by 10 min of bilateral carotid occlusion and an arterial hypotension of 40 mmHg, caused substantial damage not only to CA-1 neurons in hippocampus but also to epithelial cells in lateral ventricle choroid plexus. 2. When transient forebrain ischemia was followed b...

journal_title：Cellular and molecular neurobiology

authors： Johanson CE,Palm DE,Primiano MJ,McMillan PN,Chan P,Knuckey NW,Stopa EG

更新日期：2000-04-01 00:00:00

abstract：:1. Photoreceptor terminals in the flies Musca domestica and Drosophila melanogaster have been reconstructed in three dimensions from serial EM to reveal the surface distributions of afferent tetrad synapses. 2. The terminals are cylindrical and surround two target cells; they have synaptic sites distributed along thei...

journal_title：Cellular and molecular neurobiology

authors： Meinertzhagen IA,Hu X

更新日期：1996-12-01 00:00:00

abstract：:We investigated the postnatal alterations of neurons, astrocyte, oligodendrocyte, and microglia in the mouse hippocampal CA1 sector and dentate gyrus under the same conditions using immunohistochemistry. Neuronal nuclei (NeuN), Glial fibrillary acidic protein (GFAP), 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPas...

journal_title：Cellular and molecular neurobiology

authors： Kimoto H,Eto R,Abe M,Kato H,Araki T

更新日期：2009-12-01 00:00:00

abstract：:The anorexigenic molecule nesfatin-1 has recently been taken as a potential mood regulator, but the potential mechanisms remain unknown. Results of our previous study have demonstrated that nesfatin-1 could induce anxiety- and depression-like behaviors in rats, accompanied by the hyperactivity of the hypothalamic-pitu...

journal_title：Cellular and molecular neurobiology

authors： Chen Z,Xu YY,Ge JF,Chen FH

更新日期：2018-04-01 00:00:00

abstract：:Autophagy is an essential degradation pathway in clearing abnormal protein aggregates in mammalian cells and is responsible for protein homeostasis and neuronal health. Several studies have shown that autophagy deficits occurred in early stage of Alzheimer's disease (AD). Autophagy plays an important role in generatio...

journal_title：Cellular and molecular neurobiology

authors： Li Q,Liu Y,Sun M

更新日期：2017-04-01 00:00:00

abstract：:1. Alpha-synuclein is known to play an important role in the pathogenesis of Parkinson's disease (PD). The pathogenicity of alpha-synuclein is related to its ability to form intraneuronal inclusions. The inclusions, which are found in brains of patients with PD and diffuse Lewy body disease consist partially of C-term...

journal_title：Cellular and molecular neurobiology

authors： Zach S,Bueler H,Hengerer B,Gillardon F

更新日期：2007-06-01 00:00:00

abstract：:The role of NO in epileptogenesis has been studied in different experimental models, and the reported results have been highly contradictory. The current study aimed to determine the role of NO in mechanisms of D: ,L: -homocysteine-thiolactone (H) induced seizures by testing the action of L: -arginine (NO precursor) a...

journal_title：Cellular and molecular neurobiology

authors： Hrncić D,Rasić-Marković A,Krstić D,Macut D,Djuric D,Stanojlović O

更新日期：2010-03-01 00:00:00

abstract：:While light is the basic element for inducing vision and modulating circadian rhythms, excessive light has been reported to have a negative effect on the survival of various types of retinal cells. Among them photoreceptors and retinal pigment epithelial (RPE) cells degeneration after light exposure is widely observed...

journal_title：Cellular and molecular neurobiology

authors： Zhao Y,Shen Y

更新日期：2020-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by deposition of beta-amyloid peptides (Aβ) and progressive loss of neurons. Neural stem/progenitor cells (NSPCs) can proliferate and produce immature neurons even in the brain of AD patients. However, Aβ42 significantly decreased the expression of RhoC in NSPCs during the co-...

journal_title：Cellular and molecular neurobiology

authors： Zhang C,Ge X,Lok K,Zhao L,Yin M,Wang ZJ

更新日期：2014-04-01 00:00:00

abstract：:We previously found that xanthotoxol, one of the major active ingredients in Cnidium monnieri (L.) Cusson, exerts protective effects in a rat model of focal cerebral ischemia/reperfusion injury by alleviating brain edema, inhibiting the neutrophil infiltration, and decreasing the expression of intercellular adhesion m...

journal_title：Cellular and molecular neurobiology

authors： He W,Chen W,Zhou Y,Tian Y,Liao F

更新日期：2013-07-01 00:00:00

abstract：:1. Besides having a role in signal transduction, trimeric G proteins may also be involved in membrane trafficking events. In chromaffin cells, G alpha o has been found associated with the membrane of secretory granules. Here we examined the role of Go in regulated exocytosis using pressure microinjection combined with...

journal_title：Cellular and molecular neurobiology

authors： Vitale N,Gonon F,Thiersé D,Aunis D,Bader MF

更新日期：1997-02-01 00:00:00

abstract：:The ataxia-telangiectasia mutated (ATM) protein is regarded as the linchpin of cellular defenses to stress. Deletion of ATM results in strong oxidative stress and degenerative diseases in the nervous system. However, the role of ATM in neuronal ischemic preconditioning and lethal ischemic injury is still largely unkno...

journal_title：Cellular and molecular neurobiology

authors： Xie GH,Dai HJ,Liu F,Zhang YP,Zhu L,Nie JJ,Wu JH

更新日期：2020-07-01 00:00:00

abstract：:1. The sensory functions of the inner ear (hearing and balance) critically depend on the precise regulation of two fluid compartments of highly desparate ion composition, i.e., the endolymph and the perilymph. 2. The parameters volume, ion composition, and pH need to be held at homeostasis irrespective of the hydratio...

journal_title：Cellular and molecular neurobiology

authors： Beitz E,Zenner HP,Schultz JE

更新日期：2003-06-01 00:00:00

abstract：:Metastasis of lung cancer to the brain is associated with poor outcomes and limited therapeutic options. The blood-brain barrier (BBB) plays a major role in brain metastasis. However, little is known about the role of pericytes in brain metastasis formation. This study aimed to reveal the interaction between pericytes...

journal_title：Cellular and molecular neurobiology

authors： Fujimoto T,Nakagawa S,Morofuji Y,Watanabe D,Ujifuku K,Horie N,Izumo T,Niwa M,Banks WA,Deli MA,Matsuo T

更新日期：2020-01-01 00:00:00

abstract：:1. Human medulloblastoma (ONS-76), a central nervous system (CNS)-derived undifferentiated cell line, was found to possess glial characteristics as defined by responses in the interferon (IFN) system; ONS-76 cells produced as much IFN-beta as human fibroblast and glioma cells by viral infection and poly(I):poly(C) ind...

journal_title：Cellular and molecular neurobiology

authors： Park KC,Shimizu K,Hayakawa T

更新日期：1998-10-01 00:00:00

abstract：:1. Angiotensin II receptors have been studied by quantitative autoradiography in selected brain areas of young (2-week-old) and adult (8-week-old) rats. 2. In young rats, angiotensin II receptors were present in brain areas which did not express receptors in the adult brain, such as thalamic nuclei, cortical areas, an...

journal_title：Cellular and molecular neurobiology

authors： Tsutsumi K,Saavedra JM

更新日期：1991-04-01 00:00:00

abstract：AIM:In Alzheimer's disease (AD) it is well known that specific regions of the brain are particularly vulnerable to the pathologic insults of the disease. In particular, the hippocampus is affected very early in the disease and by end stage AD is ravaged by neurofibrillary tangles and senile plaques (i.e., the pathologi...

journal_title：Cellular and molecular neurobiology

authors： Armstrong DM,Sheffield R,Mishizen-Eberz AJ,Carter TL,Rissman RA,Mizukami K,Ikonomovic MD

更新日期：2003-10-01 00:00:00

abstract：:The effects of cholinomimetics on the release and uptake of L-glutamic acid have been studied by means of local superfusion of rat neostriatum (in vivo) and using striatum slices (in vitro). Cholinomimetics regulate the release of L-glutamic acid through both muscarinic (m-) and nicotinic (n-) choline receptors accord...

journal_title：Cellular and molecular neurobiology

authors： Godukhin OV,Budantsev AYu,Selifanova OV,Agapova VN

更新日期：1984-06-01 00:00:00

abstract：:Intrachain disulfide bond formation among the cysteine thiols of SNAP-25, a component of the SNARE protein complex required for neurotransmitter release, has been hypothesized to link oxidative stress and inhibition of synaptic transmission. However, neither the availability in vivo of SNAP-25 thiols, which are known ...

journal_title：Cellular and molecular neurobiology

authors： Foley TD,Clark AR,Stredny ES,Wierbowski BM

更新日期：2012-03-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a leading cause of death and long-term disability. Fucoidan, a sulfated polysaccharide extracted from brown algae, possesses potent anti-oxidative and anti-inflammatory effects. Considering TBI happens frequently in adults, especially in aged individuals, we herein sought to define the ...

journal_title：Cellular and molecular neurobiology

authors： Wang T,Zhu M,He ZZ

更新日期：2016-11-01 00:00:00

abstract：:Reeler heterozygous mice (reln+/-) are seemingly normal but haplodeficient in reln, a gene implicated in autism. Structural/neurochemical alterations in the reln+/- brain are subtle and difficult to demonstrate. Therefore, the usefulness of these mice in translational research is still debated. As evidence implicated ...

journal_title：Cellular and molecular neurobiology

authors： Castagna C,Merighi A,Lossi L

更新日期：2019-08-01 00:00:00

abstract：:Neuroinflammation has become an important underlying factor in many cardiovascular disorders, including hypertension. Previously we showed that elevated angiotensin II (Ang II) and angiotensin II type I receptor (AT1R) expression levels can increase neuroinflammation leading to hypertension. We also found that kinin B...

journal_title：Cellular and molecular neurobiology

authors： Parekh RU,Robidoux J,Sriramula S

更新日期：2020-07-01 00:00:00

abstract：:The intrauterinal development in mammals represents a very sensitive period of life in relation to many environmental factors, including ionizing radiation (IR). The developing nervous system is particularly vulnerable to IR, and the consequences of exposure are of importance because of its potential health risks. The...

journal_title：Cellular and molecular neurobiology

authors： Kokošová N,Tomášová L,Kisková T,Šmajda B

更新日期：2015-01-01 00:00:00

abstract：:1. Aminoalkylindoles, typified by WIN 55212-2, bind to G protein-coupled cannabinoid receptors in brain. Although cannabinoids inhibit adenylyl cyclase in NG108-15 neuroblastoma x glioma hybrid cells, cannabinoid receptor binding in these cells has not been described previously. This study compares pharmacological cha...

journal_title：Cellular and molecular neurobiology

authors： Stark S,Pacheco MA,Childers SR

更新日期：1997-10-01 00:00:00

abstract：:1. Effects of 5-hydroxytryptamine (5-HT) on neuronal nicotinic acetylcholine (ACh) receptor channels were investigated by expressing cloned channel subunits in Xenopus oocytes. 2. When channels were expressed with a combination of alpha 3 and beta 4 subunits, 5-HT (10 to 300 microM) reversibly inhibited an inward curr...

journal_title：Cellular and molecular neurobiology

authors： Nakazawa K,Akiyama T,Inoue K

更新日期：1995-08-01 00:00:00

abstract：:The intention of this review is to emphasize the current knowledge about the extent and importance of the substances co-localized with magnocellular arginine vasopressin (AVP) and oxytocin (OXY) as potential candidates for the gradual clarification of their actual role in the regulation of hydromineral homeostasis. Ma...

journal_title：Cellular and molecular neurobiology

authors： Bundzikova J,Pirnik Z,Zelena D,Mikkelsen JD,Kiss A

更新日期：2008-12-01 00:00:00

abstract：:1. Gamma-aminobutryic acid (GABA), a major inhibitory transmitter of the vertebrate retina, is synthesized from glutamate by L-glutamate decarboxylase (GAD) and mediates neuronal inhibition at GABAA receptors. GAD consists of two distinct molecular forms, GAD65 and GAD67, which have similar distribution patterns in th...

journal_title：Cellular and molecular neurobiology

authors： Brecha NC,Sternini C,Humphrey MF

更新日期：1991-10-01 00:00:00

abstract：:1. Radiotherapy has attracted increasing interest in recent years. It is known that ionizing radiation induces oxygen radical injury, whereas oxidative stress by the radiation can cause cellular responses to defense cellular injury. In this study, the metabolism of antioxidants in response to ionizing radiation to the...

journal_title：Cellular and molecular neurobiology

authors： Shimizu T,Iwanaga M,Yasunaga A,Urata Y,Goto S,Shibata S,Kondo T

更新日期：1998-06-01 00:00:00

abstract：:The original version of this article unfortunately contained a typo in co-author name. ...

journal_title：Cellular and molecular neurobiology

authors： Narayan A,Hunkele A,Xu J,Bassoni DL,Pasternak GW,Pan YX

更新日期：2020-10-31 00:00:00