Abstract:
:Alzheimer's disease (AD) is characterized by deposition of beta-amyloid peptides (Aβ) and progressive loss of neurons. Neural stem/progenitor cells (NSPCs) can proliferate and produce immature neurons even in the brain of AD patients. However, Aβ42 significantly decreased the expression of RhoC in NSPCs during the co-incubation (P < 0.01). Treating with RhoC siRNA prevented membrane from protrusion and led to a significant reduction in cell migration in responses to SDF-1. Compared with wild-type mice, the numbers of RhoC-immunoreactive cells in hippocampus and cortex were significantly down-regulated in APP/PS1 mice aged 9 months. The results suggest that Aβ42 down-regulates the expression of RhoC in NSPCs in vitro and in vivo; down-regulated RhoC expression results in decreased migration of NSPCs.
journal_name
Cell Mol Neurobioljournal_title
Cellular and molecular neurobiologyauthors
Zhang C,Ge X,Lok K,Zhao L,Yin M,Wang ZJdoi
10.1007/s10571-014-0026-0subject
Has Abstractpub_date
2014-04-01 00:00:00pages
409-17issue
3eissn
0272-4340issn
1573-6830journal_volume
34pub_type
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