Choroid plexus recovery after transient forebrain ischemia: role of growth factors and other repair mechanisms.

abstract：:Alzheimer disease is a complex neurodegenerative disorder. It is the common form of dementia in elderly people. The etiology of this disease is multifactorial, pathologically it is accompanied with accumulation of amyloid beta and neurofibrillary tangles. Accumulation of amyloid beta and mitochondrial dysfunction lead...

journal_title：Cellular and molecular neurobiology

authors： Sajjad N,Wani A,Sharma A,Ali R,Hassan S,Hamid R,Habib H,Ganai BA

更新日期：2019-04-01 00:00:00

abstract：:Neuropathic pain occurs as a result of peripheral or central nervous system injury. Its pathophysiology involves mainly a central sensitization mechanism that may be correlated to many molecules acting in regions involved in pain processing, such as the spinal cord. It has been demonstrated that reactive oxygen specie...

journal_title：Cellular and molecular neurobiology

authors： Guedes RP,Araújo AS,Janner D,Belló-Klein A,Ribeiro MF,Partata WA

更新日期：2008-12-01 00:00:00

abstract：:Microelectrophoretic application of sex hormones onto pineal cells in guinea pigs has shown different responses in pregnant females as compared to males. In pregnant females estrone caused excitation in 74% of the cells tested, while progesterone and testosterone, prolactin, and HCG were inhibitory in a majority of th...

journal_title：Cellular and molecular neurobiology

authors： Semm P,Demaine C,Vollrath L

更新日期：1981-09-01 00:00:00

abstract：:1. Long before onset of synaptogenesis in the chicken neural tube, the closely related enzymes butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) are expressed in a mutually exclusive manner. Accordingly, neuroblasts on the ventricular side of the neural tube transiently express BChE before they abruptly acc...

journal_title：Cellular and molecular neurobiology

authors： Layer PG

更新日期：1991-02-01 00:00:00

abstract：:We have screened new drugs with a view to developing effective drugs against glutamate-induced excitotoxicity. In the present work, we show effects of a new drug, 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride against glutamate-induced excitotoxicity in primary rat glial cultures. Pretreatment of glial cells...

journal_title：Cellular and molecular neurobiology

authors： Kim EA,Hahn HG,Kim KS,Kim TU,Choi SY,Cho SW

更新日期：2010-07-01 00:00:00

abstract：:Saturable sodium-independent taurine binding to mouse and rat brain synaptic membranes was exposed after two freezing-thawing cycles combined with Triton X-100 treatments. The amount of saturable taurine binding was fairly low but was enhanced after depletion of brain taurine. Saturable taurine binding was displaceabl...

journal_title：Cellular and molecular neurobiology

authors： Kontro P,Oja SS

更新日期：1983-06-01 00:00:00

abstract：:As a novel cell cycle inhibitor, PHB2 controls the G1/S transition in cycling cells in a complex manner. Its aberrant expression is closely related to cell carcinogenesis. While its expression and role in peripheral nervous system lesion and repair were still unknown. Here, we performed an acute sciatic nerve crush (S...

journal_title：Cellular and molecular neurobiology

authors： Long L,Huang Y,Wu H,Luan W,Zhang Q,Wen H,Ding T,Wang Y

更新日期：2013-07-01 00:00:00

abstract：:The insulin-like growth factor (IGF) system is linked to CNS pathological states. The functions of IGFs are modulated by a family of binding proteins termed insulin-like growth factor binding proteins (IGFBPs). Here, we demonstrate that IGFBP-6 may be associated with neuronal apoptosis in the processes of intracerebra...

journal_title：Cellular and molecular neurobiology

authors： Dai Q,Jiang P,Gu Y,Zhu L,Dai H,Yao Z,Liu H,Ma X,Duan C,Qu L

更新日期：2017-10-01 00:00:00

abstract：:: 1. Glutaric acidemia type I (GA I) is a neurometabolic disorder caused by deficiency of glutaryl-CoA dehydrogenase, which leads to tissue accumulation of predominantly glutaric acid (GA) and also 3-hydroxyglutaric acid to a lesser amount. Affected patients usually present progressive cortical atrophy and acute stria...

journal_title：Cellular and molecular neurobiology

authors： Latini A,Ferreira GC,Scussiato K,Schuck PF,Solano AF,Dutra-Filho CS,Vargas CR,Wajner M

更新日期：2007-06-01 00:00:00

abstract：:We demonstrated synchronous oscillation of intracellular Ca2+ in cultured-mouse mid-brain neurons. This synchronous oscillation was thought to result from spontaneous and synchronous neural bursts in a synaptic neural network. We also examined the role of endogenous dopamine in neural networks showing synchronous osci...

journal_title：Cellular and molecular neurobiology

authors： Yasumoto F,Negishi T,Ishii Y,Kyuwa S,Kuroda Y,Yoshikawa Y

更新日期：2004-02-01 00:00:00

abstract：:Ac2-26, a mimetic peptide of Annexin-A1, plays a vital role in the anti-inflammatory response mediated by astrocytes. In this study, we aimed to explore the underlying mechanisms of Ac2-26-mediated anti-inflammatory effect. Specifically, we investigated the inhibitory effects of Ac2-26 on lipopolysaccharide (LPS)-indu...

journal_title：Cellular and molecular neurobiology

authors： Luo Z,Wang H,Fang S,Li L,Li X,Shi J,Zhu M,Tan Z,Lu Z

更新日期：2020-05-01 00:00:00

abstract：:Accumulated evidence has shown that excessive reactive oxygen species (ROS) have been implicated in neuronal cell death related with various chronic neurodegenerative disorders. This study was designed to explore neuroprotective effects of ethyl acetate extract of Arctium lappa L. roots (EAL) on hydrogen peroxide (H2O...

journal_title：Cellular and molecular neurobiology

authors： Tian X,Guo LP,Hu XL,Huang J,Fan YH,Ren TS,Zhao QC

更新日期：2015-04-01 00:00:00

abstract：:1. An identified dopaminergic interneuron (RPeD1) of the snail Lymnaea stagnalis, makes specific synaptic connections with a number of target (VI and VJ) but not non-target (VF and RPB) neurons in vivo. When cultured in vitro with both target and non-target cells, RPeD1 re-establishes synapses with target cells only. ...

journal_title：Cellular and molecular neurobiology

authors： Spencer GE,Lukowiak K,Syed NI

更新日期：1996-10-01 00:00:00

abstract：:Endothelins have been implicated in the regulation of cell proliferation, differentiation, and apoptosis, but the mechanisms of these complex events are not yet fully understood. Although the nuclear factor-kappaB (NF-kappaB) was shown to play a prominent role in the above processes, its participation in endothelin re...

journal_title：Cellular and molecular neurobiology

authors： Mangelus M,Galron R,Naor Z,Sokolovsky M

更新日期：2001-12-01 00:00:00

abstract：:Cell cultures are characterized by their simplicity, controllability, and ability to provide detailed basic information on how a particular cell population responds to specific stimuli or insult. These characteristics led to their extensive application in the study of molecular interactions and represent a valuable to...

journal_title：Cellular and molecular neurobiology

authors： Roque C,Baltazar G

更新日期：2017-11-01 00:00:00

abstract：:1. Growth cones of cultured dorsal root ganglion neurons from mice were irradiated using a mercury lamp. 2. The flux of particles of fast retrograde axoplasmic transport decreased promptly after light irradiation without a change in velocity. 3. That of anterograde transport decreased as well, but with a significant l...

journal_title：Cellular and molecular neurobiology

authors： Kano M,Tashiro H,Kawakami T,Takenaka T,Gotoh H

更新日期：1995-06-01 00:00:00

abstract：:1. Gamma-aminobutryic acid (GABA), a major inhibitory transmitter of the vertebrate retina, is synthesized from glutamate by L-glutamate decarboxylase (GAD) and mediates neuronal inhibition at GABAA receptors. GAD consists of two distinct molecular forms, GAD65 and GAD67, which have similar distribution patterns in th...

journal_title：Cellular and molecular neurobiology

authors： Brecha NC,Sternini C,Humphrey MF

更新日期：1991-10-01 00:00:00

abstract：:The irrefutable change in the expression of brain-enriched microRNAs (miRNAs) following ischemic stroke has promoted the development of radical miRNA-based therapeutics encompassing neuroprotection and neuronal restoration. Our previous report on the systems-level prediction of miR-9 in post-stroke-induced neurogenesi...

journal_title：Cellular and molecular neurobiology

authors： Nampoothiri SS,Rajanikant GK

更新日期：2019-03-01 00:00:00

abstract：:P2X3 receptor expression in various tissues appears to be modulated by age. In the present study, we used single cell RT-PCR to determine the number of P2X3 positive myenteric neurons at different stages of guinea pig postnatal development, and we tested if similar changes also occur to other myenteric P2X receptors. ...

journal_title：Cellular and molecular neurobiology

authors： Loera-Valencia R,Jiménez-Vargas NN,Villalobos EC,Juárez EH,Lomas-Ramos TL,Espinosa-Luna R,Montaño LM,Huizinga JD,Barajas-López C

更新日期：2014-07-01 00:00:00

abstract：:1. Calcium binding properties were examined in VAT-1, an abundant 41-kDa membrane protein expressed in the cholinergic cynaptic vesicles of Torpedo. 2. An overlay assay, using 45Ca2+ as a tracer, demonstrated the ability of a recombinant VAT-1 produced from the IPTG-inducible pKK223-3 expression vector to bind calcium...

journal_title：Cellular and molecular neurobiology

authors： Levius O,Linial M

更新日期：1993-10-01 00:00:00

abstract：:Cannabinoid (CB) ligands have demonstrated neuroprotective properties. In this study we compared the effects of a diverse set of CB ligands against β amyloid-mediated neuronal toxicity and activated microglial-conditioned media-based neurotoxicity in vitro, and compared this with a capacity to directly alter β amyloid...

journal_title：Cellular and molecular neurobiology

authors： Janefjord E,Mååg JL,Harvey BS,Smid SD

更新日期：2014-01-01 00:00:00

abstract：:Metastasis of lung cancer to the brain is associated with poor outcomes and limited therapeutic options. The blood-brain barrier (BBB) plays a major role in brain metastasis. However, little is known about the role of pericytes in brain metastasis formation. This study aimed to reveal the interaction between pericytes...

journal_title：Cellular and molecular neurobiology

authors： Fujimoto T,Nakagawa S,Morofuji Y,Watanabe D,Ujifuku K,Horie N,Izumo T,Niwa M,Banks WA,Deli MA,Matsuo T

更新日期：2020-01-01 00:00:00

abstract：:1. The growth inhibitory factor (GIF) is a 68-amino acid protein which is capable of inhibiting the growth of neuronal cells in vitro. 2. We have cloned and sequenced the 5'-flanking region of the mouse GIF gene, which spans from the transcriptional initiation site to the -1854 nucleotide. 3. This region contains sequ...

journal_title：Cellular and molecular neurobiology

authors： Watabe M,Gross S,Lawyer C,Brewer GJ,Mashimo T,Watabe K

更新日期：1997-04-01 00:00:00

abstract：:We have used the nervous system of the medicinal leech as a preparation to study the molecular basis of neural repair. The leech central nervous system, unlike mammalian CNS, can regenerate to restore function, and contains identified nerve cells of known function and connectivity. We have constructed subtractive cDNA...

journal_title：Cellular and molecular neurobiology

authors： Wang WZ,Emes RD,Christoffers K,Verrall J,Blackshaw SE

更新日期：2005-03-01 00:00:00

abstract：:1. Antidepressants have been used clinically for many years; however, the neurochemical mechanism for their therapeutic effect has not been clarified yet. Recent reports indicate that chronic antidepressant treatment directly affects the postsynaptic membrane to increase the coupling between the stimulatory GTP-bindin...

journal_title：Cellular and molecular neurobiology

authors： Kamada H,Saito T,Hatta S,Toki S,Ozawa H,Watanabe M,Takahata N

更新日期：1999-02-01 00:00:00

abstract：:Repeated electrical stimulation results in development of seizures and a permanent increase in seizure susceptibility (kindling). The permanence of kindling suggests that chronic changes in gene expression are involved. Kindling at different sites produces specific effects on interictal behaviors such as spatial cogni...

journal_title：Cellular and molecular neurobiology

authors： Corcoran ME,Kroes RA,Burgdorf JS,Moskal JR

更新日期：2011-08-01 00:00:00

abstract：:We previously found that xanthotoxol, one of the major active ingredients in Cnidium monnieri (L.) Cusson, exerts protective effects in a rat model of focal cerebral ischemia/reperfusion injury by alleviating brain edema, inhibiting the neutrophil infiltration, and decreasing the expression of intercellular adhesion m...

journal_title：Cellular and molecular neurobiology

authors： He W,Chen W,Zhou Y,Tian Y,Liao F

更新日期：2013-07-01 00:00:00

abstract：:Contextual fear conditioning is a paradigm for investigating cellular mechanisms involved in hippocampus-dependent memory. Earlier, we showed that standardised extract of Bacopa monniera (CDRI-08) improves hippocampus-dependent learning in postnatal rats by elevating the level of serotonin (5-hydroxytryptamine, 5-HT),...

journal_title：Cellular and molecular neurobiology

authors： Preethi J,Singh HK,Venkataraman JS,Rajan KE

更新日期：2014-05-01 00:00:00

abstract：:1. In the retinal inner nuclear layer of the majority of species, a dopaminergic neuronal network has been visualized in either amacrine cells or the so-called interplexiform cells. 2. Binding studies of retinal dopamine receptors have revealed the existence of both D1- as well D2-subtypes. The D1-subtype was characte...

journal_title：Cellular and molecular neurobiology

authors： Schorderet M,Nowak JZ

更新日期：1990-09-01 00:00:00

abstract：:Perinatal hypoxia can lead to multiple chronic neurological deficits, e.g., mental retardation, behavioral abnormalities, and epilepsy. Levetiracetam (LEV), 2S-(2-oxo-1-pyrrolidiny1) butanamide, is an anticonvulsant drug with proven efficiency in treating patients with focal and generalized seizures. Rats were underwe...

journal_title：Cellular and molecular neurobiology

authors： Pozdnyakova N,Dudarenko M,Borisova T

更新日期：2019-07-01 00:00:00