Abstract：
:1. An identified dopaminergic interneuron (RPeD1) of the snail Lymnaea stagnalis, makes specific synaptic connections with a number of target (VI and VJ) but not non-target (VF and RPB) neurons in vivo. When cultured in vitro with both target and non-target cells, RPeD1 re-establishes synapses with target cells only. 2. To test whether exogenous dopamine exerts effects on the neurite outgrowth of both target and non-target neurons respectively, these cells were cultured in conditioned media (CM) in the presence of dopamine (10(-5) M). The growth of the non-target cells was severely restricted and retarded in the presence of dopamine. These data suggest that dopamine may regulate neurite outgrowth of non-target cells in culture. 3. The growth regulatory effects of dopamine on the non-target cells were blocked in the presence of a dopamine receptor antagonist (R(+) SCH-23390, 10(-4) M). These results indicate that dopamine-induced growth regulation of the non-target cells is mediated via dopamine receptors on these cells. 4. In the absence of conditioned media, dopamine was not sufficient to exert growth promoting effects on either target or non-target cells. 5. Taken together, our data show that dopamine differentially regulates growth of identified Lymnaea neurons in culture. Dopamine alone, however, is not sufficient to initiate and support neurite outgrowth from these cells. Rather, it functions to suppress the neurite outgrowth of the non-target cells, initiated by the conditioned media.
journal_name
Cell Mol Neurobioljournal_title
Cellular and molecular neurobiologyauthors
Spencer GE,Lukowiak K,Syed NIdoi
10.1007/BF02152058subject
Has Abstractpub_date
1996-10-01 00:00:00pages
577-89issue
5eissn
0272-4340issn
1573-6830journal_volume
16pub_type
杂志文章abstract：:1. Effects of 5-hydroxytryptamine (5-HT) on neuronal nicotinic acetylcholine (ACh) receptor channels were investigated by expressing cloned channel subunits in Xenopus oocytes. 2. When channels were expressed with a combination of alpha 3 and beta 4 subunits, 5-HT (10 to 300 microM) reversibly inhibited an inward curr...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/BF02071882
更新日期：1995-08-01 00:00:00
abstract：:Thyroid hormone (T(3)) plays an essential role in the central nervous system development. Astrocytes mediate many of the T(3) effects in the growth and differentiation of cerebellum. In culture, T(3) induces cerebellar astrocytes to secrete growth factors, mainly FGF(2), and alters the expression and organization of t...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-008-9260-7
更新日期：2008-09-01 00:00:00
abstract：:1. Compared to pineal N-acetyl transferase (NAT) activity, which exhibited a dramatic drop following acute light exposure at night, nocturnal rat pineal thyroxine type II 5'-deiodinase (5'-D) activity was minimally influenced by the same light exposure. The injection of cycloheximide, a potent inhibitor of protein syn...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/BF00711228
更新日期：1988-12-01 00:00:00
abstract：:The analgesia effects of intrathecal adenosine A1 receptor agonist, R-PIA, on the hyperalgesia and CSF-glutamate release after formalin injection into the rat paw were evaluated. R-PIA significantly and dose-dependently attenuated increases in flinching behavior, and this attenuating effect was reversed by the adenosi...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1023/a:1022997805525
更新日期：2003-04-01 00:00:00
abstract：:Neuroinflammation has become an important underlying factor in many cardiovascular disorders, including hypertension. Previously we showed that elevated angiotensin II (Ang II) and angiotensin II type I receptor (AT1R) expression levels can increase neuroinflammation leading to hypertension. We also found that kinin B...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-019-00778-1
更新日期：2020-07-01 00:00:00
abstract：:1. The HCS2 (Helix command specific 2) gene expressed in giant command neurons for withdrawal behavior of the terrestrial snail Helix lucorum encodes a unique hybrid precursor protein that contains a Ca-binding (EF-hand motif) protein and four small peptides (CNP1-CNP4) with similar Tyr-Pro-Arg-X aminoacid sequence at...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-006-9025-0
更新日期：2006-03-01 00:00:00
abstract：:Mental retardation, which occurs in phenylketonuric patients, is associated with increased levels of phenylalanine, increased oxidative stress, and an imbalance of amino acids in the brain. Recent studies have shown that oxidative stress plays a role in the pathogenesis of phenylketonuria. In this work, we aimed to co...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-017-0573-2
更新日期：2018-07-01 00:00:00
abstract：:1. Oxytocin and vasopressin secretion from the neurohypophysis (NHP) is evoked by strongly patterned bursts of action potentials. We studied excitation-secretion coupling in single isolated terminals of rat NHP using patch clamp and capacitance detection techniques. 2. The secretory response evoked by trains of depola...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1023/a:1022575126738
更新日期：1998-02-01 00:00:00
abstract：:The present study was undertaken to evaluate whether estrogen deprivation might lead to mitochondrial alteration of hippocampal neurons of ovariectomized (OVX) rats, and to evaluate the protective effect of estrogen and phytoestrogen on the mitochondrial alteration. First, OVX rats were used to mimic the pathologic ch...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-008-9265-2
更新日期：2008-09-01 00:00:00
abstract：:Alzheimer disease is a complex neurodegenerative disorder. It is the common form of dementia in elderly people. The etiology of this disease is multifactorial, pathologically it is accompanied with accumulation of amyloid beta and neurofibrillary tangles. Accumulation of amyloid beta and mitochondrial dysfunction lead...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-019-00656-w
更新日期：2019-04-01 00:00:00
abstract：:We have characterized a newly generated mouse model of obesity, a mouse strain deficient in all five previously described leptin receptor isoforms. These transgenic mice, named the db (333)/db (333) mice, were identified from an ENU mutagenesis screen and carry a point mutation in the seventh exon of the db gene encod...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-009-9427-x
更新日期：2010-01-01 00:00:00
abstract：:Diabetes damages the central nervous system, inducing cognitive dysfunction and structural changes, known as diabetic encephalopathy (DE). Some research suggests that the pathogenesis of DE may involve an inflammatory imbalance in the nervous system, along with β-amyloid deposition, similar to Alzheimer's disease. Les...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-015-0209-3
更新日期：2015-11-01 00:00:00
abstract：:Membrane responses to cyclic adenosine monophosphate (cAMP) injections have been studied by means of voltage clamp, Ca-indicator dye, and ion substitution techniques in identified neurons from the abdominal ganglion of Limax maximus. The ventral abdominal giant cell (AGC) displayed a response consisting of a decrease ...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/BF00733595
更新日期：1984-12-01 00:00:00
abstract：:1. Human medulloblastoma (ONS-76), a central nervous system (CNS)-derived undifferentiated cell line, was found to possess glial characteristics as defined by responses in the interferon (IFN) system; ONS-76 cells produced as much IFN-beta as human fibroblast and glioma cells by viral infection and poly(I):poly(C) ind...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1023/a:1026327309345
更新日期：1998-10-01 00:00:00
abstract：:1. Neural angiotensinergic circuitry located in the lamina terminalis has been proposed to be involved in blood pressure regulation and fluid homeostasis. 2. ANG II binding sites have been described to be localized throughout the lamina terminalis including the subfornical organ (SFO), the median preoptic nucleus (MnP...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1023/a:1007125413308
更新日期：2001-02-01 00:00:00
abstract：:1. Alzheimer's disease is characterized by the deposition in the brain of extracellular amyloid plaques and vascular deposits consisting mostly of amyloid beta-peptide (A beta). A beta, a polypeptide of 39-43 amino acids (M(r), approximately 4 kDa), is derived proteolytically from a family of proteins of 695-770 amino...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/BF02088713
更新日期：1994-08-01 00:00:00
abstract：:1. Estrogen exerts profound effects on mood, mental state and memory by acting on both "classical" monoamine and neuropeptide transmitter mechanisms in brain. Here we review an example of each type of action. 2. With respect to the effect of estrogen on central monoamine neurotransmission, low levels of estrogen in wo...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/BF02088099
更新日期：1996-06-01 00:00:00
abstract：:Thymosin-beta4 (Tbeta4) is a major actin monomer-binding peptide in mammalian tissues and plays a crucial role in the nervous system in synaptogenesis, neuronal survival and migration, axonal growth, and plastic changes of dendritic spines. However, it is unknown whether Tbeta4 is also involved in challenges with exte...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-009-9439-6
更新日期：2010-01-01 00:00:00
abstract：:1. Radiotherapy has attracted increasing interest in recent years. It is known that ionizing radiation induces oxygen radical injury, whereas oxidative stress by the radiation can cause cellular responses to defense cellular injury. In this study, the metabolism of antioxidants in response to ionizing radiation to the...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1023/a:1022525214871
更新日期：1998-06-01 00:00:00
abstract：:1. Sporadic Creutzfeldt-Jakob disease (CJD) is a rapidly progressive and fatal disease. Patients with CJD usually become akinetic mutism within approximately 6 months. In addition, clinical signs and symptoms at early stage of sporadic CJD may not be easy to distinguish from other neurodegenerative diseases by neurolo...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-006-9370-z
更新日期：2006-02-01 00:00:00
abstract：:Levels of cyclic nucleotides and ornithine decarboxylase (ODC) activity were examined following the application of various kinds of stimuli to superior cervical sympathetic ganglia (SCG), nodose ganglia, and vagus nerve fibers excised from the rat. The level of cyclic GMP in the SCG rose rapidly to about 4.5- to 7.5-f...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/BF00710944
更新日期：1984-03-01 00:00:00
abstract：:1. Chitin is known to promote skin wound healing. In this study, chitin, prepared from Zuwai crab shell, was used as a bridge between the proximal and distal stumps of cut hypoglossal nerves in shrews. We compared the effects of chitin on the regeneration of transected right hypoglossal nerve axons, with those of porc...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1023/a:1007055626632
更新日期：2000-10-01 00:00:00
abstract：:The contribution of axonal activity to the ionic currents which generate bursting pacemaker activity was studied by using the two-electrode voltage-clamp technique in Aplysia bursting neuron somata in conjunction with intraaxonal voltage recordings. Depolarizing voltage-clamp pulses applied to bursting cell somata tri...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/BF00711111
更新日期：1986-09-01 00:00:00
abstract：:The original version of the article unfortunately contained an error in the unit of the protein concentrations under 'Stereotactic Intraparenchymal Injections' subsection in 'Methods' section. ...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s10571-020-00872-9
更新日期：2020-07-01 00:00:00
abstract：:The original version of this article unfortunately contained a typo in co-author name. ...
journal_title：Cellular and molecular neurobiology
pub_type： 已发布勘误
doi：10.1007/s10571-020-00990-4
更新日期：2020-10-31 00:00:00
abstract：:Available treatment for Parkinson's disease (PD) is mainly symptomatic instead of halting or reversing degenerative processes affecting the disease. Research on the molecular pathogenesis of PD has suggested reduced trophic support as a possible cause or mediator of neurodegeneration. In animal models of the disease, ...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-009-9458-3
更新日期：2010-04-01 00:00:00
abstract：:1. We studied the effect of isolation stress in 3- and 12-month-old rats individually housed in metabolic cages for 7 days. Urine (24 hr) was collected daily from one group of animals of each age. The other group was tested in an open field and on a hot plate on days 1 and 7. 2. Total deambulation in the open-field te...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1023/a:1006984402291
更新日期：1999-10-01 00:00:00
abstract：:We have used the nervous system of the medicinal leech as a preparation to study the molecular basis of neural repair. The leech central nervous system, unlike mammalian CNS, can regenerate to restore function, and contains identified nerve cells of known function and connectivity. We have constructed subtractive cDNA...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-005-3151-y
更新日期：2005-03-01 00:00:00
abstract：:Spaceflight and simulated microgravity both affect learning and memory, which are mostly controlled by the hippocampus. However, data about molecular alterations in the hippocampus in real or simulated microgravity conditions are limited. Adult Wistar rats were recruited in the experiments. Here we analyzed whether sh...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-020-00922-2
更新日期：2020-07-18 00:00:00
abstract：:Cathepsin K deficiency in male mice (Ctsk-/-) results in decreased numbers of hippocampal astrocytes and altered neuronal patterning as well as learning and memory deficits. Additionally, cathepsin K carries essential roles in the thyroid gland where it contributes to the liberation of thyroid hormones (TH). Because T...
journal_title：Cellular and molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s10571-019-00765-6
更新日期：2020-07-01 00:00:00
