Sequence and functional analysis of the 5'-flanking region of the mouse growth inhibitory factor gene.

abstract：:The contribution of axonal activity to the ionic currents which generate bursting pacemaker activity was studied by using the two-electrode voltage-clamp technique in Aplysia bursting neuron somata in conjunction with intraaxonal voltage recordings. Depolarizing voltage-clamp pulses applied to bursting cell somata tri...

journal_title：Cellular and molecular neurobiology

authors： Kramer RH

更新日期：1986-09-01 00:00:00

abstract：:Adeno-associated virus (AAV) has distinct advantages over other viral vectors in delivering genes of interest to the brain. AAV mainly transfects neurons, produces no toxicity or inflammatory responses, and yields long-term transgene expression. In this study, we first tested the hypothesis that AAV serotype 2 (AAV2) ...

journal_title：Cellular and molecular neurobiology

authors： Lin LH,Dragon DN,Jin J,Talman WT

更新日期：2011-08-01 00:00:00

abstract：:The P2X4 receptor (P2X4R) is a member of a family of ATP-gated cation channels that are composed of three subunits. Each subunit has two transmembrane (TM) domains linked by a large extracellular loop and intracellularly located N- and C-termini. The receptors are expressed in excitable and non-excitable cells and hav...

journal_title：Cellular and molecular neurobiology

authors： Stojilkovic SS,Yan Z,Obsil T,Zemkova H

更新日期：2010-11-01 00:00:00

abstract：:1. We investigated the association of c-Jun with apoptosis within retinal tissue. Explants of the retina of neonatal rats were subject to a variety of procedures that cause apoptosis of specific classes of retinal cells at distinct stages of differentiation. The expression of c-Jun was detected by Western Blot, and im...

journal_title：Cellular and molecular neurobiology

authors： Chiarini LB,de Freitas FG,Leal-Ferreira ML,Tolkovsky A,Linden R

更新日期：2002-12-01 00:00:00

abstract：:1. We studied the effect of isolation stress in 3- and 12-month-old rats individually housed in metabolic cages for 7 days. Urine (24 hr) was collected daily from one group of animals of each age. The other group was tested in an open field and on a hot plate on days 1 and 7. 2. Total deambulation in the open-field te...

journal_title：Cellular and molecular neurobiology

authors： Gil MC,Aguirre JA,Lemoine AP,Segura ET,Barontini M,Armando I

更新日期：1999-10-01 00:00:00

abstract：:1. 3H-gamma-Aminobutyric acid (GABA) release elicited by a depolarizing K+ stimulus or by noradrenergic transmitter was examined in rat pineals in vitro. 2. The release of 3H-GABA was detectable at a 20 mM K+ concentration in medium and increased steadily up to 80 mM K+. 3. In a Ca2+-free medium 3H-GABA release elicit...

journal_title：Cellular and molecular neurobiology

authors： Rosenstein RE,Chuluyan HE,Pereyra EN,Cardinali DP

更新日期：1989-06-01 00:00:00

abstract：:GABA is an inhibitory neurotransmitter that appears to be associated with the action of volatile anesthetics. These anesthetics potentiate GABA-induced postsynaptic currents by synaptic GABAA receptors, although recent evidence suggests that these agents also significantly affect extrasynaptic GABA receptors. However,...

journal_title：Cellular and molecular neurobiology

authors： Diniz PH,Guatimosim C,Binda NS,Costa FL,Gomez MV,Gomez RS

更新日期：2014-01-01 00:00:00

abstract：:1. Synaptic vesicles (SVs) mediate fast regulated secretion of classical neurotransmitters. In order to perform their task SVs rely on a restrict set of membrane proteins. The mechanisms responsible for targeting these proteins to the SV membrane are still poorly understood. 2. Likewise, little is known about the intr...

journal_title：Cellular and molecular neurobiology

authors： Prado VF,Prado MA

更新日期：2002-12-01 00:00:00

abstract：:Neuropathic pain is diagnosed primarily by sensory dysfunction, which includes both spontaneous, and stimulus-evoked pain. Clinical evaluation highlights the disabilities which characterise this condition for most patients. Chronic constriction injury of the sciatic nerve (CCI) evokes sensory dysfunction characteristi...

journal_title：Cellular and molecular neurobiology

authors： Mor D,Keay KA

更新日期：2013-10-01 00:00:00

abstract：:1. Gene expression profiles in neural stem cell differentiation in vitro were determined by cDNA microarray analysis. 2. Total RNA was extracted and reverse transcripted into cDNA from differentiated and undifferentiated neural stem cells. The 33P labeled cDNA was hybridized with a cDNA microarray consisting of 14,000...

journal_title：Cellular and molecular neurobiology

authors： Wen T,Gu P,Minning TA,Wu Q,Liu M,Chen F,Liu H,Huang H

更新日期：2002-08-01 00:00:00

abstract：:Traumatic brain injury (TBI) causes permanent neurological and cognitive impairments. Effective pharmacological interventions remain elusive. Spermidine is a polyamine compound found in our body that may play a role in brain development and congenital function. In this study, we aimed to investigate the therapeutic po...

journal_title：Cellular and molecular neurobiology

authors： Huang J,Zhang H,Zhang J,Yu H,Lin Z,Cai Y

更新日期：2020-08-01 00:00:00

abstract：:Our previous study showed that RalA-binding protein 1 (RLIP76) is overexpressed in gliomas and is associated with higher tumour grade and decreased patient survival. Furthermore, RLIP76 downregulation increases chemosensitivity of glioma cells to temozolomide by inducing apoptosis. However, other mechanisms underlying...

journal_title：Cellular and molecular neurobiology

authors： Zhang C,Cai Z,Liang Q,Wang Q,Lu Y,Hu L,Hu G

更新日期：2017-04-01 00:00:00

abstract：:Cathepsin K deficiency in male mice (Ctsk-/-) results in decreased numbers of hippocampal astrocytes and altered neuronal patterning as well as learning and memory deficits. Additionally, cathepsin K carries essential roles in the thyroid gland where it contributes to the liberation of thyroid hormones (TH). Because T...

journal_title：Cellular and molecular neurobiology

authors： Dauth S,Rakov H,Sîrbulescu RF,Ilieş I,Weber J,Batbajar Dugershaw B,Braun D,Rehders M,Wirth EK,Führer D,Schweizer U,Brix K

更新日期：2020-07-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is an adult-onset, progressive, and fatal neurodegenerative disease caused by selective loss of motor neurons. Both ALS model mice and patients with sporadic ALS have increased levels of prostaglandin E2 (PGE2). Furthermore, the protein levels of microsomal PGE synthase-1 and cycloo...

journal_title：Cellular and molecular neurobiology

authors： Miyagishi H,Kosuge Y,Takano A,Endo M,Nango H,Yamagata-Murayama S,Hirose D,Kano R,Tanaka Y,Ishige K,Ito Y

更新日期：2017-04-01 00:00:00

abstract：:1. Two giant peptidergic neurons, VD1 and RPD2, of the visceral ganglion and right parietal ganglion of Lymnaea stagnalis, respectively, play an important role in the modulation of complex physiological and behavioral adjustments that occur as a result of changes in O2 availability. 2. By cDNA cloning, we have identif...

journal_title：Cellular and molecular neurobiology

authors： Bogerd J,Van Kesteren RE,Van Heerikhuizen H,Geraerts WP,Veenstra J,Smit AB,Joosse J

更新日期：1993-04-01 00:00:00

abstract：:Secretory phospholipases A2 (sPLA2) form a diverse family of enzymes involved in physiologic and pathologic processes. Common among all sPLA2 is the ability to cleave acyl groups of phospholipids at C2 of the glycerol backbone, thereby releasing fatty acid and a lysophospholipid. Several sPLA2 have been cloned and cha...

journal_title：Cellular and molecular neurobiology

authors： Kolko M,Christoffersen NR,Varoqui H,Bazan NG

更新日期：2005-11-01 00:00:00

abstract：:1. A novel tridecapeptide was isolated from extracts of bovine adrenal medulla chromaffin vesicles and the primary structure determined to be SVPHFSDEDKDPE. 2. This peptide is identical to the C termini of human and porcine 7B2 and is highly homologous to the same region of the mouse and Xenopus lavis protein. 3. In a...

journal_title：Cellular and molecular neurobiology

authors： Sigafoos J,Chestnut WG,Merrill BM,Taylor LC,Diliberto EJ Jr,Viveros OH

更新日期：1993-06-01 00:00:00

abstract：:Saturable sodium-independent taurine binding to mouse and rat brain synaptic membranes was exposed after two freezing-thawing cycles combined with Triton X-100 treatments. The amount of saturable taurine binding was fairly low but was enhanced after depletion of brain taurine. Saturable taurine binding was displaceabl...

journal_title：Cellular and molecular neurobiology

authors： Kontro P,Oja SS

更新日期：1983-06-01 00:00:00

abstract：:The inactivation process of the calcium current (ICa) was investigated in a molluscan neuron which was perfused intracellularly and voltage-clamped using a suction pipette technique. The decay phase of the ICa contained a very slowly inactivated component (persistent inward current; PIC). The decay time constant of th...

journal_title：Cellular and molecular neurobiology

authors： Oyama Y,Akaike N,Nishi K

更新日期：1986-03-01 00:00:00

abstract：:The mammalian stress response is an integrated physiological and psychological reaction to real or perceived adversity. Glucocorticoids (GCs) are an important component of this response, acting to redistribute energy resources to both optimize survival in the face of challenge and restore homeostasis after the immedia...

journal_title：Cellular and molecular neurobiology

authors： Myers B,McKlveen JM,Herman JP

更新日期：2012-02-01 00:00:00

abstract：:Thymosin-beta4 (Tbeta4) is a major actin monomer-binding peptide in mammalian tissues and plays a crucial role in the nervous system in synaptogenesis, neuronal survival and migration, axonal growth, and plastic changes of dendritic spines. However, it is unknown whether Tbeta4 is also involved in challenges with exte...

journal_title：Cellular and molecular neurobiology

authors： Yang H,Cui GB,Jiao XY,Wang J,Ju G,You SW

更新日期：2010-01-01 00:00:00

abstract：:Neuroinflammation has become an important underlying factor in many cardiovascular disorders, including hypertension. Previously we showed that elevated angiotensin II (Ang II) and angiotensin II type I receptor (AT1R) expression levels can increase neuroinflammation leading to hypertension. We also found that kinin B...

journal_title：Cellular and molecular neurobiology

authors： Parekh RU,Robidoux J,Sriramula S

更新日期：2020-07-01 00:00:00

abstract：:Cell cycle re-entry, in which Fra-1 (transcription factor FOS-related antigen 1) plays an important role, is a key process in neuronal apoptosis. However, the expression and function of Fra-1 in retinal ganglion cell (RGC) apoptosis are unknown. To investigate whether Fra-1 was involved in RGC apoptosis, we performed ...

journal_title：Cellular and molecular neurobiology

authors： Liu X,Yang X,Zhu R,Dai M,Zhu M,Shen Y,Fang H,Sang A,Chen H

更新日期：2017-01-01 00:00:00

abstract：:Besides clinical and imaging techniques, there is a lack of molecular makers for the diagnosis of Parkinson's disease (PD). There is an immense need to develop biomarkers associated with the phenotypes which may be valuable for individualized treatment. Single-nucleotide polymorphisms (PARK2: Ser167Asn (G>A) and Val38...

journal_title：Cellular and molecular neurobiology

authors： Sanyal J,Anirudhan A,Banerjee TK,Guha G,Ramakrishnan Veerabathiran,Murugesan R,Ahmed SSJS,Rao VR

更新日期：2020-04-01 00:00:00

abstract：:1. Platelet-derived growth factor (PDGF) plays an important role not only in mesenchyme-derived tissues, but also in the mammalian central nervous system. The Patch mutant (Ph/+) lacks one copy of the PDGFR-alpha gene. However, it is not clear whether there are differences in expression of PDGF receptor alpha-subunit ...

journal_title：Cellular and molecular neurobiology

authors： Zhang FX,Hutchins JB

更新日期：1996-08-01 00:00:00

abstract：:1. An identified dopaminergic interneuron (RPeD1) of the snail Lymnaea stagnalis, makes specific synaptic connections with a number of target (VI and VJ) but not non-target (VF and RPB) neurons in vivo. When cultured in vitro with both target and non-target cells, RPeD1 re-establishes synapses with target cells only. ...

journal_title：Cellular and molecular neurobiology

authors： Spencer GE,Lukowiak K,Syed NI

更新日期：1996-10-01 00:00:00

abstract：:1. 125I-Endothelin (ET)-1 binding to the rat anterior pituitary gland was saturable and single, with a Kd of 71 pM and a Bmax of 120 fmol/mg. 2. When 1.0 microM BQ-123 (ETA antagonist) was added to the incubation buffer, the binding parameters were 8.3 pM and 8.0 fmol/mg, whereas 10 nM sarafotoxin S6c (ETB agonist) ex...

journal_title：Cellular and molecular neurobiology

authors： Himeno A,Shigematsu K,Taguchi T,Niwa M

更新日期：1998-08-01 00:00:00

abstract：:Chromogranin A (CgA) is a soluble glycoprotein stored along with hormones and neuropeptides in secretory granules of endocrine cells. In the last four decades, intense efforts have been concentrated to characterize the structure and the biological function of CgA. Besides, CgA has been widely used as a diagnostic mark...

journal_title：Cellular and molecular neurobiology

authors： Elias S,Delestre C,Courel M,Anouar Y,Montero-Hadjadje M

更新日期：2010-11-01 00:00:00

abstract：:The L-type calcium channel blocker nimodipine improves clinical outcome produced by delayed cortical ischemia or vasospasm associated with subarachnoid hemorrhage. While vasoactive mechanisms are strongly implicated in these therapeutic actions of nimodipine, we sought to test whether nimodipine might also regulate ne...

journal_title：Cellular and molecular neurobiology

authors： Koskimäki J,Matsui N,Umemori J,Rantamäki T,Castrén E

更新日期：2015-03-01 00:00:00

abstract：:Cell cultures are characterized by their simplicity, controllability, and ability to provide detailed basic information on how a particular cell population responds to specific stimuli or insult. These characteristics led to their extensive application in the study of molecular interactions and represent a valuable to...

journal_title：Cellular and molecular neurobiology

authors： Roque C,Baltazar G

更新日期：2017-11-01 00:00:00