当前位置： SCI文献检索 > CELLULAR AND MOLECULAR NEUROBIOLOGY期刊下所有文献 > Function of Cathepsin K in the Central Nervous System of Male Mice is Independent of Its Role in the Thyroid Gland.

Function of Cathepsin K in the Central Nervous System of Male Mice is Independent of Its Role in the Thyroid Gland.

Abstract：

:Cathepsin K deficiency in male mice (Ctsk-/-) results in decreased numbers of hippocampal astrocytes and altered neuronal patterning as well as learning and memory deficits. Additionally, cathepsin K carries essential roles in the thyroid gland where it contributes to the liberation of thyroid hormones (TH). Because TH are essential for brain development, in particular for the cerebellum, we investigated whether cathepsin K's function in the thyroid is directly linked to the brain phenotype of Ctsk-/- mice. Serum levels of thyroid stimulating hormone, brain concentrations of free TH, and deiodinase 2 (Dio2) activity in brain parenchyma as well as cerebellar development were comparable in Ctsk-/- and WT animals, suggesting regular thyroid states and TH metabolism. Despite unaltered transcript levels, protein expression of two TH transporters was enhanced in specific brain regions in Ctsk-/- mice, suggesting altered TH supply to these regions. Thyrotropin releasing hormone (Trh) mRNA levels were enhanced threefold in the hippocampus of Ctsk-/- mice. In the striatum of Ctsk-/- mice the mRNA for Dio2 and hairless were approximately 1.3-fold enhanced, while mRNA levels for monocarboxylate transporter 8 and Trh were reduced to 60% and 40%, respectively, pointing to altered striatal physiology. We conclude that the role of cathepsin K in the thyroid gland is not directly associated with its function in the central nervous system (CNS) of mice. Future studies will show whether the brain region-specific alterations in Trh mRNA may eventually result in altered neuroprotection that could explain the neurobehavioral defects of Ctsk-/- mice.

journal_name

Cell Mol Neurobiol

journal_title

Cellular and molecular neurobiology

authors

Dauth S,Rakov H,Sîrbulescu RF,Ilieş I,Weber J,Batbajar Dugershaw B,Braun D,Rehders M,Wirth EK,Führer D,Schweizer U,Brix K

doi

10.1007/s10571-019-00765-6

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

695-710

issue

5

eissn

0272-4340

issn

1573-6830

pii

10.1007/s10571-019-00765-6

journal_volume

40

pub_type

杂志文章

相关文献

CELLULAR AND MOLECULAR NEUROBIOLOGY文献大全
  • Experimental evidence that methylmalonic acid provokes oxidative damage and compromises antioxidant defenses in nerve terminal and striatum of young rats.

    abstract：:Methylmalonic acidemia and propionic acidemia are organic acidemias biochemically characterized by predominant tissue accumulation of methylmalonic acid (MMA) and propionic acid (PA), respectively. Affected patients present predominantly neurological symptoms, whose pathogenesis is not yet fully established. In the pr...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-011-9675-4

    authors： Fernandes CG,Borges CG,Seminotti B,Amaral AU,Knebel LA,Eichler P,de Oliveira AB,Leipnitz G,Wajner M

    更新日期：2011-07-01 00:00:00

  • The Tumorgenicity of Glioblastoma Cell Line U87MG Decreased During Serial In Vitro Passage.

    abstract：:Established cancer cell lines are routinely used to study cancer. Several factors such as serial passage may affect the reproducibility of experiments with cancer cell lines, but few researches focused on these changes. In the present study, different morphology and decreased tumorigenicity were observed in late passa...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-018-0592-7

    authors： Zeng Y,Wang X,Wang J,Yi R,Long H,Zhou M,Luo Q,Zhai Z,Song Y,Qi S

    更新日期：2018-08-01 00:00:00

  • Combined actions of Pb2+, Zn2+, and Al3+ on voltage-activated calcium channel currents.

    abstract：:1. Whole-cell patch clamp experiments were performed on rat dorsal root ganglion (DRG) neurons to investigate the actions of various combinations of Pb2+, Zn2+, and Al3+ on voltage-activated calcium channel currents (VACCCs). 2. Each of these metals has been shown to reduce VACCCs. 3. We investigated the effects of si...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/BF02088688

    authors： Platt B,Büsselberg D

    更新日期：1994-12-01 00:00:00

  • Alteration of calcium conductances and outward current by cyclic adenosine monophosphate (cAMP) in neurons of Limax maximus.

    abstract：:Membrane responses to cyclic adenosine monophosphate (cAMP) injections have been studied by means of voltage clamp, Ca-indicator dye, and ion substitution techniques in identified neurons from the abdominal ganglion of Limax maximus. The ventral abdominal giant cell (AGC) displayed a response consisting of a decrease ...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/BF00733595

    authors： Hockberger P,Connor JA

    更新日期：1984-12-01 00:00:00

  • Barriers in the immature brain.

    abstract：:1. The term "blood-brain barrier" describes a range of mechanisms that control the exchange of molecules between the internal environment of the brain and the rest of the body. 2. The underlying morphological feature of these barriers is the presence of tight junctions which are present between cerebral endothelial ce...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章,评审

    doi：10.1023/a:1006991809927

    authors： Saunders NR,Knott GW,Dziegielewska KM

    更新日期：2000-02-01 00:00:00

  • Calmodulin inhibitor-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells.

    abstract：:Calmodulin is known to transduce Ca(2+) signals by interacting with specific target proteins. In order to determine the role of calmodulin in regulating neuronal survival and death, we examined, whether calmodulin inhibitors induce caspase-dependent apoptotic cell death, and whether glycogen synthase kinase-3 is invol...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-007-9172-y

    authors： Takadera T,Ohyashiki T

    更新日期：2007-09-01 00:00:00

  • Effect of ventral noradrenergic bundle lesions on concentrations of monoamine neurotransmitters and metabolites in several discrete areas of the rat brain.

    abstract：:1. The effects of radiofrequency lesions of the ventral noradrenergic bundle (VNB) on monoamine and metabolite concentrations in several discrete areas of the rat hypothalamus were examined. Monoamines and metabolites were analyzed utilizing high-performance liquid chromatography coupled with electrochemical detection...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/BF00733792

    authors： Johnston CA,Mattiace LA,Negro-Vilar A

    更新日期：1987-12-01 00:00:00

  • Annexin-1 Mimetic Peptide Ac2-26 Suppresses Inflammatory Mediators in LPS-Induced Astrocytes and Ameliorates Pain Hypersensitivity in a Rat Model of Inflammatory Pain.

    abstract：:Ac2-26, a mimetic peptide of Annexin-A1, plays a vital role in the anti-inflammatory response mediated by astrocytes. In this study, we aimed to explore the underlying mechanisms of Ac2-26-mediated anti-inflammatory effect. Specifically, we investigated the inhibitory effects of Ac2-26 on lipopolysaccharide (LPS)-indu...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-019-00755-8

    authors： Luo Z,Wang H,Fang S,Li L,Li X,Shi J,Zhu M,Tan Z,Lu Z

    更新日期：2020-05-01 00:00:00

  • Response of substances co-expressed in hypothalamic magnocellular neurons to osmotic challenges in normal and Brattleboro rats.

    abstract：:The intention of this review is to emphasize the current knowledge about the extent and importance of the substances co-localized with magnocellular arginine vasopressin (AVP) and oxytocin (OXY) as potential candidates for the gradual clarification of their actual role in the regulation of hydromineral homeostasis. Ma...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章,评审

    doi：10.1007/s10571-008-9306-x

    authors： Bundzikova J,Pirnik Z,Zelena D,Mikkelsen JD,Kiss A

    更新日期：2008-12-01 00:00:00

  • The rate of Tau synthesis is differentially regulated during postnatal development in mouse cerebellum.

    abstract：:1. Tau, which is a microtubule-associated protein, with mRNA targeted to the axon and growth cone, is involved in axonal elongation. During postnatal development in mouse, Tau expression in cerebellar granule cells is reduced afte the second postnatal week. The aim of this work was to study the regulation of the rate ...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1023/a:1013823524302

    authors： Vilá-Ortiz GJ,Santa-Coloma TA,Carminatti H,Radrizzani M

    更新日期：2001-10-01 00:00:00

  • Overexpression of alpha-synuclein down-regulates BDNF expression.

    abstract：:Parkinson's disease (PD) is a chronic progressive neurodegenerative movement disorder characterized by the selective loss of nigrostriatal dopaminergic neurons. However, the molecular pathways leading to the dopaminergic neuron degeneration have remained obscure until recently. Reports demonstrated that reduction of b...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-010-9523-y

    authors： Yuan Y,Sun J,Zhao M,Hu J,Wang X,Du G,Chen NH

    更新日期：2010-08-01 00:00:00

  • pERK1/2 Peripheral Recruitment and Filopodia Protrusion Augment Oligodendrocyte Progenitor Cell Migration: Combined Effects of PDGF-A and Fibronectin.

    abstract：:Oligodendrocyte progenitor cell (OPC) migration is critical for effective myelination of the central nervous system. Not only during normal myelination but also during remyelination, the growth factors (GFs) and extracellular matrix (ECM) protein affect the OPC migration. Studies showed the altered levels of GFs and E...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-016-0359-y

    authors： Tripathi A,Parikh ZS,Vora P,Frost EE,Pillai PP

    更新日期：2017-03-01 00:00:00

  • Role of Microglia in Regulating Cholesterol and Tau Pathology in Alzheimer's Disease.

    abstract：:Cholesterol, a principal constituent of the cell membrane, plays a crucial role in the brain by regulating the synaptic transmission, neuronal signaling, as well as neurodegenerative diseases. Defects in the cholesterol trafficking are associated with enhanced generation of hyperphosphorylated Tau and Amyloid-β protei...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章,评审

    doi：10.1007/s10571-020-00883-6

    authors： Nanjundaiah S,Chidambaram H,Chandrashekar M,Chinnathambi S

    更新日期：2020-05-28 00:00:00

  • Proteomic Analysis of the Antidepressant Effects of Shen-Zhi-Ling in Depressed Patients: Identification of Proteins Associated with Platelet Activation and Lipid Metabolism.

    abstract：:Shen-Zhi-Ling (SZL) is a Chinese medicine formulated from a Kai-Xin-San decoction that is commonly used to treat depression caused by dual deficiencies in the heart and spleen. However, the underlying mechanisms remain unclear. We investigated biological changes in depression patients (DPs) exhibiting antidepressant r...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s10571-018-0582-9

    authors： Chen C,Hu Y,Dong XZ,Zhou XJ,Mu LH,Liu P

    更新日期：2018-07-01 00:00:00

  • The use of competitive PCR mimic to evaluate a Limulus lambda phage genomic DNA library.

    abstract：:1. A lambda phage genomic DNA library for Limulus (L.) polyphemus brain was constructed using the AGEM-12 vector and the host strain KW251. 2. The primary library contained approximately 1.275 x 10(6) independent clones, increasing upon amplfication to 6.66 x 10(9) pfu/ml in a total volume of 58 ml. 3. A total of 28 c...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1023/a:1007027232412

    authors： Wang Y,Cao Z,Reid EA,Newkirk RF,Ivy MT,Townsel JG

    更新日期：2000-08-01 00:00:00

  • Serine Racemase Expression by Striatal Neurons.

    abstract：:D-serine is synthesized by serine racemase (SR) and is a co-agonist at forebrain N-methyl-D-aspartate receptors (NMDARs). D-serine and SR are expressed primarily in neurons, but not in quiescent astrocytes. In this study, we examined the localization of D-serine and SR in the mouse striatum and the effects of genetica...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-020-00880-9

    authors： Takagi S,Puhl MD,Anderson T,Balu DT,Coyle JT

    更新日期：2020-05-22 00:00:00

  • Changes in the levels of p-ERK, p-CREB, and c-fos in rat mesocorticolimbic dopaminergic system after morphine-induced conditioned place preference: the role of acute and subchronic stress.

    abstract：:ERK pathway plays a critical role in the cellular adaptive responses to environmental changes. Stressful conditions can induce the activation of activate ERK, and its downstream targets, CREB and c-fos, in neural cells. Exposure to opioids has the same effect. In this study, we investigated the effects of morphine-ind...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-013-0011-z

    authors： Haghparast A,Fatahi Z,Alamdary SZ,Reisi Z,Khodagholi F

    更新日期：2014-03-01 00:00:00

  • Inflammatory Profiles of the Interleukin Family and Network in Cerebral Hemorrhage.

    abstract：:Cerebral hemorrhage is a series of devastating cerebrovascular diseases with high mortality, morbidity and recurrence rate. Localized and systemic immuno-reactions are involved. Aggregation of immunocytes, which were both recruited from the peripheral circulation and resident in the central nervous system, is induced ...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章,评审

    doi：10.1007/s10571-018-0601-x

    authors： Ye L,Gao L,Cheng H

    更新日期：2018-10-01 00:00:00

  • Insulin-like growth factor-1 prevents dorsal root ganglion neuronal tyrosine kinase receptor expression alterations induced by dideoxycytidine in vitro.

    abstract：:Dideoxycytidine (zalcitabine, ddC) produces neurotoxic effects. It is particularly important to understand the toxic effects of ddC on different subpopulations of dorsal root ganglion (DRG) neurons which express distinct tyrosine kinase receptor (Trk) and to find therapeutic factors for prevention and therapy for ddC-...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-013-0001-1

    authors： Liu H,Lu J,He Y,Yuan B,Li Y,Li X

    更新日期：2014-03-01 00:00:00

  • Cholinesterases during development of the avian nervous system.

    abstract：:1. Long before onset of synaptogenesis in the chicken neural tube, the closely related enzymes butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) are expressed in a mutually exclusive manner. Accordingly, neuroblasts on the ventricular side of the neural tube transiently express BChE before they abruptly acc...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章,评审

    doi：10.1007/BF00712798

    authors： Layer PG

    更新日期：1991-02-01 00:00:00

  • DNA immunization against amyloid beta 42 has high potential as safe therapy for Alzheimer's disease as it diminishes antigen-specific Th1 and Th17 cell proliferation.

    abstract：:The pathogenesis of Alzheimer's disease (AD) has been strongly associated with the accumulation of amyloid beta (Aβ) peptides in brain, and immunotherapy targeting Aβ provides potential for AD prevention. A clinical trial in which AD patients were immunized with Aβ42 peptide was stopped when 6% of participants showed ...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-011-9680-7

    authors： Lambracht-Washington D,Qu BX,Fu M,Anderson LD Jr,Stüve O,Eagar TN,Rosenberg RN

    更新日期：2011-08-01 00:00:00

  • Hirudo medicinalis: a platform for investigating genes in neural repair.

    abstract：:We have used the nervous system of the medicinal leech as a preparation to study the molecular basis of neural repair. The leech central nervous system, unlike mammalian CNS, can regenerate to restore function, and contains identified nerve cells of known function and connectivity. We have constructed subtractive cDNA...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-005-3151-y

    authors： Wang WZ,Emes RD,Christoffers K,Verrall J,Blackshaw SE

    更新日期：2005-03-01 00:00:00

  • Intracellular localization of the HCS2 gene products in identified snail neurons in vivo and in vitro.

    abstract：:1. The HCS2 (Helix command specific 2) gene expressed in giant command neurons for withdrawal behavior of the terrestrial snail Helix lucorum encodes a unique hybrid precursor protein that contains a Ca-binding (EF-hand motif) protein and four small peptides (CNP1-CNP4) with similar Tyr-Pro-Arg-X aminoacid sequence at...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-006-9025-0

    authors： Ivanova JL,Leonova OG,Popenko VI,Ierusalimsky VN,Korshunova TA,Boguslavsky DV,Malyshev AY,Balaban PM,Belyavsky AV

    更新日期：2006-03-01 00:00:00

  • Nitric oxide potentiates TNF-α-induced neurotoxicity through suppression of NF-κB.

    abstract：:Modulation of enzyme activity through nitrosylation has recently been identified as a new physiological activity of nitric oxide (NO). We hypothesized that NO enhances the TNF-α-induced death of retinal neurons through a suppression of nuclear factor-κB (NF-κB) by nitrosylation. In this study, cells from the RGC-5 lin...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-011-9739-5

    authors： Nakaizumi A,Horie T,Kida T,Kurimoto T,Sugiyama T,Ikeda T,Oku H

    更新日期：2012-01-01 00:00:00

  • Interferon yield and MHC antigen expression of human medulloblastoma cells and its suppression during dibutyryl cyclic AMP-induced differentiation: do medulloblastoma cells derive from bipotent neuronal and glial progenitors?

    abstract：:1. Human medulloblastoma (ONS-76), a central nervous system (CNS)-derived undifferentiated cell line, was found to possess glial characteristics as defined by responses in the interferon (IFN) system; ONS-76 cells produced as much IFN-beta as human fibroblast and glioma cells by viral infection and poly(I):poly(C) ind...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1023/a:1026327309345

    authors： Park KC,Shimizu K,Hayakawa T

    更新日期：1998-10-01 00:00:00

  • Enhanced BDNF signaling is associated with an antidepressant-like behavioral response and changes in brain monoamines.

    abstract：:1. Neurotrophins and serotonin have both been implicated in the pathophysiology of depression and in the mechanisms of antidepressant treatments. 2. Brain-derived neurotrophic factor (BDNF) influences the growth and plasticity of serotonergic (5-HT) neurons via the activation of trkB receptor. 3. Transgenic mice overe...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-005-8468-z

    authors： Koponen E,Rantamäki T,Voikar V,Saarelainen T,MacDonald E,Castrén E

    更新日期：2005-09-01 00:00:00

  • Myosin IIA Regulated Tight Junction in Oxygen Glucose-Deprived Brain Endothelial Cells Via Activation of TLR4/PI3K/Akt/JNK1/2/14-3-3ε/NF-κB/MMP9 Signal Transduction Pathway.

    abstract：:Non-muscle myosin heavy chain IIA (NMMHC IIA), a member of Myosin II family, plays a critical role in various cellular physiological processes. Our previous research had suggested that NMMHC IIA could participate in regulating tight junction morphological changes induced by ischemia stroke. Thus, in the current study,...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-019-00654-y

    authors： Lv Y,Liu W,Ruan Z,Xu Z,Fu L

    更新日期：2019-03-01 00:00:00

  • Pentosan polysulfate regulates scavenger receptor-mediated, but not fluid-phase, endocytosis in immortalized cerebral endothelial cells.

    abstract：:1. Effects of pentosan polysulfate (PPS) and the structurally related sulfated polyanions dextran sulfate, fucoidan, and heparin on the scavenger receptor-mediated and fluidphase endocytosis in GP8 immortalized rat brain endothelial cells were investigated. 2. Using 1,1'-dioctadecyl-3,3,3,3'-tetramethylindocarboxyamin...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1023/a:1007007026500

    authors： Deli MA,Abrahám CS,Takahata H,Katamine S,Niwa M

    更新日期：2000-12-01 00:00:00

  • Down-regulation of N-type voltage-activated Ca2+ channels by gabapentin.

    abstract：:1. Although the cellular and molecular mechanisms of the anticonvulsant action of gabapentin (GBP) remain incompletely described, in vitro studies have shown that GBP binds to the alpha2delta subunit of the high voltage-activated (HVA) Ca2+ channels. 2. In this report, we analyzed the effects of GBP on the functional ...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1023/a:1019865822069

    authors： Vega-Hernández A,Felix R

    更新日期：2002-04-01 00:00:00

  • Local loperamide inhibits thermal hyperalgesia but not mechanical allodynia induced by intratibial inoculation of melanoma cells in mice.

    abstract：:The stimulation of peripheral opioid receptors counteracts thermal hyperalgesia produced by the intratibial inoculation of NCTC 2472 cells in mice, through the activation of the nitric oxide/cGMP/ATP-sensitive K+-channels (NO/cGMP/K(+) (ATP)) cascade (Menéndez et al. 2007, Neuropharmacology 53:71-80). We aimed to eluc...

    journal_title：Cellular and molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s10571-008-9272-3

    authors： Curto-Reyes V,Juárez L,García-Pérez E,Fresno MF,Hidalgo A,Menéndez L,Baamonde A

    更新日期：2008-11-01 00:00:00