Microarray analysis of neural stem cell differentiation in the striatum of the fetal rat.

abstract：:(1) This study was to evaluate the anti-cholinesterase (ChE), cognition enhancing and neuroprotective effects of FS-0311, a bis-huperzine B derivative. (2) ChE activity was evaluated using a spectrophotometric method. Cognitive deficits in mice were induced by scopolamine or transient brain ischemia and reperfusion. W...

journal_title：Cellular and molecular neurobiology

authors： Wang ZF,Yan J,Fu Y,Tang XC,Feng S,He XC,Bai DL

更新日期：2008-02-01 00:00:00

abstract：:(1) There is increasing evidence that the cerebral endothelium and the blood-brain barrier (BBB) plays an important role in the oxidative stress-induced brain damage. The aim of the present study was to investigate the role of interendothelial junctional proteins in the BBB permeability increase induced by oxidative s...

journal_title：Cellular and molecular neurobiology

authors： Krizbai IA,Bauer H,Bresgen N,Eckl PM,Farkas A,Szatmári E,Traweger A,Wejksza K,Bauer HC

更新日期：2005-02-01 00:00:00

abstract：:Oligodendrocyte precursor cell (OPC) maturation requires membrane addition for myelin sheath formation. Since the Rab system has been shown to contribute to membrane addition in other cell types, in this study, we explored the role of Rab in OPC maturation. SiRNA and shRNA techniques and conditional knockout mice prov...

journal_title：Cellular and molecular neurobiology

authors： Zhang ZH,Zhao WQ,Ma FF,Zhang H,Xu XH

更新日期：2017-10-01 00:00:00

abstract：:We have used the nervous system of the medicinal leech as a preparation to study the molecular basis of neural repair. The leech central nervous system, unlike mammalian CNS, can regenerate to restore function, and contains identified nerve cells of known function and connectivity. We have constructed subtractive cDNA...

journal_title：Cellular and molecular neurobiology

authors： Wang WZ,Emes RD,Christoffers K,Verrall J,Blackshaw SE

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:The diagnosis of multiple sclerosis (MS) is still challenging recently due to the lack of a specific diagnostic test. Proteomics analysis was applied to biomarkers discovery and their pathways study. METHODS:First, the proteins of CSF from MS patients and control group were analyzed individually with 2D-DIGE...

journal_title：Cellular and molecular neurobiology

authors： Qin Z,Qin Y,Liu S

更新日期：2009-03-01 00:00:00

abstract：:1. Nitric oxide (NO) is thought to play a neuromodulatory role in the nervous system of vertebrate and invertebrate species. In the hornworm Manduca sexta, NO-mediated signaling has been implicated in behavioral and developmental processes, but its exact function in neurons is unknown. In this study, we identify speci...

journal_title：Cellular and molecular neurobiology

authors： Zayas RM,Trimmer BA

更新日期：2007-03-01 00:00:00

abstract：:1. Hypothalamic magnocellular neurons synthesize, store, and secrete large quantities of the neuropeptides, vasopressin (VP) and oxytocin (OT), which are synthesized as protein precursors also containing proteins called neurophysins. These protein precursors are sorted through the regulated secretory pathway (RSP), pa...

journal_title：Cellular and molecular neurobiology

authors： Zhang BJ,Yamashita M,Fields R,Kusano K,Gainer H

更新日期：2005-06-01 00:00:00

abstract：:The L-type calcium channel blocker nimodipine improves clinical outcome produced by delayed cortical ischemia or vasospasm associated with subarachnoid hemorrhage. While vasoactive mechanisms are strongly implicated in these therapeutic actions of nimodipine, we sought to test whether nimodipine might also regulate ne...

journal_title：Cellular and molecular neurobiology

authors： Koskimäki J,Matsui N,Umemori J,Rantamäki T,Castrén E

更新日期：2015-03-01 00:00:00

abstract：:Podoplanin (PDPN) is a mucin-type transmembrane sialoglycoprotein expressed in multiple tissues in adult animals, including the brain, lungs, kidney, and lymphoid organs. Studies of this molecule have demonstrated its great importance in tumor metastasis, platelet aggregation, and lymphatic vessel formation. However, ...

journal_title：Cellular and molecular neurobiology

authors： Song Y,Shen J,Lin Y,Shen J,Wu X,Yan Y,Zhou L,Zhang H,Zhou Y,Cao M,Liu Y

更新日期：2014-08-01 00:00:00

abstract：:Spinal cord injury (SCI) remains a formidable challenge in the clinic. In the current study, we examined the effects of the TLX gene on the proliferation and neuronal differentiation of dermal multipotent stem cells (DMSCs) in vitro and the potential of these cells to improve SCI in rats in vivo. DMSCs were stably tra...

journal_title：Cellular and molecular neurobiology

authors： Wang T,Ren X,Xiong J,Zhang L,Qu J,Xu W

更新日期：2011-04-01 00:00:00

abstract：:Microelectrophoretic application of sex hormones onto pineal cells in guinea pigs has shown different responses in pregnant females as compared to males. In pregnant females estrone caused excitation in 74% of the cells tested, while progesterone and testosterone, prolactin, and HCG were inhibitory in a majority of th...

journal_title：Cellular and molecular neurobiology

authors： Semm P,Demaine C,Vollrath L

更新日期：1981-09-01 00:00:00

abstract：:1. Amphetamine-induced c-fos and egr-1 expression in the striatum was used as a model in which to study the effects of antisense oligodeoxynucleotides (ODNs) directed at c-fos. Using direct infusions of ODNs into the striata of animals we have demonstrated that c-fos antisense ODNs retain most of their biological acti...

journal_title：Cellular and molecular neurobiology

authors： Chiasson BJ,Armstrong JN,Hooper ML,Murphy PR,Robertson HA

更新日期：1994-10-01 00:00:00

abstract：:Voltage-gated sodium channels are crucial mediators of neuronal damage in ischemic and excitotoxicity disease models. Fenamates have been reported to have anti-inflammatory properties following a decrease in prostaglandin synthesis. Several researches showed that fenamates appear to be ion channel modulators and poten...

journal_title：Cellular and molecular neurobiology

authors： Sun JF,Zhao MY,Xu YJ,Su Y,Kong XH,Wang ZY

更新日期：2020-11-01 00:00:00

abstract：:1. Accumulation of different c-erbA transcripts was studied, during rat brain maturation and in cortical neurons differentiating in a serum-free medium, by quantitative Northern blot hybridization. 2. The alpha and beta forms of c-erbA mRNAs exhibit different patterns of accumulation, with a precocious increase in the...

journal_title：Cellular and molecular neurobiology

authors： Castiglia D,Cestelli A,Di Liegro C,Bonfanti L,Di Liegro I

更新日期：1992-06-01 00:00:00

abstract：:1. Besides having a role in signal transduction, trimeric G proteins may also be involved in membrane trafficking events. In chromaffin cells, G alpha o has been found associated with the membrane of secretory granules. Here we examined the role of Go in regulated exocytosis using pressure microinjection combined with...

journal_title：Cellular and molecular neurobiology

authors： Vitale N,Gonon F,Thiersé D,Aunis D,Bader MF

更新日期：1997-02-01 00:00:00

abstract：AIMS:Treatments that increase acetylcholine release from brain slices decrease the synthesis of phosphatidylcholine by, and its levels in, the slices. We examined whether adding cytidine or uridine to the slice medium, which increases the utilization of choline to form phospholipids, also decreases acetylcholine levels...

journal_title：Cellular and molecular neurobiology

authors： Ulus IH,Watkins CJ,Cansev M,Wurtman RJ

更新日期：2006-07-01 00:00:00

abstract：:1. Long before onset of synaptogenesis in the chicken neural tube, the closely related enzymes butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) are expressed in a mutually exclusive manner. Accordingly, neuroblasts on the ventricular side of the neural tube transiently express BChE before they abruptly acc...

journal_title：Cellular and molecular neurobiology

authors： Layer PG

更新日期：1991-02-01 00:00:00

abstract：:Modulation of enzyme activity through nitrosylation has recently been identified as a new physiological activity of nitric oxide (NO). We hypothesized that NO enhances the TNF-α-induced death of retinal neurons through a suppression of nuclear factor-κB (NF-κB) by nitrosylation. In this study, cells from the RGC-5 lin...

journal_title：Cellular and molecular neurobiology

authors： Nakaizumi A,Horie T,Kida T,Kurimoto T,Sugiyama T,Ikeda T,Oku H

更新日期：2012-01-01 00:00:00

abstract：:Levels of cyclic nucleotides and ornithine decarboxylase (ODC) activity were examined following the application of various kinds of stimuli to superior cervical sympathetic ganglia (SCG), nodose ganglia, and vagus nerve fibers excised from the rat. The level of cyclic GMP in the SCG rose rapidly to about 4.5- to 7.5-f...

journal_title：Cellular and molecular neurobiology

authors： Ando M,Miwa M,Nagata Y

更新日期：1984-03-01 00:00:00

abstract：:Overexpression of suppressor of cytokine signalling 2 (SOCS2) has been shown to promote hippocampal neurogenesis in vivo and promote neurite outgrowth of neurons in vitro. In the adult mouse brain, SOCS2 is most highly expressed in the hippocampal CA3 region and at lower levels in the dentate gyrus, an expression patt...

journal_title：Cellular and molecular neurobiology

authors： Basrai HS,Turbic A,Christie KJ,Turnley AM

更新日期：2017-07-01 00:00:00

abstract：:(1) Following acute spinal cord injury, progesterone modulates several molecules essential for motoneuron function, although the morphological substrates for these effects are unknown. (2) The present study analyzed morphological changes in motoneurons distal to the lesion site from rats with or without progesterone t...

journal_title：Cellular and molecular neurobiology

authors： González SL,López-Costa JJ,Labombarda F,González Deniselle MC,Guennoun R,Schumacher M,De Nicola AF

更新日期：2009-02-01 00:00:00

abstract：:1. Taurine applied to mouse brain slices evokes a long-lasting enhancement (LLE) of corticostriatal synaptic transmission, LLE(TAU). 2. The occurrence of LLE(TAU) was significantly decreased in the presence of the specific antagonists at either D1 (SCH23390) or D2 (raclopride) dopamine (DA) receptors. 3. LLE(TAU) was ...

journal_title：Cellular and molecular neurobiology

authors： Chepkova AN,Sergeeva OA,Haas HL

更新日期：2005-06-01 00:00:00

abstract：:The insulin-like growth factor (IGF) system is linked to CNS pathological states. The functions of IGFs are modulated by a family of binding proteins termed insulin-like growth factor binding proteins (IGFBPs). Here, we demonstrate that IGFBP-6 may be associated with neuronal apoptosis in the processes of intracerebra...

journal_title：Cellular and molecular neurobiology

authors： Dai Q,Jiang P,Gu Y,Zhu L,Dai H,Yao Z,Liu H,Ma X,Duan C,Qu L

更新日期：2017-10-01 00:00:00

abstract：:1. Calcium binding properties were examined in VAT-1, an abundant 41-kDa membrane protein expressed in the cholinergic cynaptic vesicles of Torpedo. 2. An overlay assay, using 45Ca2+ as a tracer, demonstrated the ability of a recombinant VAT-1 produced from the IPTG-inducible pKK223-3 expression vector to bind calcium...

journal_title：Cellular and molecular neurobiology

authors： Levius O,Linial M

更新日期：1993-10-01 00:00:00

abstract：:1. The aim of the present study is to map the incipient phase of Fos expression in the sacral spinal cord neuronal pools of multiple cauda equina constrictions canine model. 2. Fos-positive neurons were found bilaterally in the lateral portion of superficial dorsal horn layers (Laminae I-III) and along the lateral edg...

journal_title：Cellular and molecular neurobiology

authors： Orendácová J,Marsala M,Cízková D,Kafka J,Raceková E,Sulla I,Vanický I,Marsala J

更新日期：2001-08-01 00:00:00

abstract：:1. The term "blood-brain barrier" describes a range of mechanisms that control the exchange of molecules between the internal environment of the brain and the rest of the body. 2. The underlying morphological feature of these barriers is the presence of tight junctions which are present between cerebral endothelial ce...

journal_title：Cellular and molecular neurobiology

authors： Saunders NR,Knott GW,Dziegielewska KM

更新日期：2000-02-01 00:00:00

abstract：:1. Alzheimer's disease is characterized by the deposition in the brain of extracellular amyloid plaques and vascular deposits consisting mostly of amyloid beta-peptide (A beta). A beta, a polypeptide of 39-43 amino acids (M(r), approximately 4 kDa), is derived proteolytically from a family of proteins of 695-770 amino...

journal_title：Cellular and molecular neurobiology

authors： Lahiri DK

更新日期：1994-08-01 00:00:00

abstract：:1. Although the cellular and molecular mechanisms of the anticonvulsant action of gabapentin (GBP) remain incompletely described, in vitro studies have shown that GBP binds to the alpha2delta subunit of the high voltage-activated (HVA) Ca2+ channels. 2. In this report, we analyzed the effects of GBP on the functional ...

journal_title：Cellular and molecular neurobiology

authors： Vega-Hernández A,Felix R

更新日期：2002-04-01 00:00:00

abstract：:1. Studies conducted on the rat arcuate nucleus, an area involved in the development and control of LH and FSH secretion, have shown the existence of hormonally regulated developmental sex differences in synaptic patterns and estrogen-induced synaptic plasticity during adult life. Several questions raised by these fin...

journal_title：Cellular and molecular neurobiology

authors： Naftolin F,Leranth C,Horvath TL,Garcia-Segura LM

更新日期：1996-04-01 00:00:00

abstract：:The expression of muscarinic acetylcholine binding sites and of cholinesterases was studied in extracts prepared from discrete regions of the human fetal brain, between the gestational ages of 14 and 24 weeks. The specific binding of [3H]N-methyl-4-piperidyl benzilate [( 4H]-4NMPB) to muscarinic binding sites ranged b...

journal_title：Cellular and molecular neurobiology

authors： Egozi Y,Sokolovsky M,Schejter E,Blatt I,Zakut H,Matzkel A,Soreq H

更新日期：1986-03-01 00:00:00