Suppression of glutamate-induced excitotoxicity by 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride in rat glial cultures.

abstract：:Abeta accumulation, a hallmark of Alzheimer's disease, promotes the disease progress in multiple facets. Abeta is formed through amyloidogenic cleavage pathway of amyloid precursor protein (APP). Production of Abeta can be decreased via activation of 5-HT2C receptor, which enhances alternative APP non-amyloidogenic cl...

journal_title：Cellular and molecular neurobiology

authors： Tian XL,Yu LH,Li WQ,Hu Y,Yin M,Wang ZJ

更新日期：2015-04-01 00:00:00

abstract：:Transient forebrain ischemia and reperfusion induces delayed neuronal death (DND) in the hippocampal Cornu Ammonis 1 (CA1) subfield of stroke-prone spontaneously hypertensive rat (SHRSP). The vulnerability to DND is potentially related to the genetic susceptibility to stroke in this strain. To elucidate the mechanism ...

journal_title：Cellular and molecular neurobiology

authors： Daisu M,Hatta T,Sakurai-Yamashita Y,Nabika T,Moritake K

更新日期：2009-06-01 00:00:00

abstract：:1. Angiotensin II receptors have been studied by quantitative autoradiography in selected brain areas of young (2-week-old) and adult (8-week-old) rats. 2. In young rats, angiotensin II receptors were present in brain areas which did not express receptors in the adult brain, such as thalamic nuclei, cortical areas, an...

journal_title：Cellular and molecular neurobiology

authors： Tsutsumi K,Saavedra JM

更新日期：1991-04-01 00:00:00

abstract：:1. An identified dopaminergic interneuron (RPeD1) of the snail Lymnaea stagnalis, makes specific synaptic connections with a number of target (VI and VJ) but not non-target (VF and RPB) neurons in vivo. When cultured in vitro with both target and non-target cells, RPeD1 re-establishes synapses with target cells only. ...

journal_title：Cellular and molecular neurobiology

authors： Spencer GE,Lukowiak K,Syed NI

更新日期：1996-10-01 00:00:00

abstract：:Consisting of a fragment of ACTH(4-7) and C-terminal PGP tripeptide, the polypeptide Semax is successfully used for acute stroke therapy. Previous experiments showed rapid induction of Bdnf, Ngf, and TrkB expression in intact rat hippocampus following Semax treatment. To investigate the mRNA expression of neurotrophin...

journal_title：Cellular and molecular neurobiology

authors： Dmitrieva VG,Povarova OV,Skvortsova VI,Limborska SA,Myasoedov NF,Dergunova LV

更新日期：2010-01-01 00:00:00

abstract：AIM:In Alzheimer's disease (AD) it is well known that specific regions of the brain are particularly vulnerable to the pathologic insults of the disease. In particular, the hippocampus is affected very early in the disease and by end stage AD is ravaged by neurofibrillary tangles and senile plaques (i.e., the pathologi...

journal_title：Cellular and molecular neurobiology

authors： Armstrong DM,Sheffield R,Mishizen-Eberz AJ,Carter TL,Rissman RA,Mizukami K,Ikonomovic MD

更新日期：2003-10-01 00:00:00

abstract：:Early-life experiences have been linked to individual's epigenetic status and social behaviour. Therefore, the present study aims to test whether the presence of mother suppress the early-life stressful social experience (SSE)-induced effect on social behaviour of adolescent and adult rats, and associated epigenetic c...

journal_title：Cellular and molecular neurobiology

authors： Karen C,Rajan KE

更新日期：2019-04-01 00:00:00

abstract：:: 1. Glutaric acidemia type I (GA I) is a neurometabolic disorder caused by deficiency of glutaryl-CoA dehydrogenase, which leads to tissue accumulation of predominantly glutaric acid (GA) and also 3-hydroxyglutaric acid to a lesser amount. Affected patients usually present progressive cortical atrophy and acute stria...

journal_title：Cellular and molecular neurobiology

authors： Latini A,Ferreira GC,Scussiato K,Schuck PF,Solano AF,Dutra-Filho CS,Vargas CR,Wajner M

更新日期：2007-06-01 00:00:00

abstract：:1. Gene expression profiles in neural stem cell differentiation in vitro were determined by cDNA microarray analysis. 2. Total RNA was extracted and reverse transcripted into cDNA from differentiated and undifferentiated neural stem cells. The 33P labeled cDNA was hybridized with a cDNA microarray consisting of 14,000...

journal_title：Cellular and molecular neurobiology

authors： Wen T,Gu P,Minning TA,Wu Q,Liu M,Chen F,Liu H,Huang H

更新日期：2002-08-01 00:00:00

abstract：:1. Alzheimer's disease is characterized by the deposition in the brain of extracellular amyloid plaques and vascular deposits consisting mostly of amyloid beta-peptide (A beta). A beta, a polypeptide of 39-43 amino acids (M(r), approximately 4 kDa), is derived proteolytically from a family of proteins of 695-770 amino...

journal_title：Cellular and molecular neurobiology

authors： Lahiri DK

更新日期：1994-08-01 00:00:00

abstract：:1. Spatio-temporal changes in phosphorylated (pNFP) and nonphosphorylated (npNFP) neurofilament proteins were assessed immunocytochemicaly in adult rat cerebellum, 2-30 days following unilateral injection of kainic acid (KA) or physiological saline (s.c.). 2. Analysis of the staining intensity and pattern demonstrated...

journal_title：Cellular and molecular neurobiology

authors： Milenkovic I,Filipovic R,Nedeljkovic N,Pekovic S,Culic M,Rakic L,Stojiljkovic M

更新日期：2004-06-01 00:00:00

abstract：:In chromaffin cells, SNARE proteins, forming the basic exocytotic machinery are present in membrane clusters of 500-600 nm in diameter. These microdomains containing both SNAP-25 and syntaxin-1 are dynamic and the expression of altered forms of SNAREs modifies not only their motion but also the mobility of the associa...

journal_title：Cellular and molecular neurobiology

authors： Torregrosa-Hetland CJ,Villanueva J,López-Font I,Garcia-Martinez V,Gil A,Gonzalez-Vélez V,Segura J,Viniegra S,Gutiérrez LM

更新日期：2010-11-01 00:00:00

abstract：:1. We measured changes in resting membrane potential (Em) and Na-K pump activity, assayed by ouabain-sensitive 86Rb uptake, in response to carbamylcholine (CCh) and its continued presence in single rat skeletal myotubes in culture. 2. CCh caused immediate depolarization from control Em (-80 to -85 mV) to near 0 follow...

journal_title：Cellular and molecular neurobiology

authors： Brodie C,Sampson SR

更新日期：1988-12-01 00:00:00

abstract：:Cannabinoid (CB) ligands have demonstrated neuroprotective properties. In this study we compared the effects of a diverse set of CB ligands against β amyloid-mediated neuronal toxicity and activated microglial-conditioned media-based neurotoxicity in vitro, and compared this with a capacity to directly alter β amyloid...

journal_title：Cellular and molecular neurobiology

authors： Janefjord E,Mååg JL,Harvey BS,Smid SD

更新日期：2014-01-01 00:00:00

abstract：:Neuronal degeneration and astrogliosis are hallmarks of prion disease. Synthetic prion protein (PrP) peptide 106-126 (PrP106-126) can induce death of neurons and proliferation of astrocytes in vitro and this neurotoxic effect depends on the expression of cellular PrP (PrPC) and is hence believed to be PrP(C) -mediated...

journal_title：Cellular and molecular neurobiology

authors： Ning ZY,Zhao DM,Liu HX,Yang JM,Han CX,Cui YL,Meng LP,Wu CD,Liu ML,Zhang TX

更新日期：2005-12-01 00:00:00

abstract：:The NMDA receptor is the most widely studied ionotropic glutamate receptor, and it is central to many physiological and pathophysiological processes in the central nervous system. GluN2A is one of the two main types of GluN2 NMDA receptor subunits in the forebrain. The proper activity of GluN2A is important to brain f...

journal_title：Cellular and molecular neurobiology

authors： Sun Y,Zhan L,Cheng X,Zhang L,Hu J,Gao Z

更新日期：2017-04-01 00:00:00

abstract：:Perinatal hypoxia can lead to multiple chronic neurological deficits, e.g., mental retardation, behavioral abnormalities, and epilepsy. Levetiracetam (LEV), 2S-(2-oxo-1-pyrrolidiny1) butanamide, is an anticonvulsant drug with proven efficiency in treating patients with focal and generalized seizures. Rats were underwe...

journal_title：Cellular and molecular neurobiology

authors： Pozdnyakova N,Dudarenko M,Borisova T

更新日期：2019-07-01 00:00:00

abstract：:1. Hypothalamic magnocellular neurons synthesize, store, and secrete large quantities of the neuropeptides, vasopressin (VP) and oxytocin (OT), which are synthesized as protein precursors also containing proteins called neurophysins. These protein precursors are sorted through the regulated secretory pathway (RSP), pa...

journal_title：Cellular and molecular neurobiology

authors： Zhang BJ,Yamashita M,Fields R,Kusano K,Gainer H

更新日期：2005-06-01 00:00:00

abstract：:The sympathoneural and the adrenomedullary systems are involved in regulation of immune processes. Their impairment has been suggested in patients with rheumatoid arthritis (RA). In this study, sympathetic response to orthostasis was evaluated in 22 RA females with <40 years of age and in 15 matched healthy controls. ...

journal_title：Cellular and molecular neurobiology

authors： Vlcek M,Rovensky J,Eisenhofer G,Radikova Z,Penesova A,Kerlik J,Imrich R

更新日期：2012-07-01 00:00:00

abstract：:1. The visual transduction system of the vertebrate retina is a well-studied model for biochemical and molecular studies of signal transduction. The structure and function of rhodopsin, a prototypical G protein-coupled receptor, and transducin or Gt, the photoreceptor G protein, have been particularly well studied. Me...

journal_title：Cellular and molecular neurobiology

authors： Hamm HE

更新日期：1991-12-01 00:00:00

abstract：:The original version of the article unfortunately contained an error in the unit of the protein concentrations under 'Stereotactic Intraparenchymal Injections' subsection in 'Methods' section. ...

journal_title：Cellular and molecular neurobiology

authors： Riabinska A,Zille M,Terzi MY,Cordell R,Nieminen-Kelhä M,Klohs J,Piña AL

更新日期：2020-07-01 00:00:00

abstract：:An understanding of pattern recognition receptors (PRRs) and immunomodulatory approach based on activation of these receptors has provided insights critical for the management of neurological health disorders. Toll-like receptors (TLRs) are one of the most widely explored PRRs and have been exploited in the recent pas...

journal_title：Cellular and molecular neurobiology

authors： Tiwari RK,Singh S,Gupta CL,Bajpai P

更新日期：2020-07-20 00:00:00

abstract：:Oxidative glutamate toxicity plays a vital role in the neurodegeneration diseases, including Alzheimer's diseases (AD). This study set out with the aim to investigate the beneficial effects of fangchinoline (FAN), a natural alkaloid, against glutamate-induced oxidative damage, and to clarify the underlying cellular an...

journal_title：Cellular and molecular neurobiology

authors： Bao F,Tao L,Zhang H

更新日期：2019-11-01 00:00:00

abstract：:Thymosin-beta4 (Tbeta4) is a major actin monomer-binding peptide in mammalian tissues and plays a crucial role in the nervous system in synaptogenesis, neuronal survival and migration, axonal growth, and plastic changes of dendritic spines. However, it is unknown whether Tbeta4 is also involved in challenges with exte...

journal_title：Cellular and molecular neurobiology

authors： Yang H,Cui GB,Jiao XY,Wang J,Ju G,You SW

更新日期：2010-01-01 00:00:00

abstract：:Hemorrhagic transformation (HT) is a common complication after thrombolysis with recombinant tissue-type plasminogen activator (rt-PA) in ischemic stroke. In this article, recent research progress of HT in vivo and in vitro studies was reviewed. We have discussed new potential mechanisms and possible experimental mode...

journal_title：Cellular and molecular neurobiology

authors： Liu C,Xie J,Sun S,Li H,Li T,Jiang C,Chen X,Wang J,Le A,Wang J,Li Z,Wang J,Wang W

更新日期：2020-10-30 00:00:00

abstract：:One of the few areas of the adult CNS, that are known to be competent for neuronal proliferation, is the subventricular zone (SVZ) lining the brain lateral ventricles. Cells proliferating in the SVZ migrate along a defined pathway, the rostral migratory stream (RMS), where their proliferation continues until reaching ...

journal_title：Cellular and molecular neurobiology

authors： Bálentová S,Raceková E,Martoncíková M,Misúrová E

更新日期：2006-10-01 00:00:00

abstract：:1. Amphetamine-induced c-fos and egr-1 expression in the striatum was used as a model in which to study the effects of antisense oligodeoxynucleotides (ODNs) directed at c-fos. Using direct infusions of ODNs into the striata of animals we have demonstrated that c-fos antisense ODNs retain most of their biological acti...

journal_title：Cellular and molecular neurobiology

authors： Chiasson BJ,Armstrong JN,Hooper ML,Murphy PR,Robertson HA

更新日期：1994-10-01 00:00:00

abstract：:Cell cultures are characterized by their simplicity, controllability, and ability to provide detailed basic information on how a particular cell population responds to specific stimuli or insult. These characteristics led to their extensive application in the study of molecular interactions and represent a valuable to...

journal_title：Cellular and molecular neurobiology

authors： Roque C,Baltazar G

更新日期：2017-11-01 00:00:00

abstract：:Non-muscle myosin heavy chain IIA (NMMHC IIA), a member of Myosin II family, plays a critical role in various cellular physiological processes. Our previous research had suggested that NMMHC IIA could participate in regulating tight junction morphological changes induced by ischemia stroke. Thus, in the current study,...

journal_title：Cellular and molecular neurobiology

authors： Lv Y,Liu W,Ruan Z,Xu Z,Fu L

更新日期：2019-03-01 00:00:00

abstract：:MicroRNAs are small non-coding RNAs which mediate post-transcriptional gene regulation. Recently, microRNAs have also been found to be localized to the extracellular space, often encapsulated in secreted extracellular vesicles (EVs). This tandem of EVs and tissue-specific expressed/secreted microRNAs that can be taken...

journal_title：Cellular and molecular neurobiology

authors： Bronisz A,Godlewski J,Chiocca EA

更新日期：2016-04-01 00:00:00